Biological Psychiatry, ISSN 0006-3223, 09/2017, Volume 82, Issue 5, pp. 322 - 329
Abstract Background The genetics of depression has been explored in genome-wide association studies that focused on major depressive disorder or depressive...
Psychiatry | Depressive symptoms | FHIT gene | Genome-wide association study | Major depressive disorder | Psychiatric Genomics Consortium | CHARGE consortium | Depression/genetics | Depressive Disorder/genetics | European Continental Ancestry Group/genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Phenotype | Acid Anhydride Hydrolases/genetics | Humans | Neoplasm Proteins/genetics | Genetic Loci | SUBTHRESHOLD DEPRESSION | POPULATION | PSYCHIATRY | MINOR DEPRESSION | RISK | SYMPTOMS | MAJOR DEPRESSION | NEUROSCIENCES | HERITABILITY | NATIONAL COMORBIDITY SURVEY | DISORDER | STRESS | Genomics | Analysis | Genetic aspects | major depressive disorder | genome-wide association study
Psychiatry | Depressive symptoms | FHIT gene | Genome-wide association study | Major depressive disorder | Psychiatric Genomics Consortium | CHARGE consortium | Depression/genetics | Depressive Disorder/genetics | European Continental Ancestry Group/genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Phenotype | Acid Anhydride Hydrolases/genetics | Humans | Neoplasm Proteins/genetics | Genetic Loci | SUBTHRESHOLD DEPRESSION | POPULATION | PSYCHIATRY | MINOR DEPRESSION | RISK | SYMPTOMS | MAJOR DEPRESSION | NEUROSCIENCES | HERITABILITY | NATIONAL COMORBIDITY SURVEY | DISORDER | STRESS | Genomics | Analysis | Genetic aspects | major depressive disorder | genome-wide association study
Journal Article
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10023, pp. 1085 - 1093
Summary Background Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium...
Internal Medicine | I DISORDER | GADL1 | MEDICINE, GENERAL & INTERNAL | PHARMACOGENETICS | THERAPY | GENOTYPE IMPUTATION | Genome-Wide Association Study | Prospective Studies | Humans | Middle Aged | Genotype | Male | Treatment Outcome | Bipolar Disorder - drug therapy | Bipolar Disorder - genetics | Glial Cell Line-Derived Neurotrophic Factor Receptors - genetics | Genetic Variation | Phenotype | Lithium Compounds - therapeutic use | Polymorphism, Single Nucleotide - genetics | Female | Medical research | Genomics | Medicine, Experimental | Genetic research | Bipolar disorder | Genetic aspects | Transportation equipment industry | Studies | Lithium | Genomes | Gene expression | Drug therapy | Psykiatri | Psychiatry
Internal Medicine | I DISORDER | GADL1 | MEDICINE, GENERAL & INTERNAL | PHARMACOGENETICS | THERAPY | GENOTYPE IMPUTATION | Genome-Wide Association Study | Prospective Studies | Humans | Middle Aged | Genotype | Male | Treatment Outcome | Bipolar Disorder - drug therapy | Bipolar Disorder - genetics | Glial Cell Line-Derived Neurotrophic Factor Receptors - genetics | Genetic Variation | Phenotype | Lithium Compounds - therapeutic use | Polymorphism, Single Nucleotide - genetics | Female | Medical research | Genomics | Medicine, Experimental | Genetic research | Bipolar disorder | Genetic aspects | Transportation equipment industry | Studies | Lithium | Genomes | Gene expression | Drug therapy | Psykiatri | Psychiatry
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 10, pp. 1363 - 1373
Summary Background Oesophageal adenocarcinoma represents one of the fastest rising cancers in high-income countries. Barrett's oesophagus is the premalignant...
Hematology, Oncology and Palliative Medicine | HIATAL-HERNIA | GASTROESOPHAGEAL-REFLUX | GENE | VARIANTS | ONCOLOGY | DISEASE | RISK | CYSTIC-FIBROSIS | IDENTIFICATION | Genome-Wide Association Study | Esophageal Neoplasms - genetics | Humans | Risk | Adenocarcinoma - genetics | Polymorphism, Single Nucleotide | Barrett Esophagus - genetics | Adenocarcinoma | Analysis | Genomics | Genetic research | Genetic aspects | Esophageal cancer | Cancer
Hematology, Oncology and Palliative Medicine | HIATAL-HERNIA | GASTROESOPHAGEAL-REFLUX | GENE | VARIANTS | ONCOLOGY | DISEASE | RISK | CYSTIC-FIBROSIS | IDENTIFICATION | Genome-Wide Association Study | Esophageal Neoplasms - genetics | Humans | Risk | Adenocarcinoma - genetics | Polymorphism, Single Nucleotide | Barrett Esophagus - genetics | Adenocarcinoma | Analysis | Genomics | Genetic research | Genetic aspects | Esophageal cancer | Cancer
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 1, pp. 130 - 136
Background Atopic dermatitis (AD) is characterized by epidermal barrier failure and immune-mediated inflammation. Evidence on AD as a potential risk factor for...
