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index medicus (239) 239
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myelin sheath - metabolism (57) 57
central-nervous-system (55) 55
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expression (45) 45
proteins (45) 45
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proteolipid protein (44) 44
cell biology (42) 42
female (42) 42
physiological aspects (42) 42
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brain (39) 39
cells, cultured (39) 39
myelination (39) 39
oligodendrocytes (38) 38
rats (38) 38
disease models, animal (35) 35
nervous-system (34) 34
axons (33) 33
myelin proteins - genetics (31) 31
biochemistry & molecular biology (30) 30
oligodendrocyte (30) 30
article (29) 29
axons - metabolism (28) 28
axons - physiology (28) 28
biochemistry (28) 28
myelin sheath - ultrastructure (28) 28
neuroscience (28) 28
cells (27) 27
chemistry (27) 27
gene expression (27) 27
multidisciplinary sciences (27) 27
myelin proteolipid protein - genetics (27) 27
neurons - metabolism (27) 27
cns myelin (25) 25
differentiation (25) 25
genetic aspects (25) 25
metallurgy (25) 25
multiple-sclerosis (25) 25
myelin sheath - physiology (25) 25
mouse (24) 24
mutation (24) 24
schwann-cells (24) 24
analysis (23) 23
myelin sheath - pathology (23) 23
brain - metabolism (22) 22
nerve tissue proteins - genetics (22) 22
nerve tissue proteins - metabolism (22) 22
pelizaeus-merzbacher disease (22) 22
schwann cells (22) 22
transgenic mice (22) 22
beer (21) 21
biology (21) 21
cell differentiation - physiology (21) 21
compositions or test papers therefor (21) 21
condition-responsive control in microbiological orenzymological processes (21) 21
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measuring or testing processes involving enzymes, nucleicacids or microorganisms (21) 21
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1. Full Text Conditional mutagenesis in oligodendrocyte lineage cells
by Goebbels, Sandra and Nave, Klaus-Armin
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1936, pp. 249 - 274
Cell-type-specific gene targeting with the Cre/loxP system has become an indispensable technique in experimental neuroscience, particularly for the study of... 
Cell-type-specific targeting | Oligodendrocyte | Myelin | Cre | Transgenic mice | Index Medicus
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2. Full Text Neuroscience: A mechanism for myelin injury
by Saab, Aiman S and Nave, Klaus-Armin
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7587, pp. 474 - 475
Protons | Animals | Myelin Sheath - pathology | Calcium - metabolism | Brain Ischemia - pathology | Brain Ischemia - metabolism | Female | Male | Transient Receptor Potential Channels - metabolism | Myelin Sheath - metabolism | Index Medicus
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3. Full Text Neuregulin-ERBB signaling in nervous system development and neuropsychiatric diseases
by Mei, Lin and Nave, Klaus-Armin
Neuron, ISSN 0896-6273, 7/2014, Volume 83, Issue 1, pp. 27 - 49
Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor tyrosine kinases. NRG s and their receptors ERBBs have been... 
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4. Full Text Adapting brain metabolism to myelination and long-range signal transduction
: CNS White Matter Metabolism
by Hirrlinger, Johannes and Nave, Klaus-Armin
Glia, ISSN 0894-1491, 11/2014, Volume 62, Issue 11, pp. 1749 - 1761
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5. Full Text Oligodendrocytes and the " Micro Brake" of Progenitor Cell Proliferation
by Nave, Klaus-Armin
Neuron, ISSN 0896-6273, 03/2010, Volume 65, Issue 5, pp. 577 - 579
A large fraction of mammalian genes is regulated posttranscriptionally by microRNAs. In the developing nervous system, a small subset of these short RNA... 
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6. Full Text Oligodendrocytes and the “Micro Brake” of Progenitor Cell Proliferation
by Nave, Klaus-Armin
Neuron, ISSN 0896-6273, 2010, Volume 65, Issue 5, pp. 577 - 579
A large fraction of mammalian genes is regulated posttranscriptionally by microRNAs. In the developing nervous system, a small subset of these short RNA... 
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7. Full Text Time to revisit oligodendrocytes in multiple sclerosis
by Nave, Klaus-Armin and Ehrenreich, Hannelore
Nature Medicine, ISSN 1078-8956, 03/2019, Volume 25, Issue 3, pp. 364 - 366
The analysis of autopsy material from individuals with multiple sclerosis with single-cell transcriptomics and 14C carbon dating calls for a reevaluation of... 
