Multiple Sclerosis Journal, ISSN 1352-4585, 10/2019, p. 135245851987289
Journal Article
Journal of the Neurological Sciences, ISSN 0022-510X, 2009, Volume 286, Issue 1, pp. 104 - 108
Abstract Multiple sclerosis is an immune-mediated disease of the central nervous system caused by a complex interplay between several different genetic as well...
Neurology | Prevention | Multiple sclerosis | Treatment | Disease modifying | Vitamin D | 25-HYDROXYVITAMIN-D LEVELS | RISK-FACTORS | RELAPSE RATE | D DEFICIENCY | SEASONAL-VARIATION | NEUROSCIENCES | CLINICAL NEUROLOGY | DISEASE-ACTIVITY | SUN EXPOSURE | D-RECEPTOR GENE | SERUM 25-HYDROXYVITAMIN-D | 1,25-DIHYDROXYVITAMIN D-3 | Multiple Sclerosis - complications | Animals | Multiple Sclerosis - blood | Humans | Vitamin D - administration & dosage | Multiple Sclerosis - diet therapy | Vitamin D - blood | Development and progression | Analysis | Vitamins
Neurology | Prevention | Multiple sclerosis | Treatment | Disease modifying | Vitamin D | 25-HYDROXYVITAMIN-D LEVELS | RISK-FACTORS | RELAPSE RATE | D DEFICIENCY | SEASONAL-VARIATION | NEUROSCIENCES | CLINICAL NEUROLOGY | DISEASE-ACTIVITY | SUN EXPOSURE | D-RECEPTOR GENE | SERUM 25-HYDROXYVITAMIN-D | 1,25-DIHYDROXYVITAMIN D-3 | Multiple Sclerosis - complications | Animals | Multiple Sclerosis - blood | Humans | Vitamin D - administration & dosage | Multiple Sclerosis - diet therapy | Vitamin D - blood | Development and progression | Analysis | Vitamins
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 02/2020, Volume 339, p. 577091
Fingolimod is used to treat patients with relapsing-remitting multiple sclerosis; it crosses the blood-brain barrier and modulates sphingosine-1-phosphate...
Multiple sclerosis | Sphingosine-1-phosphate receptors | Quantitative proteomics | Fingolimod | Cuprizone | Remyelination
Multiple sclerosis | Sphingosine-1-phosphate receptors | Quantitative proteomics | Fingolimod | Cuprizone | Remyelination
Journal Article
Multiple Sclerosis and Related Disorders, ISSN 2211-0348, 11/2019, Volume 36, p. 101408
Cognitive impairment is a common symptom in all stages of multiple sclerosis (MS), yet it is underreported and not routinely evaluated. The Brief International...
BICAMS | Multiple sclerosis | Cognition | Neuropsychology | Cognitive impairment
BICAMS | Multiple sclerosis | Cognition | Neuropsychology | Cognitive impairment
Journal Article
Journal of neurology, neurosurgery, and psychiatry, ISSN 0022-3050, 2014, Volume 85, Issue 10, pp. 1109 - 1115
Objectives To identify MRI biomarkers associated with long-term disability progression in patients with multiple sclerosis (MS), and to define the rate of...
SURGERY | LONG-TERM DISABILITY | WHITE-MATTER | PSYCHIATRY | PATHOLOGY | CLINICAL NEUROLOGY | GRAY-MATTER ATROPHY | CLINICALLY ISOLATED SYNDROMES | CORTICAL ATROPHY | LESION LOAD | RELAPSING-REMITTING MS | GREY | VOLUME CHANGES | Disability Evaluation | Neuroimaging | Follow-Up Studies | Humans | Atrophy - pathology | Male | Disease Progression | Magnetic Resonance Imaging | Nerve Fibers, Unmyelinated - pathology | Nerve Fibers, Myelinated - pathology | Brain - pathology | Multiple Sclerosis - pathology | Adult | Female | Disability | Multiple sclerosis | Care and treatment | Risk factors
SURGERY | LONG-TERM DISABILITY | WHITE-MATTER | PSYCHIATRY | PATHOLOGY | CLINICAL NEUROLOGY | GRAY-MATTER ATROPHY | CLINICALLY ISOLATED SYNDROMES | CORTICAL ATROPHY | LESION LOAD | RELAPSING-REMITTING MS | GREY | VOLUME CHANGES | Disability Evaluation | Neuroimaging | Follow-Up Studies | Humans | Atrophy - pathology | Male | Disease Progression | Magnetic Resonance Imaging | Nerve Fibers, Unmyelinated - pathology | Nerve Fibers, Myelinated - pathology | Brain - pathology | Multiple Sclerosis - pathology | Adult | Female | Disability | Multiple sclerosis | Care and treatment | Risk factors
Journal Article
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Full Text
Survival and cause of death in multiple sclerosis: a 60-year longitudinal population study
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 08/2017, Volume 88, Issue 8, pp. 621 - 625
ObjectiveSurvival and causes of death (COD) in multiple sclerosis (MS) provide ultimate endpoints. We aimed to investigate survival and COD in a 60-year...
