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1. Full Text Azathioprine is essential following cyclosporine for patients with steroid-refractory ulcerative colitis
by Nobuyuki Miyake Takafumi Ando Kazuhiro Ishiguro Osamu Maeda Osamu Watanabe Yutaka Hirayama Keiko Maeda Kazuhiro Morise Masanobu Matsushita Kazuhiro Furukawa Kohei Funasaka Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto
世界胃肠病学杂志：英文版, ISSN 1007-9327, 2015, Volume 21, Issue 1, pp. 254 - 261
AIM: To evaluate long-term prognosis following cyclosporine treatment by examining the rate of surgery avoidance among cyclosporine responders.METHODS: We... 
Ulcerative | therap | colitis;Cyclosporine;Maintenance | Long-term prognosis | Cyclosporine | Azathioprine | Maintenance therapy | Ulcerative colitis | MANAGEMENT | PROGNOSIS | GUIDELINES | INTRAVENOUS CYCLOSPORINE | RISK | COLECTOMY | MALIGNANCY | INFLAMMATORY-BOWEL-DISEASE | CORTICOSTEROIDS | GASTROENTEROLOGY & HEPATOLOGY | ADVERSE EVENTS | Azathioprine - administration & dosage | Humans | Middle Aged | Male | Young Adult | Time Factors | Adult | Female | Retrospective Studies | Colitis, Ulcerative - drug therapy | Drug Therapy, Combination | Child | Drug Resistance | Immunosuppressive Agents - administration & dosage | Drug Administration Schedule | Japan | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Adrenal Cortex Hormones - adverse effects | Colitis, Ulcerative - diagnosis | Cyclosporine - adverse effects | Adolescent | Cyclosporine - administration & dosage | Immunosuppressive Agents - adverse effects | Infusions, Intravenous | Azathioprine - adverse effects | Adrenal Cortex Hormones - administration & dosage | Index Medicus | Retrospective Study
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2. Investigation on temperature acceleration in insulation reliability of printed wiring board
by Nakamura, Kazuhiro
Journal of Japan Institute of Electronics Packaging, ISSN 1343-9677, 09/2018, Volume 21, Issue 6, pp. 590 - 593
Solder resist | THBT | Pwb | HAST | ECM
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3. Full Text A thermosensory pathway that controls body temperature
by Nakamura, Kazuhiro and Morrison, Shaun F
Nature Neuroscience, ISSN 1097-6256, 01/2008, Volume 11, Issue 1, pp. 62 - 71
Defending body temperature against environmental thermal challenges is one of the most fundamental homeostatic functions that are governed by the nervous... 
EFFERENT PROJECTIONS | THERMOREGULATORY FUNCTIONS | PHASEOLUS-VULGARIS-LEUKOAGGLUTININ | SYMPATHETIC PREMOTOR NEURONS | DORSOMEDIAL HYPOTHALAMUS | PREOPTIC AREA | BROWN ADIPOSE-TISSUE | EVOKED THERMOGENESIS | NEUROSCIENCES | PARABRACHIAL NUCLEUS | PROSTAGLANDIN EP3 RECEPTOR | Brain | Preoptic Area - drug effects | Male | Phosphopyruvate Hydratase - metabolism | Membrane Potentials - radiation effects | Health Services Research | Preoptic Area - physiology | Membrane Potentials - drug effects | Cholera Toxin - metabolism | Body Temperature Regulation | Rats | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Preoptic Area - radiation effects | Body Temperature | Membrane Potentials - physiology | Electroencephalography - methods | Neurons, Afferent - physiology | Rats, Sprague-Dawley | Action Potentials - physiology | Animals | Brachial Plexus - cytology | Analysis of Variance | Afferent Pathways - physiology | Brain Mapping | Physiological aspects | Regulation | Research | Neurons | Body temperature | Index Medicus
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4. Full Text The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)
by Yamagami, Keitaro and Kurogi, Ryota and Kurogi, Ai and Nishimura, Kunihiro and Onozuka, Daisuke and Ren, Nice and Kada, Akiko and Nishimura, Ataru and Arimura, Koichi and Ido, Keisuke and Mizoguchi, Masahiro and Sakamoto, Tetsuya and Kayama, Takamasa and Suzuki, Michiyasu and Arai, Hajime and Hagihara, Akihito and Iihara, Koji and Masayoshi, Takigami and Kenji, Kamiyama and Kiyohiro, Houkin and Shougo, Nishi and Tetsuyuki, Yoshimoto and Sadao, Kaneko and Koji, Oka and Hiroshi, Ooyama and Kyousuke, Kamada and Kenichi, Makino and Naoki, Tokumitsu and Kazuhiro, Sako and Susumu, Suzuki and Nozomi, Suzuki and Naoto, Izumi and Kazumi, Nitta and Masahumi, Ootaki and Masanori, Isobe and Mikio, Nishiya and Takaaki, Yamazaki and Syouji, Mabuchi and Kuniaki, Ogasawara and Naohiko, Kubo and Yukihiko, Shimizu and Keiichi, Saito and Tatumi, Yamanome and Atsuo, Yoshino and Mitsuyuki, Fujitsuka and Masaaki, Takami and Hirotoshi, Ohtaka and Teruyuki, Hirano and Yosiaki, Shiokawa and Takaharu, Okada and Ichiro, Suzuki and Michihiro, Kohno and Jou, Haraoka and Yoshinori, Arai and Noriyoshi, Kawamura and Akira, Isoshima and Masaharu, Yasue and Mitsuhiko, Hokari and Takayoshi, Kobayashi and Kensuke, Kawai and Taketoshi, Maehara and Hajime, Arai and Makoto, Noguchi and Haruhiko, Hoshino and Hirofumi, Hiyama and Kensaku, Yoshida and Osamu, Utsugi and Yasuaki, Takeda and Kouichi, Tamaki and Hirohide, Karasudani and Takao, Urabe and Shiro, Kobayashi and Michio, Nakamura and Yorio, Koguchi and Junichi, Ono and Sumio, Suda and Hiromu, Hadeishi and Toshio, Fukutake and Kenji, Wakui and Hirokazu, Tanno and Naoki, Ishige and Takashi, Ohasi and Hideki, Sakai and Yasuaki, Nishimura and Takayuki, Watanabe and Takashi, Matsumoto and Naoki, Koketsu and Yuichi, Hirose and Manabu, Doyu and Toshinori, Hasegawa and Naoto, Kuwayama and Shinichi, Terao and Nobuhiko, Mizutani and Noriyuki, Suzaki and Satoshi, Okuda and Keizo, Yasui and Yukio, Seki and Yasuhiro, Hasegawa and Akira, Ikeda and Youtarou, Takeuchi and ... and J-ASPECT Study Collaborators
World Neurosurgery, ISSN 1878-8750, 2019
Background: The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging... 
