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1. Full Text P2-027Impact of chemotherapy on overall survival and hospitalization in elderly patients with gastric cancer
by Murakawa, Yasuko and Sakayori, Masato and Otsuka, Kazunori
Annals of Oncology, ISSN 0923-7534, 10/2019, Volume 30, Issue Supplement_6
Abstract Background Research on chemotherapy (CT) for elderly patients with cancer is currently being performed. We studied how CT affects overall survival... 
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2. Full Text Lipid remodeling under acidic conditions and its interplay with low Pi stress in Arabidopsis
by Murakawa, Masato and Ohta, Hiroyuki and Shimojima, Mie
Plant Molecular Biology, ISSN 0167-4412, 9/2019, Volume 101, Issue 1, pp. 81 - 93
Here we show that accumulation of galactose-containing lipids in plastid membranes in shoots and the other membranes in roots maintains Arabidopsis growth... 
Life Sciences | Biochemistry, general | Plant Pathology | Galactolipid | Lipid remodeling | Phosphate starvation | Digalactosyldiacylglycerol (DGDG) | Acidic stress | Plant Sciences | MGDG synthase (MGD) | LOW-PH | ROOT | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHLOROPLAST | PLASMA-MEMBRANE | PLANT SCIENCES | INNER ENVELOPE | GALACTOLIPID SYNTHESIS | DIGALACTOSYLDIACYLGLYCEROL SYNTHASE | GENES | MGDG | Phosphates | Arabidopsis thaliana | Lipids | Analysis | Biodegradation | Membranes | Lipid composition | Starvation | Nutrient deficiency | Toxicity | Acidic soils | Phospholipid degradation | Roots | Acidification | Phosphorus | Phospholipids | Lipid metabolism | Shoots | Galactose
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3. Full Text O3-3-3The effectiveness of cancer chemotherapy among elderly patients: a retrospective study in Miyagi Cancer Center
by Murakawa, Yasuko and Sakayori, Masato and Otsuka, Kazunori
Annals of Oncology, ISSN 0923-7534, 10/2018, Volume 29, Issue suppl_7
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4. Full Text Klebsormidium flaccidum genome reveals primary factors for plant terrestrial adaptation
by Hori, Koichi and Maruyama, Fumito and Fujisawa, Takatomo and Togashi, Tomoaki and Yamamoto, Nozomi and Seo, Mitsunori and Sato, Syusei and Yamada, Takuji and Mori, Hiroshi and Tajima, Naoyuki and Moriyama, Takashi and Ikeuchi, Masahiko and Watanabe, Mai and Wada, Hajime and Kobayashi, Koichi and Saito, Masakazu and Masuda, Tatsuru and Sasaki-Sekimoto, Yuko and Mashiguchi, Kiyoshi and Awai, Koichiro and Shimojima, Mie and Masuda, Shinji and Iwai, Masako and Nobusawa, Takashi and Narise, Takafumi and Kondo, Satoshi and Saito, Hikaru and Sato, Ryoichi and Murakawa, Masato and Ihara, Yuta and Oshima-Yamada, Yui and Ohtaka, Kinuka and Satoh, Masanori and Sonobe, Kohei and Ishii, Midori and Ohtani, Ryosuke and Kanamori-Sato, Miyu and Honoki, Rina and Miyazaki, Daichi and Mochizuki, Hitoshi and Umetsu, Jumpei and Higashi, Kouichi and Shibata, Daisuke and Kamiya, Yuji and Sato, Naoki and Nakamura, Yasukazu and Tabata, Satoshi and Ida, Shigeru and Kurokawa, Ken and Ohta, Hiroyuki
Nature Communications, ISSN 2041-1723, 05/2014, Volume 5, Issue 1, p. 3978
The colonization of land by plants was a key event in the evolution of life. Here we report the draft genome sequence of the filamentous terrestrial alga... 