HETEROGENEITY | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Multiple Sclerosis | Oligodendroglia | Humans | Myelin Sheath | Autoimmunity | Multiple sclerosis | Research | Autopsies | Myelin | Autopsy | Carbon 14 | Oligodendrocytes | Index Medicus
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8. Full Text A bloody brake on myelin repair
by Nave, Klaus-Armin and Ehrenreich, Hannelore
Nature, ISSN 0028-0836, 01/2018, Volume 553, Issue 7686, pp. 1 - 2
In multiple sclerosis, the blood-coagulation factor fibrinogen can enter the brain. It emerges that fibrinogen inhibits the maturation of cells called... 
Physiological aspects | Multiple sclerosis | Myelin proteins | Studies | Brain | Enzymes | Neurosciences | Cell growth | Blood-brain barrier | Myelin | Neurons | Blood clots | Index Medicus
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9. Full Text Erratum: Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system
by Micu, Ileana and Plemel, Jason R and Caprariello, Andrew V and Nave, Klaus-Armin and Stys, Peter K
Nature Reviews Neuroscience, ISSN 1471-003X, 01/2018, Volume 19, Issue 1, pp. 58 - 58
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10. Full Text Erratum: Axo-myelinic neurotransmission: A novel mode of cell signalling in the central nervous system (Nature Reviews Neuroscience (2018) 19 (49-57) DOI: 10.1038/nrn.2017.128)
Nature Reviews Neuroscience, ISSN 1471-003X, 01/2018, Volume 19, Issue 1, p. 58
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11. Full Text β1 integrins in radial glia but not in migrating neurons are essential for the formation of cell layers in the cerebral cortex
by Belvindrah, Richard and Graus-Porta, Diana and Goebbels, Sandra and Nave, Klaus-Armin and Müller, Ulrich
Journal of Neuroscience, ISSN 0270-6474, 12/2007, Volume 27, Issue 50, pp. 13854 - 13865
Nervous system | Radial glia | Cerebral cortex | Integrin | Reelin | Cell migration
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12. Full Text Adapting brain metabolism to myelination and long‐range signal transduction
by Hirrlinger, Johannes and Nave, Klaus‐Armin
Glia, ISSN 0894-1491, 11/2014, Volume 62, Issue 11, pp. 1749 - 1761
In the mammalian brain, the subcortical white matter comprises long‐range axonal projections and their associated glial cells. Here, astrocytes and... 
myelin | cholesterol | axon | astrocytes | energy metabolism | oligodendrocyte | Axon | Energy metabolism | Oligodendrocyte | Astrocytes | Myelin | Cholesterol | PROTEOLIPID PROTEIN | ACETYL-L-ASPARTATE | MONOCARBOXYLATE TRANSPORTERS | WHITE-MATTER | NMDA RECEPTORS | INTERNODAL POTASSIUM CONDUCTANCE | NEUROSCIENCES | N-ACETYLASPARTYLGLUTAMATE NAAG | GLUTAMATE CARBOXYPEPTIDASE II | GAP-JUNCTIONS | CENTRAL-NERVOUS-SYSTEM | Brain - metabolism | Animals | Energy Metabolism | Humans | Adaptation, Physiological - physiology | Signal Transduction - physiology | Myelin Sheath - metabolism | Physiological aspects | Glucose metabolism | Cellular signal transduction | Metabolites | Glycogen | Index Medicus
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13. Full Text Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
by Fünfschilling, Ursula and Supplie, Lotti M and Mahad, Don and Boretius, Susann and Saab, Aiman S and Edgar, Julia and Brinkmann, Bastian G and Kassmann, Celia M and Tzvetanova, Iva D and Möbius, Wiebke and Diaz, Francisca and Meijer, Dies and Suter, Ueli and Hamprecht, Bernd and Sereda, Michael W and Moraes, Carlos T and Frahm, Jens and Goebbels, Sandra and Nave, Klaus-Armin
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 517 - 521
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity(1-3). However, the underlying support... 
