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humans (43) 43
phosphorylation (33) 33
index medicus (32) 32
nadph oxidases - metabolism (30) 30
nadph oxidase (25) 25
neutrophils (20) 20
immunology (19) 19
neutrophils - metabolism (19) 19
reactive oxygen species - metabolism (19) 19
respiratory burst oxidase (18) 18
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chronic granulomatous-disease (15) 15
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protein-kinase-c (15) 15
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phosphoproteins - metabolism (14) 14
activation (13) 13
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biochemistry & molecular biology (13) 13
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cell biology (11) 11
enzyme activation (11) 11
inflammation (11) 11
research (11) 11
respiratory burst (11) 11
reactive oxygen species (10) 10
n-formylmethionine leucyl-phenylalanine - pharmacology (9) 9
neutrophils - drug effects (9) 9
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blotting, western (8) 8
colony-stimulating factor (8) 8
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p47phox (8) 8
cells, cultured (7) 7
oxidative stress (7) 7
physiological aspects (7) 7
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mitogen-activated protein kinase 3 - metabolism (5) 5
mitogen-activated protein kinases - metabolism (5) 5
nadph oxidase 2 (5) 5
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phagocytes - enzymology (5) 5
pharmacology & pharmacy (5) 5
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superoxide (5) 5
superoxide-production (5) 5
superoxides - metabolism (5) 5
tetradecanoylphorbol acetate - pharmacology (5) 5
translocation (5) 5
abridged index medicus (4) 4
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biochemistry (4) 4
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cytosol - metabolism (4) 4
enzyme inhibitors - pharmacology (4) 4
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neutrophils - physiology (4) 4
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pathology (4) 4
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phagocytes - metabolism (4) 4
phosphoproteins - genetics (4) 4
priming (4) 4
protein kinases (4) 4
rac gtp-binding proteins - metabolism (4) 4
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biochemistry, molecular biology (3) 3
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1. Full Text Phosphorylation of p47phox sites by PKC α, βII, δ, and ζ: Effect on binding to p22phox and on NADPH oxidase activation
by Fontayne, Alexandre and Dang, Pham My-Chan and Gougerot-Pocidalo, Marie-Anne and El Benna, Jamel
Biochemistry, ISSN 0006-2960, 06/2002, Volume 41, Issue 24, pp. 7743 - 7750
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2. Full Text Moroccan strains of Leishmania major and Leishmania tropica differentially impact on nitric oxide production by macrophages
by Maksouri, Hasnaa and Dang, Pham My-Chan and Rodrigues, Vasco and Estaquier, Jérôme and Riyad, Myriam and Akarid, Khadija
Parasites and Vectors, ISSN 1756-3305, 10/2017, Volume 10, Issue 1, pp. 506 - 10
Background: Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by protozoa of the genus Leishmania. In Morocco, CL is a public health... 
Cutaneous leishmaniasis | macrophages | Nitric oxide | Leishmania tropica | NO donors | Soluble Leishmania antigens | Leishmania major | ACTIVATION | LIPOPHOSPHOGLYCAN | DONOVANI | MURINE MACROPHAGES | INOS EXPRESSION | INDUCTION | TROPICAL MEDICINE | BALB/C MICE | PROGRAMMED CELL-DEATH | PARASITOLOGY | CHAGASI | Cell Line | Macrophages - ultrastructure | Nitric Oxide - biosynthesis | Nitric Oxide - pharmacology | Leishmania major - drug effects | Leishmania tropica - physiology | Leishmania major - physiology | Zoonoses | Antigens, Protozoan | Macrophages - parasitology | Macrophages - metabolism | Animals | Leishmaniasis, Cutaneous - parasitology | Microscopy | Leishmania tropica - drug effects | Morocco - epidemiology | Leishmaniasis, Cutaneous - epidemiology | Macrophages - drug effects | Mice | Host-parasite relationships | Health aspects | Leishmania | Proteins | Dendritic cells | Parasitic diseases | Strains | Infections | Parasites | Macrophages | Life Sciences
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3. Phagocyte NADPH oxidase: A multicomponent enzyme essential for host defenses
by El-Benna, Jamel and Dang, Pham My-Chan and Gougerot-Pocidalo, Marie-Anne and Elbim, Carole
Archivum Immunologiae et Therapiae Experimentalis, ISSN 0004-069X, 05/2005, Volume 53, Issue 3, pp. 199 - 206
Phagocytes such as neutrophils and monocytes play an essential role in host defenses against microbial pathogens. Reactive oxygen species (ROS), such as... 