PHOTOPROTECTION | EVOLUTION | PROTEIN | GREEN-ALGA | SALICYLIC-ACID | MULTIDISCIPLINARY SCIENCES | LIGHT | LAND | MULTIPLE SEQUENCE ALIGNMENT | CYCLIC ELECTRON FLOW | INSIGHTS | Protein Structure, Tertiary | Electron Transport | Multigene Family | Signal Transduction | Genes, Plant | Fluorescence | Molecular Sequence Data | Chlorophyll - metabolism | Genome, Plant | Phylogeny | Streptophyta - genetics | Microscopy, Interference | Sequence Analysis, DNA | Adaptation, Physiological - genetics | Mass Spectrometry | Plant Growth Regulators - metabolism
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5. Full Text Impact of palliative chemotherapy and best supportive care on overall survival and length of hospitalization in patients with incurable Cancer: A 4-year single institution experience in Japan
by Murakawa, Yasuko and Sakayori, Masato and Otsuka, Kazunori
BMC Palliative Care, ISSN 1472-684X, 06/2019, Volume 18, Issue 1, pp. 45 - 8
This study aimed to analyze the determinants of patients' choice between palliative chemotherapy and best supportive care (BSC) and to investigate how this... 
Best supportive care | Hospitalization | Performance status | Palliative chemotherapy | Quality of life | Health care | Decision making | Colorectal cancer | Oncology | Patients | Cancer therapies | Stomach cancer | Esophagus | Confidence intervals | Chemotherapy | Medical prognosis | Palliative care | Tumors
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6. Full Text A Monogalactosyldiacylglycerol Synthase Found in the Green Sulfur Bacterium Chlorobaculum tepidum Reveals Important Roles for Galactolipids in Photosynthesis
by Shinji Masuda and Jiro Harada and Makio Yokono and Yuichi Yuzawa and Mie Shimojima and Kazuhiro Murofushi and Hironori Tanaka and Hanako Masuda and Masato Murakawa and Tsuyoshi Haraguchi and Maki Kondo and Mikio Nishimura and Hideya Yuasa and Masato Noguchi and Hirozo Oh-oka and Ayumi Tanaka and Hitoshi Tamiaki and Hiroyuki Ohta
The Plant Cell, ISSN 1040-4651, 7/2011, Volume 23, Issue 7, pp. 2644 - 2658
Monogalactosyldiacylglycerol (MGDG), which is conserved in almost all photosynthetic organisms, is the most abundant natural polar lipid on Earth. In plants,... 
Polymerase chain reaction | Enzymes | Chloroplasts | Galactolipids | Lipids | Biosynthesis | Plants | Photosynthesis | Plant cells | Chlorobi | PHOSPHATE STARVATION | NATURAL TRANSFORMATION | ARABIDOPSIS-THALIANA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT SCIENCES | CELL BIOLOGY | 3-DIMENSIONAL STRUCTURE | COMPLETE GENOME SEQUENCE | FMO ANTENNA PROTEIN | UDP-GLUCOSYLTRANSFERASE | CHLOROPLAST DEVELOPMENT | PHOTOSYSTEM-II | CHLOROBIUM-TEPIDUM | Chlorobi - chemistry | Arabidopsis - enzymology | Galactosyltransferases - classification | Molecular Sequence Data | Galactosyltransferases - genetics | Phylogeny | Genetic Complementation Test | Gene Knockdown Techniques | Arabidopsis Proteins - metabolism | Plants, Genetically Modified | Photosynthesis - physiology | Amino Acid Sequence | Chlorobi - enzymology | Arabidopsis Proteins - genetics | Chloroplasts - ultrastructure | Bacterial Proteins - genetics | Galactolipids - biosynthesis | Galactosyltransferases - metabolism | Chlorobi - physiology | Chloroplasts - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Phenotype | Sequence Alignment | Arabidopsis - anatomy & histology | Bacterial Proteins - metabolism | Bacterial Proteins - classification | Chlorobi - genetics | Phytochemistry | Diacylglycerol | Physiological aspects | Research | Plant lipids | Green sulfur bacteria
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7. Full Text ITPA gene variation and ribavirin‐induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin
by Murakawa, Miyako and Asahina, Yasuhiro and Nagata, Hiroko and Nakagawa, Mina and Kakinuma, Sei and Nitta, Sayuri and Kawai‐Kitahata, Fukiko and Otani, Satoshi and Kaneko, Shun and Miyoshi, Masato and Tsunoda, Tomoyuki and Asano, Yu and Sato, Ayako and Itsui, Yasuhiro and Azuma, Seishin and Nouchi, Toshihiko and Furumoto, Yohei and Asano, Tooru and Chuganji, Yoshimichi and Tohda, Shuji and Watanabe, Mamoru
Hepatology Research, ISSN 1386-6346, 10/2017, Volume 47, Issue 11, pp. 1212 - 1218
Aim Sofosbuvir (SOF) and ribavirin (RBV) combination therapy produces a sustained response in many patients with genotype 2 chronic hepatitis C. However,... 