CYTOCHROME-C-OXIDASE | RAT OLIGODENDROCYTES | OPTIC-NERVE | CELL-DEVELOPMENT | GLUCOSE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | LACTATE | MICE LACKING | BRAIN | DEFICIENCY | Protons | Mitochondria - enzymology | Oligodendroglia - metabolism | Electron Transport Complex IV - antagonists & inhibitors | Demyelinating Diseases - genetics | Alkyl and Aryl Transferases - metabolism | Axons - physiology | Demyelinating Diseases - metabolism | Electron Transport Complex IV - metabolism | Myelin Sheath - metabolism | Action Potentials | Brain - metabolism | Membrane Proteins - deficiency | Oligodendroglia - drug effects | Cell Respiration | Mitochondria - genetics | Time Factors | Alkyl and Aryl Transferases - genetics | Membrane Proteins - metabolism | Oligodendroglia - cytology | Demyelinating Diseases - pathology | Alkyl and Aryl Transferases - deficiency | Brain - cytology | Demyelinating Diseases - enzymology | Magnetic Resonance Spectroscopy | Cell Survival | Membrane Proteins - genetics | Lactic Acid - metabolism | Mutant Proteins - genetics | Mutant Proteins - metabolism | Mitochondria - metabolism | Schwann Cells - metabolism | Electron Transport Complex IV - genetics | Mitochondria - pathology | Animals | Glycolysis | Oligodendroglia - enzymology | Mice | Schwann Cells - enzymology | Physiological aspects | Oligodendroglia | Axons | Health aspects | Electrodes | Medical research | Mitochondria | Metabolites | Rodents | Nervous system | Apoptosis | Index Medicus
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14. Full Text Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue
by Snaidero, Nicolas and Möbius, Wiebke and Czopka, Tim and Hekking, Liesbeth H.P and Mathisen, Cliff and Verkleij, Dick and Goebbels, Sandra and Edgar, Julia and Merkler, Doron and Lyons, David A and Nave, Klaus-Armin and Simons, Mikael
Cell, ISSN 0092-8674, 01/2014, Volume 156, Issue 1-2, pp. 277 - 290
Central nervous system myelin is a multilayered membrane sheath generated by oligodendrocytes for rapid impulse propagation. However, the underlying mechanisms... 
LOCALIZATION | TRANSPORT | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | ENSHEATHMENT | MECHANISMS | GLIAL-CELLS | OLIGODENDROCYTES | REVEALS | CELL BIOLOGY | Oligodendroglia - metabolism | Animals | Central Nervous System - metabolism | Cells, Cultured | Axons - metabolism | Neuroglia - metabolism | Zebrafish | Mice | Myelin Sheath - metabolism | Index Medicus
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15. Full Text An ageing view of myelin repair: when the myelin layer that covers neuronal processes is lost through disease, neural stem cells recapitulate the developmental program of 'myelination'. The underlying molecular mechanisms often fail in the ageing brain
by Nave, Klaus-Armin
Nature, ISSN 0028-0836, 09/2008, Volume 455, Issue 7212, p. 478
Physiological aspects | Aging | Stem cell research | Myelination | Brain research | Research
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16. Full Text Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte-Neuron Communication
by Frühbeis, Carsten and Fröhlich, Dominik and Kuo, Wen Ping and Amphornrat, Jesa and Thilemann, Sebastian and Saab, Aiman S and Kirchhoff, Frank and Möbius, Wiebke and Goebbels, Sandra and Nave, Klaus-Armin and Schneider, Anja and Simons, Mikael and Klugmann, Matthias and Trotter, Jacqueline and Krämer-Albers, Eva-Maria
PLoS Biology, ISSN 1544-9173, 07/2013, Volume 11, Issue 7, pp. e1001604 - e1001604
Reciprocal interactions between neurons and oligodendrocytes are not only crucial for myelination, but also for long-term survival of axons. Degeneration of... 
MAJOR MYELIN | NMDA RECEPTORS | GLUTAMATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | MICROVESICLES | DEATH | RELEASE | PROTEINS | GLIA | PRECURSOR CELLS | TROPHIC SUPPORT | Exosomes - drug effects | Cell Survival - drug effects | Glutamic Acid - pharmacology | Mice, Inbred C57BL | Male | Neurons - cytology | Animals | Oligodendroglia - drug effects | Signal Transduction - drug effects | Neurotransmitter Agents - pharmacology | Cell Communication - drug effects | Female | Mice | Oligodendroglia - cytology | Neurons - drug effects | Index Medicus | Proteins | Medical research | Enzymes | Brain research | Neurons | Communication
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17. Full Text A role for Schwann cell-derived neuregulin-1 in remyelination
by Stassart, Ruth M and Fledrich, Robert and Velanac, Viktorija and Brinkmann, Bastian G and Schwab, Markus H and Meijer, Dies and Sereda, Michael W and Nave, Klaus-Armin
Nature Neuroscience, ISSN 1097-6256, 01/2013, Volume 16, Issue 1, pp. 48 - 54
After peripheral nerve injury, axons regenerate and become remyelinated by resident Schwann cells. However, myelin repair never results in the original myelin... 
