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Journal of Clinical Investigation, ISSN 0021-9738, 10/2016, Volume 126, Issue 10, pp. 3814 - 3826
Potent CD19-directed immunotherapies, such as chimeric antigen receptor T cells (CART) and blinatumomab, have drastically changed the outcome of patients with... 
CHIMERIC RECEPTORS | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | EFFECTOR FUNCTIONS | B-CELL | ACUTE-LYMPHOBLASTIC-LEUKEMIA | IN-VIVO | ALPHA CHAIN | ACUTE MYELOID-LEUKEMIA | BLINATUMOMAB | RECEPTOR T-CELLS | Immunotherapy - methods | Interleukin-3 Receptor alpha Subunit - administration & dosage | Neoplasm Recurrence, Local - prevention & control | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Drug Resistance, Neoplasm | Antineoplastic Agents - administration & dosage | Mice, SCID | T-Lymphocytes - transplantation | Xenograft Model Antitumor Assays | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Animals | Neoplastic Stem Cells - metabolism | Cell Line, Tumor | Receptors, Antigen, T-Cell - administration & dosage | Mice, Inbred NOD | T-Lymphocytes - immunology | Antigens, CD19 - metabolism | Interleukin-3 Receptor alpha Subunit - metabolism | Antigen-antibody reactions | Cellular proteins | Care and treatment | Immunotherapy | Patient outcomes | Development and progression | Genetic aspects | Acute lymphocytic leukemia | Properties | Health aspects | Methods | Antigens | Pediatrics | Medical research | Flow cytometry | Immunoglobulins | Leukemia | Colleges & universities | Clinical trials | T cell receptors | Experiments | Cancer therapies | Patients | Genotype & phenotype | Institutional repositories | Lymphocytes | Medical prognosis | Response rates | Stem cells | Laboratory animals | Tumors | Cancer
Journal Article
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7709, pp. 307 - 312
Cancer immunotherapy based on genetically redirecting T cells has been used successfully to treat B cell malignancies(1-3). In this strategy, the T cell genome... 
B-CELL | 5-METHYLCYTOSINE | CONVERSION | MULTIDISCIPLINARY SCIENCES | 5-HYDROXYMETHYLCYTOSINE | MUTATIONS | PROTEINS | CD28 COSTIMULATION | DNA INTEGRATION | 5-FORMYLCYTOSINE | LYMPHOCYTES | Clone Cells - cytology | Dioxygenases - metabolism | Immunotherapy - methods | Epigenesis, Genetic | Humans | Male | Adoptive Transfer | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Recombinant Fusion Proteins - metabolism | T-Lymphocytes - transplantation | T-Lymphocytes - metabolism | Clone Cells - immunology | HEK293 Cells | Cell Differentiation | Transgenes | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Antigens, CD19 - immunology | Clinical Trials as Topic | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Dioxygenases - genetics | 5-Methylcytosine - metabolism | T-Lymphocytes - cytology | Alleles | Recombinant Fusion Proteins - genetics | T-Lymphocytes - immunology | Aged | Mutation | Genetic engineering | Research | T cells | Immunotherapy | Oncology, Experimental | Cancer | Leukemia | Differentiation (biology) | Insertion | Genomes | Lymphocytes T | Lymph nodes | Anticancer properties | Proteins | Infusion | Receptors | Lymphocytes | Peripheral blood | Bone marrow | Remission | Oxidation | Bioinformatics | Deoxyribonucleic acid--DNA | Dioxygenase | Antigens | Chronic lymphatic leukemia | Phenotypes | Transposons | CD19 antigen | Cloning | T cell receptors | Cell differentiation | Patients | Progeny | Lymphocytes B | Stem cells | Epigenetics | Tumors
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2016, Volume 6, Issue 6, pp. 664 - 679
Journal Article
Gastroenterology, ISSN 0016-5085, 07/2018, Volume 155, Issue 1, pp. 29 - 32
Journal Article
Blood, ISSN 0006-4971, 07/2016, Volume 128, Issue 3, pp. 360 - 370
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 556 - 556
Abstract Abstract CAR T cell therapy in relapsed B-ALL can result in complete response (CR) rates of 80-90%, but relapse-free survival declines to 60% within... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 281 - 281
Abstract T cells bearing a second-generation anti-CD19 chimeric antigen receptor (CAR) induce complete remission in >90% of patients with acute lymphoblastic... 
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 966 - 966
Abstract Relapsing/refractory (r/r) B-cell Acute Lymphoblastic Leukemia (ALL) is associated with a poor prognosis in both pediatric and adult patients. Novel... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 2523 - 2523
Abstract Introduction: Anti-CD19 chimeric antigen receptor T cells (CART19) and bi-specific anti-CD19/CD3 antibodies (blinatumomab) generate unprecedented... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 683 - 683
Background Targeted immunotherapy with T cells expressing a chimeric antigen receptor (CAR) can produce dramatic anti-tumor responses. We previously... 
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 163 - 163
Abstract Background Recent advances in T cell engineering have enabled clinical trials to evaluate the potential for adoptive transfer of T cells to target... 
Journal Article
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