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1. Full Text Assessment of Anticancer Drug Effects on Pancreatic Cancer Cells under Glucose-Depleted Conditions Using Intracellular and Extracellular Amino Acid Metabolomics
by Tomita, Ryoko and Todoroki, Kenichiro and Hayama, Tadashi and Yoshida, Hideyuki and Fujioka, Toshihiro and Nakashima, Manabu and Yamaguchi, Masatoshi and Nohta, Hitoshi and School of Pharmaceutical Sciences and Fukuoka University and aFaculty of Pharmaceutical Sciences and bLaboratory of Analytical and Bio-Analytical Chemistry and University of Shizuoka
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 2, pp. 220 - 228
pancreatic cancer cell | amino acid metabolomics | glucose depletion | biomarker candidate | Pancreatic cancer cell | Amino acid metabolomics | Biomarker candidate | Glucose depletion | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Pancreatic Neoplasms - metabolism | Humans | Amino Acids - chemistry | Deoxycytidine - pharmacology | Chromatography, High Pressure Liquid | Pancreatic Neoplasms - drug therapy | Amino Acids - metabolism | Tandem Mass Spectrometry | Biomarkers, Tumor - metabolism | Antimetabolites, Antineoplastic - pharmacology | Hypoglycemia - blood | Principal Component Analysis | Intracellular Fluid - metabolism | Cell Survival - drug effects | Pancreatic Neoplasms - blood | Reproducibility of Results | Blood Glucose - analysis | Hypoglycemia - metabolism | Metabolomics - methods | Discriminant Analysis | Biomarkers, Tumor - blood | Extracellular Fluid - metabolism | Cell Line, Tumor | Glucose - metabolism | Hydrophobic and Hydrophilic Interactions | Hypoglycemia - complications | Least-Squares Analysis | Pancreatic Neoplasms - complications | Deoxycytidine - analogs & derivatives | Pyrvinium Compounds - pharmacology | Drugs | Metabolomics | Discriminant analysis | Starvation | Gemcitabine | Amino acids | Mass spectroscopy | Glucose | Drug resistance | Anticancer properties | Antitumor agents | Pancreatic cancer | Pretreatment | Intracellular | Mass spectrometry | Index Medicus
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2. Full Text J-CKD-DB: a nationwide multicentre electronic health record-based chronic kidney disease database in Japan
by Nakagawa, Naoki and Sofue, Tadashi and Kanda, Eiichiro and Nagasu, Hajime and Matsushita, Kunihiro and Nangaku, Masaomi and Maruyama, Shoichi and Wada, Takashi and Terada, Yoshio and Yamagata, Kunihiro and Narita, Ichiei and Yanagita, Motoko and Sugiyama, Hitoshi and Shigematsu, Takashi and Ito, Takafumi and Tamura, Kouichi and Isaka, Yoshitaka and Okada, Hirokazu and Tsuruya, Kazuhiko and Yokoyama, Hitoshi and Nakashima, Naoki and Kataoka, Hiromi and Ohe, Kazuhiko and Okada, Mihoko and Kashihara, Naoki
Scientific reports, ISSN 2045-2322, 04/2020, Volume 10, Issue 1, pp. 7351 - 7351
Humans | Middle Aged | Male | Glomerular Filtration Rate - physiology | Electronic Health Records - statistics & numerical data | Renal Insufficiency, Chronic - epidemiology | Young Adult | Multicenter Studies as Topic | Adolescent | Aged, 80 and over | Adult | Female | Aged | Asian Continental Ancestry Group - statistics & numerical data | Databases | Hospitals | Kidneys | Epidermal growth factor receptors | Information storage | Kidney diseases | Patients | Electronic medical records | Glomerular filtration rate | Proteinuria | Index Medicus
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3. Full Text Proposal for diagnostic criteria for IgG4-related kidney disease
by Kawano, Mitsuhiro and Saeki, Takako and Nakashima, Hitoshi and Nishi, Shinichi and Yamaguchi, Yutaka and Hisano, Satoshi and Yamanaka, Nobuaki and Inoue, Dai and Yamamoto, Motohisa and Takahashi, Hiroki and Nomura, Hideki and Taguchi, Takashi and Umehara, Hisanori and Makino, Hirofumi and Saito, Takao
Clinical and experimental nephrology, ISSN 1342-1751, 10/2011, Volume 15, Issue 5, pp. 615 - 626
Nephrology | Medicine & Public Health | Diagnostic criteria | Tubulointerstitial nephritis | IgG4 | Urology | IgG4-related kidney disease | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Immunohistochemistry | Immunoglobulin G - blood | Kidney - pathology | Kidney Diseases - pathology | Nephritis, Interstitial - diagnosis | Humans | Kidney Diseases - diagnosis | Middle Aged | Pancreas - pathology | Male | Tomography, X-Ray Computed | Autoimmune Diseases - diagnosis | Algorithms | Nephritis, Interstitial - pathology | Aged, 80 and over | Adult | Female | Pancreatitis - pathology | Aged | Autoimmune Diseases - pathology | Urine | Medical colleges | CT imaging | Lymphocytes | Analysis | Immunoglobulin G | Pancreatitis | Immunoglobulin E | Kidney diseases | Universities and colleges | Diagnosis | Index Medicus
