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1. Full Text Analysis of Skin Permeability and Toxicological Properties of Amorphous Silica Particles
by Matsuo, Kazuhiko and Hirobe, Sachiko and Okada, Naoki and Nakagawa, Shinsaku and Present address:Division of Chemotherapy and Kindai University Faculty of Pharmacy and Laboratory of Biotechnology and Therapeutics and Osaka University and Graduate School of Pharmaceutical Sciences
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 7, pp. 1201 - 1205
toxicity | skin penetration | silica particle | Skin penetration | Toxicity | Silica particle | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Particle Size | Animals | Silicon Dioxide - toxicity | Skin - metabolism | Silicon Dioxide - pharmacokinetics | Female | Skin Absorption | Permeability | Nanoparticles - toxicity | Mice, Inbred ICR | Skin - drug effects | Index Medicus
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2. Full Text Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response
by Shimizu, Taro and Ichihara, Masako and Yoshioka, Yasuo and Ishida, Tatsuhiro and Nakagawa, Shinsaku and Kiwada, Hiroshi and The University of Tokushima and Department of Pharmacokinetics and Biopharmaceutics and Institute of Health Biosciences and Department of Biotechnology and Therapeutics and Osaka University and Graduate School of Pharmaceutical Sciences and Subdivision of Biopharmaceutical Sciences
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2012, Volume 35, Issue 8, pp. 1336 - 1342
PEGylation | anti-polyethylene glycol immunoglobulin M | liposome | adenovirus | Anti-polyethylene glycol immunoglobulin M | Liposome | Adenovirus | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Injections, Intravenous | Ovalbumin - immunology | Rats, Wistar | Serum Albumin - administration & dosage | Rats | Male | Ovalbumin - pharmacology | Polyethylene Glycols - administration & dosage | Immunoglobulin M - metabolism | Splenectomy | Serum Albumin - immunology | Animals | Ovalbumin - administration & dosage | Serum Albumin - pharmacology | Cattle | Adenoviridae - immunology | Liposomes - pharmacology | Liposomes - immunology | Polyethylene Glycols - pharmacology | Index Medicus | Immunoglobulin M | Bovine serum albumin | Ovalbumin | Polyethylene | Immune response | Intravenous administration | nanoparticles | Immunogenicity | Polyethylene glycol | Cross-reactivity | Liposomes
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3. Full Text Frontiers of transcutaneous vaccination systems: Novel technologies and devices for vaccine delivery
by Matsuo, Kazuhiko and Hirobe, Sachiko and Okada, Naoki and Nakagawa, Shinsaku
Vaccine, ISSN 0264-410X, 2013, Volume 31, Issue 19, pp. 2403 - 2415
Allergy and Immunology | Skin | Transcutaneous vaccination | Microneedle | Patch formulation | Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) | Microbiology | Applied microbiology | Antigens - administration & dosage | Drug Delivery Systems - instrumentation | Vaccination - methods | Skin - metabolism | Vaccination - instrumentation | Humans | Antigens - immunology | Antigens - metabolism | Administration, Cutaneous | Vaccines - administration & dosage | Drug Delivery Systems - methods | Skin - immunology | Proteins | Chemotherapy | Vaccination | Cancer | Severe acute respiratory syndrome | Lipids | Vaccines | Permeability | Drug resistance | Tropical diseases | Studies | Nanoparticles | Infectious diseases | E coli | Lymphocytes | Fatalities | Immune system | Index Medicus | Antigen-presenting cells | DT, diphtheria toxoid | CSSS, cyanoacrylate skin surface stripping | DC, dendritic cell | SPS, skin preparation system | LT, heat-labile enterotoxin | TR, TexasRed | ELISA, enzyme-linked immunosorbent assay | SCI, subcutaneous immunization | TT, tetanus toxoid | LC, Langerhans cell | PAMPs, pattern-associated molecular patterns | APC, antigen-presenting cell | SC, stratum corneum | ICDRG, International Contact Dermatitis Research Group | TCI, transcutaneous immunization | CT, cholera toxin | dDC, dermal dendritic cell | FITC, fluorescein isothiocyanate | FL, flexible liposome | IMI, intramuscular immunization | HA, hemagglutinin | Ag, antigen | OVA, ovalbumin | MH, MicroHyala | INI, intranasal immunization | EpCAM, epithelial cell adhesion molecule