Epidemiology | Neuroepidemiology | SURGERY | RELATIVE MORTALITY | PROGNOSTIC-FACTORS | PSYCHIATRY | GUIDELINES | NORWAY | TRENDS | CLINICAL NEUROLOGY | MODELS | DISEASE | COHORT | CERTIFICATES | DIAGNOSTIC-CRITERIA | Multiple Sclerosis - mortality | Humans | Middle Aged | Male | Cause of Death | Multiple Sclerosis, Chronic Progressive - mortality | Life Expectancy | Norway - epidemiology | Age of Onset | Multiple Sclerosis, Relapsing-Remitting - mortality | Aged, 80 and over | Female | Aged | Longitudinal Studies | Multiple sclerosis | Usage | Demographic aspects | Epidemiologic methods | Patient outcomes | Departments | Life expectancy | Comorbidity | Mortality | Cardiovascular disease | Gender | Patients | Studies | Neurology | Hospitals | Womens health | Medical prognosis | Population | Trends | Health risk assessment | Age | Multiple Sclerosis | 1507 | 1506
Epidemiology | Neuroepidemiology | SURGERY | RELATIVE MORTALITY | PROGNOSTIC-FACTORS | PSYCHIATRY | GUIDELINES | NORWAY | TRENDS | CLINICAL NEUROLOGY | MODELS | DISEASE | COHORT | CERTIFICATES | DIAGNOSTIC-CRITERIA | Multiple Sclerosis - mortality | Humans | Middle Aged | Male | Cause of Death | Multiple Sclerosis, Chronic Progressive - mortality | Life Expectancy | Norway - epidemiology | Age of Onset | Multiple Sclerosis, Relapsing-Remitting - mortality | Aged, 80 and over | Female | Aged | Longitudinal Studies | Multiple sclerosis | Usage | Demographic aspects | Epidemiologic methods | Patient outcomes | Departments | Life expectancy | Comorbidity | Mortality | Cardiovascular disease | Gender | Patients | Studies | Neurology | Hospitals | Womens health | Medical prognosis | Population | Trends | Health risk assessment | Age | Multiple Sclerosis | 1507 | 1506
Journal Article
Multiple Sclerosis Journal, ISSN 1352-4585, 3/2018, Volume 24, Issue 3, pp. 270 - 278
Background: Whether large body size increases multiple sclerosis (MS) risk in men is not well understood. Concurrently, physical exercise could be an...
physical endurance | Multiple sclerosis | body mass index | physical fitness | body size | exercise | historical cohort study | risk factor | FITNESS | QUALITY | MASS INDEX | FATIGUE | NORWAY | CHILDHOOD | NEUROSCIENCES | CLINICAL NEUROLOGY | OBESITY | DISEASE | COHORT | PROGRESSION | Body mass index | Physical fitness | Exercise | Body size | Body weight | Population studies | Fitness
physical endurance | Multiple sclerosis | body mass index | physical fitness | body size | exercise | historical cohort study | risk factor | FITNESS | QUALITY | MASS INDEX | FATIGUE | NORWAY | CHILDHOOD | NEUROSCIENCES | CLINICAL NEUROLOGY | OBESITY | DISEASE | COHORT | PROGRESSION | Body mass index | Physical fitness | Exercise | Body size | Body weight | Population studies | Fitness
Journal Article
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 11, pp. 1353 - 1362
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants...
