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myocardial reperfusion injury - pathology (5) 5
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reactive oxygen species (5) 5
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acetylation (4) 4
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medicine (4) 4
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metabolomics (3) 3
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1. Full Text Direct Stimulation of Glycolysis Accounts for Cellular Metabolic Benefits of the NAD.sup.+ Precursor Nicotinamide Mononucleotide
by Nadtochiy, Sergiy M and Brookes, Paul S
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, p. 161
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.freeradbiomed.2017.10.247 
Niacinamide | Lactates | Glucose metabolism | Lysine
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2. Full Text 234 - Direct Stimulation of Glycolysis Accounts for Cellular Metabolic Benefits of the NAD+ Precursor Nicotinamide Mononucleotide (NMN)
by Nadtochiy, Sergiy M and Brookes, Paul S
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, pp. 161 - 161
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3. Full Text Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase
by Nadtochiy, Sergiy M and Zhu, Qiuyu and Urciuoli, William and Rafikov, Ruslan and Black, Stephen M and Brookes, Paul S
Journal of Biological Chemistry, ISSN 0021-9258, 01/2012, Volume 287, Issue 5, pp. 3573 - 3580
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4. Full Text Erratum: Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1 (The journal of biological chemistry (2012) 287 (3573-3580))
by Nadtochiy, Sergiy M and Zhu, Qiuyu Martin and Urciuoli, William and Rafikov, Ruslan and Black, Stephen M and Brookes, Paul S
Journal of Biological Chemistry, ISSN 0021-9258, 12/2015, Volume 290, Issue 51, p. 30267
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5. Full Text Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
by Chouchani, Edward T and Pell, Victoria R and Gaude, Edoardo and Aksentijević, Dunja and Sundier, Stephanie Y and Robb, Ellen L and Logan, Angela and Nadtochiy, Sergiy M and Ord, Emily N. J and Smith, Anthony C and Eyassu, Filmon and Shirley, Rachel and Hu, Chou-Hui and Dare, Anna J and James, Andrew M and Rogatti, Sebastian and Hartley, Richard C and Eaton, Simon and Costa, Ana S. H and Brookes, Paul S and Davidson, Sean M and Duchen, Michael R and Saeb-Parsy, Kourosh and Shattock, Michael J and Robinson, Alan J and Work, Lorraine M and Frezza, Christian and Krieg, Thomas and Murphy, Michael P
Nature, ISSN 0028-0836, 11/2014, Volume 515, Issue 7527, pp. 431 - 435
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then restored, and underlies many disorders, notably heart attack and... 
STROKE | HYPOXIA-ISCHEMIA | MECHANISM | COMPLEX-I | SUPEROXIDE-PRODUCTION | MULTIDISCIPLINARY SCIENCES | PURINE NUCLEOTIDE CYCLE | CONSEQUENCES | CARDIOPROTECTION | HYPERTENSIVE-RATS | DEHYDROGENASE | Metabolomics | Mitochondria - enzymology | Electron Transport | Reactive Oxygen Species - metabolism | Ischemia - enzymology | Male | Electron Transport Complex I - metabolism | Myocytes, Cardiac - enzymology | Myocardium - metabolism | Malates - metabolism | Reperfusion Injury - metabolism | NAD - metabolism | Disease Models, Animal | Myocardial Infarction - enzymology | Adenosine Monophosphate - metabolism | Reperfusion Injury - enzymology | Ischemia - metabolism | Mitochondria - metabolism | Myocardial Infarction - metabolism | Citric Acid Cycle | Myocardium - cytology | Stroke - enzymology | Myocardium - enzymology | Stroke - metabolism | Animals | Succinic Acid - metabolism | Fumarates - metabolism | Myocytes, Cardiac - metabolism | Aspartic Acid - metabolism | Succinate Dehydrogenase - metabolism | Mice | Reactive oxygen species | Research | Succinates | Health aspects | Analysis | Reperfusion injury | Heart | Stroke | Glucose | Metabolites | Metabolism | Carbon | Index Medicus
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6. Full Text Mitochondrially targeted nitro-linoleate: a new tool for the study of cardioprotection
: TPP+-LNO2and cardioprotection
by Nadtochiy, Sergiy M and Madukwe, Jerry and Hagen, Fred and Brookes, Paul S
British Journal of Pharmacology, ISSN 0007-1188, 04/2014, Volume 171, Issue 8, pp. 2091 - 2098
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7. Full Text SIRT3 deficiency exacerbates ischemia-reperfusion injury: Implication for aged hearts
by Porter, George A and Urciuoli, William R and Brookes, Paul S and Nadtochiy, Sergiy M
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 06/2014, Volume 306, Issue 12, pp. H1602 - H1609
Ischemia-reperfusion (IR) injury is significantly worse in aged hearts, but the underlying mechanisms are poorly understood. Age-related damage to mitochondria... 