Aging | Hospital mortality | Prognosis | Traumatic brain injury | Subdural hematoma | Index Medicus
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5. Investigation of electrochemical migration phenomenon in printed circuit boards by HAST
by Nakamura, Kazuhiro
Journal of Japan Institute of Electronics Packaging, ISSN 1343-9677, 2018, Volume 21, Issue 1, pp. 90 - 98
HAST | Electrochemical Migration (ECM) | Dendrite | Printed Circuit Boards
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6. Full Text Hypersensitivity Reactions to Oxaliplatin: Identifying the Risk Factors and Judging the Efficacy of a Desensitization Protocol
by Okayama, Tetsuya, MD, PhD and Ishikawa, Takeshi, MD, PhD and Sugatani, Kazuko and Yoshida, Naohisa and Kokura, Satoshi, MD, PhD and Matsuda, Kiyomi and Tsukamoto, Shigeru and Ihara, Norihiko and Kuriu, Yoshiaki, MD, PhD and Nakanishi, Masayoshi, MD, PhD and Nakamura, Terukazu, MD, PhD and Kamada, Kazuhiro, MD, PhD and Katada, Kazuhiro, MD, PhD and Uchiyama, Kazuhiko, MD, PhD and Takagi, Tomohisa, MD, PhD and Handa, Osamu, MD, PhD and Konishi, Hideyuki, MD, PhD and Yagi, Nobuaki, MD, PhD and Naito, Yuji, MD, PhD and Otsuji, Eigo, MD, PhD and Hosoi, Hajime, MD, PhD and Miki, Tsuneharu, MD, PhD and Itoh, Yoshito, MD, PhD
Clinical Therapeutics, ISSN 0149-2918, 2015, Volume 37, Issue 6, pp. 1259 - 1269
Abstract Purpose We examined the clinical data of patients treated with oxaliplatin to determine the risk factors of oxaliplatin-related hypersensitivity... 
Internal Medicine | Medical Education | oxaliplatin | colorectal cancer | hypersensitivity reaction | desensitization | SINGLE INSTITUTE | MANAGEMENT | CARBOPLATIN HYPERSENSITIVITY | PHARMACOLOGY & PHARMACY | EXPERIENCE | CLINICAL-FEATURES | OPTIMOX1 | ADVANCED COLORECTAL-CANCER | Drug Hypersensitivity - etiology | Colorectal Neoplasms - blood | Cell Count | Humans | Middle Aged | Risk Factors | Male | Antineoplastic Agents - administration & dosage | Organoplatinum Compounds - administration & dosage | Oxaliplatin | Antineoplastic Agents - adverse effects | Colorectal Neoplasms - drug therapy | Sex Factors | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Organoplatinum Compounds - adverse effects | Desensitization, Immunologic - methods | Eosinophils | Allergy | Medical colleges | Allergic reaction | Risk factors | College graduates | Studies | Variables | Chemotherapy | Neurotoxicity | Epidermal growth factor | Medical prognosis | Multivariate analysis | Vascular endothelial growth factor | Tumors | Index Medicus
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7. Full Text The Japanese space gravitational wave antenna: DECIGO
by Kawamura, Seiji and Ando, Masaki and Seto, Naoki and Sato, Shuichi and Nakamura, Takashi and Tsubono, Kimio and Kanda, Nobuyuki and Tanaka, Takahiro and Yokoyama, Jun'ichi and Funaki, Ikkoh and Numata, Kenji and Ioka, Kunihito and Takashima, Takeshi and Agatsuma, Kazuhiro and Akutsu, Tomotada and Aoyanagi, Koh-suke and Arai, Koji and Araya, Akito and Asada, Hideki and Aso, Yoichi and Chen, Dan and Chiba, Takeshi and Ebisuzaki, Toshikazu and Ejiri, Yumiko and Enoki, Motohiro and Eriguchi, Yoshiharu and Fujimoto, Masa-Katsu and Fujita, Ryuichi and Fukushima, Mitsuhiro and Futamase, Toshifumi and Harada, Tomohiro and Hashimoto, Tatsuaki and Hayama, Kazuhiro and Hikida, Wataru and Himemoto, Yoshiaki and Hirabayashi, Hisashi and Hiramatsu, Takashi and Hong, Feng-Lei and Horisawa, Hideyuki and Hosokawa, Mizuhiko and Ichiki, Kiyotomo and Ikegami, Takeshi and Inoue, Kaiki T and Ishidoshiro, Koji and