CGD | NADPH oxidase | Neutrophils | Phagocyte | P47(PHOX) PHOSPHORYLATION | PROTEIN-KINASE-C | OXIDATIVE STRESS | CHRONIC GRANULOMATOUS-DISEASE | CELL-FREE SYSTEM | IMMUNOLOGY | phagocyte | RESPIRATORY BURST OXIDASE | HUMAN-NEUTROPHILS | REACTIVE OXYGEN | neutrophils | NF-KAPPA-B | SH3 DOMAIN | Immune System - physiology | Reactive Oxygen Species - metabolism | Neutrophils - enzymology | Humans | NADPH Oxidases - metabolism | Anions | Animals | Superoxides | Cytosol - metabolism | Cell Membrane - metabolism | Enzyme Activation | Granulomatous Disease, Chronic - pathology | NADPH Oxidases - physiology | Phagocytes - enzymology
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4. Full Text TNF-α induces phosphorylation of p47phox in human neutrophils: Partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-α and granulocyte-macrophage colony-stimulating factor
by Dewas, Cédric and Dang, Pham My-Chan and Gougerot-Pocidalo, Marie-Anne and El-Benna, Jamel
Journal of Immunology, ISSN 0022-1767, 10/2003, Volume 171, Issue 8, pp. 4392 - 4398
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5. Full Text Priming of the neutrophil respiratory burst: role in host defense and inflammation
by El‐Benna, Jamel and Hurtado‐Nedelec, Margarita and Marzaioli, Viviana  and Marie, Jean‐Claude and Gougerot‐Pocidalo, Marie‐Anne and Dang, Pham My‐Chan
Immunological Reviews, ISSN 0105-2896, 09/2016, Volume 273, Issue 1, pp. 180 - 193
Summary Neutrophils are the major circulating white blood cells in humans. They play an essential role in host defense against pathogens. In healthy... 
priming | superoxide/ROS‐production | NADPH oxidase/NOX2 | neutrophils | superoxide/ROS-production | PROTEIN-KINASE-C | FACTOR GM-CSF | COLONY-STIMULATING FACTOR | OXIDATIVE BURST | PHAGOCYTE NADPH OXIDASE | ACUTE LUNG INJURY | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | INDUCED CONFORMATIONAL-CHANGES | PROLYL ISOMERASE PIN1 | PLATELET-ACTIVATING-FACTOR | Animals | Reactive Oxygen Species - metabolism | Neutrophil Activation | Transendothelial and Transepithelial Migration | Respiratory Burst | Humans | Neutrophils - physiology | Cell Communication | Inflammation - immunology | Immunity, Innate | Life Sciences | Innate immunity | Immunology
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6. Full Text Thymoquinone is a potent NOX2 inhibitor in human neutrophils
by Kaouthar, Boudiaf and Sahra Amel, Belambri and Margarita, Hurtado-Nedelec and Mustapha, Benoubetra and Jamel, El Benna and My-Chan, Dang Pham
Frontiers in Immunology, ISSN 1664-3224, 2015, Volume 6
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7. Full Text Eugenol prevents fMLF-induced superoxide anion production in human neutrophils by inhibiting ERK1/2 signaling pathway and p47phox phosphorylation
by Chniguir, Amina and Pintard, Coralie and Liu, Dan and Dang, Pham My-Chan and El-Benna, Jamel and Bachoual, Rafik
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1
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8. Full Text NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits
by Belambri, Sahra A and Rolas, Loïc and Raad, Houssam and Hurtado‐Nedelec, Margarita and Dang, Pham My‐Chan and El‐Benna, Jamel
European Journal of Clinical Investigation, ISSN 0014-2972, 11/2018, Volume 48, Issue S2, pp. e12951 - n/a
Neutrophils are key cells of innate immunity and during inflammation. Upon activation, they produce large amounts of superoxide anion (O2−.) and ensuing... 