Heart | Mitochondria | Reperfusion | Ischemia | Aging | Acetylation | SIRT3 | LIFE-SPAN | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | mitochondria | ACUTE CARDIOPROTECTION | EMERGING CHARACTERIZATION | KNOCKOUT MICE | S-NITROSATION | heart | ischemia | acetylation | SKELETAL-MUSCLE | MITOCHONDRIAL COMPLEX-I | PERIPHERAL VASCULAR DISEASE | RAT-HEART | aging | reperfusion | CALORIE RESTRICTION | Heart Rate | Sirtuin 3 - genetics | Ventricular Function, Left | Down-Regulation | Mice, Inbred C57BL | Risk Factors | Male | Sirtuin 3 - deficiency | Myocardial Reperfusion Injury - epidemiology | Mice, Knockout | Myocardial Reperfusion Injury - metabolism | Animals | Myocardium - metabolism | Mice | In Vitro Techniques | Aging - metabolism | Disease Models, Animal | Physiological aspects | Myocardial ischemia | Research | Cardiovascular research | Proteins | Simulation | Cells | Index Medicus | Call for Papers
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8. Full Text Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex i
by Chouchani, Edward T and Methner, Carmen and Nadtochiy, Sergiy M and Logan, Angela and Pell, Victoria R and Ding, Shujing and James, Andrew M and Cochemé, Helena M and Reinhold, Johannes and Lilley, Kathryn S and Partridge, Linda and Fearnley, Ian M and Robinson, Alan J and Hartley, Richard C and Smith, Robin A J and Krieg, Thomas and Brookes, Paul S and Murphy, Michael P
Nature Medicine, ISSN 1078-8956, 06/2013, Volume 19, Issue 6, pp. 753 - 759
Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to ischemia-reperfusion injury in myocardial infarction and stroke. The... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTECTION | PROTEIN-KINASE-G | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | NITROSOTHIOL | CELL BIOLOGY | ISCHEMIA-REPERFUSION INJURY | ELECTROPHORESIS | DISEASE | NITRIC-OXIDE | MEMBRANE-PROTEINS | NITROSYLATION | Protein Subunits | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Mice, Inbred C57BL | Rats | Male | Nitrosation | Electron Transport Complex I - metabolism | Animals | Mitochondrial Proteins - metabolism | Cysteine - metabolism | Mice | Myocardial Reperfusion Injury - prevention & control | Reactive oxygen species | Care and treatment | Cysteine | Physiological aspects | Genetic aspects | Research | Reperfusion injury | Mitochondria | Heart attacks | Ischemia | Cardiology | Nitric oxide | Index Medicus
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9. Full Text Acidic pH is a metabolic switch for 2-Hydroxyglutarate generation and signaling
by Sergiy, M. Nadtochiy and Xenia, Schafer and Dragony, Fu and Keith, Nehrke and Joshua, Munger and Brookes, Paul S
Journal of Biological Chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 38, pp. 20188 - 20197
2-Hydroxyglutarate (2-HG) is an important epigenetic regulator, with potential roles in cancer and stem cell biology. The d-(R)-enantiomer (d-2-HG) is an... 