Ishihara, Hideki and Ishikawa, Takehiko and Ishizaki, Hideharu and Ito, Hiroyuki and Itoh, Yousuke and Izumi, Kiwamu and Kawano, Isao and Kawashima, Nobuki and Kawazoe, Fumiko and Kishimoto, Naoko and Kiuchi, Kenta and Kobayashi, Shiho and Kohri, Kazunori and Koizumi, Hiroyuki and Kojima, Yasufumi and Kokeyama, Keiko and Kokuyama, Wataru and Kotake, Kei and Kozai, Yoshihide and Kunimori, Hiroo and Kuninaka, Hitoshi and Kuroda, Kazuaki and Kuroyanagi, Sachiko and Maeda, Kei-ichi and Matsuhara, Hideo and Matsumoto, Nobuyuki and Michimura, Yuta and Miyakawa, Osamu and Miyamoto, Umpei and Miyoki, Shinji and Morimoto, Mutsuko Y and Morisawa, Toshiyuki and Moriwaki, Shigenori and Mukohyama, Shinji and Musha, Mitsuru and Nagano, Shigeo and Naito, Isao and Nakamura, Kouji and Nakano, Hiroyuki and Nakao, Kenichi and Nakasuka, Shinichi and Nakayama, Yoshinori and Nakazawa, Kazuhiro and Nishida, Erina and Nishiyama, Kazutaka and Nishizawa, Atsushi and Niwa, Yoshito and Noumi, Taiga and Obuchi, Yoshiyuki and Ohashi, Masatake and Ohishi, Naoko and Ohkawa, Masashi and Okada, Kenshi and Okada, Norio and Oohara, Kenichi and Sago, Norichika and ...
Classical and Quantum Gravity, ISSN 0264-9381, 05/2011, Volume 28, Issue 9, p. 094011
The objectives of the DECi-hertz Interferometer Gravitational Wave Observatory (DECIGO) are to open a new window of observation for gravitational wave... 
PHYSICS, MULTIDISCIPLINARY | COMPACT BINARIES | ASTRONOMY & ASTROPHYSICS | PHYSICS, PARTICLES & FIELDS
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8. Full Text Central efferent pathways for cold‐defensive and febrile shivering
by Nakamura, Kazuhiro and Morrison, Shaun F
The Journal of Physiology, ISSN 0022-3751, 07/2011, Volume 589, Issue 14, pp. 3641 - 3658
Non‐technical summary  Shivering is an involuntary somatic motor response that occurs in skeletal muscles to produce heat during exposure to cold environments... 
PHYSIOLOGY | NONSHIVERING THERMOGENESIS | 5-HT1A RECEPTORS | SYMPATHETIC PREMOTOR NEURONS | SPINAL-CORD | DORSOMEDIAL HYPOTHALAMUS | BROWN ADIPOSE-TISSUE | EXPRESSING PREOPTIC NEURONS | BODY-TEMPERATURE | NEUROSCIENCES | PROSTAGLANDIN EP3 RECEPTOR | RAPHE PALLIDUS | Skin Temperature - physiology | Neural Pathways - drug effects | Efferent Pathways - physiology | Fever - metabolism | Male | Preoptic Area - metabolism | Neural Pathways - physiology | Fever - physiopathology | N-Methylaspartate - pharmacology | Neurons - metabolism | Medulla Oblongata - physiology | Preoptic Area - physiology | Dinoprostone - pharmacology | Body Temperature Regulation - physiology | Shivering - physiology | Rats | Mediodorsal Thalamic Nucleus - drug effects | Tachycardia - metabolism | Raphe Nuclei - drug effects | Raphe Nuclei - physiology | Neural Pathways - metabolism | Adipose Tissue, Brown - drug effects | Receptors, GABA-A - metabolism | Muscimol - pharmacology | Rats, Wistar | Preoptic Area - drug effects | Sympathetic Nervous System - drug effects | GABA-A Receptor Antagonists - metabolism | Sympathetic Nervous System - metabolism | Raphe Nuclei - metabolism | Thermogenesis - physiology | Heart Rate - drug effects | Mediodorsal Thalamic Nucleus - metabolism | Sympathetic Nervous System - physiology | Shivering - drug effects | Neurons - physiology | Heart Rate - physiology | Blood Pressure - drug effects | Blood Pressure - physiology | Tachycardia - pathology | Mediodorsal Thalamic Nucleus - physiology | Neurons - drug effects | Receptor, Serotonin, 5-HT1A - metabolism | Cold Temperature | Medulla Oblongata - drug effects | Medulla Oblongata - metabolism | Adipose Tissue, Brown - physiology | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Efferent Pathways - metabolism | Animals | Thermogenesis - drug effects | GABA | Heart beat | Neurons | Analysis | Prostaglandins E | Heart rate | Skin | Cooling | Thermogenesis | Cold | Rodents | Index Medicus | Integrative
