X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
disease (3) 3
genetics (3) 3
index medicus (3) 3
neuronal ceroid lipofuscinosis (3) 3
proteins (3) 3
survival (3) 3
acyclic or carbocyclic compounds (2) 2
animal models (2) 2
biochemistry (2) 2
chemistry (2) 2
enzyme replacement therapy (2) 2
enzymes (2) 2
genetics & heredity (2) 2
medicine, research & experimental (2) 2
metallurgy (2) 2
mice (2) 2
molecular biology (2) 2
organic chemistry (2) 2
original (2) 2
original article (2) 2
peptidase (2) 2
research (2) 2
research article (2) 2
stem cells (2) 2
studies (2) 2
tripeptidyl peptidase 1 (2) 2
actin (1) 1
adhesives (1) 1
adsorptive transcytosis (1) 1
aging (1) 1
alleles (1) 1
alpha-synuclein (1) 1
amino acid sequence (1) 1
aminopeptidases - deficiency (1) 1
aminopeptidases - genetics (1) 1
animal models of disease (1) 1
animal studies (1) 1
animals (1) 1
apolipoprotein e (1) 1
apolipoproteins e - chemistry (1) 1
apolipoproteins e - pharmacokinetics (1) 1
artificial gene amplification and extension (1) 1
autophagy (1) 1
bioindicators (1) 1
biological cultures (1) 1
biology and life sciences (1) 1
biomarkers (1) 1
biotechnology (1) 1
biotechnology & applied microbiology (1) 1
biotin (1) 1
blood brain barrier (1) 1
blood-brain barrier (1) 1
blood-brain barrier - drug effects (1) 1
blood-brain barrier - metabolism (1) 1
brain - drug effects (1) 1
brain - enzymology (1) 1
brain - pathology (1) 1
brain research (1) 1
cancer (1) 1
canine model (1) 1
causes of (1) 1
cell culture (1) 1
cell cycle (1) 1
cell lines (1) 1
cell research (1) 1
cells (1) 1
children (1) 1
cho cells (1) 1
chronic (1) 1
cln2 disease (1) 1
comedians (1) 1
corruption (1) 1
cre recombinase (1) 1
cytology (1) 1
delivery (1) 1
dipeptidyl-peptidases and tripeptidyl-peptidases - deficiency (1) 1
dipeptidyl-peptidases and tripeptidyl-peptidases - genetics (1) 1
disease models, animal (1) 1
diseases (1) 1
dosage and administration (1) 1
drug carriers (1) 1
drug dosages (1) 1
dyes (1) 1
endocytosis (1) 1
endothelial cells (1) 1
endothelial cells - drug effects (1) 1
endothelial cells - metabolism (1) 1
endothelial cells - pathology (1) 1
enzyme replacement therapy - methods (1) 1
enzymology (1) 1
experimental organism systems (1) 1
experiments (1) 1
forkhead protein (1) 1
foxo3 protein (1) 1
gene expression (1) 1
gene expression regulation (1) 1
gene therapy (1) 1
gene-transfer (1) 1
genetic aspects (1) 1
genetic engineering (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular Therapy, ISSN 1525-0016, 07/2017, Volume 25, Issue 7, pp. 1531 - 1543
We have investigated delivery of protein therapeutics from the bloodstream into the brain using a mouse model of late-infantile neuronal ceroid lipofuscinosis... 
blood brain barrier | intravenous | enzyme replacement therapy | tripeptidyl peptidase 1 | MEDICINE, RESEARCH & EXPERIMENTAL | WHEAT-GERM-AGGLUTININ | HORSERADISH-PEROXIDASE | LYSOSOMAL-ENZYME | TRANSPORT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ADSORPTIVE TRANSCYTOSIS | MOUSE MODEL | I ACTIVITY | GENETICS & HEREDITY | MANNOSE 6-PHOSPHATE RECEPTOR | POLYCATIONS | NEURONAL CEROID-LIPOFUSCINOSIS | Neuronal Ceroid-Lipofuscinoses - enzymology | Serine Proteases - genetics | Injections, Intravenous | Humans | Peptides - pharmacokinetics | Brain - enzymology | Infant | Apolipoproteins E - pharmacokinetics | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - deficiency | Neuronal Ceroid-Lipofuscinoses - pathology | Drug Carriers | Endocytosis | Neuronal Ceroid-Lipofuscinoses - genetics | Serine Proteases - deficiency | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics | Disease Models, Animal | Amino Acid Sequence | Neuronal Ceroid-Lipofuscinoses - therapy | Aminopeptidases - genetics | Peptides - chemistry | Endothelial Cells - metabolism | Gene Expression Regulation | Treatment Outcome | Aminopeptidases - deficiency | Blood-Brain Barrier - drug effects | Apolipoproteins E - chemistry | Blood-Brain Barrier - metabolism | Brain - drug effects | Enzyme Replacement Therapy - methods | Animals | Survival Analysis | Brain - pathology | Mice | Endothelial Cells - pathology | Endothelial Cells - drug effects | Animal models | Intravenous administration | Disease | Peptides | Toxicity | Liver | Experiments | Proteins | Blood-brain barrier | Apolipoprotein E | Neuronal ceroid lipofuscinosis | Drug dosages | Enzymes | Peptidase | Kidneys | Biotin | Grants | Endothelial cells | Studies | Brain research | Life span | Morphology | Scientific imaging | Mass spectrometry | Cancer | Original
Journal Article
Molecular Therapy - Methods & Clinical Development, ISSN 2329-0501, 03/2017, Volume 4, Issue C, pp. 204 - 212
Late infantile neuronal ceroid lipofuscinosis (LINCL) is a fatal inherited neurodegenerative disease caused by loss of lysosomal protease tripeptidyl peptidase... 
intrathecal | enzyme replacement therapy | neuronal ceroid lipofuscinosis | tripeptidyl peptidase 1 | chronic | PEPTIDASE-I ACTIVITY | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | CANINE MODEL | THERAPY | METACHROMATIC LEUKODYSTROPHY | LYSOSOMAL STORAGE | GENE-TRANSFER | CLN2 DISEASE | PATHOLOGY | DELIVERY
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.