Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (24) 24
humans (15) 15
animals (7) 7
male (7) 7
cell biology (6) 6
data processing, computer science, computer systems (6) 6
genetics & heredity (6) 6
oncology (6) 6
article (5) 5
biochemistry & molecular biology (5) 5
cancer (5) 5
cell line, tumor (5) 5
evolution (5) 5
genomes (5) 5
genomics (5) 5
microsporidia (5) 5
mutation (5) 5
prostate cancer (5) 5
research article (5) 5
androgen receptor (4) 4
computational biology (4) 4
evolutionary biology (4) 4
expression (4) 4
metabolism (4) 4
microbiology (4) 4
microsporidia - genetics (4) 4
parasites (4) 4
phosphorylation (4) 4
proteins (4) 4
receptors, androgen - metabolism (4) 4
research (4) 4
004 (3) 3
abiraterone (3) 3
analysis (3) 3
binding (3) 3
bioinformatics (3) 3
biological evolution (3) 3
biology (3) 3
biotechnology (3) 3
child (3) 3
child, preschool (3) 3
entamoeba-histolytica (3) 3
eukaryotes (3) 3
evolution, molecular (3) 3
female (3) 3
gene duplication (3) 3
genetic aspects (3) 3
genome sequence (3) 3
genome, fungal (3) 3
health aspects (3) 3
infant (3) 3
mutations (3) 3
parasite (3) 3
parasitology (3) 3
pathway (3) 3
phylogeny (3) 3
protein (3) 3
proteomics (3) 3
receptors, androgen - genetics (3) 3
research paper (3) 3
rna interference (3) 3
abstracts (2) 2
acquired immune deficiency syndrome (2) 2
acquired immune deficiency syndrome--aids (2) 2
acquired immunodeficiency syndrome - microbiology (2) 2
adolescent (2) 2
adult (2) 2
aids (2) 2
algorithms (2) 2
amino acid (2) 2
amino acid sequence (2) 2
androgen antagonists - pharmacology (2) 2
anilides - pharmacology (2) 2
antineoplastic agents - pharmacology (2) 2
automation (2) 2
base sequence (2) 2
biosynthesis (2) 2
cell proliferation - drug effects (2) 2
cell proliferation - genetics (2) 2
classification (2) 2
computational biology - methods (2) 2
cytoplasm (2) 2
data mining (2) 2
deoxyribonucleic acid--dna (2) 2
deubiquitinating enzyme usp12 (2) 2
diversity (2) 2
dk/atira/pure/researchoutput/pubmedpublicationtype/d013485 (2) 2
dk/atira/pure/researchoutput/pubmedpublicationtype/d016428 (2) 2
dna methylation (2) 2
e coli (2) 2
encephalitozoon-cuniculi (2) 2
enzalutamide (2) 2
experiments (2) 2
fungal proteins - genetics (2) 2
fungi (2) 2
gene (2) 2
gene expression (2) 2
gene expression regulation, neoplastic - drug effects (2) 2
gene regulation, chromatin and epigenetics (2) 2
gene-expression (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study
by Schwalbe, Edward C, PhD and Lindsey, Janet C, PhD and Nakjang, Sirintra, PhD and Crosier, Stephen, PhD and Smith, Amanda J, MSc and Hicks, Debbie, PhD and Rafiee, Gholamreza, PhD and Hill, Rebecca M, PhD and Iliasova, Alice, MSc and Stone, Thomas, MRes and Pizer, Barry, Prof and Michalski, Antony, PhD and Joshi, Abhijit, MBBS and Wharton, Stephen B, Prof and Jacques, Thomas S, PhD and Bailey, Simon, Prof and Williamson, Daniel, PhD and Clifford, Steven C, Prof
Lancet Oncology, The, ISSN 1470-2045, 2017, Volume 18, Issue 7, pp. 958 - 971
Summary Background International consensus recognises four medulloblastoma molecular subgroups: WNT (MBWNT ), SHH (MBSHH ), group 3 (MBGrp3 ), and group 4... 