Allergy and Immunology | epidemiology | type 1 diabetes | cohort study | Atopic dermatitis | rheumatoid arthritis | inflammatory bowel disease | CROHNS-DISEASE | SECONDARY DATA-ANALYSIS | ULCERATIVE-COLITIS | SUSCEPTIBILITY LOCI | MENTAL-HEALTH | IMMUNOLOGY | ADULTS DEGS1 | ALLERGY | BIRTH COHORT | GERMAN HEALTH INTERVIEW | SOCIOECONOMIC-STATUS | GENOME-WIDE ASSOCIATION | Diabetes Mellitus, Type 1 - epidemiology | Prevalence | Dermatitis, Atopic - epidemiology | Humans | Risk Factors | Arthritis, Rheumatoid - epidemiology | Child, Preschool | Infant | Male | Germany - epidemiology | Incidence | Young Adult | Inflammatory Bowel Diseases - epidemiology | Adolescent | Adult | Female | Odds Ratio | Child | Infant, Newborn | Rheumatoid factor | Medical colleges | Type 1 diabetes | Comorbidity | Gastrointestinal diseases | Environmental health | Arthritis | Inflammation | Molecular biology | Risk factors | Medical research | Medicine, Experimental | Epidemiology | Inflammatory bowel disease | Studies | Health care access | Diabetes | Socioeconomic factors | Data bases
Allergy and Immunology | epidemiology | type 1 diabetes | cohort study | Atopic dermatitis | rheumatoid arthritis | inflammatory bowel disease | CROHNS-DISEASE | SECONDARY DATA-ANALYSIS | ULCERATIVE-COLITIS | SUSCEPTIBILITY LOCI | MENTAL-HEALTH | IMMUNOLOGY | ADULTS DEGS1 | ALLERGY | BIRTH COHORT | GERMAN HEALTH INTERVIEW | SOCIOECONOMIC-STATUS | GENOME-WIDE ASSOCIATION | Diabetes Mellitus, Type 1 - epidemiology | Prevalence | Dermatitis, Atopic - epidemiology | Humans | Risk Factors | Arthritis, Rheumatoid - epidemiology | Child, Preschool | Infant | Male | Germany - epidemiology | Incidence | Young Adult | Inflammatory Bowel Diseases - epidemiology | Adolescent | Adult | Female | Odds Ratio | Child | Infant, Newborn | Rheumatoid factor | Medical colleges | Type 1 diabetes | Comorbidity | Gastrointestinal diseases | Environmental health | Arthritis | Inflammation | Molecular biology | Risk factors | Medical research | Medicine, Experimental | Epidemiology | Inflammatory bowel disease | Studies | Health care access | Diabetes | Socioeconomic factors | Data bases
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 132, Issue 2, pp. 371 - 377
Background Atopic dermatitis (AD) is a common inflammatory skin disease. Previous studies have revealed shared genetic determinants among different...