p22phox | p47phox | p67phox and p40phox | NADPH oxidase | Rac2 | protein phosphorylation | gp91phox | neutrophils | NOX2 | p67 | gp91 | p22 | and p40 | p47 | MEDICINE, RESEARCH & EXPERIMENTAL | p67(phox) and p40(phox) | PROTEIN-KINASE-C | COLONY-STIMULATING FACTOR | CHRONIC GRANULOMATOUS-DISEASE | P47PHOX PHOSPHORYLATION | gp91(phox) | p22(phox) | RESPIRATORY BURST OXIDASE | MEDICINE, GENERAL & INTERNAL | p47(phox) | CYTOSOLIC COMPONENT | SRC HOMOLOGY-3 DOMAINS | PHOSPHATIDIC-ACID | ISOMERASE PIN1 | THREONINE 154 | Enzyme Activators - pharmacology | Phosphorylation - physiology | Neutrophils - enzymology | Bacterial Proteins - pharmacokinetics | NADPH Oxidase 2 - metabolism | Humans | NADPH Oxidases - metabolism | Phosphoproteins - metabolism | Enzyme Activation - physiology | Tetradecanoylphorbol Acetate - pharmacokinetics | Oxidases | Superoxide | Membrane proteins | Protons | Cytochrome | Phosphorylation | GTP | Reactive oxygen species | Oxidase | Innate immunity | Activation | Phospholipids | Immunity | NAD(P)H oxidase | Inflammatory diseases | Proteins | GDP | Cell activation | Microorganisms | CYBB protein | Catalysis | Enzymes | Neutrophils | Leukocytes (neutrophilic) | Rac2 protein | Cytochrome b558 | Cytochromes | Life Sciences | Immunology
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9. Full Text A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites
by Dang, Pham My-Chan and Stensballe, Allan and Boussetta, Tarek and Raad, Houssam and Dewas, Cedric and Kroviarski, Yolande and Hayem, Gilles and Jensen, Ole N and Gougerot-Pocidalo, Marie-Anne and El-Benna, Jamel
Journal of Clinical Investigation, ISSN 0021-9738, 07/2006, Volume 116, Issue 7, pp. 2033 - 2043
Neutrophil NADPH oxidase plays a key role in host defense and in inflammation by releasing large amounts of superoxide and other ROSs. Proinflammatory... 
Tumor Necrosis Factor-alpha - metabolism | Amino Acid Sequence | Cell Line | Phosphorylation | Reactive Oxygen Species - metabolism | Enzyme Inhibitors - metabolism | Neutrophils - enzymology | Peptides - chemistry | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Humans | NADPH Oxidases - metabolism | Peptides - genetics | Molecular Sequence Data | Serine - metabolism | Inflammation - metabolism | Peptides - metabolism | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Genistein - metabolism | NADPH Oxidases - genetics | Enzyme Activation | Synovial Fluid - cytology | Arthritis, Rheumatoid - immunology | Mitogen-Activated Protein Kinases - metabolism
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10. Full Text Phosphorylation of the NADPH oxidase component p67PHOX by ERK2 and P38MAPK: Selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region
by Dang, Pham My-Chan and Morel, Françoise and Gougerot-Pocidalo, Marie-Anne and El Benna, Jamel
Biochemistry, ISSN 0006-2960, 04/2003, Volume 42, Issue 15, pp. 4520 - 4526
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11. Full Text p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases
by El-Benna, Jamel and Dang, Pham My-Chan and Gougerot-Pocidalo, Marie-Anne and Marie, Jean-Claude and Braut-Boucher, Françoise
Experimental and Molecular Medicine, ISSN 1226-3613, 04/2009, Volume 41, Issue 4, pp. 217 - 225
Phagocytes such as neutrophils play a vital role in host defense against microbial pathogens. The anti-microbial function of neutrophils is based on the... 
Reactive Oxygen Species | CYBB protein, human | NADPH oxidase | review | neutrophils | phosphorylation | neutrophil cytosolic factor 1 | Neutrophil cytosolic factor 1 | Phosphorylation | Reactive oxygen species | Neutrophils | Review | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN-KINASE-C | COLONY-STIMULATING FACTOR | CHRONIC GRANULOMATOUS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPONENT P47(PHOX) | RESPIRATORY BURST OXIDASE | SUBUNIT P47(PHOX) | HUMAN-NEUTROPHILS | DINUCLEOTIDE PHOSPHATE OXIDASE | reactive oxygen species | SMOOTH-MUSCLE-CELLS | SH3 DOMAIN | NADPH Oxidases - chemistry | Disease | Membrane Glycoproteins - metabolism | Humans | Membrane Glycoproteins - chemistry | NADPH Oxidases - metabolism | Phagocytes - metabolism | NADPH Oxidase 2 | NADPH Oxidases - genetics | Protein Conformation | Phagocytes - cytology | Enzyme Activation | 생화학
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12. Full Text Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane
by El-Benna, Jamel and Dang, Pham My-Chan and Gougerot-Pocidalo, Marie-Anne
Seminars in Immunopathology, ISSN 1863-2297, 7/2008, Volume 30, Issue 3, pp. 279 - 289
Neutrophils play an essential role in host defense against microbial pathogens and in the inflammatory reaction. Upon activation, neutrophils produce... 