hepatitis C virus | inosine triphosphatase | single nucleotide polymorphism | anemia | VIRUS | EFFICACY | CIRRHOSIS | ALPHA | INFECTION | OUTCOMES | GASTROENTEROLOGY & HEPATOLOGY | INTERFERON THERAPY | Medical research | Care and treatment | Anemia | Genes | Albumin | Glycosylated hemoglobin | Ribavirin | Complications and side effects | Medicine, Experimental | Genetic research | Genetic aspects | Single nucleotide polymorphisms | Hepatitis C | Hepatitis C virus | Genotype & phenotype | Hepatitis | Triphosphatase | Hemolytic anemia | Hemoglobin | Interferon | Genetic diversity | ITPA gene
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8. Full Text LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells
by Miyoshi, Masato and Kakinuma, Sei and Kamiya, Akihide and Tsunoda, Tomoyuki and Tsuchiya, Jun and Sato, Ayako and Kaneko, Shun and Nitta, Sayuri and Kawai-Kitahata, Fukiko and Murakawa, Miyako and Itsui, Yasuhiro and Nakagawa, Mina and Nakagawa, Mina and Azuma, Seishin and Nakauchi, Hiromitsu and Nakauchi, Hiromitsu and Asahina, Yasuhiro and Watanabe, Mamoru and Watanabe, Mamoru
Scientific Reports, ISSN 2045-2322, 02/2019, Volume 9, Issue 1, pp. 2072 - 13
Human induced pluripotent stem (iPS) cells can differentiate into hepatocyte lineages, although the phenotype of the differentiated cells is immature compared... 
PLURIPOTENT STEM-CELLS | DERIVATION | IN-VITRO | GENE | LHX2 | MULTIDISCIPLINARY SCIENCES | MOUSE | HUMAN LIVER | GENERATION | DIFFERENTIATION | FIBROBLASTS | Cell culture | Stellate cells | Phenotypes | Mesenchyme | Liver | Epithelium | Cell interactions | Progenitor cells | Homeobox | Genotype & phenotype | Vitamin A | Laminin | Hepatocytes | Collagen | Rodents | Cell lines | Stem cells | Pluripotency
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9. Full Text Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients
by Nitta, S and Asahina, Y and Kato, T and Tsuchiya, J and Inoue-Shinomiya, E and Sato, A and Tsunoda, T and Miyoshi, M and Kawai-Kitahate, F and Murakawa, M and Itsui, Y and Nakagawa, M and Azumal, S and Kakinuma, S and Hikita, H and Takehara, T and Watanabe, M
SCIENTIFIC REPORTS, ISSN 2045-2322, 04/2019, Volume 9, Issue 1, pp. 5722 - 9
Resistance-associated substitutions (RASs) of hepatitis C virus (HCV) in the NS5A region impair the efficacy of NS5A inhibitors. In this study, we evaluated... 