AUTOIMMUNE | ALLELES | METAANALYSIS | GENOTYPE IMPUTATION | GENETIC RISK | INFORMATION | ANNOTATION | PRIMARY BILIARY-CIRRHOSIS | DISEASE | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Genetic Variation | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Humans | Multiple Sclerosis - immunology | Genotype | Multiple Sclerosis - genetics | Chromosome Mapping | Polymorphism, Single Nucleotide | Genetic Loci | Multiple sclerosis | Chromosome mapping | Genetic susceptibility | Genetic variation | Genetic aspects | Identification and classification | Methods | Testing | Confidence intervals | Disease | Quality control | Genomes | Stratigraphy | Autoimmune diseases | Gene expression | Meta-analysis | Teknik och teknologier | TEKNIKVETENSKAP | Engineering and Technology | TECHNOLOGY
AUTOIMMUNE | ALLELES | METAANALYSIS | GENOTYPE IMPUTATION | GENETIC RISK | INFORMATION | ANNOTATION | PRIMARY BILIARY-CIRRHOSIS | DISEASE | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Genetic Variation | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Gene Frequency | Humans | Multiple Sclerosis - immunology | Genotype | Multiple Sclerosis - genetics | Chromosome Mapping | Polymorphism, Single Nucleotide | Genetic Loci | Multiple sclerosis | Chromosome mapping | Genetic susceptibility | Genetic variation | Genetic aspects | Identification and classification | Methods | Testing | Confidence intervals | Disease | Quality control | Genomes | Stratigraphy | Autoimmune diseases | Gene expression | Meta-analysis | Teknik och teknologier | TEKNIKVETENSKAP | Engineering and Technology | TECHNOLOGY
Journal Article
Analytical Chemistry, ISSN 0003-2700, 04/2009, Volume 81, Issue 7, pp. 2581 - 2590
The discriminating variable (DIVA) test and the selectivity ratio (SR) plot are developed as quantitative tools for revealing the variables in spectral or...
CHEMISTRY, ANALYTICAL | METABOLOMICS | SPECTROSCOPY | ALIGNMENT | REGRESSION-MODELS | PLS | VALIDATION | PARTIAL LEAST-SQUARES | IDENTIFICATION | DATASETS | OPLS | Metabolomics | Multivariate Analysis | Models, Chemical | Humans | Biomarkers - analysis | Peptides - cerebrospinal fluid | Chromatography | Discriminant Analysis | Reference Standards | Mass Spectrometry | Sensitivity and Specificity | Proteomics | Least-Squares Analysis | Spectra (Spectroscopy) | Ionization | Research | Biological markers | Properties | Mass spectrometry | Methods
CHEMISTRY, ANALYTICAL | METABOLOMICS | SPECTROSCOPY | ALIGNMENT | REGRESSION-MODELS | PLS | VALIDATION | PARTIAL LEAST-SQUARES | IDENTIFICATION | DATASETS | OPLS | Metabolomics | Multivariate Analysis | Models, Chemical | Humans | Biomarkers - analysis | Peptides - cerebrospinal fluid | Chromatography | Discriminant Analysis | Reference Standards | Mass Spectrometry | Sensitivity and Specificity | Proteomics | Least-Squares Analysis | Spectra (Spectroscopy) | Ionization | Research | Biological markers | Properties | Mass spectrometry | Methods
Journal Article
Multiple Sclerosis Journal, ISSN 1352-4585, 10/2019, p. 135245851987724
Background: Risk of cancer in multiple sclerosis (MS) patients compared to their siblings is unknown. Objective: The objective was to prospectively investigate...
Journal Article
11.
Full Text
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Nature, ISSN 0028-0836, 08/2011, Volume 476, Issue 7359, pp. 214 - 219
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically...
HETEROGENEITY | ALLELES | VARIANTS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | HAPLOTYPES | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Immunity, Cellular - genetics | Major Histocompatibility Complex - genetics | Humans | Multiple Sclerosis - genetics | Europe - ethnology | Genome, Human - genetics | HLA-DR Antigens - genetics | Cell Differentiation - immunology | Immunity, Cellular - immunology | Sample Size | T-Lymphocytes, Helper-Inducer - immunology | HLA-DRB1 Chains | Alleles | HLA-A Antigens - genetics | T-Lymphocytes, Helper-Inducer - cytology | Multiple Sclerosis - immunology | Polymorphism, Single Nucleotide - genetics | Physiological aspects | Multiple sclerosis | Genetic aspects | Immune response | Research | Epidemiology | Genealogy | Disease | Quality control | Genetics | Genomes | Statistical methods | Mutation | Regression analysis | Autoimmune diseases | Meta-analysis | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
HETEROGENEITY | ALLELES | VARIANTS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | HAPLOTYPES | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Immunity, Cellular - genetics | Major Histocompatibility Complex - genetics | Humans | Multiple Sclerosis - genetics | Europe - ethnology | Genome, Human - genetics | HLA-DR Antigens - genetics | Cell Differentiation - immunology | Immunity, Cellular - immunology | Sample Size | T-Lymphocytes, Helper-Inducer - immunology | HLA-DRB1 Chains | Alleles | HLA-A Antigens - genetics | T-Lymphocytes, Helper-Inducer - cytology | Multiple Sclerosis - immunology | Polymorphism, Single Nucleotide - genetics | Physiological aspects | Multiple sclerosis | Genetic aspects | Immune response | Research | Epidemiology | Genealogy | Disease | Quality control | Genetics | Genomes | Statistical methods | Mutation | Regression analysis | Autoimmune diseases | Meta-analysis | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Molecular and Cellular Proteomics, ISSN 1535-9476, 11/2014, Volume 13, Issue 11, pp. 3152 - 3163
In this study, the human cerebrospinal fluid (CSF) proteome was mapped using three different strategies prior to Orbitrap LC-MS/MS analysis: SDS-PAGE and mixed...
