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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 01/2013, Volume 110, Issue 2, pp. 648 - 653
The coagulation protease activated protein C (aPC) confers cytoprotective effects in various in vitro and in vivo disease models, including diabetic... 
APOPTOSIS | OXIDATIVE STRESS | GLOMERULOPATHY | LONGEVITY GENE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | P66SHC | MECHANISMS | ANTICOAGULANT PROTEIN | PODOCYTES | EXPRESSION | Proteins | Prevention | Physiological aspects | Oxidative stress | Health aspects | Diabetic nephropathies
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2007, Volume 13, Issue 11, pp. 1349 - 1358
Data providing direct evidence for a causative link between endothelial dysfunction, microvascular disease and diabetic end-organ damage are scarce. Here we... 
MEDICINE, RESEARCH & EXPERIMENTAL | POLY(ADP-RIBOSE) POLYMERASE INHIBITORS | ANTICOAGULANT PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | ALPHA | CELL BIOLOGY | THROMBOMODULIN | INFLAMMATION | DYSFUNCTION | CELL | RECEPTOR-1 | SEVERE SEPSIS | Kidney Glomerulus - blood supply | Diabetic Nephropathies - enzymology | Protein C - physiology | Diabetes Mellitus, Experimental - enzymology | Humans | Diabetes Mellitus, Experimental - genetics | Podocytes - enzymology | Apoptosis - genetics | Endothelium, Vascular - enzymology | Thrombomodulin - physiology | Diabetes Mellitus, Experimental - prevention & control | Mice, Mutant Strains | Diabetic Nephropathies - prevention & control | Kidney Glomerulus - enzymology | Diabetic Nephropathies - pathology | Mice, Inbred C57BL | Cells, Cultured | Diabetic Nephropathies - genetics | Mice, Transgenic | Signal Transduction - genetics | Kidney Glomerulus - pathology | Podocytes - pathology | Protein C - biosynthesis | Animals | Microcirculation - pathology | Microcirculation - enzymology | Diabetes Mellitus, Experimental - pathology | Amino Acid Substitution - genetics | Cytoprotection - genetics | Endothelium, Vascular - pathology | Mice | Enzyme Activation - genetics | Cell Line, Transformed | Protein C - genetics | Proteins | Diabetes | Kidney diseases | Cellular biology | Rodents | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 2, pp. 648 - 653
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 11/2016, Volume 43, Issue 12, pp. 2105 - 2113
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 4/2014, Volume 41, Issue 4, pp. 694 - 701
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e89422
Aims: The receptor for advanced glycation endproducts, RAGE, is a multiligand receptor and NF-kappa B activator leading to perpetuation of inflammation. We... 
LEUKOCYTE RECRUITMENT | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | IN-VIVO | P-SELECTIN | SEPTIC SHOCK | INFLAMMATORY CELL RECRUITMENT | DIABETIC-NEPHROPATHY | IMPROVES SURVIVAL | GLYCATION END-PRODUCTS | ENDPRODUCTS RAGE | Tumor Necrosis Factor-alpha - metabolism | Endothelial Protein C Receptor | Humans | Tumor Necrosis Factor-alpha - genetics | Male | Anti-Inflammatory Agents - metabolism | Inflammation - metabolism | Thrombomodulin - metabolism | Vascular Cell Adhesion Molecule-1 - genetics | Thrombomodulin - genetics | Receptor for Advanced Glycation End Products | Cell Adhesion - genetics | Endothelial Cells - metabolism | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Up-Regulation - genetics | Signal Transduction - genetics | Mice, Knockout | Intercellular Adhesion Molecule-1 - metabolism | Animals | Intercellular Adhesion Molecule-1 - genetics | Inflammation - genetics | Mice | Protein C - metabolism | Receptors, Immunologic - genetics | Vascular Cell Adhesion Molecule-1 - metabolism | Leukocytes - metabolism | Protein C - genetics | Receptors, Immunologic - metabolism | Receptors, Cell Surface - genetics | Anti-inflammatory drugs | RNA | Tumor necrosis factor | Analysis | Protein C | Inflammation | Research | Mediation | Endothelium | Animal models | Vascular cell adhesion molecule 1 | Laboratories | Activation | Biochemistry | mRNA | Kinases | Experiments | Cell adhesion & migration | Recruitment | Proteins | Signal transduction | Mouse devices | Rodents | Thrombomodulin | NF-κB protein | Advanced glycosylation end products | Antiinflammatory agents | Cytokines | Intercellular adhesion molecule 1 | Muscles | MAP kinase | Glycosylation | Activated protein C | Tumor necrosis factor-α | Trauma | Adhesion | Endothelial cells | White blood cells | Signaling | Microscopy | Binding sites | Cell migration
Journal Article
Journal Article