GENOTYPE 1 | VELPATASVIR | POLYMORPHISMS | EFFICACY | MULTIDISCIPLINARY SCIENCES | DACLATASVIR | GLOBAL EPIDEMIOLOGY | INHIBITOR | ANTIVIRAL DRUGS | HCV INFECTION | NS3 | Disease resistance | Hepatitis | Antigens | Clonal deletion | Infectivity | Viruses | Replication | Interferon | Hepatitis C | Patients | Ribavirin | Genotypes
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10. Full Text Bone morphogenetic protein‐4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells
by Goto, Fumio and Kakinuma, Sei and Miyoshi, Masato and Tsunoda, Tomoyuki and Kaneko, Shun and Sato, Ayako and Asano, Yu and Otani, Satoshi and Azuma, Seishin and Nagata, Hiroko and Kawai‐Kitahata, Fukiko and Murakawa, Miyako and Nitta, Sayuri and Itsui, Yasuhiro and Nakagawa, Mina and Asahina, Yasuhiro and Watanabe, Mamoru
Hepatology Research, ISSN 1386-6346, 08/2017, Volume 47, Issue 9, pp. 941 - 952
Aim Fetal hepatic stem/progenitor cells, called hepatoblasts, play central roles in liver organogenesis; however, molecular mechanisms regulating proliferation... 
cholangiocytic cyst | cyclinD1 | calcium/calmodulin‐dependent protein kinase II | Wnt5a | hepatoblast | calcium/calmodulin-dependent protein kinase II | PROGENITOR CELLS | SIGNALING PATHWAYS | MOUSE | MATURATION | HEPATOBLASTS | HEPATOCELLULAR-CARCINOMA | ONCOSTATIN-M | GROWTH-FACTOR | LIVER DEVELOPMENT | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Bone morphogenetic proteins | Analysis | Cell proliferation | Bone morphogenetic protein 4 | Phosphorylation | Wnt protein | Fetuses | Stem cell transplantation | Extracellular signal-regulated kinase | MAP kinase | AKT protein | Kinases | Organogenesis | Proteins | Molecular modelling | Calcium-binding protein | Stem cells | Ca2+/calmodulin-dependent protein kinase II
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11. Full Text Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C
by Nagata, Hiroko and Nakagawa, Mina and Asahina, Yasuhiro and Sato, Ayako and Asano, Yu and Tsunoda, Tomoyuki and Miyoshi, Masato and Kaneko, Shun and Otani, Satoshi and Kawai-Kitahata, Fukiko and Murakawa, Miyako and Nitta, Sayuri and Itsui, Yasuhiro and Azuma, Seishin and Kakinuma, Sei and Nouchi, Toshihiko and Sakai, Hideki and Tomita, Makoto and Watanabe, Mamoru and Ochanomizu Liver Conf Study Grp and Ochanomizu Liver Conference Study Group
Journal of Hepatology, ISSN 0168-8278, 2017, Volume 67, Issue 5, pp. 933 - 939
Graphical abstract 
Gastroenterology and Hepatology | HCC recurrence | Wisteria floribunda agglutinin positive Mac-2 binding protein | HCC occurrence | Hepatocarcinogenesis | Direct-acting antiviral agent | VIRUS-INFECTION | PROTEIN | ALPHA | RISK | RIBAVIRIN | HCV INFECTION | IL28B | SIMPLE NONINVASIVE INDEX | PREDICT | SIGNIFICANT FIBROSIS | GASTROENTEROLOGY & HEPATOLOGY | Membrane Glycoproteins - analysis | Japan - epidemiology | Risk Assessment - methods | Carcinoma, Hepatocellular - epidemiology | Carcinoma, Hepatocellular - prevention & control | Humans | Middle Aged | Neoplasm Recurrence, Local - virology | Plant Lectins - analysis | Hepatitis C, Chronic - complications | Neoplasm Recurrence, Local - etiology | alpha-Fetoproteins - analysis | Liver Neoplasms - etiology | Liver Neoplasms - physiopathology | Adult | Female | Liver Neoplasms - pathology | Antigens, Neoplasm - analysis | Receptors, N-Acetylglucosamine - analysis | Liver Neoplasms - prevention & control | Carcinoma, Hepatocellular - physiopathology | Biomarkers, Tumor - analysis | Risk Factors | Neoplasm Recurrence, Local - diagnosis | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Interferons - administration & dosage | Carcinoma, Hepatocellular - pathology | Aged | Biological response modifiers | Hepatitis C | Interferon
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12. Full Text Association of serum interferon‐λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct‐acting antiviral agents
by Inoue‐Shinomiya, Emi and Murakawa, Miyako and Asahina, Yasuhiro and Nakagawa, Mina and Tsuchiya, Jun and Sato, Ayako and Tsunoda, Tomoyuki and Miyoshi, Masato and Nitta, Sayuri and Kawai‐Kitahata, Fukiko and Itsui, Yasuhiro and Azuma, Seishin and Kakinuma, Sei and Murata, Kazumoto and Mizokami, Masashi and Watanabe, Mamoru
Hepatology Research, ISSN 1386-6346, 05/2019, Volume 49, Issue 5, pp. 500 - 511
Aim Although the efficacy of hepatitis C virus (HCV) treatment is improved dramatically by direct‐acting antiviral agents (DAAs), the assessment of... 
