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Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 2171 - 2171
Journal Article
2008, AD-a481 709.
We have recently found that CDK5 is active in prostate cancer cell lines and in almost all human metastatic prostate cancers, and inhibition of CDK5 activity... 
cdk5 | cells(biology) | cultures(biology) | molecular imaging | chemotherapy | cdk5 inhibitor | bioluminescent cells | cell motility | skeleton | prostate cancer | xenograft | metastasis | pharmacology | neoplasms
Government Document
Journal Article
Cancer Research, ISSN 0008-5472, 06/2010, Volume 70, Issue 11, pp. 4460 - 4469
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 11/2018, Volume 128, Issue 11, pp. 4924 - 4937
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2015, Volume 14, Issue 7, pp. 1532 - 1539
KRAS is activated by mutation in the vast majority of cases of pancreatic cancer; unfortunately, therapeutic attempts to inhibit KRAS directly have been... 
NEURONAL MIGRATION | CARCINOMA-CELLS | SMALL MOLECULES | K-RAS | CDK5 | ONCOLOGY | ONCOGENIC KRAS | PROSTATE-CANCER CELLS | IN-VIVO | MEDIATED NUCLEOTIDE EXCHANGE | AKT INHIBITOR | Immunohistochemistry | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Pyridinium Compounds - administration & dosage | Pancreatic Neoplasms - drug therapy | Neoplasm Metastasis | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Drug Administration Schedule | Administration, Oral | Pancreatic Neoplasms - pathology | Retinoblastoma Protein - metabolism | Injections, Intraperitoneal | Treatment Outcome | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Xenograft Model Antitumor Assays - methods | Cyclin-Dependent Kinase 5 - metabolism | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Cyclin-Dependent Kinase 5 - antagonists & inhibitors | Animals | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Heterocyclic Compounds, 3-Ring - administration & dosage | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | KRAS | cyclin-dependent kinase | patient-derived xenograft | Pancreatic cancer
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 06/2019
Differentiated thyroid cancer (DTC) responds to vascular endothelial growth factor (VEGF) receptors inhibitors. VEGF signals through RAS/RAF/MEK signaling. We... 
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 10/2011, Volume 12, Issue 7, pp. 598 - 609
Pancreatic cancer is one of the most lethal of human malignancies, and potent therapeutic options are lacking. Inhibition of cell cycle progression through... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | SCH727965 | Translational research | Cyclin-dependent kinases | Pancreatic cancer | Cell cycle | Dinaciclib | Xenograft mouse models | SURVIVAL | CELLS | ACTIVATION | TGF-BETA | dinaciclib | cell cycle | GEMCITABINE | xenograft mouse models | PLATFORM | pancreatic cancer | INVASION | cyclin-dependent kinases | ONCOLOGY | translational research | CARCINOMA | TUMOR INITIATION | PARADIGM | Receptors, Notch - metabolism | Humans | Pyridinium Compounds - administration & dosage | Deoxycytidine - pharmacology | Male | Receptors, Notch - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pancreatic Neoplasms - drug therapy | ral GTP-Binding Proteins - metabolism | Cyclin-Dependent Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Signal Transduction | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Retinoblastoma Protein - metabolism | Enzyme Inhibitors - pharmacology | Pancreatic Neoplasms - genetics | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Pancreatic Neoplasms - embryology | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Transforming Growth Factor beta - metabolism | Deoxycytidine - analogs & derivatives | Research Paper
Journal Article
Cancer Research, ISSN 0008-5472, 06/2003, Volume 63, Issue 11, pp. 2948 - 2956
Journal Article
Cancer Research, ISSN 0008-5472, 04/2001, Volume 61, Issue 7, pp. 3200 - 3205
Journal Article