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9. Central circuit mechanism for body temperature regulation
by Nakamura, Kazuhiro
Japanese Journal of Neuropsychopharmacology, ISSN 1340-2544, 08/2016, Volume 36, Issue 4, pp. 93 - 99
Psychological stress | Autonomic nervous system | Thermoregulation | Brown adipose tissue | Fever
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10. Full Text Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients
by Aiba, Yoshihiro and Nakamura, Minoru and Joshita, Satoru and Inamine, Tatsuo and Komori, Atsumasa and Yoshizawa, Kaname and Umemura, Takeji and Horie, Hitomi and Migita, Kiyoshi and Yatsuhashi, Hiroshi and Nakamuta, Makoto and Fukushima, Nobuyoshi and Saoshiro, Takeo and Hayashi, Shigeki and Kouno, Hiroshi and Ota, Hajime and Muro, Toyokichi and Watanabe, Yukio and Nakamura, Yoko and Komeda, Toshiki and Shimada, Masaaki and Masaki, Naohiko and Komatsu, Tatsuji and Yagura, Michiyasu and Sugi, Kazuhiro and Koga, Michiaki and Tsukamoto, Kazuhiro and Tanaka, Eiji and Ishibashi, Hiromi and PBC Study Grp NHOSLJ and PBC Study Group in NHOSLJ and The PBC Study Group in NHOSLJ
Journal of Gastroenterology, ISSN 0944-1174, 10/2011, Volume 46, Issue 10, pp. 1203 - 1212
Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis (PBC). In order to dissect the genetic... 
PBC | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | SNPs | Autoantibody | Oncology | Internal Medicine | CTLA4 | SLC4A2 | Surgical Oncology | ANTIBODIES | VARIANTS | SUSCEPTIBILITY | HAPLOTYPES | RISK | ABNORMAL EXPRESSION | AUTOIMMUNITY | T-LYMPHOCYTE ANTIGEN-4 | GASTROENTEROLOGY & HEPATOLOGY | CLASS-II | PROGRESSION | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | SLC4A Proteins | Case-Control Studies | Liver Cirrhosis, Biliary - immunology | Antiporters - genetics | Polymerase Chain Reaction | Aged, 80 and over | Chloride-Bicarbonate Antiporters | Nuclear Pore Complex Proteins - immunology | Adult | Female | Genetic Predisposition to Disease | Liver Cirrhosis, Biliary - physiopathology | Japan | Risk Factors | CTLA-4 Antigen - genetics | Liver Cirrhosis, Biliary - genetics | Disease Progression | Autoantibodies - immunology | Polymorphism, Restriction Fragment Length | Centromere - immunology | Aged | Polymorphism, Single Nucleotide | Anion Transport Proteins - genetics | Autoimmunity | Medical colleges | Antigens | Autoantibodies | Genetic research | Development and progression | Disease susceptibility | Genetic aspects | Biliary cirrhosis | Risk factors | Index Medicus
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11. Full Text Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma
by Koikawa, Kazuhiro and Ohuchida, Kenoki and Ando, Yohei and Kibe, Shin and Nakayama, Hiromichi and Takesue, Shin and Endo, Sho and Abe, Toshiya and Okumura, Takashi and Iwamoto, Chika and Moriyama, Taiki and Nakata, Kohei and Miyasaka, Yoshihiro and Ohtsuka, Takao and Nagai, Eishi and Mizumoto, Kazuhiro and Hashizume, Makoto and Nakamura, Masafumi
Cancer Letters, ISSN 0304-3835, 07/2018, Volume 425, pp. 65 - 77
Stroma invasion is an important step in pancreatic cancer progression. However, how pancreatic ductal adenocarcinoma (PDAC) with ductal structure invades the... 
