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Journal Article
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3717 - 3717
Polycomb repressive complex (PRC) resides in two major complexes PRC1 and PRC2. They cooperate with each other to coordinate proper developmental process by... 
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2017, Volume 214, Issue 10, pp. 2901 - 2913
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 16, pp. 4817 - 4830
Purpose: EZH2 and EZH1, the catalytic components of polycomb repressive complex 2 (PRC2), trigger trimethylation of H3K27 (H3K27me3) to repress the... 
MULTIPLE-MYELOMA | APOPTOSIS | STEM-CELLS | ONCOLOGY | NUCLEAR RECEPTORS | B-CELL LYMPHOMAS | PROSTATE-CANCER | THERAPEUTIC TARGET | GROWTH | ACUTE MYELOID-LEUKEMIA | SOMATIC MUTATIONS | Polycomb Repressive Complex 2 - antagonists & inhibitors | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Polycomb Repressive Complex 2 - genetics | Humans | Male | Bortezomib - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pyridones - administration & dosage | Multiple Myeloma - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Proteasome Inhibitors - pharmacology | Proteasome Inhibitors - administration & dosage | Cells, Cultured | Mice, SCID | Multiple Myeloma - metabolism | Mice, Knockout | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Bortezomib - administration & dosage | Cell Line, Tumor | Mice, Inbred NOD | Proteasome Endopeptidase Complex - metabolism | Polycomb Repressive Complex 2 - metabolism | Multiple Myeloma - genetics | Pyridones - pharmacology | Therapy | Biotechnology | Transcription | Pathogenesis | Multiple myeloma | Myc protein | E2F protein | Xenografts | Catalysis | Inhibition | Sensitizing | Bortezomib | Tumor cell lines | Ribonucleic acid--RNA | Proteasome inhibitors | Polycomb group proteins | Inhibitors | Protease inhibitors | Experimental design | Derepression | Cell lines | Epigenetics | Tumor suppressor genes | Methylation | Prostate cancer | Prostate | Tumors | Cancer
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3761 - 3761
INTRODUCTION Inappropriate recruitment of functional Polycomb-Group proteins (PcG) may trigger epigenetic unbalance at very specific genomic loci that... 
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2017, Volume 49, Issue 8, pp. 1274 - 1281
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 100 - 100
Abstract Introduction: PcG proteins form two main multiprotein complexes, Polycomb repressive complex 1 (PRC1) and PRC2. They repress the transcription of... 
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 4400 - 4400
PI3K/Akt pathway is constitutively activated in multiple myeloma (MM). A plethora of studies extensively investigated Akt inhibitors, alone or in combination;... 
Journal Article
Journal Article
Experimental Hematology, ISSN 0301-472X, 09/2017, Volume 53, pp. S96 - S96
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0132041
Journal Article