Allergy and Immunology | persistent atopic dermatitis | soluble IL-6 receptor | Atopic dermatitis | inflammation | single nucleotide polymorphism | longitudinal study | population-based cohort | prognosis | candidate association study | genetic risk factor | PATHWAYS | FOLLOW-UP | MECHANISMS | IMMUNOLOGY | CHILDHOOD | CHILDREN | ALLERGY | DISEASE | ASTHMA | MUTATIONS | BIRTH COHORT | ASSOCIATION | Dermatitis, Atopic - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Interleukin-6 - genetics | Receptors, Interleukin-6 - genetics | Humans | Risk Factors | Child, Preschool | Genotype | Infant | Male | Adolescent | Alleles | Female | Polymorphism, Single Nucleotide | Receptors, Interleukin-6 - blood | Child | Interleukin-6 - metabolism | Infant, Newborn | Cohort Studies | Risk factors | Genes | Independent study | Population | Age | Immune system | Asthma | Meta-analysis
Allergy and Immunology | persistent atopic dermatitis | soluble IL-6 receptor | Atopic dermatitis | inflammation | single nucleotide polymorphism | longitudinal study | population-based cohort | prognosis | candidate association study | genetic risk factor | PATHWAYS | FOLLOW-UP | MECHANISMS | IMMUNOLOGY | CHILDHOOD | CHILDREN | ALLERGY | DISEASE | ASTHMA | MUTATIONS | BIRTH COHORT | ASSOCIATION | Dermatitis, Atopic - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Interleukin-6 - genetics | Receptors, Interleukin-6 - genetics | Humans | Risk Factors | Child, Preschool | Genotype | Infant | Male | Adolescent | Alleles | Female | Polymorphism, Single Nucleotide | Receptors, Interleukin-6 - blood | Child | Interleukin-6 - metabolism | Infant, Newborn | Cohort Studies | Risk factors | Genes | Independent study | Population | Age | Immune system | Asthma | Meta-analysis
Journal Article
Journal of Pediatrics, The, ISSN 0022-3476, 2011, Volume 159, Issue 5, pp. 825 - 831.e1
Objective To identify genetic and nongenetic risk factors that contribute to the severity of the bladder exstrophy-epispadias complex (BEEC). Study design...
Pediatrics | European Study Cohort | In vitro fertilization | Bladder exstrophy-epispadias complex | North American Study Cohort | OEIS | Ventricular septal defect | Intracytoplasmic sperm injection | VSD | CBE | EUROCAT | Omphalocele, exstrophy, imperforate anus, and spinal defects complex | Classic bladder exstrophy | ES cohort | Cleft lip with or without cleft palate | ICSI | CL-P | NAS cohort | Cloacal exstrophy | Epispadias | IVF | European Surveillance of Congenital Malformations network | BEEC | RISK | PEDIATRICS | DEFECTS | CLOACAL EXSTROPHY | POSSIBLE ASSOCIATION | BIRTHS | Folic Acid - therapeutic use | Sperm Injections, Intracytoplasmic - statistics & numerical data | Paternal Age | Humans | Middle Aged | Male | Pregnancy Trimester, First | Antacids - therapeutic use | Maternal Age | Adult | Female | Surveys and Questionnaires | Fertilization in Vitro - statistics & numerical data | Severity of Illness Index | Cleft Lip - epidemiology | Vitamin B Complex - therapeutic use | Risk Factors | Europe - epidemiology | Bladder Exstrophy - epidemiology | Pregnancy | Radiography - utilization | Phenotype | Smoking - epidemiology | Sex Distribution | Epispadias - epidemiology | Cleft Palate - epidemiology | North America - epidemiology | Prenatal Care | Oncology, Experimental | Genetic research | Birth defects | Genetic aspects | Research | Universities and colleges | Risk factors | Cancer
Pediatrics | European Study Cohort | In vitro fertilization | Bladder exstrophy-epispadias complex | North American Study Cohort | OEIS | Ventricular septal defect | Intracytoplasmic sperm injection | VSD | CBE | EUROCAT | Omphalocele, exstrophy, imperforate anus, and spinal defects complex | Classic bladder exstrophy | ES cohort | Cleft lip with or without cleft palate | ICSI | CL-P | NAS cohort | Cloacal exstrophy | Epispadias | IVF | European Surveillance of Congenital Malformations network | BEEC | RISK | PEDIATRICS | DEFECTS | CLOACAL EXSTROPHY | POSSIBLE ASSOCIATION | BIRTHS | Folic Acid - therapeutic use | Sperm Injections, Intracytoplasmic - statistics & numerical data | Paternal Age | Humans | Middle Aged | Male | Pregnancy Trimester, First | Antacids - therapeutic use | Maternal Age | Adult | Female | Surveys and Questionnaires | Fertilization in Vitro - statistics & numerical data | Severity of Illness Index | Cleft Lip - epidemiology | Vitamin B Complex - therapeutic use | Risk Factors | Europe - epidemiology | Bladder Exstrophy - epidemiology | Pregnancy | Radiography - utilization | Phenotype | Smoking - epidemiology | Sex Distribution | Epispadias - epidemiology | Cleft Palate - epidemiology | North America - epidemiology | Prenatal Care | Oncology, Experimental | Genetic research | Birth defects | Genetic aspects | Research | Universities and colleges | Risk factors | Cancer
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2007, Volume 120, Issue 4, pp. 975 - 977
 Most cases of HAE are attributable to mutations in the SERPING1 gene, resulting in defective serpin C1 inhibitor (C1Inh; HAE types I and II, Mendelian...
