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science & technology (36) 36
life sciences & biomedicine (30) 30
animals (27) 27
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mitochondria (18) 18
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ischemic preconditioning, myocardial (10) 10
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reperfusion injury (6) 6
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myocardial reperfusion injury - pathology (5) 5
myocardial reperfusion injury - physiopathology (5) 5
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reactive oxygen species (5) 5
reactive oxygen species - metabolism (5) 5
acetylation (4) 4
bioenergetics (4) 4
hypoxia (4) 4
in vitro techniques (4) 4
ischemic preconditioning (4) 4
medicine (4) 4
mitochondria - physiology (4) 4
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laboratory animals (3) 3
lysine - metabolism (3) 3
membrane potential, mitochondrial - drug effects (3) 3
metabolomics (3) 3
mitochondria, heart - physiology (3) 3
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nitrosation (3) 3
obesity (3) 3
permeability (3) 3
ros, reactive oxygen species (3) 3
science (3) 3
signal transduction - physiology (3) 3
sirtuins (3) 3
abridged index medicus (2) 2
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aging (2) 2
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1. Full Text Mediterranean diet and cardioprotection: The role of nitrite, polyunsaturated fatty acids, and polyphenols
by Nadtochiy, Sergiy M., Ph.D and Redman, Emily K
Nutrition (Burbank, Los Angeles County, Calif.), ISSN 0899-9007, 2011, Volume 27, Issue 7, pp. 733 - 744
Gastroenterology and Hepatology | Polyphenols | Nitrite | Mediterranean diet | PUFA | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Fundamental and applied biological sciences. Psychology | Feeding. Feeding behavior | Biological and medical sciences | Vertebrates: anatomy and physiology, studies on body, several organs or systems | Antioxidants - therapeutic use | Diet, Mediterranean | Humans | Fatty Acids, Unsaturated - therapeutic use | Myocardial Infarction - prevention & control | Phytotherapy | Polyphenols - therapeutic use | Plant Extracts - therapeutic use | Nitrites - therapeutic use | Studies | Plasma | Heart attacks | Homeostasis | Nitrates | FDA approval | Index Medicus
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2. Full Text SIRT3 deficiency exacerbates ischemia-reperfusion injury: Implication for aged hearts
by Porter, George A and Urciuoli, William R and Brookes, Paul S and Nadtochiy, Sergiy M
American journal of physiology. Heart and circulatory physiology, ISSN 0363-6135, 06/2014, Volume 306, Issue 12, pp. H1602 - H1609
Heart | Mitochondria | Reperfusion | Ischemia | Aging | Acetylation | SIRT3 | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Heart Rate | Sirtuin 3 - genetics | Ventricular Function, Left | Down-Regulation | Mice, Inbred C57BL | Risk Factors | Male | Sirtuin 3 - deficiency | Myocardial Reperfusion Injury - epidemiology | Mice, Knockout | Myocardial Reperfusion Injury - metabolism | Animals | Myocardium - metabolism | Mice | In Vitro Techniques | Aging - metabolism | Disease Models, Animal | Physiological aspects | Myocardial ischemia | Research | Cardiovascular research | Proteins | Simulation | Cells | Index Medicus | Call for Papers | acetylation | mitochondria | aging | reperfusion | heart | ischemia
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3. Full Text Acidic pH is a metabolic switch for 2-Hydroxyglutarate generation and signaling
by Sergiy, M. Nadtochiy and Xenia, Schafer and Dragony, Fu and Keith, Nehrke and Joshua, Munger and Brookes, Paul S
The Journal of biological chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 38, pp. 20188 - 20197
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | L-Lactate Dehydrogenase - metabolism | Malate Dehydrogenase - metabolism | Isoenzymes - genetics | Alcohol Oxidoreductases - metabolism | Male | Hypoxia-Inducible Factor 1 - metabolism | Hypoxia-Inducible Factor 1 - genetics | Malate Dehydrogenase - genetics | Alcohol Oxidoreductases - genetics | Animals | L-Lactate Dehydrogenase - genetics | Isoenzymes - metabolism | Signal Transduction - physiology | Glutarates - metabolism | Mice | Hydrogen-Ion Concentration | Index Medicus | hypoxia | cancer | 2-hydroxyglutarate | Metabolism | acidosis | epigenetics
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4. Full Text Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
by Chouchani, Edward T and Pell, Victoria R and Gaude, Edoardo and Aksentijević, Dunja and Sundier, Stephanie Y and Robb, Ellen L and Logan, Angela and Nadtochiy, Sergiy M and Ord, Emily N. J and Smith, Anthony C and Eyassu, Filmon and Shirley, Rachel and Hu, Chou-Hui and Dare, Anna J and James, Andrew M and Rogatti, Sebastian and Hartley, Richard C and Eaton, Simon and Costa, Ana S. H and Brookes, Paul S and Davidson, Sean M and Duchen, Michael R and Saeb-Parsy, Kourosh and Shattock, Michael J and Robinson, Alan J and Work, Lorraine M and Frezza, Christian and Krieg, Thomas and Murphy, Michael P