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4. Distribution of spiral grain within stem and the spirality pattern on Larix leptolepis Gordon
by Nakagawa, Shinsaku
1972, 24
Dendrochronology
Book
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5. Full Text Optimized PEGylated Adenovirus Vector Reduces the Anti-vector Humoral Immune Response against Adenovirus and Induces a Therapeutic Effect against Metastatic Lung Cancer
by Eto, Yusuke and Yoshioka, Yasuo and Ishida, Tatsuhiro and Yao, Xinglei and Morishige, Tomohiro and Narimatsu, Shogo and Mizuguchi, Hiroyuki and Mukai, Yohei and Okada, Naoki and Kiwada, Hiroshi and Nakagawa, Shinsaku and aDepartment of Biotechnology and Therapeutics and The University of Tokushima and cDepartment of Pharmacokinetics and Biopharmaceutics and Osaka University and Institute of Health Biosciences and eLaboratory of Gene Transfer and Regulation and Graduate School of Pharmaceutical Sciences and bThe Center for Advanced Medical Engineering and Informatics and National Institute of Biomedical Innovation and dDepartment of Biochemistry and Molecular Biology and Subdivision of Biopharmaceutical Sciences
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2010, Volume 33, Issue 9, pp. 1540 - 1544
adenovirus vector | polyethylene glycol | gene therapy | neutralizing antibody | metastasis | Metastasis | Gene therapy | Adenovirus vector | Polyethylene glycol | Neutralizing antibody | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Lung Neoplasms - drug therapy | Rats, Wistar | Humans | Melanoma, Experimental - drug therapy | Male | Genetic Vectors - therapeutic use | Antibodies, Viral - blood | Polyethylene Glycols - therapeutic use | Melanoma, Experimental - immunology | Melanoma, Experimental - secondary | HEK293 Cells | Adenoviridae - genetics | Female | Adenoviridae - immunology | Antibodies, Viral - biosynthesis | Genetic Vectors - immunology | Antiviral Agents - therapeutic use | Mice, Inbred C57BL | Rats | Lung Neoplasms - virology | Genetic Vectors - genetics | Lung Neoplasms - immunology | Animals | Mice | Genetic Therapy - methods | Index Medicus | Immunoglobulin M | Side effects | Immune response | Colonies | Immunoglobulin G | Lung cancer | Antitumor activity | Immune response (humoral) | Tumor necrosis factor- alpha | Expression vectors | Metastases
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6. Full Text Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch
by Hirobe, Sachiko and Azukizawa, Hiroaki and Hanafusa, Takaaki and Matsuo, Kazuhiko and Quan, Ying-Shu and Kamiyama, Fumio and Katayama, Ichiro and Okada, Naoki and Nakagawa, Shinsaku
Biomaterials, ISSN 0142-9612, 2015, Volume 57, pp. 50 - 58
Advanced Basic Science | Dentistry | Drug delivery | Immune response | Hyaluronic acid | ELISA | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Influenza A Virus, H1N1 Subtype - immunology | Influenza Vaccines - administration & dosage | Humans | Middle Aged | Male | Administration, Cutaneous | Hemagglutinins - immunology | Young Adult | Hemagglutinins - adverse effects | Adult | Influenza A virus - immunology | Immunization - adverse effects | Hyaluronic Acid - chemistry | Influenza Vaccines - adverse effects | Solubility | Influenza A Virus, H3N2 Subtype - immunology | Transdermal Patch - adverse effects | Hemagglutinins - administration & dosage | Animals | Influenza Vaccines - immunology | Immunization - instrumentation | Chickens | Antibody Formation | Influenza, Human - prevention & control | Influenza, Human - immunology | Influenza vaccines | Clinical trials | Influenza | Vaccination | Index Medicus | Antigens | Biomedical materials | Effectiveness | Needles | Vaccines | Dissolution | Strain
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7. Full Text Characterization of Transcutaneous Protein Delivery by a Hydrogel Patch in Animal, Human, and Tissue-Engineered Skin Models
by Matsuo, Kazuhiko and Ishii, Yumiko and Quan, Ying-Shu and Kamiyama, Fumio and Mukai, Yohei and Okada, Naoki and Nakagawa, Shinsaku and aDepartment of Biotechnology and Therapeutics and bCosMED Pharmaceuticals Co and Osaka University and Graduate School of Pharmaceutical Sciences and Ltd