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4. Full Text Chitin-based barrier immunity and its loss predated mucus-colonization by indigenous gut microbiota
by Nakashima, Keisuke and Kimura, Satoshi and Ogawa, Yu and Watanabe, Soichi and Soma, Satoshi and Kaneko, Toyoji and Yamada, Lixy and Sawada, Hitoshi and Tung, Che-Huang and Lu, Tsai-Ming and Yu, Jr-Kai and Villar-Briones, Alejandro and Kikuchi, Sakura and Satoh, Noriyuki
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3402 - 13
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Ciona - immunology | Mice, Inbred C57BL | Chordata - immunology | Male | Gastrointestinal Microbiome - physiology | Intestinal Mucosa - microbiology | Ciona - microbiology | Fishes - immunology | Fishes - microbiology | Mucus - microbiology | Animals | Intestinal Mucosa - immunology | Mice | Chordata - microbiology | Chitin - immunology | Nanofibers | Membranes | Digestive system | Mucosa | Innovations | Mucus | Chitin | Mammals | Epithelium | Immunity | Microorganisms | Microbiota | Intestine | Proteomes | Intestinal microflora | Digestive tract | Colonization | Immune system | Index Medicus | Life Sciences | Populations and Evolution | Immunology | Biodiversity | Polymers | Chemical Sciences
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5. Full Text Comprehensive analysis of hazard of ultraviolet radiation emitted during arc welding of cast iron
by Takahashi, Jyunya and Nakashima, Hitoshi and Fujii, Nobuyuki and Okuno, Tsutomu
Journal of occupational health, ISSN 1348-9585, 01/2020, Volume 62, Issue 1, pp. e12091 - n/a
ultraviolet radiation | effective irradiance | cast iron | hazard | arc welding | Life Sciences & Biomedicine | Public, Environmental & Occupational Health | Science & Technology | Gas metal arc welding | Welding | U.V. radiation | Fillers | Cast iron | Radiation hazards | Aluminum alloys | Hazards | Iron | Gas tungsten arc welding | Electrodes | Ultraviolet radiation | Keratoconjunctivitis | Tungsten | Chromium | Nickel | Sensors | Metal workers | Erythema | Shielded metal arc welding | Index Medicus
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6. Full Text Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma
by Nakashima, Chie and Yamamoto, Kazuhiko and Fujiwara‐Tani, Rina and Luo, Yi and Matsushima, Sayako and Fujii, Kiyomu and Ohmori, Hitoshi and Sasahira, Tomonori and Sasaki, Takamitsu and Kitadai, Yasuhiko and Kirita, Tadaaki and Kuniyasu, Hiroki
Cancer science, ISSN 1347-9032, 06/2018, Volume 109, Issue 6, pp. 2036 - 2045
malic enzyme | cancer invasion | glutamine | prognosis | stemness | Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | Epithelial-Mesenchymal Transition - drug effects | Transplantation, Heterologous | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Malate Dehydrogenase - genetics | Cytosol - enzymology | Malate Dehydrogenase - antagonists & inhibitors | Oxidation-Reduction - drug effects | Mouth Neoplasms - genetics | Mouth Neoplasms - enzymology | Carcinoma, Squamous Cell - enzymology | Cell Proliferation - genetics | Disease Progression | Cell Movement - drug effects | Oligonucleotides, Antisense - genetics | Lanthanoid Series Elements - pharmacology | Cell Line, Tumor | Mouth Neoplasms - pathology | Cell Proliferation - drug effects | Malate Dehydrogenase - biosynthesis | Lactates | Glucose metabolism | Enzymes | Squamous cell carcinoma | Analysis | Development and progression | Fermentation | Glutamine | Cell proliferation | Tricarboxylic acid cycle | Energy metabolism | Phosphorylation | Dehydrogenases | Mesenchyme | Amino acids | Kinases | Cancer therapies | Cell adhesion & migration | Mitochondria | Cell growth | Feedback | NADP | Lipogenesis | Personal information | Oral carcinoma | Oral squamous cell carcinoma | Citric acid | Malic enzyme | Oxidative phosphorylation | Medical prognosis | Glycolysis | Lactic acid | Tumors | Index Medicus | Original
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7. Full Text Amino Acid Metabolomics Using LC-MS/MS: Assessment of Cancer-Cell Resistance in a Simulated Tumor Microenvironment
by TOMITA, Ryoko and TODOROKI, Kenichiro and MARUOKA, Hiroshi and YOSHIDA, Hideyuki and FUJIOKA, Toshihiro and NAKASHIMA, Manabu and YAMAGUCHI, Masatoshi and NOHTA, Hitoshi
Analytical sciences, ISSN 0910-6340, 2016, Volume 32, Issue 8, pp. 893 - 900
5-fluorouracil | liquid chromatography-tandem mass spectrometry | hypoxia | Amino acid metabolomics | hypoglycemia | Hypoxia | Liquid chromatography-tandem mass spectrometry | Hypoglycemia | Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Index Medicus