Biomedicine | Immunology | p47phox | NADPH oxidase | Neutrophils | ROS | Internal Medicine | Priming | Review | NOX2 | RHEUMATOID-ARTHRITIS | priming | PROTEIN-KINASE-C | FACTOR GM-CSF | COLONY-STIMULATING FACTOR | CHRONIC GRANULOMATOUS-DISEASE | FORMYL-PEPTIDES | IMMUNOLOGY | PATHOLOGY | FACTOR-ALPHA | RESPIRATORY BURST OXIDASE | TUMOR-NECROSIS-FACTOR | review | TOLL-LIKE RECEPTORS | neutrophils | Phosphorylation | Animals | Neutrophils - enzymology | Humans | NADPH Oxidases - metabolism | Neutrophils - immunology | NADPH Oxidases - immunology | Neutrophil Activation - physiology | Enzyme Activation - physiology | Protein Transport | Phosphates | Oxidases | Niacinamide | Hydroxides | Hydrogen peroxide | Peptides | Superoxide | Cell membranes | Inflammation | Purines | Cytochrome b | Proteases | Physiological aspects | Air pollution | Mitogens | Index Medicus
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13. Full Text Tumor necrosis factor-α-induced colitis increases NADPH oxidase 1 expression, oxidative stress, and neutrophil recruitment in the Colon: Preventive effect of apocynin
by Mouzaoui, Souad and Mouzaoui, Souad and Djerdjouri, Bahia and Djerdjouri, Bahia and Makhezer, Nesrine and Makhezer, Nesrine and Kroviarski, Yolande and Kroviarski, Yolande and El-Benna, Jamel and El-Benna, Jamel and Dang, Pham My-Chan and Dang, Pham M.y-Chan
Mediators of Inflammation, ISSN 0962-9351, 2014, Volume 2014, pp. 312484 - 15
Reactive oxygen species-(ROS-) mediated injury has been implicated in several inflammatory disorders, including inflammatory bowel disease (IBD). NADPH... 
RESPIRATORY BURST OXIDASE | IMMUNE-RESPONSE | PROTEIN-KINASE-C | INFLAMMATORY-BOWEL-DISEASE | EPITHELIAL-CELLS | CROHNS-DISEASE | SUPEROXIDE-PRODUCTION | GASTROINTESTINAL-TRACT | REACTIVE OXYGEN METABOLITES | IMMUNOLOGY | ANTIOXIDANT DEFENSES | CELL BIOLOGY | Oxidative Stress - physiology | NADPH Oxidases - metabolism | Male | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Colon - metabolism | NADPH Oxidase 1 | Neutrophil Infiltration - physiology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Colitis - chemically induced | Acetophenones - pharmacology | Colitis - drug therapy | Mice | NADH, NADPH Oxidoreductases - metabolism | Neutrophils - metabolism
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14. Full Text Priming of human neutrophil respiratory burst by granulocyte/macrophage colony-stimulating factor (GM-CSF) involves partial phosphorylation of p47(phox)
by Dang, Pham My-Chan and Dewas, Cedric and Gaudry, Murielle and Fay, Michèle and Pedruzzi, Eric and Gougerot-Pocidalo, Marie-Anne and El Benna, Jamel
Journal of Biological Chemistry, ISSN 0021-9258, 07/1999, Volume 274, Issue 29, pp. 20704 - 20708
Neutrophil superoxide production can be potentiated by prior exposure to "priming" agents such as granulocyte/macrophage colony stimulating factor (GM-CSF),... 
CYTOSOLIC OXIDASE COMPONENTS | NADPH OXIDASE | TRANSLOCATION | PROTEIN-KINASE-C | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | NECROSIS-FACTOR-ALPHA | PLASMA-MEMBRANE | ASSOCIATION | SUBUNIT | NADPH Oxidases | Phosphorylation | Humans | Neutrophils - drug effects | Enzyme Inhibitors - pharmacology | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Protein Kinase C - antagonists & inhibitors | Phosphoproteins - metabolism | Respiratory Burst - drug effects | Biological Transport | Superoxides - metabolism | N-Formylmethionine Leucyl-Phenylalanine - pharmacology | Neutrophils - metabolism
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