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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 12
Plant-derived lignans have numerous biological effects including anti-tumor and anti-inflammatory activities. Screening of purified constituents of Rubia... 
NF-κB protein | Astrocytes | p53 Protein | Glioblastoma | Caspase | Protein biosynthesis | Inflammation | Survivin | Plants | Caspase-8 | FLICE-inhibitory protein | Chemotherapy | Tumor necrosis factor | Glioblastoma cells | TRAIL protein | Death receptors | Apoptosis
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 21956
The aim of this study was to discover small-molecule anticoagulants from Scolopendra subspinipes mutilans (SSM). A new acylated polyamine (1) and a new... 
COAGULATION CASCADE | IN-VITRO | PLATELET-AGGREGATION | PHOSPHORYLATION | CENTIPEDE | MULTIDISCIPLINARY SCIENCES | SURFACE | PROFIBRINOLYTIC ACTIVITIES | VEIN ENDOTHELIAL-CELLS | TYPE-1 | PLASMINOGEN-ACTIVATOR INHIBITOR | Prothrombin Time | Thrombin - antagonists & inhibitors | Alkaloids - isolation & purification | Male | Fibrinolytic Agents - isolation & purification | Quinolines - pharmacology | Pulmonary Embolism - pathology | Thrombin - biosynthesis | Platelet Aggregation - drug effects | Thrombosis - blood | Anticoagulants - isolation & purification | Acylation | Disease Models, Animal | Quinolines - isolation & purification | Alkaloids - pharmacology | Mice, Inbred C57BL | Polymerization | Drug Discovery | Pulmonary Embolism - blood | Factor Xa - biosynthesis | Fibrinolytic Agents - pharmacology | Thrombosis - pathology | Polyamines - pharmacology | Animals | Diterpene Alkaloids | Polyamines - isolation & purification | Drugs, Chinese Herbal - chemistry | Indoleacetic Acids - pharmacology | Partial Thromboplastin Time | Anticoagulants - pharmacology | Fibrin - antagonists & inhibitors | Pulmonary Embolism - drug therapy | Mice | Thrombosis - drug therapy | Fibrin - metabolism | Anticoagulants | Indole | Thrombin | Platelet aggregation | Thrombosis | Embolism | Thromboplastin | Coagulation factors | Alkaloids | Fibrin | Prothrombin | Acetic acid | Food
Journal Article
Journal Article
Journal Article
Inflammation, ISSN 0360-3997, 4/2015, Volume 38, Issue 2, pp. 784 - 799
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2017, Volume 7, Issue 1, p. 46035
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 7934 - 13
The edible grasshopper Oxya chinensis sinuosa is consumed worldwide for its various medicinal effects. The purpose of this study was to investigate potential... 
MYOCARDIAL-INFARCTION | BLOOD-COAGULATION | ANTI-IIA | MULTIDISCIPLINARY SCIENCES | IN-VIVO | HIRUDIN | THROMBIN INHIBITION | ANTICOAGULANT | THROMBOLYSIS | PROFIBRINOLYTIC ACTIVITIES | PEPTIDE | Stereoisomers | Animal models | Platelet aggregation | Histocompatibility antigen H-2 | Drug development | Thrombosis | Bleeding | Embolism
Journal Article
Marine Drugs, ISSN 1660-3397, 03/2019, Volume 17, Issue 3, p. 171
An ilimquinone (IQ) mixture isolated from Hippiospongia metachromia, consisting of IQ and epi-ilimaquinone (epi-IQ), exerts anti-HIV, anti-microbial,... 
Ilimaquinone | HPLC-MS/MS | Stereo-selective pharmacokinetics | Rat | Epi-ilimaquinone | APOPTOSIS | CELLS | ETHYLSMENOQUINONE | METABOLITES | ACTIVATION | CHEMISTRY, MEDICINAL | rat | HUMAN PLASMA | HPLC-MS | epi-ilimaquinone | stereo-selective pharmacokinetics | ilimaquinone
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 04/2018, Volume 62, Issue 7, pp. e1700769 - n/a
Scope Momordica charantia (M. charantia) has antidiabetic effects, and cucurbitane‐type triterpenoid is one of the compounds of M. charantia. This study aims... 
insulin sensitivity | glycogen storage | Cucurbitane‐type triterpenoids | glucose uptake | skeletal muscle | Cucurbitane-type triterpenoids | ACTIVATION | PROTEIN-KINASE | FOOD SCIENCE & TECHNOLOGY | AKT | MELLITUS | SKELETAL-MUSCLE | DRUGS | RESISTANCE | ROSIGLITAZONE | GLUT4 | EXPRESSION | Diabetes Mellitus, Experimental - drug therapy | Triterpenes - pharmacology | Streptozocin | Momordica charantia - chemistry | Triterpenes - therapeutic use | Male | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Diabetes Mellitus, Experimental - blood | Triterpenes - chemistry | Glycogen - metabolism | Muscle, Skeletal - drug effects | Molecular Structure | Diabetes Mellitus, Experimental - metabolism | Republic of Korea | Hypoglycemic Agents - therapeutic use | Absorption, Physiological - drug effects | Cell Line | Hyperglycemia - prevention & control | Fruit - chemistry | Insulin Resistance | Organ Specificity | Drug Discovery | Mice, Inbred ICR | Hypoglycemic Agents - pharmacology | Hypoglycemic Agents - isolation & purification | Ethnopharmacology | Animals | Diabetes Mellitus, Experimental - pathology | Glucose - metabolism | Triterpenes - isolation & purification | Mice | Muscle, Skeletal - pathology | Glucose metabolism | Hyperglycemia | Blood sugar | Glycogen | Ana