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8. Full Text IgG4-related kidney disease and retroperitoneal fibrosis: An update
by Kawano, Mitsuhiro and Saeki, Takako and Nakashima, Hitoshi
Modern rheumatology, ISSN 1439-7595, 03/2019, Volume 29, Issue 2, pp. 231 - 239
IgG4 | tubulointerstitial nephritis | membranous glomerulonephritis | IgG4-related kidney disease | Life Sciences & Biomedicine | Rheumatology | Science & Technology | Index Medicus
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9. Full Text Fume particle size distribution and fume generation rate during arc welding of cast iron
by Takahashi, Jyunya and Nakashima, Hitoshi and Fujii, Nobuyuki
Industrial health, ISSN 0019-8366, 01/2020, Volume 58, Issue 4, pp. 325 - 334
Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Environmental aspects | Health aspects | Smoke | Gas metal arc welding | Iron constituents | Particle size | Steel constituents | Size distribution | Welding | Welding current | Cast iron | Iron | Diameters | Stainless steels | Electrodes | Dust | Particle size distribution | Stainless steel | Low carbon steels | Chromium | Nickel | Fumes | Steel wire | Shielded metal arc welding | Respirable dust | Respirators | Arc welding | Original | Fume generation rate
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10. Full Text Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors
by Shirasu, Mika and Yoshikawa, Keiichi and Takai, Yoshiki and Nakashima, Ai and Takeuchi, Haruki and Sakano, Hitoshi and Touhara, Kazushige
Neuron (Cambridge, Mass.), ISSN 0896-6273, 01/2014, Volume 81, Issue 1, pp. 165 - 178
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Membrane Potentials - genetics | Olfactory Receptor Neurons - physiology | Humans | Fatty Acids, Monounsaturated | Green Fluorescent Proteins - genetics | Odorants | Dose-Response Relationship, Drug | Olfactory Pathways - physiology | Smell - drug effects | Smell - physiology | Olfactory Pathways - drug effects | Olfactory Bulb - cytology | Membrane Potentials - drug effects | Green Fluorescent Proteins - metabolism | Cycloparaffins - pharmacology | Colforsin - pharmacology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Xenopus laevis | Proto-Oncogene Proteins c-fos - metabolism | Mice, Transgenic | Olfactory Receptor Neurons - drug effects | Gene Expression Regulation - drug effects | Animals | Olfactory Bulb - surgery | Neural Cell Adhesion Molecules - metabolism | Receptors, Odorant - genetics | Mice | Ketones | Neurons | Cosmetics industry | Kinases | Gene expression | Experiments | Rodents | Methods | Index Medicus
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11. Full Text Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia
by Kiyoi, Hitoshi and Morris, Joan D and Oh, Iekuni and Maeda, Yoshinobu and Minami, Hironobu and Miyamoto, Toshihiro and Sakura, Toru and Iida, Hiroatsu and Tuglus, Catherine A and Chen, Yuqi and Dos Santos, Cedric and Kalabus, James and Anderson, Abraham and Hata, Tomoko and Nakashima, Yasuhiro and Kobayashi, Yukio
Cancer science, ISSN 1347-9032, 04/2020, Volume 111, Issue 4, pp. 1314 - 1323
clinical study | refractory | phase 1b | acute lymphoblastic leukemia | Japan | relapsed | blinatumomab | Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasm, Residual - pathology | Lymphoma, B-Cell - blood | Humans | Middle Aged | Antibodies, Bispecific - pharmacokinetics | Male | Antigens, CD19 - genetics | Dose-Response Relationship, Drug | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | CD3 Complex - genetics | Antibodies, Bispecific - administration & dosage | Adult | Female | Antibodies, Bispecific - blood | B-Lymphocytes - pathology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood | Antigens, CD19 - immunology | Lymphoma, B-Cell - drug therapy | Dexamethasone - administration & dosage | Kaplan-Meier Estimate | Neoplasm, Residual - blood | Remission Induction | Disease-Free Survival | Antibodies, Bispecific - adverse effects | CD3 Complex - immunology | Lymphoma, B-Cell - pathology | Neoplasm, Residual - drug therapy | T-Lymphocytes - immunology | Aged | Interferon-gamma - blood | CD19 antigen | Acute lymphatic leukemia | Cytokines | Hematology | Leukemia | Minimal residual disease | Cytotoxicity | Lymphocytes T | CD3 antigen | Lymphatic leukemia | Patients | Chemotherapy | Blood platelets | Lymphocytes B | Lymphocytes | Medical prognosis | Immunotherapy | Bone marrow | Remission | Pharmacokinetics | Index Medicus | Original
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