BIOMARKERS | MULTIPLE-SCLEROSIS PATIENTS | PEPTIDES | LIQUID-CHROMATOGRAPHY | BIOCHEMICAL RESEARCH METHODS | GLYCOPROTEINS | HUMAN CHORIONIC-GONADOTROPIN | IDENTIFICATION | PROTEINS | MASS-SPECTROMETRY | ALPHA-FETOPROTEIN | Electrophoresis, Polyacrylamide Gel | Humans | Glycopeptides - chemistry | Glycopeptides - isolation & purification | Gene Expression Profiling | Proteome - analysis | Healthy Volunteers | Glycopeptides - analysis | Tandem Mass Spectrometry | Cerebrospinal Fluid - metabolism | Glycoproteins - isolation & purification | Chromatography, Liquid | Glycoproteins - analysis | Proteomics - methods | Glycoproteins - chemistry | Resource
BIOMARKERS | MULTIPLE-SCLEROSIS PATIENTS | PEPTIDES | LIQUID-CHROMATOGRAPHY | BIOCHEMICAL RESEARCH METHODS | GLYCOPROTEINS | HUMAN CHORIONIC-GONADOTROPIN | IDENTIFICATION | PROTEINS | MASS-SPECTROMETRY | ALPHA-FETOPROTEIN | Electrophoresis, Polyacrylamide Gel | Humans | Glycopeptides - chemistry | Glycopeptides - isolation & purification | Gene Expression Profiling | Proteome - analysis | Healthy Volunteers | Glycopeptides - analysis | Tandem Mass Spectrometry | Cerebrospinal Fluid - metabolism | Glycoproteins - isolation & purification | Chromatography, Liquid | Glycoproteins - analysis | Proteomics - methods | Glycoproteins - chemistry | Resource
Journal Article
Expert Opinion on Pharmacotherapy, ISSN 1465-6566, 10/2017, Volume 18, Issue 15, pp. 1627 - 1635
Introduction: Despite recent progress, currently available therapies for relapsing remitting multiple sclerosis (MS) are only partly effective, and their use...
treatment | Multiple sclerosis | cladribine | review | ALEMTUZUMAB | PLACEBO | DISEASE-ACTIVITY | B-CELLS | ORAL CLADRIBINE | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | INFECTION | DIAGNOSTIC-CRITERIA | T-CELLS | Multiple Sclerosis, Relapsing-Remitting - immunology | Administration, Oral | Multiple Sclerosis, Relapsing-Remitting - drug therapy | Humans | Immunosuppressive Agents - therapeutic use | Treatment Outcome | Cladribine - administration & dosage | Randomized Controlled Trials as Topic | Neoplasms - chemically induced | Cladribine - therapeutic use | Immunosuppressive Agents - adverse effects | Cladribine - adverse effects | Immunosuppressive Agents - administration & dosage | Neoplasms - epidemiology | Medisinske Fag: 700 | VDP | Artikkel
treatment | Multiple sclerosis | cladribine | review | ALEMTUZUMAB | PLACEBO | DISEASE-ACTIVITY | B-CELLS | ORAL CLADRIBINE | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | INFECTION | DIAGNOSTIC-CRITERIA | T-CELLS | Multiple Sclerosis, Relapsing-Remitting - immunology | Administration, Oral | Multiple Sclerosis, Relapsing-Remitting - drug therapy | Humans | Immunosuppressive Agents - therapeutic use | Treatment Outcome | Cladribine - administration & dosage | Randomized Controlled Trials as Topic | Neoplasms - chemically induced | Cladribine - therapeutic use | Immunosuppressive Agents - adverse effects | Cladribine - adverse effects | Immunosuppressive Agents - administration & dosage | Neoplasms - epidemiology | Medisinske Fag: 700 | VDP | Artikkel
Journal Article