Hematology, Oncology and Palliative Medicine | TUMOR | ONCOLOGY | PATHWAY | GENETIC PROFILES | EXPRESSION | BETA-CATENIN STATUS | Risk Assessment - methods | Age Factors | Humans | Zinc Finger Protein Gli2 | Transcriptome | Child, Preschool | N-Myc Proto-Oncogene Protein - genetics | Infant | Male | Patched-1 Receptor - genetics | Smoothened Receptor - genetics | Tumor Suppressor Protein p53 - genetics | DNA Methylation | Medulloblastoma - radiotherapy | Telomerase - genetics | Medulloblastoma - pathology | Female | Retrospective Studies | Cerebellar Neoplasms - pathology | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Nuclear Proteins - genetics | Child | Infant, Newborn | Risk Factors | Repressor Proteins - genetics | Survival Rate | Cerebellar Neoplasms - genetics | beta Catenin - genetics | Disease-Free Survival | Gene Amplification | Adolescent | Proto-Oncogene Proteins c-myc - genetics | Mutation | Cerebellar Neoplasms - radiotherapy | Kruppel-Like Transcription Factors - genetics | Medulloblastoma - classification | Medulloblastoma | Children's hospitals | Genomics | DNA microarrays | Brain tumors | Leukemia | Oncology, Experimental | Research | Methylation | Cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Evolutionary conservation and in vitro reconstitution of microsporidian iron-sulfur cluster biosynthesis
by Freibert, Sven-A and Goldberg, Alina V and Hacker, Christian and Molik, Sabine and Dean, Paul and Williams, Tom A and Nakjang, Sirintra and Long, Shaojun and Sendra, Kacper and Bill, Eckhard and Heinz, Eva and Hirt, Robert P and Lucocq, John M and Embley, T. Martin and Lill, Roland
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, p. 13932
Microsporidians are obligate intracellular parasites that have minimized their genome content and sub-cellular structures by reductive evolution. Here, we... 
CFD1-NBP35 COMPLEX | MONOTHIOL GLUTAREDOXINS | PROTEIN | SULFHYDRYL OXIDASE | BIOGENESIS | MULTIDISCIPLINARY SCIENCES | EUKARYOTES | MATURATION | MULTIPLE SEQUENCE ALIGNMENT | MITOCHONDRIAL REMNANT | SCAFFOLD | Biological Evolution | Cell Nucleus - metabolism | Fungal Proteins - biosynthesis | Iron-Sulfur Proteins - genetics | Cytosol - metabolism | Iron-Sulfur Proteins - biosynthesis | Mitochondria - metabolism | Pansporablastina - genetics | Fungal Proteins - genetics | Pansporablastina - metabolism | Phylogeny
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text The Pioneering Role of GATA2 in Androgen Receptor Variant Regulation Is Controlled by Bromodomain and Extraterminal Proteins in Castrate-Resistant Prostate Cancer
by Chaytor, Lewis and Simcock, Matthew and Nakjang, Sirintra and Heath, Richard and Walker, Laura and Robson, Craig and Jones, Dominic and Gaughan, Luke
Molecular cancer research : MCR, ISSN 1541-7786, 06/2019, Volume 17, Issue 6, pp. 1264 - 1278
The androgen receptor (AR) is a key driver of prostate cancer development. Antiandrogens effectively inactivate the AR, but subsequent AR reactivation... 
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text A novel extracellular metallopeptidase domain shared by animal Host-Associated mutualistic and pathogenic microbes
by Nakjang, Sirintra and Ndeh, Didier A and Wipat, Anil and Bolam, David N and Hirt, Robert P
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e30287
The mucosal microbiota is recognised as an important factor for our health, with many disease states linked to imbalances in the normal community structure.... 