hypoxia | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-KETOGLUTARATE | ACIDIFICATION | L-2-HYDROXYGLUTARIC ACIDURIA | SIGNATURE | epigenetics | DEHYDROGENASE | ANOXIA | acidosis | cancer | metabolism | 2-hydroxyglutarate | L-Lactate Dehydrogenase - metabolism | Malate Dehydrogenase - metabolism | Isoenzymes - genetics | Alcohol Oxidoreductases - metabolism | Male | Hypoxia-Inducible Factor 1 - metabolism | Hypoxia-Inducible Factor 1 - genetics | Malate Dehydrogenase - genetics | Alcohol Oxidoreductases - genetics | Animals | L-Lactate Dehydrogenase - genetics | Isoenzymes - metabolism | Signal Transduction - physiology | Glutarates - metabolism | Mice | Hydrogen-Ion Concentration | Index Medicus | Metabolism
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10. Full Text Direct Stimulation of Glycolysis Accounts for Cellular Metabolic Benefits of the NAD(+) Precursor Nicotinamide Mononucleotide (NMN)
by Nadtochiy, SM and Brookes, PS
FREE RADICAL BIOLOGY AND MEDICINE, ISSN 0891-5849, 11/2017, Volume 112, pp. 161 - 161
BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM
Conference Proceeding
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11. Full Text Redox regulation of the mitochondrial KATP channel in cardioprotection
by Queliconi, Bruno B and Wojtovich, Andrew P and Nadtochiy, Sergiy M and Kowaltowski, Alicia J and Brookes, Paul S
Biochimica et Biophysica Acta - Molecular Cell Research, ISSN 0167-4889, 07/2011, Volume 1813, Issue 7, pp. 1309 - 1315
The mitochondrial ATP-sensitive potassium channel (mK ) is important in the protective mechanism of ischemic preconditioning (IPC). The channel is reportedly... 
channel | Redox | Ischemia | Preconditioning | Nitric oxide
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12. Full Text Redox regulation of the mitochondrial K.sub.ATP channel in cardioprotection
by Queliconi, Bruno B and Wojtovich, Andrew P and Nadtochiy, Sergiy M and Kowaltowski, Alicia J and Brookes, Paul S
BBA - Molecular Cell Research, ISSN 0167-4889, 07/2011, Volume 1813, Issue 7, p. 1309
The mitochondrial ATP-sensitive potassium channel (mK.sub.ATP) is important in the protective mechanism of ischemic preconditioning (IPC). The channel is... 
Laws, regulations and rules | Analysis | Nitric oxide | Mitochondrial DNA
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13. Full Text A Mitochondria-Targeted S-Nitrosothiol Modulates Respiration, Nitrosates Thiols, and Protects against Ischemia-Reperfusion Injury
by Tracy A. Prime and Frances H. Blaikie and Cameron Evans and Sergiy M. Nadtochiy and Andrew M. James and Christina C. Dahm and Dario A. Vitturi and Rakesh P. Patel and C. Robin Hiley and Irina Abakumova and Raquel Requejo and Edward T. Chouchani and Thomas R. Hurd and John F. Garvey and Cormac T. Taylor and Paul S. Brookes and Robin A. J. Smith and Michael P. Murphy and Salvador Moncada
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2009, Volume 106, Issue 26, pp. 10764 - 10769
Nitric oxide $(NO^ \bullet )$ competitively inhibits oxygen consumption by mitochondria at cytochrome c oxidase and 5-nitrosates thiol proteins. We developed... 
Oxidases | Electrodes | Mitochondria | Thiols | Cytochromes | Oxides | Oxygen consumption | Hypoxia | Respiration | Reperfusion injury | S-nitrosation | Nitric oxide | OXYGEN | nitric oxide | VIVO | COMPLEX-I | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | PROTEINS | CARDIOPROTECTION | Mitochondria, Heart - metabolism | Humans | Male | Membrane Potential, Mitochondrial - drug effects | S-Nitrosothiols - metabolism | Electron Transport Complex I - metabolism | Myoblasts - drug effects | Myoblasts - metabolism | Sulfhydryl Compounds - metabolism | Aorta, Thoracic - physiology | Mass Spectrometry | Myoblasts - cytology | Aorta, Thoracic - drug effects | Reperfusion Injury - metabolism | Heart - physiopathology | Cell Line | S-Nitrosothiols - pharmacology | S-Nitrosothiols - chemical synthesis | Mice, Inbred C57BL | Rats | Mitochondria - metabolism | Rats, Sprague-Dawley | Nitric Oxide - secretion | Animals | Reperfusion Injury - prevention & control | Mitochondria, Heart - physiology | Oxygen Consumption - drug effects | Nitrosation - drug effects | Reperfusion Injury - physiopathology | Heart - drug effects | Mice | HeLa Cells | Vasodilation - drug effects | In Vitro Techniques | Mitochondria - physiology | Prevention | Physiological aspects | Properties | Proteins | Oxygen | Membranes | Ischemia | Index Medicus | Biological Sciences
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14. Full Text Nitrolinoleate modifies ANT, KATP channels and complex II and modulates their activity
by Nadtochiy, Sergiy M and Wojtovich, Andrew P and Brookes, Paul S
Biochimica et Biophysica Acta (BBA) - Bioenergetics, ISSN 0005-2728, 07/2010, Volume 1797, p. 81
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15. Full Text SIRT1-mediated acute cardioprotection
by Sergiy M. Nadtochiy and Hongwei Yao and Michael W. McBurney and Wei Gu and Leonard Guarente and Irfan Rahman and Paul S. Brookes
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 10/2011, Volume 301, Issue 4, pp. 1506 - 1512
Overexpression studies have revealed a role for silent information regulator of transcription 1 (SIRT1) lysine deacetylase in cardioprotection against... 
