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Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7691, pp. 189 - 194
Journal Article
Gynecologic Oncology Reports, ISSN 2352-5789, 02/2019, Volume 27, pp. 74 - 74
Journal Article
Pathology, ISSN 0031-3025, 02/2013, Volume 45, Issue 2, pp. 116 - 126
BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds to BRCA1. BAP1 is a tumour suppressor that is believed to mediate its... 
pathology | familial cancer | uveal melanoma | skin | diagnosis | inherited tumour susceptibility | melanoma | 3p21 loss syndrome | atypical Spitz tumour | germline mutation | BAP1 | Pathology | Inherited tumour susceptibility | Melanoma | Uveal melanoma | Atypical Spitz tumour | Familial cancer | Germline mutation | Skin | Diagnosis | PLEURAL MESOTHELIOMA | DNA-DAMAGE RESPONSE | BRCA1-ASSOCIATED PROTEIN-1 | RENAL-CELL CARCINOMA | BREAST-CANCER | POLYCOMB GROUP PROTEINS | SPITZ NEVI | HISTONE DEACETYLASE INHIBITORS | MALIGNANT MESOTHELIOMA | MYELODYSPLASTIC SYNDROMES | Neoplasms - metabolism | Carcinoma, Neuroendocrine - diagnosis | Melanoma - diagnosis | Humans | Lung Neoplasms - metabolism | Meningioma - genetics | Neoplasms - diagnosis | Paraganglioma - diagnosis | Adenocarcinoma - metabolism | Neoplasms - genetics | DNA Mutational Analysis | Melanoma - genetics | Gene Deletion | Nevus, Epithelioid and Spindle Cell - genetics | Skin Neoplasms - diagnosis | Tumor Suppressor Proteins - genetics | Biomarkers, Tumor - metabolism | Adenocarcinoma - genetics | Uveal Neoplasms - metabolism | Carcinoma, Neuroendocrine - metabolism | Lung Neoplasms - genetics | Melanoma - metabolism | Uveal Neoplasms - genetics | Genetic Predisposition to Disease | Meningioma - metabolism | Paraganglioma - genetics | Carcinoma, Neuroendocrine - genetics | Mesothelioma - diagnosis | Mesothelioma - genetics | Nevus, Epithelioid and Spindle Cell - metabolism | Ubiquitin Thiolesterase - genetics | Skin Neoplasms - metabolism | Immunohistochemistry - methods | Nevus, Epithelioid and Spindle Cell - diagnosis | Adenocarcinoma - diagnosis | Mesothelioma - metabolism | Paraganglioma - metabolism | Skin Neoplasms - genetics | Uveal Neoplasms - diagnosis | Biomarkers, Tumor - genetics | Meningioma - diagnosis | Mutation | Lung Neoplasms - diagnosis
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 12/2012, Volume 6, pp. 391 - 405
The purpose of this study is to review the development of BRAF inhibitors, with emphasis on the trials conducted with dabrafenib (GSK2118436) and the evolving... 
Vemurafenib | BRAF inhibitor | Clinical trial | GSK1120212 | GSK2118436 | BRAF mutation | clinical trial | CHEMISTRY, MEDICINAL | TUMOR PROGRESSION | vemurafenib | ACQUIRED-RESISTANCE | IMPROVED SURVIVAL | OPEN-LABEL | TYROSINE KINASE INHIBITORS | RANDOMIZED PHASE-III | RAS MUTATIONS | CUTANEOUS MELANOMA | BRAIN METASTASES | PHARMACOLOGY & PHARMACY | SQUAMOUS-CELL CARCINOMAS | Skin Neoplasms - drug therapy | Oximes - adverse effects | Humans | Oximes - therapeutic use | Antineoplastic Agents - therapeutic use | Neoplasm Metastasis | Antineoplastic Agents - adverse effects | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Imidazoles - therapeutic use | Skin Neoplasms - pathology | Imidazoles - adverse effects | Clinical Trials as Topic | Imidazoles - pharmacology | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Disease-Free Survival | Indoles - adverse effects | Sulfonamides - therapeutic use | Melanoma - drug therapy | Oximes - pharmacology | Sulfonamides - adverse effects | Indoles - therapeutic use | Chemotherapy, Combination | Care and treatment | Gene mutations | Melanoma | Research | Drug therapy | Observations | Cancer | Brain | Squamous cell carcinoma | Toxicity | MEK inhibitors | Clinical trials | MAP kinase | Metastasis | Kinases | Patients | Fever | Metastases | Proteins | Dacarbazine | Signal transduction | Chemotherapy | Protein kinase | New combinations | Response rates | Mutation | Genotypes
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7573, pp. 453 - 457
Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report... 
GENE | CHROMATIN | MULTIDISCIPLINARY SCIENCES | FRAMEWORK | RECEPTOR | NEUROBLASTOMA | MUTATIONS | DNA-SEQUENCING DATA | IDENTIFICATION | SEQ | DISCOVERY | NIH 3T3 Cells | Cell Proliferation | Molecular Weight | Histones - chemistry | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Molecular Sequence Data | RNA, Messenger - analysis | Isoenzymes - chemistry | RNA Polymerase II - metabolism | Neoplasms - genetics | HEK293 Cells | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Lysine - metabolism | Transcription Initiation, Genetic | Gene Expression Regulation, Neoplastic - genetics | Oncogenes - genetics | Introns - genetics | Signal Transduction | Isoenzymes - genetics | RNA, Messenger - genetics | Neoplasms - enzymology | Protein Structure, Tertiary - genetics | Neoplasms - drug therapy | Animals | Receptor Protein-Tyrosine Kinases - genetics | Cell Transformation, Neoplastic | Alleles | Cell Line, Tumor | Mice | Histones - metabolism | Isoenzymes - biosynthesis | Methylation | Isoenzymes - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - chemistry | Development and progression | Genetic aspects | Genetic transcription | Health aspects | Oncogenes | Cancer | Proteins | Phosphorylation | Thyroid cancer | Genes | Melanoma | Tumorigenesis | Metastasis | Kinases | Cancer therapies | Binding sites | Tumors
Journal Article
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 10, pp. 1226 - 1231
Journal Article