Basement membrane destruction | Pancreatic stellate cells | Organoid | MT1MMP | Pancreatic cancer | MMP2 | METALLOPROTEASE | TUMOR PROGRESSION | CARCINOMA CELLS | IV COLLAGEN | PROLIFERATION | MT1-MMP | CANCER INVASION | MICROENVIRONMENT | ONCOLOGY | LINE THERAPY | EXPRESSION | Neoplasm Transplantation | Cell Proliferation | Pancreatic Neoplasms - metabolism | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | Coculture Techniques | Humans | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - metabolism | Pancreatic Neoplasms - genetics | Matrix Metalloproteinase 14 - metabolism | Basement Membrane - pathology | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - genetics | Matrix Metalloproteinase 2 - genetics | Animals | Pancreatic Stellate Cells - cytology | Matrix Metalloproteinase 14 - genetics | Cell Line, Tumor | Female | Mice | Organ Culture Techniques | Cell Movement | Adenocarcinoma | Development and progression | Collagen | Medical research | Stellate cells | Destruction | Laboratories | Research & development--R&D | Collagens | Stroma | Metastasis | Matrix metalloproteinase | Gelatinase A | Proteins | Organoids | Medical prognosis | Morphology | Penicillin | Metalloproteinase | Growth factors | Cancer | Tumors
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12. Full Text Leucovorin, fluorouracil, and oxaliplatin plus bevacizumab versus S-1 and oxaliplatin plus bevacizumab in patients with metastatic colorectal cancer (SOFT): an open-label, non-inferiority, randomised phase 3 trial
by Yamada, Yasuhide, Dr and Takahari, Daisuke, MD and Matsumoto, Hiroshi, MD and Baba, Hideo, Prof and Nakamura, Masato, MD and Yoshida, Kazuhiro, Prof and Yoshida, Motoki, MD and Iwamoto, Shigeyoshi, MD and Shimada, Ken, MD and Komatsu, Yoshito, MD and Sasaki, Yasutsuna, Prof and Satoh, Taroh, MD and Takahashi, Keiichi, MD and Mishima, Hideyuki, Prof and Muro, Kei, MD and Watanabe, Masahiko, Prof and Sakata, Yuh, MD and Morita, Satoshi, Prof and Shimada, Yasuhiro, MD and Sugihara, Kenichi, Prof
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 13, pp. 1278 - 1286
Summary Background Studies done in Asia have shown that a regimen of S-1 plus oxaliplatin (SOX) has promising efficacy and safety in patients with metastatic... 
Hematology, Oncology and Palliative Medicine | CAPECITABINE | GERCOR | EFFICACY | ONCOLOGY | 1ST-LINE THERAPY | FLUOROPYRIMIDINES | Leucovorin - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Bevacizumab | Organoplatinum Compounds - administration & dosage | Antibodies, Monoclonal, Humanized - administration & dosage | Fluorouracil - administration & dosage | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Female | Chemotherapy, Adjuvant | Drug Administration Schedule | Japan | Kaplan-Meier Estimate | Treatment Outcome | Oxonic Acid - administration & dosage | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Tegafur - administration & dosage | Aged | Infusions, Intravenous | Colorectal Neoplasms - pathology | Neoplasm Staging | Drug Combinations | Medical colleges | Care and treatment | Colorectal cancer | Leucovorin | Metastasis | Antineoplastic agents | Antimitotic agents | Cancer patients | Chemotherapy | Product development | Cross infection | Nosocomial infections | Cancer | Index Medicus
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