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Nippon Suisan Gakkaishi (Japanese Edition), ISSN 0021-5392, 2019, Volume 85, Issue 1, p. 85
Journal Article
NIPPON SUISAN GAKKAISHI, ISSN 0021-5392, 01/2019, Volume 85, Issue 1, pp. 85 - 85
Journal Article
PLoS Pathogens, ISSN 1553-7366, 06/2018, Volume 14, Issue 6, pp. e1007124 - e1007124
Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and hepatocellular carcinoma. Chronic HBV infection is a key factor in... 
CLOSED CIRCULAR DNA | CELLS | STABILITY | MICROBIOLOGY | IDENTIFICATION | EXCISION-REPAIR | SUBSTRATE-BINDING | REPLICATION | VIROLOGY | INFECTION | INHIBITORS | EXPRESSION | PARASITOLOGY | Flap Endonucleases - antagonists & inhibitors | Hepatitis B - genetics | Humans | DNA, Viral - metabolism | Enzyme Inhibitors - pharmacology | Hepatitis B - virology | Virion - genetics | DNA, Circular - genetics | Hepatocytes - metabolism | Flap Endonucleases - metabolism | DNA, Circular - metabolism | Hepatitis B - enzymology | Hep G2 Cells | Virus Replication | Hepatitis B virus - genetics | Virion - enzymology | Hepatocytes - virology | DNA, Viral - genetics | Flap Endonucleases - genetics | Hepatocytes - drug effects | Genetic aspects | Hepatitis B virus | Research | Circular DNA | Structure | Cell culture | Immunoprecipitation | DNA polymerase | Liver | Chronic infection | Viruses | Hepatocellular carcinoma | Genomes | Infections | DNA repair | Proteins | Hepatitis | Etiology | Genetics | Cleavage | Deoxyribonucleic acid--DNA | University graduates | Recombinant | CRISPR | Liver diseases | siRNA | Gene expression | Substrates | FEN1 protein | Virology | Polymerase | Cirrhosis | Infectious diseases | Hepatocytes | Mutation | Endonuclease | DNA-directed DNA polymerase | Hepatitis B | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
FASEB Journal, ISSN 0892-6638, 02/2017, Volume 31, Issue 2, pp. 781 - 792
Journal Article
IEEE Transactions on Communications, ISSN 0090-6778, 06/2010, Volume 58, Issue 6, pp. 1610 - 1614
Journal Article
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2014, Volume 62, Issue 8, pp. 744 - 753
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2017, Volume 65, Issue 11, pp. 1058 - 1077
It has been hypothesized that selective inhibition of phosphodiesterase (PDE) 2A could potentially be a novel approach to treat cognitive impairment in... 
pyrazolo[1,5-a]pyrimidine | structure-based drug design | schizophrenia | phototoxicity | intramolecular hydrogen bond | phospodiesterase 2A | Phototoxicity | Pyrazolo[1,5-a]pyrimidine | Schizophrenia | Phospodiesterase 2A | Structure-based drug design | Intramolecular hydrogen bond | CHEMISTRY, MEDICINAL | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | NEGATIVE SYMPTOMS | PDE2A INHIBITORS | DIFFRACTION DATA | SYNAPTIC PLASTICITY | CHEMISTRY, MULTIDISCIPLINARY | ANTIPSYCHOTIC-DRUGS | ANIMAL-MODELS | CGMP | PHARMACOLOGY & PHARMACY | RAT-BRAIN | Cyclic Nucleotide Phosphodiesterases, Type 2 - antagonists & inhibitors | Pyridines - chemistry | Humans | Rats, Long-Evans | Cercopithecus aethiops | Cognition Disorders - metabolism | Male | Structure-Activity Relationship | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Thermodynamics | Pyrazoles - chemistry | Molecular Structure | Phosphodiesterase Inhibitors - chemistry | Pyrazoles - pharmacology | Cell Survival - drug effects | Administration, Oral | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Solubility | Phosphodiesterase Inhibitors - pharmacology | Rats | Pyrimidines - pharmacology | Cognition Disorders - drug therapy | Drug Discovery | Mice, Inbred ICR | Phosphodiesterase Inhibitors - administration & dosage | Pyrazines - chemistry | Animals | Mice | Mice, Inbred BALB C | Pyridines - pharmacology | Powder Diffraction | Pyrazines - pharmacology | COS Cells | 3T3 Cells | Brain | Neurodegenerative diseases | Mental disorders | Guanosine | Memory | Cognitive ability | Disorders | Inhibition (psychology) | Selectivity | Lead compounds | Drug development | Augmentation | Learning | MK-801 | Signaling | Inhibitors | Pyrazine | Rodents | Cyclic GMP | Cognitive tasks | Phosphodiesterase | Index Medicus
Journal Article
Drug Discoveries & Therapeutics, ISSN 1881-7831, 2018, Volume 12, Issue 1, pp. 37 - 41
Smoking cessation efforts in Japan reduce smoking rates. A future zero-smoking policy would completely prohibit smoking (0% rate). We therefore analyzed the... 
Tobacco | welfare analysis | disease burden | zero-smoking policy
Journal Article
Journal Article
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 10/2018, Volume 115, Issue 43, pp. 11036 - 11041
Journal Article
Journal Article