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2011, Volume 34, Issue 4, pp. 586 - 589
vaccine device | hydrogel patch | transcutaneous protein delivery | Hydrogel patch | Transcutaneous protein delivery | Vaccine device | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Transdermal Patch | Guinea Pigs | Skin - metabolism | Humans | Male | Mice, Inbred Strains | Animals | Proteins - metabolism | Vaccination - methods | Hydrogel, Polyethylene Glycol Dimethacrylate | Proteins - administration & dosage | Female | Models, Animal | Mice | Tissue Engineering | Index Medicus
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8. Full Text Compositional Optimization and Safety Assessment of a Hydrogel Patch as a Transcutaneous Immunization Device
by Matsuo, Kazuhiko and Ishii, Yumiko and Quan, Ying-Shu and Kamiyama, Fumio and Asada, Hideo and Mukai, Yohei and Okada, Naoki and Nakagawa, Shinsaku and bCosMED Pharmaceuticals Co and Osaka University and aLaboratory of Biotechnology and Therapeutics and Graduate School of Pharmaceutical Sciences and Ltd and cDepartment of Dermatology and Nara Medical University
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2011, Volume 34, Issue 12, pp. 1835 - 1840
hydrogel patch | transcutaneous immunization | composition | skin hydration | safety | Hydrogel patch | Composition | Safety | Transcutaneous immunization | Skin hydration | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Antigens - toxicity | Diphtheria Toxin - administration & dosage | Hydrogel, Polyethylene Glycol Dimethacrylate - toxicity | Skin Tests | Rats, Wistar | Humans | Tetanus Toxin - toxicity | Rats | Male | Administration, Cutaneous | Diphtheria Toxin - toxicity | Transdermal Patch - adverse effects | Antigens - administration & dosage | Ovalbumin - toxicity | Rats, Hairless | Animals | Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage | Ovalbumin - administration & dosage | Vaccination - methods | Tetanus Toxin - administration & dosage | Female | In Vitro Techniques | Skin - drug effects | Index Medicus
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9. Full Text A Cytolethal Distending Toxin Gene-Based Multiplex PCR Assay for Campylobacter jejuni, C. fetus, C. coli, C. upsaliensis, C. hyointestinalis, and C. lari
by Kamei, Kazumasa and Kawabata, Hiroki and Asakura, Masahiro and Samosornsuk, Worada and Hinenoya, Atsushi and Nakagawa, Shinsaku and Yamasaki, Shinji
Japanese journal of infectious diseases, ISSN 1344-6304, 2016, Volume 69, Issue 3, pp. 256 - 258
multiplex PCR | diagnosis | cytolethal distending toxin | Campylobacter | Life Sciences & Biomedicine | Infectious Diseases | Science & Technology | Campylobacter Infections - diagnosis | Campylobacter lari - genetics | Campylobacter upsaliensis - isolation & purification | Diagnosis, Differential | Multiplex Polymerase Chain Reaction - methods | Campylobacter lari - isolation & purification | Species Specificity | Campylobacter hyointestinalis - isolation & purification | Humans | Campylobacter upsaliensis - genetics | Campylobacter Infections - microbiology | Campylobacter coli - genetics | DNA Primers - chemistry | Campylobacter jejuni - isolation & purification | DNA, Bacterial - genetics | Campylobacter fetus - isolation & purification | Campylobacter fetus - genetics | Sensitivity and Specificity | Bacterial Toxins - genetics | Campylobacter coli - isolation & purification | Campylobacter hyointestinalis - genetics | Campylobacter jejuni - genetics | Index Medicus
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10. Full Text Visualization of Lymph/Blood Flow in Laparoscopic Colorectal Cancer Surgery by ICG Fluorescence Imaging (Lap-IGFI)
by Nishigori, Naoto and Nishigori, Naoto and Koyama, Fumikazu and Koyama, Fumikazu and Nakagawa, Tadashi and Nakagawa, Tadashi and Nakamura, Shinji and Nakamura, Shinji and Ueda, Takeshi and Ueda, Takeshi and Inoue, Takashi and Inoue, Takashi and Kawasaki, Keijirou and Kawasaki, Keijirou and Obara, Shinsaku and Obara, Shinsaku and Nakamoto, Takayuki and Nakamoto, Takayuki and Fujii, Hisao and Fujii, Hisao and Nakajima, Yoshiyuki and Nakajima, Yoshiyuki
Annals of surgical oncology, ISSN 1068-9265, 2/2016, Volume 23, Issue S2, pp. 266 - 274