Allergy and Immunology | ALLERGY | IMMUNOLOGY | Factor XII - genetics | Pedigree | Humans | Female | Male | Complement C1 Inhibitor Protein - genetics | Mutation | Angioedema - genetics | Families & family life | Plasma | Females | Womens health | Angioedema | Innate immunity | Complement C1 Inhibitor Protein | Factor XII | Life Sciences | Immunology | Genetics | Human genetics
Allergy and Immunology | ALLERGY | IMMUNOLOGY | Factor XII - genetics | Pedigree | Humans | Female | Male | Complement C1 Inhibitor Protein - genetics | Mutation | Angioedema - genetics | Families & family life | Plasma | Females | Womens health | Angioedema | Innate immunity | Complement C1 Inhibitor Protein | Factor XII | Life Sciences | Immunology | Genetics | Human genetics
Journal Article
Journal of Psychiatry and Neuroscience, ISSN 1180-4882, 2014, Volume 39, Issue 6, pp. 386 - 396
Background Schizophrenia is a complex neuropsychiatric disorder of unclear etiology. The strongest known genetic risk factor is the 22q11.2 microdeletion....
Medical Education | Psychiatry
Medical Education | Psychiatry
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2010, Volume 64, Issue 4, pp. e45 - e50
Background In 1925, Dr Marie Unna described a rare form of hereditary hypotrichosis in a German multigenerational family. This was later termed “Marie Unna...
Dermatology | U2HR | hypotrichosis | hair loss | alopecia | loss of function mutation | Point Mutation | Pedigree | Humans | Hypotrichosis - genetics | Family Health | Hypotrichosis - congenital | Transcription Factors - genetics | Germany | Family
Dermatology | U2HR | hypotrichosis | hair loss | alopecia | loss of function mutation | Point Mutation | Pedigree | Humans | Hypotrichosis - genetics | Family Health | Hypotrichosis - congenital | Transcription Factors - genetics | Germany | Family
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e13950
Background: Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first...
PATHWAYS | POPULATION | IDENTIFIES VARIANTS | DEMENTIA | DATABASE | MICROGLIA | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | RISK | GENOME-WIDE ASSOCIATION | APOLIPOPROTEIN-E | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Humans | Chromosome Mapping | Cholesterol - metabolism | Apolipoproteins E - metabolism | Immune System - metabolism | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Alzheimer Disease - immunology | Genome, Human | Genes | Genomics | Physiological aspects | Mineral industry | Disease susceptibility | Genetic aspects | Apolipoproteins | Mining industry | Epidemiology | Alzheimer's disease | Cholesterol | Neurosciences | Physicians | Pathogenesis | Diagnostic tests | Psychotherapy | Genomes | Data mining | Apolipoprotein E | Dementia disorders | Aging | Genetics | Trends | Lipid metabolism | Drug dosages | Public health | Immune system | Medical research | Immune response | Neurodegenerative diseases | Data processing | Inflammation | Dentistry | Metabolism | Medicine | Neurology | Brain research | Hospitals | Councils | Alzheimers disease | Health risk assessment | Psychiatry | Dementia
PATHWAYS | POPULATION | IDENTIFIES VARIANTS | DEMENTIA | DATABASE | MICROGLIA | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | RISK | GENOME-WIDE ASSOCIATION | APOLIPOPROTEIN-E | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Humans | Chromosome Mapping | Cholesterol - metabolism | Apolipoproteins E - metabolism | Immune System - metabolism | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Alzheimer Disease - immunology | Genome, Human | Genes | Genomics | Physiological aspects | Mineral industry | Disease susceptibility | Genetic aspects | Apolipoproteins | Mining industry | Epidemiology | Alzheimer's disease | Cholesterol | Neurosciences | Physicians | Pathogenesis | Diagnostic tests | Psychotherapy | Genomes | Data mining | Apolipoprotein E | Dementia disorders | Aging | Genetics | Trends | Lipid metabolism | Drug dosages | Public health | Immune system | Medical research | Immune response | Neurodegenerative diseases | Data processing | Inflammation | Dentistry | Metabolism | Medicine | Neurology | Brain research | Hospitals | Councils | Alzheimers disease | Health risk assessment | Psychiatry | Dementia
Journal Article