MAINTENANCE | PERIPHERAL-NERVE REGENERATION | MYELIN SHEATH THICKNESS | GROWTH | INJURY | PROLIFERATION | ENSHEATHMENT | MECHANISMS | RECEPTORS | EXPRESSION | NEUROSCIENCES | Electric Stimulation | Recovery of Function - drug effects | Evoked Potentials, Motor - drug effects | Ki-67 Antigen - metabolism | Ganglia, Spinal - cytology | RNA, Messenger - metabolism | Neuregulin-1 - genetics | Time Factors | Statistics, Nonparametric | Neurons - metabolism | Disease Models, Animal | Animals, Newborn | Myelin Basic Protein - metabolism | Neurons - chemistry | Enzyme Inhibitors - pharmacology | Rats | Sciatic Neuropathy - pathology | Mice, Transgenic | S100 Proteins - metabolism | Schwann Cells - metabolism | Signal Transduction - genetics | Schwann Cells - ultrastructure | Signal Transduction - drug effects | Axons - pathology | NAV1.6 Voltage-Gated Sodium Channel - metabolism | Mice | Locomotion - genetics | Evoked Potentials, Motor - physiology | Culture Media, Conditioned - pharmacology | Demyelinating Diseases - metabolism | Myelin Sheath - metabolism | Octamer Transcription Factor-6 - metabolism | Hedgehog Proteins - genetics | Axons - ultrastructure | Sciatic Nerve - cytology | Demyelinating Diseases - etiology | Neurons - drug effects | Schwann Cells - drug effects | Microscopy, Electron, Transmission | Recovery of Function - genetics | Myelin Sheath - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Axons - drug effects | Animals | Neuregulin-1 - metabolism | Early Growth Response Protein 2 - metabolism | Sciatic Neuropathy - physiopathology | Cell Proliferation - drug effects | Myelin P0 Protein - metabolism | Neurons | Schwann cells | Physiological aspects | Genetic aspects | Research | Myelin sheath | Gene expression | Index Medicus
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18. Full Text Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thickness
by Furusho, Miki and Dupree, Jeffrey L and Nave, Klaus-Armin and Bansal, Rashmi
Journal of Neuroscience, ISSN 0270-6474, 05/2012, Volume 32, Issue 19, pp. 6631 - 6641
Formation of the CNS white matter is developmentally tightly regulated, but the molecules and mechanisms of myelination control in the postnatal CNS are poorly... 
FGF | LINEAGE CELLS | CNS | CENTRAL-NERVOUS-SYSTEM | MICE | RAT-BRAIN | FACTOR-I | SCHWANN-CELLS | DIFFERENTIATION | GLIAL-CELLS | NEUROSCIENCES | Animals, Newborn | Oligodendroglia - metabolism | Myelin Sheath - physiology | Cells, Cultured | Male | Signal Transduction - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 1 - physiology | Oligodendroglia - ultrastructure | Mice, Knockout | Myelin Sheath - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - physiology | Animals | Oligodendroglia - physiology | Receptors, Fibroblast Growth Factor - genetics | Female | Mice | Myelin Sheath - ultrastructure | Mutation | Receptors, Fibroblast Growth Factor - physiology | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Index Medicus | myelin | oligodendrocyte
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19. Full Text Axonal prion protein is required for peripheral myelin maintenance
by Weis, Joachim and Tiberi, Cinzia and Steele, Andrew D and Aguzzi, Adriano and Toyka, Klaus V and Fischer, Heike and Schwarz, Petra and Wessig, Carsten and Nave, Klaus-Armin and Baumann, Frank and Bremer, Juliane
Nature Neuroscience, ISSN 1097-6256, 03/2010, Volume 13, Issue 3, pp. 310 - 318
The integrity of peripheral nerves relies on communication between axons and Schwann cells. The axonal signals that ensure myelin maintenance are distinct from... 
SIGNAL-TRANSDUCTION | AMINO-TERMINUS | SCRAPIE | NEURITE OUTGROWTH | MICE DEFICIENT | MOUSE | KNOCKOUT | DOPPEL | CLEAVAGE | NEUROSCIENCES | PRP | Peripheral Nerves - ultrastructure | Prions - genetics | Alternative Splicing | GPI-Linked Proteins | Axons - physiology | Nerve Fibers, Myelinated - ultrastructure | Polyneuropathies - metabolism | Demyelinating Diseases - metabolism | Sciatic Nerve - metabolism | Neurons - ultrastructure | Peripheral Nerves - physiology | Axons - ultrastructure | Nerve Fibers, Myelinated - physiology | Neurons - physiology | Schwann Cells - physiology | PrPC Proteins - metabolism | Demyelinating Diseases - pathology | PrPC Proteins - genetics | Prions - metabolism | Myelin Sheath - physiology | Sciatic Nerve - pathology | Mice, Inbred C57BL | Mice, Transgenic | Mice, Inbred Strains | Mice, Knockout | Animals | Schwann Cells - ultrastructure | Polyneuropathies - pathology | Mice | Mice, Inbred BALB C | Myelin Sheath - ultrastructure | Chronic Disease | Neurons | Prions | Physiological aspects | Nervous system | Genetic aspects | Degeneration | Research | Index Medicus
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