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | Life Sciences & Biomedicine | Science & Technology | Lymph Node Excision | Colorectal Neoplasms - surgery | Prognosis | Prospective Studies | Colorectal Neoplasms - blood supply | Follow-Up Studies | Coloring Agents | Humans | Middle Aged | Indocyanine Green | Fluorescence | Male | Laparoscopy | Aged, 80 and over | Adult | Female | Aged | Sentinel Lymph Node Biopsy | Colorectal Neoplasms - pathology | Neoplasm Staging | Optical Imaging - methods | Laparoscopic surgery | Colonoscopy | Colorectal cancer | Index Medicus
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11. Full Text Clinical study of a retinoic acid-loaded microneedle patch for seborrheic keratosis or senile lentigo
by Hirobe, Sachiko and Otsuka, Risa and Iioka, Hiroshi and Quan, Ying-Shu and Kamiyama, Fumio and Asada, Hideo and Okada, Naoki and Nakagawa, Shinsaku
Life sciences (1973), ISSN 0024-3205, 01/2017, Volume 168, pp. 24 - 27
Seborrheic keratosis | All-trans retinoic acid | Senile lentigo | Microneedle | Clinical study | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Keratosis, Seborrheic - pathology | Keratolytic Agents - therapeutic use | Tretinoin - administration & dosage | Skin - metabolism | Humans | Middle Aged | Keratolytic Agents - adverse effects | Lentigo - drug therapy | Lentigo - pathology | Male | Transdermal Patch - adverse effects | Keratosis, Seborrheic - drug therapy | Tretinoin - therapeutic use | Aged, 80 and over | Tretinoin - adverse effects | Female | Needles | Aged | Keratolytic Agents - administration & dosage | Skin - drug effects | Skin - pathology | Clinical trials | Self-care, Health | Keratosis | Tretinoin | Medical research | Therapy | Stratum corneum | Senile | Medical treatment | Psychology | Pharmacology | Side effects | Acids | Skin diseases | Skin | Drug therapy | Lesions | Retinoic acid | Manganese | Irritation | Index Medicus
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12. Full Text The Utility of Poly(.GAMMA.-glutamic acid) Nanoparticles as Antigen Delivery Carriers in Dendritic Cell-Based Cancer Immunotherapy
by Matsuo, Keisuke and Ishii, Yumiko and Matsuo, Kazuhiko and Yoshinaga, Tomoyo and Akashi, Mitsuru and Mukai, Yohei and Yoshioka, Yasuo and Okada, Naoki and Nakagawa, Shinsaku and aDepartment of Biotechnology and Therapeutics and cDepartment of Applied Chemistry and Graduate School of Engineering and Osaka University and Graduate School of Pharmaceutical Sciences and bThe Center for Advanced Medical Engineering and Informatics
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2010, Volume 33, Issue 12, pp. 2003 - 2007
poly(γ-glutamic acid) nanoparticle | dendritic cell | antigen delivery carrier | Antigen delivery carrier | Dendritic cell | Poly(γ -glutamic acid) nanoparticle | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Major Histocompatibility Complex | Dendritic Cells | Lymphocyte Activation | Mice, Inbred C57BL | Drug Carriers | Antigens - administration & dosage | Nanoparticles | Polyglutamic Acid - analogs & derivatives | Neoplasms - therapy | Animals | T-Lymphocytes - metabolism | Neoplasms - immunology | Immunotherapy | Female | Mice | Dendritic cells | Biodegradability | Effector cells | Cytotoxicity | Immunosurveillance | Lymphocytes T | Cell activation | Major histocompatibility complex | nanoparticles | Antigen-presenting cells | Antigen (tumor-associated) | Cancer | Tumors | Index Medicus
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13. Full Text The Resolution of Helicobacter suis-associated Gastric Lesions after Eradication Therapy
by Nakagawa, Satoru and Shimoyama, Tadashi and Nakamura, Masahiko and Chiba, Daisuke and Kikuchi, Hidezumi and Sawaya, Manabu and Chinda, Daisuke and Mikami, Tatsuya and Fukuda, Shinsaku
Internal medicine (Tokyo, 1992), ISSN 0918-2918, 2018, Volume 57, Issue 2, pp. 203 - 207
Helicobacter suis | PCR | immunohistochemistry | Immunohistochemistry | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Therapy | Stomach | IgG antibody | Mucosa | Immunoglobulin G | Chronic infection | Infections | Lymphoma | Gastritis | Omeprazole | Polymerase chain reaction | Urea | Endoscopes | Biopsy | Amoxicillin | Endoscopy | Metronidazole | Lesions | Index Medicus | Case Report
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