BACILLUS-THURINGIENSIS | TRICHOMONAS-VAGINALIS | GENOME SEQUENCE | CARBOHYDRATE-BINDING MODULES | MULTIDISCIPLINARY SCIENCES | PARASITE ENTAMOEBA-HISTOLYTICA | ESCHERICHIA-COLI | BIOLOGICAL ROLES | INTESTINAL MUCIN | VIBRIO-CHOLERAE | PAENIBACILLUS-LARVAE | Amino Acid Sequence | Invertebrates - microbiology | Adaptation, Biological - genetics | Humans | Invertebrates - enzymology | Invertebrates - genetics | Metalloproteases - genetics | Molecular Sequence Data | Protein Structure, Tertiary - genetics | Adaptation, Biological - physiology | Symbiosis - genetics | Digestive System - pathology | Sequence Homology, Amino Acid | Animals | Host-Pathogen Interactions - genetics | Base Sequence | Digestive System - microbiology | Metalloproteases - chemistry | Amino acids | Peptides | Microbiota (Symbiotic organisms) | Proteases | Genomics | Mucins | Commensals | Mucosa | Genomes | Cell surface | Data bases | Proteins | Microorganisms | Microbiota | Work capacity | User interface | Phylogenetics | Metalloproteinase | Bioinformatics | Digestive tract | Anchoring | Recombinant | Biomedical engineering | Binding | Biodegradation | Community structure | Carbohydrates | Enzymes | Pathogens | Peptidase | Glycoproteins | Industrial applications | Mucinase | Zinc | Glycan | Peptidases | Acids | Molecular biology | Colonization | Signal peptides
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12
by McClurg, Urszula L and Chit, Nay C. T. H and Azizyan, Mahsa and Edwards, Joanne and Nabbi, Arash and Riabowol, Karl T and Nakjang, Sirintra and McCracken, Stuart R and Robson, Craig N
Oncogene, ISSN 0950-9232, 08/2018, Volume 37, Issue 34, pp. 4679 - 4691
The TP53-MDM2-AR-AKT signalling network plays a critical role in the development and progression of prostate cancer. However, the molecular mechanisms... 
ANDROGEN RECEPTOR | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CISPLATIN RESISTANCE | AKT | INDEPENDENT PROSTATE-CANCER | CELL BIOLOGY | CELL LUNG-CANCER | DEUBIQUITINATING ENZYME USP12 | ONCOLOGY | PATHWAY | GENETICS & HEREDITY | MDM2 | INHIBITORS | Prostatic Neoplasms - metabolism | Neoplasm Recurrence, Local - metabolism | Humans | Receptors, Androgen - metabolism | Tumor Suppressor Protein p53 - metabolism | Cercopithecus aethiops | Male | Animals | Cell Line, Tumor | Ubiquitin Thiolesterase - metabolism | Signal Transduction - physiology | Proto-Oncogene Proteins c-akt - metabolism | COS Cells | Proto-Oncogene Proteins c-mdm2 - metabolism | Molecular targeted therapy | Care and treatment | Proteases | Innovations | Development and progression | Cellular signal transduction | Genetic aspects | Health aspects | Prostate cancer | MDM2 protein | Molecular modelling | Therapeutic applications | p53 Protein | AKT protein | Gene expression | Prostate | Tumors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text The Genome of the Obligate Intracellular Parasite Trachipleistophora hominis: New Insights into Microsporidian Genome Dynamics and Reductive Evolution
by Heinz, Eva and Williams, Tom A and Nakjang, Sirintra and Noël, Christophe J and Swan, Daniel C and Goldberg, Alina V and Harris, Simon R and Weinmaier, Thomas and Markert, Stephanie and Becher, Dörte and Bernhardt, Jörg and Dagan, Tal and Hacker, Christian and Lucocq, John M and Schweder, Thomas and Rattei, Thomas and Hall, Neil and Hirt, Robert P and Embley, T. Martin
PLoS Pathogens, ISSN 1553-7366, 10/2012, Volume 8, Issue 10, p. e1002979
The dynamics of reductive genome evolution for eukaryotes living inside other eukaryotic cells are poorly understood compared to well-studied model systems... 
