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Cell, ISSN 0092-8674, 10/2019, Volume 179, Issue 2, pp. 527 - 542.e19
Much of current molecular and cell biology research relies on the ability to purify cell types by fluorescence-activated cell sorting (FACS). FACS typically... 
single-cell transcriptomics | bisulphite sequencing | flow cytometry | optimization algorithm | FACS gate prediction and normalization | machine learning | cell type purification | zebrafish hematopoiesis | human pancreas
Journal Article
Developmental Cell, ISSN 1534-5807, 01/2019, Volume 48, Issue 1, pp. 32 - 48.e5
Cell fate transitions are essential for specification of stem cells and their niches, but the precise timing and sequence of molecular events during embryonic... 
hair follicle morphogenesis | stem cell niche | single cell | dermal condensate precursors | cell fate specification | dermal papilla | placode progenitors | hair follicle formation | SOX2 | MORPHOGENESIS | STEM-CELLS | HAIR-GROWTH | GENE-EXPRESSION | PROLIFERATION | DEVELOPMENTAL BIOLOGY | KAPPA-B | ENRICHMENT ANALYSIS | TRANSCRIPTOME ATLAS | PLASTICITY | CELL BIOLOGY
Journal Article
ISSN 0028-0836, 2017
During puberty, the mouse mammary gland develops into a highly branched epithelial network. Owing to the absence of exclusive stem cell markers, the location,... 
Mammary Glands, Animal | Cell Proliferation | Models, Molecular | Gene Expression Profiling | Stem Cells | Morphogenesis | Cell Lineage | Animals | Stochastic Processes | Female | Mice | Single-Cell Analysis | Sexual Maturation
Journal Article
Cell Reports, ISSN 2211-1247, 12/2017, Volume 21, Issue 11, pp. 3271 - 3284
Adult neurogenesis in the murine dentate gyrus occurs in a specialized microenvironment that sustains the generation of neurons during life. To fully... 
adult neurogenesis | dentate gyrus | single cell RNA sequencing | neural stem cells | hippocampal niche | neural progenitors | aging | microglia | IDENTITY | NEURAL STEM-CELLS | PROGENITORS | ADULT NEUROGENESIS | MICROGLIA | TRANSCRIPTIONAL NETWORK | MOUSE | BRAIN MACROPHAGES | DIVERSITY | SEQ | CELL BIOLOGY
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1469 - 10
Environmental stimuli often lead to heterogeneous cellular responses and transcriptional output. We developed single-cell RNA and Immunodetection (RAID) to... 
STEM-CELLS | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | TISSUES | SKIN | PROTEINS | EXPRESSION | Transcription | Stem cells | Keratinocytes | Intracellular | Focal adhesion kinase | Gene expression | Environmental effects
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2018, Volume 115, Issue 4, pp. E610 - E619
Journal Article
DEVELOPMENT, ISSN 0950-1991, 06/2019, Volume 146, Issue 12, p. dev173716
During pancreatic development, endocrine cells appear from the pancreatic epithelium when Neurog3-positive cells delaminate and differentiate into alpha-,... 
PROGENITORS | Neurog3 | Endocrine progenitors | ENDOCRINE | MOUSE | PAX4 | DEVELOPMENTAL BIOLOGY | ORGANOGENESIS | Beta cells | Single cell transcriptome sequencing | MORPHOGENESIS | GENE | GENERATION | Pancreas development | Alpha cells | CHARACTERISTIC FEATURES | REVEALS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2018, Volume 115, Issue 4, p. E610
The adult mouse subependymal zone provides a niche for mammalian neural stem cells (NSCs). However, the molecular signature, self-renewal potential, and fate... 
Target recognition | Wnt protein | Brain stem | Homeostasis | Stem cell transplantation | Subependymal zone | Ribonucleic acid--RNA | Gene sequencing | Cell fate | Cell number | Rodents | Stem cells | Genetic analysis | Alleles | Neural stem cells | Stochastic models | Stochasticity | Gene mapping | Quantitative analysis
Journal Article
ISSN 0027-8424, 2018
The adult mouse subependymal zone provides a niche for mammalian neural stem cells (NSCs). However, the molecular signature, self-renewal potential, and fate... 
single-cell sequencing | modeling | neural stem cells | cellular dynamics | ki67
Journal Article
CANCER DISCOVERY, ISSN 2159-8274, 07/2019, Volume 9, Issue 7, pp. 852 - 871
Previous studies have described that tumor organoids can capture the diversity of defined human carcinoma types. Here, we describe conditions for long-term... 
GROWTH-FACTOR RECEPTOR | IN-VITRO | CARBOPLATIN | CISPLATIN | MODELS | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | GENE-EXPRESSION | HUMAN-PAPILLOMAVIRUS | INHIBITOR | HUMAN HEAD
Journal Article
Cell Stem Cell, ISSN 1934-5909, 08/2016, Volume 19, Issue 2, p. 266
Adult mitotic tissues like the intestine, skin, and blood undergo constant turnover throughout the life of an organism. Knowing the identity of the stem cell... 
Journal Article