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Pharmaceutical Research, ISSN 0724-8741, 3/2017, Volume 34, Issue 3, pp. 535 - 543
Tissue partitioning is an important component of drug distribution and half-life. Protein binding and lipid partitioning together determine drug... 
Biochemistry, general | Biomedical Engineering | microsomal partitioning | Biomedicine | molecular modeling | Pharmacy | drug distribution | Medical Law | Pharmacology/Toxicology | Drugs | Models | Drug wholesalers | Analysis | Protein binding | Proteins | Tissue | Drug delivery systems | Membranes | Lungs | Binding sites
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 3/2017, Volume 34, Issue 3, pp. 529 - 534
Journal Article
2014, Methods in molecular biology, ISBN 9781627037570, Volume 1113
Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with ?enzyme kinetic concepts utilized regularly in... 
Enzymes | Pharmaceutical Preparations | metabolism | Pharmacokinetics
Web Resource
2014, Methods in molecular biology, ISBN 9781627037570, Volume 1113
Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with ?enzyme kinetic concepts utilized regularly in... 
Drugs | Enzymes | Pharmaceutical Preparations | Enzyme kinetics | Pharmacokinetics | Metabolism
Web Resource
Pharmaceutical Research, ISSN 0724-8741, 02/2014, Volume 31, Issue 2, p. 335
  The impact of efflux transporters in intracellular concentrations of a drug can be predicted with modeling techniques. In Part 1, several compartmental... 
Models | Glycoproteins | Pharmacology | Kinetics
Journal Article
Xenobiotica, ISSN 0049-8254, 10/2019, pp. 1 - 9
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 05/2018, Volume 15, Issue 5, pp. 1979 - 1995
Time-dependent inactivation (TDI) of cytochrome P450s (CYPs) is a leading cause of clinical drug-drug interactions (DDIs). Current methods tend to overpredict... 
drug-drug interactions | time-dependent inhibition | enzyme kinetic models | numerical method | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Cytochrome P-450 CYP3A - metabolism | Humans | Liver - metabolism | Microsomes, Liver - metabolism | Drug Interactions - physiology | Kinetics | drug–drug interactions
Journal Article
Xenobiotica; the fate of foreign compounds in biological systems, ISSN 0049-8254, 06/2017, pp. 1 - 28
Time dependent inhibition (TDI) may confound drug interaction predictions. Recently, models were generated for an array of TDI kinetic schemes using numerical... 
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 01/2018, Volume 33, Issue 1, pp. S19 - S19
Journal Article
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2010, Volume 678, pp. 124 - 132
Pharmacokinetics of anticancer drugs used in breast cancer therapy are well established. This chapter reviews preclinical and clinical pharmacokinetics of the... 
Memory - drug effects | Menopause - drug effects | Humans | Aging - drug effects | Endpoint Determination | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Antineoplastic Agents - therapeutic use | Breast Neoplasms - drug therapy
Conference Proceeding
Current Pharmacology Reports, ISSN 2198-641X, 10/2019, Volume 5, Issue 5, pp. 391 - 399
Prior to human studies, knowledge of drug disposition in the body is useful to inform decisions on drug safety and efficacy, first in human dosing, and dosing... 
Biomedicine, general | Membrane partitioning | Biomedicine | Prediction models | Distribution | Cancer Research | Molecular Medicine | Volume of distribution | Pharmacology/Toxicology | Tissue:plasma partition coefficients
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2008, Volume 36, Issue 2, pp. 322 - 330
Journal Article
Biopharmaceutics & Drug Disposition, ISSN 0142-2782, 04/2016, Volume 37, Issue 3, pp. 123 - 141
Journal Article
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