TRANSPORTER SUPERFAMILY | ENCEPHALITOZOON-CUNICULI | TRYPANOSOMA-BRUCEI | TRANSPOSABLE ELEMENTS | MICROBIOLOGY | ENTAMOEBA-HISTOLYTICA | SPOROGONIAL STAGES | VIROLOGY | CHITIN-SYNTHASE | BACILLUS-SUBTILIS | PROTEIN FAMILIES | PARASITOLOGY | RNA-POLYMERASE | Proteome - genetics | Humans | Acquired Immunodeficiency Syndrome - microbiology | Phylogeny | Sequence Analysis, DNA | Biological Evolution | Mitochondria | Genome, Fungal | RNA Interference | Microsporidia - isolation & purification | Proteomics | Microsporidia - genetics | RNA, Small Interfering | Energy Metabolism - genetics | Evolution, Molecular | Microbial genetics | Genomics | Physiological aspects | Genetic aspects | Research | Microsporidia | Health aspects | Proteins | Eukaryotes | Parasites | Acquired immune deficiency syndrome--AIDS | AIDS | Acquired immune deficiency syndrome
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Identification of Cmtm Family Proteins As Tumor Suppressor and Membrane Regulator in B Cell Precursor Acute Lymphoblastic Leukemia
by Eswaran, Jeyanthy and Sinclair, Paul and Nakjang, Sirintra and Harrison, Christine J
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 3582 - 3582
Abstract Acute lymphoblastic leukemia (ALL) is characterized by the expansion of immature hematopoietic cells in the bone marrow and blood. It is the most... 
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Plasma Membrane-Located Purine Nucleotide Transport Proteins Are Key Components for Host Exploitation by Microsporidian Intracellular Parasites
by Heinz, Eva and Hacker, Christian and Dean, Paul and Mifsud, John and Goldberg, Alina V and Williams, Tom A and Nakjang, Sirintra and Gregory, Alison and Hirt, Robert P and Lucocq, John M and Kunji, Edmund R. S and Embley, T. Martin
PLoS Pathogens, ISSN 1553-7366, 12/2014, Volume 10, Issue 12, p. e1004547
Microsporidia are obligate intracellular parasites of most animal groups including humans, but despite their significant economic and medical importance there... 
ATP/ADP | GENOME SEQUENCE | EVOLUTION | VIROLOGY | SPECIFICITY | ALIGNMENT | MICROBIOLOGY | RICKETTSIA-PROWAZEKII | DIVERSITY | MITOCHONDRIAL REMNANT | PARASITOLOGY | DNA, Fungal - genetics | Humans | RNA, Fungal - biosynthesis | Acquired Immunodeficiency Syndrome - microbiology | Fungal Proteins - genetics | Microsporidia - metabolism | Purine Nucleotides - metabolism | Carrier Proteins - genetics | DNA, Fungal - biosynthesis | Carrier Proteins - metabolism | Biological Transport, Active - physiology | Microsporidia - isolation & purification | Microsporidia - genetics | RNA, Fungal - genetics | Fungal Proteins - metabolism | Microbiological research | Protein research | Carrier proteins | Host-parasite relationships | Cell membranes | Purine nucleotides | Research | Health aspects | Microsporidia | Plasma | AIDS | Biosynthesis | Genomes | Parasites | Metabolism | Experiments | Proteins | Acquired immune deficiency syndrome | HIV | E coli | Microscopy | Protein synthesis | Deoxyribonucleic acid | DNA | Human immunodeficiency virus | Cytoplasm
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Characterisation of the genomic landscape of CRLF2‐rearranged acute lymphoblastic leukemia
by Russell, Lisa J and Jones, Lisa and Enshaei, Amir and Tonin, Stefano and Ryan, Sarra L and Eswaran, Jeyanthy and Nakjang, Sirintra and Papaemmanuil, Elli and Tubio, Jose M. C and Fielding, Adele K and Vora, Ajay and Campbell, Peter J and Moorman, Anthony V and Harrison, Christine J
Genes, Chromosomes and Cancer, ISSN 1045-2257, 05/2017, Volume 56, Issue 5, pp. 363 - 372
Deregulated expression of the type I cytokine receptor, CRLF2, is observed in 5–15% of precursor B‐cell acute lymphoblastic leukaemia (B‐ALL). We aimed to... 
REARRANGEMENT | ONCOLOGY | USP9X | JAK | GENETICS & HEREDITY | ADULTS | MUTATIONS | IKZF1 | B-PROGENITOR | IGH-AT TRANSLOCATIONS | GENETIC ALTERATIONS | CRLF2 | Prognosis | Follow-Up Studies | Humans | Middle Aged | Child, Preschool | In Situ Hybridization, Fluorescence | Infant | Male | Mutation - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Young Adult | Oncogene Proteins, Fusion - genetics | Gene Rearrangement | Adolescent | Adult | Female | Biomarkers, Tumor - genetics | High-Throughput Nucleotide Sequencing | Genome, Human | Neoplasm Staging | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Child | Receptors, Cytokine - genetics | Genetic aspects | Down syndrome | Analysis | Cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL
by Szoltysek, Katarzyna and Blair, Helen and Nakjang, Sirintra and Tirtakusuma, Ricky and Singh, Mankaran and Nelson, Ryan and McNeill, Hesta and Dodd, Catherine and Beckett, Melanie and McKenzie, Lynsey and Law, Edward and Vormoor, Josef and Pal, Deepali and Heidenreich, Olaf
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3952 - 3952
Acute lymphoblastic leukemia (ALL) is the most common type of childhood leukaemia. Recently improved risk stratification resulted in therapy optimization and... 