Myocardial infarction | Nicotinamide adenine dinucleotide | Ischemic preconditioning | Silent information regulator of transcription | Lysine deacetylation | RESVERATROL | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | NITRIC-OXIDE SYNTHASE | myocardial infarction | CARDIAC MYOCYTES | ischemic preconditioning | lysine deacetylation | AUTOPHAGY | FOXO TRANSCRIPTION FACTORS | CELL-SURVIVAL | SIRT1 DEACETYLASE | nicotinamide adenine dinucleotide | HEART | silent information regulator of transcription | PERIPHERAL VASCULAR DISEASE | ISCHEMIA/REPERFUSION | Animals, Genetically Modified | Heart - physiology | Mice, Inbred C57BL | Signal Transduction - genetics | Sirtuin 1 - antagonists & inhibitors | Sirtuin 1 - genetics | Blotting, Western | Myocardial Reperfusion Injury - physiopathology | Mice, Knockout | Animals | Forkhead Transcription Factors - metabolism | Ischemic Preconditioning, Myocardial | Sirtuin 1 - physiology | Cytosol - metabolism | Signal Transduction - physiology | Forkhead Box Protein O1 | Lysine - metabolism | Mice | Acetylation | In Vitro Techniques | Myocardial Reperfusion Injury - prevention & control | NAD - metabolism | Superoxide Dismutase - metabolism | Prevention | Physiological aspects | Research | Genetic transcription | Lysine | Reperfusion injury | Amino acids | Phosphorylation | Pharmacology | Ischemia | Gene expression | Rodents | Index Medicus | Signaling and Stress Response
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16. Full Text Lysine deacetylation in ischaemic preconditioning: The role of SIRT1
by Nadtochiy, Sergiy M and Redman, Emily and Rahman, Irfan and Brookes, Paul S
Cardiovascular Research, ISSN 0008-6363, 02/2011, Volume 89, Issue 3, pp. 643 - 649
Aims Acute ischaemic preconditioning (IPC) induces protection against cardiac ischaemia-reperfusion (IR) via post-translational modification of key proteins.... 
Ischaemia | Sirtuins | Lysine acetylation | SUMO | Preconditioning | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | REPERFUSION INJURY | CARDIAC MYOCYTES | HEART-FAILURE | NUCLEAR TRANSLOCATION | PROMOTES CELL-SURVIVAL | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE | STRESS | CARDIOPROTECTION | NF-KAPPA-B | Sirtuin 1 - metabolism | Myocytes, Cardiac - cytology | Mice, Inbred C57BL | Male | Myocardial Reperfusion Injury - metabolism | Animals | Ischemic Preconditioning, Myocardial | Myocardium - metabolism | Myocytes, Cardiac - metabolism | Lysine - metabolism | Mice | Acetylation | NAD - metabolism | Disease Models, Animal | Index Medicus | Original
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17. Full Text Direct evidence for S-nitrosation of mitochondrial complex I
by Burwell, Lindsay S and Nadtochiy, Sergiy M and Tompkins, Andrew J and Young, Sara and Brookes, Paul S
Biochemical Journal, ISSN 0264-6021, 03/2006, Volume 394, Issue 3, pp. 627 - 634
NO. (nitric oxide) is a pleiotropic signalling molecule, with many of its effects on cell function being elicited at the level of the mitochondrion. In... 
