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Nature Chemistry, ISSN 1755-4330, 06/2015, Volume 7, Issue 6, pp. 502 - 508
The emergence of an RNA catalyst capable of self-replication is considered a key transition in the origin of life. However, how such replicase ribozymes... 
REPLICATION | BASE CATALYSIS | EUTECTIC PHASE | LIGATION | POLYMERIZATION | TEMPLATE | RNA-POLYMERASE RIBOZYME | FUNCTIONAL COMPLEXITY | CHEMISTRY, MULTIDISCIPLINARY | HAIRPIN RIBOZYME | LIFE | Biopolymers - chemistry | Temperature | DNA-Directed RNA Polymerases - chemistry | Nucleic Acid Conformation | RNA, Catalytic - chemistry | Freezing
Journal Article
Journal Article
Journal Article
ChemBioChem, ISSN 1439-4227, 10/2019, Volume 20, Issue 20, pp. 2533 - 2534
Bottom‐up synthetic biology uses both biological and artificial chemical building blocks to create biomimetic systems, including artificial cells. Existing and... 
Organic chemistry | Synthetic biology | Biology | New technology | Biomimetics | Microfluidics
Journal Article
Journal of Molecular Medicine, ISSN 0946-2716, 12/2011, Volume 89, Issue 12, pp. 1183 - 1194
Cell death in bacteria can be triggered by activation of self-inflicted molecular mechanisms. Pathogenic bacteria often make use of suicide mechanisms in which... 
Human Genetics | Infectiology | Biomedicine | Cell death | Antimicrobial peptides | Internal Medicine | Molecular Medicine | Biochemistry | Drug development | Drug resistance | Anti-Bacterial Agents | Animals | Plasmids | Humans | Virulence | Cell Death | Drug Design | Drug Resistance, Bacterial | Antitoxins - physiology | Toxins, Biological - physiology | Chromosomes, Bacterial | Index Medicus | Review
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3643 - 9
Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via complex coacervation, which may have... 
PHASE-SEPARATION | CELLS | IN-VITRO | PROTEIN | CLEAVING HAMMERHEAD RIBOZYMES | MOBILITY | MULTIDISCIPLINARY SCIENCES | COMPLEX COACERVATION | MODEL | VIROID RNA | DROPLETS | Cell Compartmentation | Cellular Microenvironment | Catalysis | Origin of Life | Artificial Cells | RNA, Catalytic - metabolism | Coacervation | Phase separation | Oligonucleotides | Ribonucleic acid--RNA | Polymers | Molecular weight | Weight
Journal Article
Chemistry – An Asian Journal, ISSN 1861-4728, 01/2020, Volume 15, Issue 2, pp. 199 - 199
The cover feature illustrates various environmental factors influencing nucleic acid catalysis on early Earth, including temperature, pH, metal ion... 
catalysis | ribozymes | origin of life | nucleic acids | deoxyribozymes
Journal Article
Journal of Molecular Medicine, ISSN 0946-2716, 12/2011, Volume 89, Issue 12, p. 1183
Cell death in bacteria can be triggered by activation of self-inflicted molecular mechanisms. Pathogenic bacteria often make use of suicide mechanisms in which... 
Drug resistance in microorganisms | Care and treatment | Cell death | Research | Diagnosis | Suicide | Risk factors
Journal Article
New Journal of Physics, ISSN 1367-2630, 05/2018, Volume 20, Issue 5, p. 55008
Early protocells are commonly assumed to consist of an amphiphilic membrane enclosing an RNA-based self-replicating genetic system and a primitive metabolism... 
origin of life | giant unilamellar vesicles | freeze-thaw | liposomes | protocells | TRANSFORMATION | FUSION | PHYSICS, MULTIDISCIPLINARY | ENCAPSULATION | MEMBRANES | DIVISION | FATTY-ACID VESICLES | GROWTH | COMPARTMENTALIZATION | GIANT LIPOSOMES | REPRODUCTION
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 10/2010, Volume 17, Issue 10, pp. 1195 - 1201
Phosphorylation of the C-terminal domain (CTD) of RNA polymerase II controls the co-transcriptional assembly of RNA processing and transcription factors.... 
COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | CTD FUNCTION | SACCHAROMYCES-CEREVISIAE | PROCESSING FACTORS | PRE-MESSENGER-RNA | CELL BIOLOGY | YEAST | BIOPHYSICS | IICTD | GENE-EXPRESSION | CAPPING ENZYME | DIFFERENT PHOSPHORYLATED FORMS | Phosphorylation | Transcription Factors - chemistry | mRNA Cleavage and Polyadenylation Factors - metabolism | Humans | mRNA Cleavage and Polyadenylation Factors - chemistry | Molecular Sequence Data | RNA Polymerase II - metabolism | Conserved Sequence | Transcription, Genetic | RNA Polymerase II - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Peptide Fragments - metabolism | RNA-Binding Proteins - chemistry | Models, Molecular | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Protein Interaction Mapping | Sequence Homology, Amino Acid | Transcription Factors - metabolism | Point Mutation | Peptide Fragments - chemistry | Sequence Alignment | Saccharomyces cerevisiae Proteins - metabolism | Serine-Arginine Splicing Factors | Protein Conformation | Protein Processing, Post-Translational | Phosphoserine - chemistry | RNA-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Physiological aspects | Transcription factors | Research | RNA polymerases | Binding sites (Biochemistry) | Proteins | RNA polymerase | Mutation | Molecular structure | Molecular biology
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2014, Volume 136, Issue 14, pp. 5193 - 5196
Ribonucleoside 2′,3′-cyclic phosphates (N>p’s) are generated by multiple prebiotically plausible processes and are credible building blocks for the assembly of... 
MIXTURES | RIBOZYME | BASE CATALYSIS | WATER-ICE | PHOSPHORYLATION | KINETICS | EUTECTIC PHASE | LIGATION | POLYMERIZATION | FUNCTIONAL COMPLEXITY | CHEMISTRY, MULTIDISCIPLINARY | Models, Molecular | Molecular Structure | Ribonucleotides - chemistry | RNA - chemistry | Phosphates - chemistry | Oligomers | Phosphates | Research | RNA | Communication
Journal Article
NATURE CHEMISTRY, ISSN 1755-4330, 09/2019, Volume 11, Issue 9, pp. 779 - 788
Non-equilibrium conditions must have been crucial for the assembly of the first informational polymers of early life, by supporting their formation and... 
PATTERN-FORMATION | NUCLEOTIDES | CYCLES | BOND FORMATION | DIFFUSION | POLYMERIZATION | ACCUMULATION | SELECTION | SURFACE-TENSION | CHEMISTRY, MULTIDISCIPLINARY | WATER | Encapsulation | Equilibrium conditions | Enrichment | Phosphorylation | Hydrogels | Crystals | Oligonucleotides | Lipids | Ribonucleic acid--RNA | Biopolymers | Monomers | Prebiotics | Organic chemistry | Molecular evolution | Bubbles | Earth crust | Ribozymes
Journal Article