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by Yamagami, Keitaro and Kurogi, Ryota and Kurogi, Ai and Nishimura, Kunihiro and Onozuka, Daisuke and Ren, Nice and Kada, Akiko and Nishimura, Ataru and Arimura, Koichi and Ido, Keisuke and Mizoguchi, Masahiro and Sakamoto, Tetsuya and Kayama, Takamasa and Suzuki, Michiyasu and Arai, Hajime and Hagihara, Akihito and Iihara, Koji and Takigami, Masayoshi and Kamiyama, Kenji and Houkin, Kiyohiro and Nishi, Shougo and Yoshimoto, Tetsuyuki and Kaneko, Sadao and Oka, Koji and Ooyama, Hiroshi and Kamada, Kyousuke and Makino, Kenichi and Tokumitsu, Naoki and Sako, Kazuhiro and Suzuki, Susumu and Suzuki, Nozomi and Izumi, Naoto and Nitta, Kazumi and Ootaki, Masahumi and Isobe, Masanori and Nishiya, Mikio and Yamazaki, Takaaki and Mabuchi, Syouji and Ogasawara, Kuniaki and Kubo, Naohiko and Shimizu, Yukihiko and Saito, Keiichi and Yamanome, Tatumi and Yoshino, Atsuo and Fujitsuka, Mitsuyuki and Takami, Masaaki and Ohtaka, Hirotoshi and Hirano, Teruyuki and Shiokawa, Yosiaki and Okada, Takaharu and Suzuki, Ichiro and Kohno, Michihiro and Haraoka, Jou and Arai, Yoshinori and Kawamura, Noriyoshi and Isoshima, Akira and Yasue, Masaharu and Takayoshi Kobayashi, Mitsuhiko Hokari and Kawai, Kensuke and Maehara, Taketoshi and Arai, Hajime and Noguchi, Makoto and Hoshino, Haruhiko and Hiyama, Hirofumi and Yoshida, Kensaku and Utsugi, Osamu and Takeda, Yasuaki and Tamaki, Kouichi and Karasudani, Hirohide and Urabe, Takao and Kobayashi, Shiro and Nakamura, Michio and Koguchi, Yorio and Ono, Junichi and Suda, Sumio and Hadeishi, Hiromu and Fukutake, Toshio and Wakui, Kenji and Tanno, Hirokazu and Ishige, Naoki and Ohasi, Takashi and Sakai, Hideki and Nishimura, Yasuaki and Watanabe, Takayuki and Matsumoto, Takashi and Koketsu, Naoki and Hirose, Yuichi and Doyu, Manabu and Hasegawa, Toshinori and Kuwayama, Naoto and Terao, Shinichi and Mizutani, Nobuhiko and Suzaki, Noriyuki and Okuda, Satoshi and Yasui, Keizo and Seki, Yukio and Hasegawa, Yasuhiro and Ikeda, Akira and Takeuchi, Youtarou and Ohara, Sigeki and ... and J-ASPECT Study Collaborators
World Neurosurgery, ISSN 1878-8750, 10/2019, Volume 130, pp. e26 - e46
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 4, pp. 657 - 660
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 2, pp. 272 - 276
Methylglyoxal, a highly reactive dicarbonyl compound, is formed as a by-product of glycolysis and plays an important role in the pathogenesis of diabetic... 
adenylyl cyclase | diabetic complication | retina | large-conductance Ca2+-activated K+ channel | β2-adrenoceptor | β | adrenoceptor | Adenylyl cyclase | Large-conductance Ca | Diabetic complication | channel | Retina | activated K
Journal Article
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 08/2019, Volume 393, Issue 1, pp. 35 - 41
Transient receptor potential vanilloid 4 (TRPV4) channel, a cation channel expressed in nearly all cell types, plays an important role in the regulation of... 