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text The SF3b Splicing Complex Regulates DNA Damage Response in Acute Lymphoblastic Leukemia
by Sankar, Shalini and Guillen Navarro, Miriam and Ponthan, Frida and Bomken, Simon and Nakjang, Sirintra and Grinev, Vasily and McNeill, Hesta and Zwaan, Michel C and Vormoor, Josef and Stam, Ronald W and Heidenreich, Olaf
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 1237 - 1237
To identify potential regulators of propagation and self-renewal of Acute Lymphoblastic Leukaemia (ALL), we performed an explorative genome-wide RNAi screen... 
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Chemical inhibition of wild-type p53-induced phosphatase 1 (WIP1/PPM1D) by GSK2830371 potentiates the sensitivity to MDM2 inhibitors in a p53-dependent manner
by Esfandiari, Arman and Hawthorne, Thomas A and Nakjang, Sirintra and Lunec, John
Molecular Cancer Therapeutics, ISSN 1535-7163, 03/2016, Volume 15, Issue 3, pp. 379 - 391
Sensitivity to MDM2 inhibitors is widely different among responsive TP53 wild-type cell lines and tumors. Understanding the determinants of MDM2 inhibitor... 
DRUG-SENSITIVITY | APOPTOSIS | PPM1D MUTATIONS | ONCOLOGY | PHOSPHORYLATION | DNA-DAMAGE | GENE-EXPRESSION | WIP1 PHOSPHATASE | P53 PATHWAY | CANCER | G1 CHECKPOINT | Caspase 7 - metabolism | Neoplasms - metabolism | Apoptosis - drug effects | Protein Phosphatase 2C - metabolism | para-Aminobenzoates - pharmacology | Humans | Caspase 3 - metabolism | Ubiquitin - metabolism | Apoptosis - genetics | Drug Resistance, Neoplasm | Tumor Suppressor Protein p53 - genetics | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Proteolysis - drug effects | Protein Phosphatase 2C - antagonists & inhibitors | Neoplasms - genetics | Transcription, Genetic | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Cell Survival - drug effects | Dipeptides - pharmacology | Tumor Suppressor Protein p53 - metabolism | Imidazoles - pharmacology | Piperazines - pharmacology | Drug Synergism | Catalysis - drug effects | Aminopyridines - pharmacology | Cell Line, Tumor | Mutation | Protein Phosphatase 2C - genetics | Potentiation | GSK2830371 | WIP1 | PPM1D | TP53 | MDM2 inhibitor
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Transport proteins of parasitic protists and their role in nutrient salvage
by Dean, Paul and Major, Peter and Nakjang, Sirintra and Hirt, Robert P and Martin Embley, T
Frontiers in Plant Science, ISSN 1664-462X, 04/2014, Volume 5
The loss of key biosynthetic pathways is a common feature of important parasitic protists, making them heavily dependent on scavenging nutrients from their... 
Protozoa | Hexose | Amino acid | Parasite | Purine | Transport | Transporter | Protist | amino acid | INOSINE-GUANOSINE TRANSPORTER | CONFER DRUG-RESISTANCE | FUNCTIONAL-CHARACTERIZATION | transport | protozoa | PLANT SCIENCES | BINDING CASSETTE TRANSPORTER | PFNT1 NUCLEOSIDE TRANSPORTER | parasite | GLUCOSE-TRANSPORTER | PLASMODIUM-FALCIPARUM | transporter | protist | purine | hexose | MALARIA PARASITE | TOXOPLASMA-GONDII | LEISHMANIA-DONOVANI | nutrient
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights