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2009, Advances in experimental medicine and biology, ISBN 9781441911445, Volume 656., xvi, 131
The Apc protein is a multifunctional participant in a diverse array of cellular functions. This book provides an overview of the functions performed by the Apc... 
Adenomatous Polyposis Coli | Colorectal Neoplasms | Colon (Anatomy) | metabolism | Adenomatous Polyposis Coli Protein | Tumor suppressor proteins | Genes, APC | Cancer
Book
2009, Advances in experimental medicine and biology, ISBN 9781441911445, Volume 656
Web Resource
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2007, Volume 176, Issue 2, pp. 183 - 195
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an... 
Tetraploidy | Polyploidy | HCT116 cells | Mitosis | Kinetochores | Small interfering RNA | Antibodies | Cells | Apoptosis | Mitotic spindle apparatus | KINETOCHORES | DOMINANT MUTATION | COLORECTAL-CANCER | DYNAMICS | TUMOR-SUPPRESSOR PROTEIN | POLYPOSIS-COLI PROTEIN | SPINDLE ASSEMBLY CHECKPOINT | CELL-CYCLE | QUANTITATIVE-ANALYSIS | CHROMOSOMAL INSTABILITY | CELL BIOLOGY | Protein Kinases - metabolism | Chromatin - metabolism | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Apoptosis - drug effects | beta Catenin - analysis | Humans | Intestines - chemistry | Protein-Serine-Threonine Kinases | Caspase 3 - metabolism | Nocodazole - pharmacology | Apoptosis - genetics | Intestines - metabolism | Mitosis - genetics | Cyclin B1 | Spindle Apparatus - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Chromatin - chemistry | Fibroblasts - metabolism | Adenomatous Polyposis Coli Protein - genetics | Intestines - pathology | HCT116 Cells | Mice, Transgenic | beta Catenin - metabolism | Animals | Mitosis - drug effects | Histones - analysis | Mitosis - physiology | Models, Biological | Fibroblasts - drug effects | Cell Line, Tumor | Cyclin B - metabolism | Mice | Apoptosis - physiology | Adenomatous Polyposis Coli Protein - deficiency | Cell Cycle Proteins | Staurosporine - pharmacology | Proteins | Cell division | Mutation | Tumors | Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 6/2002, Volume 157, Issue 6, pp. 1041 - 1048
Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to... 
Epithelial cells | Vestibular hair cells | Microtubules | Centrosomes | Antibodies | Cultured cells | Cell membranes | Cells | P branes | Adenomatous polyposis coli | Cochlea | Microtubule hook decoration | Cytoskeleton | Min mouse | Microtubule organization | cochlea | cytoskeleton | CENTROSOME | microtubule organization | min mouse | CELL BIOLOGY | GENE | NINEIN | EB1 | microtubule hook decoration | SITES | TUMOR-SUPPRESSOR PROTEIN | REORGANIZATION | NUCLEATION | APC MUTATIONS | CAPTURE | Adenomatous Polyposis Coli Protein - genetics | Cell Line | Cell Polarity | Cochlea - ultrastructure | Epithelial Cells - metabolism | Guinea Pigs | Humans | Epithelial Cells - ultrastructure | Cell Membrane - ultrastructure | Cochlea - cytology | Adenomatous Polyposis Coli Protein - ultrastructure | Subcellular Fractions - metabolism | Subcellular Fractions - ultrastructure | Microtubules - metabolism | Animals | Cochlea - metabolism | Mice, Mutant Strains | Microtubules - genetics | Adenomatous Polyposis Coli Protein - metabolism | Microtubules - ultrastructure | Heterozygote | Cell Membrane - metabolism | Mice | Epithelial Cells - cytology | Physiological aspects | Protein metabolism | Polyposis, Familial | Colorectal cancer | Index Medicus | microtubule organization; microtubule hook decoration; cytoskeleton; cochlea; min mouse
Journal Article
Oncogene, ISSN 0950-9232, 12/2010, Volume 29, Issue 49, pp. 6418 - 6427
Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initiating event of colorectal cancer. Although the control of WNT signalling... 
mitotic spindle assembly checkpoint | APC | Taxol | WNT signalling | HOMEOSTASIS | INSTABILITY | SUPPRESSOR GENE | MICROTUBULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | CANCER | CELL BIOLOGY | ONCOLOGY | GENETICS & HEREDITY | POLYPOSIS-COLI PROTEIN | MUTATIONS | EXPRESSION | PROGRESSION | Adenomatous Polyposis Coli Protein - physiology | Cell Cycle - genetics | Sequence Deletion | Male | Vinblastine - therapeutic use | Wnt Proteins - metabolism | Adenomatous Polyposis Coli - pathology | Spindle Apparatus - metabolism | Vinblastine - analogs & derivatives | Cell Transformation, Neoplastic - genetics | Spindle Apparatus - genetics | Enterocytes - pathology | Antineoplastic Agents, Phytogenic - therapeutic use | Adenomatous Polyposis Coli Protein - genetics | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Paclitaxel - therapeutic use | Chromosomal Instability - genetics | Drug Resistance, Neoplasm - genetics | Animals | Enterocytes - drug effects | Adenomatous Polyposis Coli - drug therapy | Mice | Cell Transformation, Neoplastic - drug effects | Cell Cycle - drug effects | Cell Transformation, Neoplastic - pathology | Gene mutations | Cell cycle | Colorectal cancer | Genetic aspects | Polyposis, Familial | Research | Health aspects | Risk factors | Chemotherapy | Mutation | Drug resistance | Cells | Index Medicus | Mitotic spindle assembly checkpoint | WNT signaling
Journal Article
Cell, ISSN 0092-8674, 1992, Volume 68, Issue 5, pp. 899 - 910
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 05/2018, Volume 217, Issue 5, pp. 1667 - 1685
During late mitosis and the early G1 phase, the origins of replication are licensed by binding to double hexamers of MCM2-7. In this study, we investigated how... 
Index Medicus
Journal Article
Seminars in Developmental Biology, ISSN 1044-5781, 1995, Volume 6, Issue 2, pp. 89 - 95
Cadherins comprise a large family of membrane glycoproteins that mediate Ca -dependent cell adhesion during development and in the adult. Although the... 
catenins | cadherins | growth factors | signal transduction | cell adhesion
Journal Article
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