hepatitis C virus | interferon‐λ3 | HCC | direct‐acting antiviral agent | SVR | interferon-λ3 | direct-acting antiviral agent | Antiviral agents | Alanine | Liver | Hepatocellular carcinoma | Chemiluminescence | Enzyme immunoassay | Gene polymorphism | Carcinogenesis | Nodules | Hepatitis | Fibrosis | Alanine transaminase | Interferon | Hepatitis C
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13. Full Text Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus
by Kaneko, Shun and Kakinuma, Sei and Asahina, Yasuhiro and Kamiya, Akihide and Miyoshi, Masato and Tsunoda, Tomoyuki and Nitta, Sayuri and Asano, Yu and Nagata, Hiroko and Otani, Satoshi and Kawai-Kitahata, Fukiko and Murakawa, Miyako and Itsui, Yasuhiro and Nakagawa, Mina and Azuma, Seishin and Nakauchi, Hiromitsu and Nishitsuji, Hironori and Ujino, Saneyuki and Shimotohno, Kunitada and Iwamoto, Masashi and Watashi, Koichi and Wakita, Takaji and Watanabe, Mamoru
Scientific Reports, ISSN 2045-2322, 07/2016, Volume 6, Issue 1, p. 29358
Hepatitis B virus (HBV) is not eradicated by current antiviral therapies due to persistence of HBV covalently closed circular DNA (cccDNA) in host cells, and... 
CLOSED CIRCULAR DNA | HEPATOCYTES | ENZYME-INDUCTION | ENTRY | MULTIDISCIPLINARY SCIENCES | LIVER | HEPG2 CELLS | TAUROCHOLATE COTRANSPORTING POLYPEPTIDE | MEMBRANE TRANSPORTER | INFECTION | EXPRESSION | Cell Proliferation | Hepatitis B - metabolism | Hepatitis B - genetics | Humans | Hepatitis B - virology | DNA, Circular - genetics | Hepatocytes - metabolism | MAP Kinase Signaling System | Organic Anion Transporters, Sodium-Dependent - genetics | Hepatitis B - immunology | Hepatocytes - cytology | Transfection | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Hepatitis B virus - immunology | Induced Pluripotent Stem Cells - metabolism | DNA, Circular - immunology | Cell Line | Induced Pluripotent Stem Cells - virology | Hepatocytes - immunology | Immunity, Innate | Hepatitis B virus - physiology | Symporters - metabolism | Hep G2 Cells | DNA, Viral - immunology | Virus Replication | Models, Biological | Symporters - genetics | Hepatitis B virus - genetics | Hepatocytes - virology | Induced Pluripotent Stem Cells - immunology | DNA, Viral - genetics | Organic Anion Transporters, Sodium-Dependent - metabolism
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14. Full Text Hepatic IFNL4 expression is associated with non‐response to interferon‐based therapy through the regulation of basal interferon‐stimulated gene expression in chronic hepatitis C patients
by Murakawa, Miyako and Asahina, Yasuhiro and Kawai‐Kitahata, Fukiko and Nakagawa, Mina and Nitta, Sayuri and Otani, Satoshi and Nagata, Hiroko and Kaneko, Shun and Asano, Yu and Tsunoda, Tomoyuki and Miyoshi, Masato and Itsui, Yasuhiro and Azuma, Seishin and Kakinuma, Sei and Tanaka, Yasuhito and Iijima, Sayuki and Tsuchiya, Kaoru and Izumi, Namiki and Tohda, Shuji and Watanabe, Mamoru
Journal of Medical Virology, ISSN 0146-6615, 07/2017, Volume 89, Issue 7, pp. 1241 - 1247
Single nucleotide polymorphisms (SNPs) within or near interferon lambda 4 (IFNL4) gene located upstream of IFNL3 are associated with response to anti‐HCV... 