Intravenous administration | Arterioles | Blood vessels | Retina | Activation | Potassium conductance | Injection | Potassium channels (calcium-gated) | Resistance | Transient receptor potential proteins | Infusion | Digital imaging | Inhibitors | Arginine | Calcium conductance | Nitric oxide | Ion channels | Blood pressure | Conductance | Intravenous infusion | Calcium ions
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 2013, Volume 123, Issue 2, pp. 79 - 84
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2015, Volume 38, Issue 11, pp. 1765 - 1771
We previously demonstrated that rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), protects against N-methyl-D-aspartic acid (NMDA)-induced... 
mammalian target of rapamycin (mTOR) | Müller cell | excitotoxicity | extracellular signal-regulated kinase (ERK) | glutamate | Extracellular signal-regulated kinase (ERK) | Mammalian target of rapamycin (mTOR) | Glutamate | Excitotoxicity | RAPAMYCIN | ACTIVATION | REPERFUSION INJURY | CAPILLARY DEGENERATION | ISCHEMIA | Muller cell | CELL-DEATH | INHIBITION | IN-VIVO | PHARMACOLOGY & PHARMACY | MULLER CELLS | Inflammation - chemically induced | Neuroprotective Agents - therapeutic use | Retina - drug effects | Phosphorylation | Retina - metabolism | Leukocyte Common Antigens - metabolism | Intravitreal Injections | TOR Serine-Threonine Kinases - metabolism | Retinal Diseases - chemically induced | Male | Retinal Diseases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Retinal Ganglion Cells - metabolism | Retinal Ganglion Cells - pathology | TOR Serine-Threonine Kinases - antagonists & inhibitors | N-Methylaspartate - adverse effects | Inflammation - metabolism | Neuroprotective Agents - pharmacology | Inflammation - drug therapy | Retinal Diseases - pathology | Everolimus - therapeutic use | Disease Models, Animal | In Situ Nick-End Labeling | Everolimus - pharmacology | Rats, Sprague-Dawley | Sirolimus - pharmacology | Animals | Protein Kinase Inhibitors - therapeutic use | Protein Kinase Inhibitors - pharmacology | Retinal Diseases - drug therapy | Retina - pathology | Retinal Ganglion Cells - drug effects
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 10, pp. 1586 - 1592
Resveratrol, which is a polyphenol found in grapes, peanuts, and other plants, has health benefits for various chronic diseases. The aim of the present study... 
cataract | streptozotocin | lens | diabetes | oxidative stress | Oxidative stress | Cataract | Lens | Diabetes | Streptozotocin | ANTIOXIDANTS | PROTEIN OXIDATION | CATARACT FORMATION | ALDOSE REDUCTASE INHIBITOR | POLYOL PATHWAY | IN-VITRO | HYPERGLYCEMIA | PHARMACOLOGY & PHARMACY | COMPLICATIONS | PROGRESSION | Crystallins - metabolism | Protein Carbonylation | Diabetes Mellitus, Experimental - drug therapy | Rats, Wistar | Plant Extracts - pharmacology | Hyperglycemia - complications | Male | Resveratrol - therapeutic use | Glucose | Lens, Crystalline - pathology | Sorbitol - metabolism | Diabetes Mellitus, Experimental - complications | Phytotherapy | Diabetes Complications - prevention & control | Resveratrol - pharmacology | Cataract - etiology | Lens, Crystalline - metabolism | Aldehyde Reductase | Antioxidants - pharmacology | Diabetes Complications - etiology | Antioxidants - therapeutic use | Animals | Cataract - prevention & control | Hyperglycemia - etiology | Oxidative Stress - drug effects | Blood Glucose - metabolism | Lens, Crystalline - drug effects | Dietary Supplements | Plant Extracts - therapeutic use | Cataracts | Sorbitol | Drinking water | Carbonyl compounds | Nuts | Peanuts | Streptozocin | Diabetes mellitus | Digital cameras | Proteins | Hyperglycemia | Digital imaging | Rodents | Resveratrol | Attenuation | Supplementation | Carbonyls | Quantitative analysis | Lenses
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1560 - 11
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 4, pp. 657 - 660
We previously reported that systemic administration with sodium hydrogen sulfide, a rapid-release donor compound of hydrogen sulfide (H2S), protected retinal... 
GYY4137 | hydrogen sulfide | retina | N-methyl-D-aspartic acid | extended-release | Neurons | Hydrogen | Xylazine | Retina | Glutamic acid receptors | Injection | Eye | Hydrogen sulfide | DNA nucleotidylexotransferase | Injury prevention | Deoxyguanosine | Ketamine | Sodium | Neurodegeneration | Eye injuries | Rodents | Excitotoxicity | Mice | Aspartic acid | D-aspartic acid | N-Methyl-D-aspartic acid | Hydrogen ion concentration
Journal Article
Journal Article