Nature (London), ISSN 0028-0836, 11/2014, Volume 515, Issue 7527, pp. 431 - 435
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Metabolomics | Mitochondria - enzymology | Electron Transport | Reactive Oxygen Species - metabolism | Ischemia - enzymology | Male | Electron Transport Complex I - metabolism | Myocytes, Cardiac - enzymology | Myocardium - metabolism | Malates - metabolism | Reperfusion Injury - metabolism | NAD - metabolism | Disease Models, Animal | Myocardial Infarction - enzymology | Adenosine Monophosphate - metabolism | Reperfusion Injury - enzymology | Ischemia - metabolism | Mitochondria - metabolism | Myocardial Infarction - metabolism | Citric Acid Cycle | Myocardium - cytology | Stroke - enzymology | Myocardium - enzymology | Stroke - metabolism | Animals | Succinic Acid - metabolism | Fumarates - metabolism | Myocytes, Cardiac - metabolism | Aspartic Acid - metabolism | Succinate Dehydrogenase - metabolism | Mice | Reactive oxygen species | Research | Succinates | Health aspects | Analysis | Reperfusion injury | Heart | Stroke | Glucose | Metabolites | Metabolism | Carbon | Index Medicus
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5. Full Text Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex i
by Chouchani, Edward T and Methner, Carmen and Nadtochiy, Sergiy M and Logan, Angela and Pell, Victoria R and Ding, Shujing and James, Andrew M and Cochemé, Helena M and Reinhold, Johannes and Lilley, Kathryn S and Partridge, Linda and Fearnley, Ian M and Robinson, Alan J and Hartley, Richard C and Smith, Robin A J and Krieg, Thomas and Brookes, Paul S and Murphy, Michael P
Nature medicine, ISSN 1078-8956, 06/2013, Volume 19, Issue 6, pp. 753 - 759
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Protein Subunits | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Mice, Inbred C57BL | Rats | Male | Nitrosation | Electron Transport Complex I - metabolism | Animals | Mitochondrial Proteins - metabolism | Cysteine - metabolism | Mice | Myocardial Reperfusion Injury - prevention & control | Reactive oxygen species | Care and treatment | Cysteine | Physiological aspects | Genetic aspects | Research | Reperfusion injury | Mitochondria | Heart attacks | Ischemia | Cardiology | Nitric oxide | Index Medicus
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6. Full Text SIRT1-mediated acute cardioprotection
by Sergiy M. Nadtochiy and Hongwei Yao and Michael W. McBurney and Wei Gu and Leonard Guarente and Irfan Rahman and Paul S. Brookes
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2011, Volume 301, Issue 4, pp. 1506 - 1512
Myocardial infarction | Nicotinamide adenine dinucleotide | Ischemic preconditioning | Silent information regulator of transcription | Lysine deacetylation | Cardiac & Cardiovascular Systems | Physiology | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Animals, Genetically Modified | Heart - physiology | Mice, Inbred C57BL | Signal Transduction - genetics | Sirtuin 1 - antagonists & inhibitors | Sirtuin 1 - genetics | Blotting, Western | Myocardial Reperfusion Injury - physiopathology | Mice, Knockout | Animals | Forkhead Transcription Factors - metabolism | Ischemic Preconditioning, Myocardial | Sirtuin 1 - physiology | Cytosol - metabolism | Signal Transduction - physiology | Forkhead Box Protein O1 | Lysine - metabolism | Mice | Acetylation | In Vitro Techniques | Myocardial Reperfusion Injury - prevention & control | NAD - metabolism | Superoxide Dismutase - metabolism | Prevention | Physiological aspects | Research | Genetic transcription | Lysine | Reperfusion injury | Amino acids | Phosphorylation | Pharmacology | Ischemia | Gene expression | Rodents | Index Medicus | nicotinamide adenine dinucleotide | ischemic preconditioning | silent information regulator of transcription | lysine deacetylation | Signaling and Stress Response | myocardial infarction
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7. Full Text Lysine deacetylation in ischaemic preconditioning: The role of SIRT1
by Nadtochiy, Sergiy M and Redman, Emily and Rahman, Irfan and Brookes, Paul S
Cardiovascular research, ISSN 0008-6363, 02/2011, Volume 89, Issue 3, pp. 643 - 649
Ischaemia | Sirtuins | Lysine acetylation | SUMO | Preconditioning | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Medical sciences | Sirtuin 1 - metabolism | Myocytes, Cardiac - cytology | Mice, Inbred C57BL | Male | Myocardial Reperfusion Injury - metabolism | Animals | Ischemic Preconditioning, Myocardial | Myocardium - metabolism | Myocytes, Cardiac - metabolism | Lysine - metabolism | Mice | Acetylation | NAD - metabolism | Disease Models, Animal | Index Medicus | Original
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