hepatitis C virus | genetic variation | innate immunity | interferon | gene expression | VIRUS | INTERLEUKIN 28B | RIBAVIRIN | LAMBDA 4 | ANTIVIRAL RESPONSE | IL28B | VIROLOGY | GENOTYPE 1 INFECTION | VIRAL CLEARANCE | GENOME-WIDE ASSOCIATION | Liver - virology | Ubiquitins - genetics | Humans | Middle Aged | Drug Resistance, Viral | Hepacivirus - genetics | Male | Interferons - therapeutic use | Interleukins - metabolism | Interleukins - genetics | Liver - immunology | Liver - drug effects | Adult | Female | Cytokines - genetics | Suppressor of Cytokine Signaling 1 Protein - genetics | Ribavirin - therapeutic use | Gene Expression Regulation | Interferon-alpha - therapeutic use | Genotype | Hepatitis C, Chronic - drug therapy | Ribavirin - adverse effects | Hepatitis C, Chronic - immunology | Aged | Polymorphism, Single Nucleotide | Hepatitis C, Chronic - genetics | Myxovirus Resistance Proteins - genetics | RNA, Messenger | Care and treatment | RNA | Genes | Genetic research | Interferon | Single nucleotide polymorphisms | Hepatitis C | Biological response modifiers | Hepatitis C virus | Gene expression | Therapy | Myxovirus resistance proteins | Liver | Linkage disequilibrium | Innate immunity | Infections | Single-nucleotide polymorphism | Immunity | Patients | Ribavirin | Hepatitis | Polyethylene glycol | Genotypes
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15. Full Text Arabidopsis phosphatidic acid phosphohydrolases are essential for growth under nitrogen-depleted conditions
by Yoshitake, Yushi and Sato, Ryoichi and Madoka, Yuka and Ikeda, Keiko and Murakawa, Masato and Suruga, Ko and Sugiura, Daisuke and Noguchi, Ko and Ohta, Hiroyuki and Shimojima, Mie
Frontiers in Plant Science, ISSN 1664-462X, 10/2017, Volume 8, p. 1847
The Arabidopsis homologs of mammalian lipin, PAH1 and PAH2, are cytosolic phosphatidic acid phosphohydrolases that are involved in phospholipid biosynthesis... 
Arabidopsis thaliana | Monogalactosyldiacylglycerol | Photosynthetic membrane | Lipin | Phosphatidic acid phosphohydrolase | Thylakoid membrane | Nitrogen starvation | Chloroplast | phosphatidic acid phosphohydrolase | nitrogen starvation | monogalactosyldiacylglycerol | SEEDLING GROWTH | PHYSIOLOGICAL-RESPONSES | ENVIRONMENTAL-CHANGES | PLANT SCIENCES | INNER ENVELOPE | GALACTOLIPID SYNTHESIS | chloroplast | thylakoid membrane | NITRATE TRANSPORTER NRT2.1 | photosynthetic membrane | GENE-EXPRESSION | STARVATION | lipin | PHOSPHOLIPASE D-EPSILON | PHOSPHATIDYLGLYCEROL BIOSYNTHESIS | Physiological aspects | Growth
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