Mitochondrion | Reactive oxygen species | Complex I | S-nitrosothiol | Nitric oxide | PERSISTENT INHIBITION | RESPIRATORY-CHAIN | nitric oxide | PEROXYNITRITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISCHEMIC MYOCARDIUM | mitochondrion | CYTOCHROME-C-OXIDASE | reactive oxygen species | NITRIC-OXIDE | complex I | CELL | HEART-MITOCHONDRIA | PARKINSONS-DISEASE | Rats | Male | Mitochondria - metabolism | Nitrosation | S-Nitrosothiols - metabolism | Electron Transport Complex I - metabolism | Rats, Sprague-Dawley | Nitrates - metabolism | Animals | Ischemic Preconditioning, Myocardial | Myocardium - metabolism | Sensitivity and Specificity | Mitochondria - chemistry | Index Medicus | DETA-NONOate, (Z)-1-[2-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate | SNO, S-nitrosothiol(s) | IPC, ischaemic preconditioning | MALDI-TOF-MS, matrix-assisted laser-desorption ionization–time-of-flight MS | GSNO, S-nitrosoglutathione | NO•, nitric oxide | ROS, reactive oxygen species | DTPA, diethylenetriaminepenta-acetic acid
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18. Full Text Cyclophilin D Knock-out mice show enhanced resistance to osteoporosis and to metabolic changes observed in aging bone
by Shum, Laura C and White, Noelle S and Nadtochiy, Sergiy M and De Mesy Bentley, Karen L and Brookes, Paul S and HJonason, Jennifer and Eliseev, Roman A
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, pp. e0155709 - e0155709
Pathogenic factors associated with aging, such as oxidative stress and hormone depletion converge on mitochondria and impair their function via opening of the... 
MITOCHONDRIAL PERMEABILITY TRANSITION | OXIDATIVE STRESS | OSTEOBLAST DIFFERENTIATION | MULTIDISCIPLINARY SCIENCES | PORE | DISEASE | INVOLVEMENT | CELL-DEATH | REVEALS | Bone and Bones - pathology | Age Factors | Cyclophilins - deficiency | Male | X-Ray Microtomography | Osteoporosis - metabolism | Bone Resorption - genetics | Bone and Bones - diagnostic imaging | Bone and Bones - metabolism | Osteoporosis - diagnostic imaging | Bone Resorption - metabolism | Osteoporosis - genetics | Disease Resistance - genetics | Disease Models, Animal | Genetic Predisposition to Disease | Bone Density | Metabolome | Mitochondria - metabolism | Metabolomics - methods | Osteoclasts - metabolism | Mice, Knockout | Biomechanical Phenomena | Phenotype | Animals | Osteoporosis - pathology | Mice | Osteoporosis | Care and treatment | Research | Cyclophilin | Analysis | Mitochondrial membranes | Brain | Oxidative stress | Metabolomics | Phosphorylation | Mitochondrial permeability transition pore | Oxidative metabolism | Impairment | Membrane permeability | Osteocytes | Mitochondrial DNA | Nucleotides | Mitochondria | Bone growth | NADH | Clonal deletion | Rodents | Deletion | Aging | Biocompatibility | Bone loss | Age | Cardiac muscle | Muscles | Permeability | Dentistry | Metabolism | Breeding of animals | Electron microscopy | Medicine | NAD | Biomechanics | Pathology | Bone mass | Stem cells | Nicotinamide adenine dinucleotide | Glycolysis | Bone | Anesthesiology | MPTP | Laboratory animals | Alzheimers disease | Osteogenesis | Apoptosis | Index Medicus
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19. Full Text Cardiac metabolic effects of KNa1.2 channel deletion and evidence for its mitochondrial localization
by Smith, Charles O and Wang, Yves T and Nadtochiy, Sergiy M and Miller, James H and Jonas, Elizabeth A and Dirksen, Robert T and Nehrke, Keith and Brookes, Paul S
FASEB Journal, ISSN 0892-6638, 11/2018, Volume 32, Issue 11, pp. 6135 - 6149
Patch clamp | Slo2.1 | Bithionol | Slick
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