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Rapid Communications in Mass Spectrometry, ISSN 0951-4198, 11/2019, Volume 33, Issue 21, pp. 1643 - 1651
Rationale The complexity of central nervous system (CNS) drug delivery is the main obstacle with the blood–brain barrier (BBB) known to restrict access of most... 
Spectroscopy | Brain | Antiretroviral drugs | Drug delivery systems | Cerebral cortex | Central nervous system | Ions | Liquid chromatography | Desorption | Chromatography | Spatial distribution | Penetration | Ionization | Scientific imaging | Mass spectrometry | Deposition | Pharmaceuticals
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2017, Volume 56, Issue 15, pp. 4100 - 4109
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 05/2015, Volume 2015, Issue 13, pp. 2861 - 2867
We report a mild and efficient Cu(OAc)2‐catalysed protocol for the oxidative C–N cross‐coupling of terminal alkynes and N‐deprotected sulfonimidamides. The... 
C–H activation | C–N coupling | Sulfonimidamides | Synthetic methods | Sulfur | Copper | Alkynes | C-H activation | C-N coupling
Journal Article
Journal Article
Journal of Molecular Histology, ISSN 1567-2379, 12/2019, Volume 50, Issue 6, pp. 593 - 599
Central nervous system (CNS) HIV infection causes brain tissue inflammation and tissue deficit that contributes to neuroAIDS. This complication is escalated by... 
Life Sciences | Biomedicine, general | BBB | Pharmacokinetics and mass spectrometric imaging | HIV | CNS | Developmental Biology | NeuroAIDS | Cell Biology | Neuroimaging | Antiretroviral drugs | Nevirapine | Blood-brain barrier | Neurodegeneration | Human immunodeficiency virus--HIV | Central nervous system | Mass spectroscopy | Localization
Journal Article
ChemPhysChem, ISSN 1439-4235, 05/2019, Volume 20, Issue 9, pp. 1126 - 1134
β‐lactam antibiotics, which are used to treat infectious diseases, are currently the most widely used class of antibiotics. This study focused on the chemical... 
β-lactam antibiotics | activation energy | force constant (FC) | transition state (TS) | ring strain energy (RSE)
Journal Article
Journal Article
Assay and Drug Development Technologies, ISSN 1540-658X, 10/2019, Volume 17, Issue 7, pp. 322 - 329
The central nervous system has been identified as an anatomical reservoir for HIV due the difficulties in delivering therapeutic agents into the brain and this... 
Drugs | Neuroimaging | Brain | Spectroscopy | Cerebral cortex | Cortex | Central nervous system | Globus pallidus | Ions | Lamivudine | Mass spectroscopy | Cognition | Liquid chromatography | Pharmacology | Chemical compounds | Corpus callosum | Blood-brain barrier | Neurodegeneration | Human immunodeficiency virus--HIV | Neostriatum | Scientific imaging | Pharmacokinetics | Mass spectrometry | Zidovudine
Journal Article
Journal of Molecular Structure, ISSN 0022-2860, 03/2020, Volume 1204, p. 127497
Journal Article
RSC Advances, 01/2018, Volume 8, Issue 22, pp. 11902 - 11907
Bedaquiline (BDQ) is the first-in-class United States Food and Drug Administration (US FDA) approved anti-tuberculosis (anti-TB) drug, which is a novel... 
Spectroscopy | Brain | Regulatory agencies | Drug delivery systems | Central nervous system | Ions | Liquid chromatography | Desorption | Chemotherapy | Tuberculosis | Antibiotics | Ionization | Rodents | Mass spectrometry
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 1451 - 1456
Herein, we report the effect of nine FDA approved protease inhibitor drugs against a new HIV-1 subtype C mutant protease, E35D↑G↑S. The mutant has five... 
thermodynamics | HIV | inhibitor | mutant | Protease | HIV Protease Inhibitors - pharmacology | Thermodynamics | HIV Protease - drug effects | HIV Protease - genetics | Inhibitory Concentration 50 | HIV Protease Inhibitors - chemistry | HIV-1 - enzymology | Molecular Docking Simulation | Kinetics | Mutation | HIV Protease - metabolism
Journal Article
Xenobiotica; the fate of foreign compounds in biological systems, ISSN 0049-8254, 08/2019, pp. 1 - 10
HIV replication in the brain is unopposed due to reduced antiretroviral drug penetration into the central nervous system (CNS). Prevalence of HIV-associated... 
Index Medicus
Journal Article
Chemical Communications, ISSN 1359-7345, 07/2013, Volume 49, Issue 57, pp. 6382 - 6384
Highly regio- and stereoselective remote aziridination of 2,4-dienals has been developed, based on a vinylogous iminium-ion-dienamine catalytic cascade... 
ALCOHOLS | DIELS-ALDER | ACTIVATION | HETEROCYCLIC CARBENE CATALYSIS | GAMMA-ALKYLATION | AMINE CATALYSIS | ALPHA,BETA-UNSATURATED ALDEHYDES | BETA-HYDROXY | ENONES | CHEMISTRY, MULTIDISCIPLINARY | MICHAEL ADDITION
Journal Article