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1. Full Text Mechanisms of disease: Psoriasis
by Nestle, Frank O and Kaplan, Daniel H and Barker, Jonathan
New England Journal of Medicine, ISSN 0028-4793, 07/2009, Volume 361, Issue 5, pp. 444 - 509
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2. Full Text The IL-23Th17 axis in the immunopathogenesis of psoriasis
by Di Cesare, Antonella and Di Meglio, Paola and Nestle, Frank O
Journal of Investigative Dermatology, ISSN 0022-202X, 06/2009, Volume 129, Issue 6, pp. 1339 - 1350
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3. Pathogenesis and treatment of psoriasis: Exploiting pathophysiological pathways for precision medicine
by Alwan, Wisam and Nestle, Frank O
Clinical and Experimental Rheumatology, ISSN 0392-856X, 2015, Volume 33, Issue 5, pp. 2 - 6
Psoriasis is a common, chronic inflammatory skin disease associated with multi-system manifestations including arthritis and obesity. Our knowledge of the... 
Immunology | Treatment | Precision medicine | Psoriasis | Pathogenesis | Genomics | Microbiome | Psoriatic arthritis | treatment | SUSCEPTIBILITY LOCI | HLA-C | MONOCLONAL-ANTIBODY | RHEUMATOLOGY | microbiome | pathogenesis | IMMUNE-SYSTEM | psoriasis | PLAQUE PSORIASIS | DISEASE | precision medicine | genomics | psoriatic arthritis | SKIN | immunology | NF-KAPPA-B | ASSOCIATION | INNATE IMMUNITY | Psoriasis - immunology | Genetic Predisposition to Disease | Psoriasis - drug therapy | Humans | Psoriasis - diagnosis | Risk Factors | Psoriasis - etiology | Genetic Markers | Molecular Targeted Therapy | Patient Selection | Phenotype | Psoriasis - genetics | Animals | Signal Transduction - drug effects | Anti-Inflammatory Agents - therapeutic use | Precision Medicine
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4. Full Text Pathogenesis and immunotherapy in cutaneous psoriasis: what can rheumatologists learn?
by Alexander, Helen and Nestle, Frank O
Current Opinion in Rheumatology, ISSN 1040-8711, 01/2017, Volume 29, Issue 1, pp. 71 - 78
PURPOSE OF REVIEWThis review presents our current understanding of the pathogenesis and treatment of psoriasis with a particular focus on recent areas of... 
Biomarkers | Treatment | Psoriasis | Pathogenesis | Immunotherapy | treatment | LONG NONCODING RNAS | biomarkers | SUSCEPTIBILITY LOCI | RHEUMATOLOGY | ARTHRITIS | pathogenesis | DRUG SURVIVAL | SECUKINUMAB | psoriasis | immunotherapy | SEVERE PLAQUE PSORIASIS | DOUBLE-BLIND | ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY | PLACEBO-CONTROLLED TRIAL | EXPRESSION | Adaptive Immunity | Psoriasis - immunology | Immunotherapy - methods | Epigenomics | Skin - microbiology | Humans | Psoriasis - etiology | Gene Expression Profiling - methods | Biomarkers - blood | Microbiota | Genomics - methods | Cytokines - immunology | Immunologic Factors - therapeutic use | Psoriasis - therapy
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5. Full Text TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis
by Flutter, Barry and Nestle, Frank O
European Journal of Immunology, ISSN 0014-2980, 12/2013, Volume 43, Issue 12, pp. 3138 - 3146
Psoriasis is an inflammatory disease of the skin affecting 2–3% of the population, characterized by a thickening of the epidermis and immune infiltrates... 
Animal models | TLR7 | Psoriasis | Imiquimod | DENDRITIC CELLS | DELTA T-CELLS | IMMUNOLOGY | IL-22 | LANGERHANS CELLS | DISEASE | PLAQUE-FORMATION | IMMUNE-RESPONSE MODIFIER | POTENTIAL ROLE | SKIN INFLAMMATION | ACTINIC KERATOSIS | Psoriasis - immunology | Toll-Like Receptor 7 - agonists | Adjuvants, Immunologic - pharmacology | Humans | Membrane Glycoproteins - agonists | Adjuvants, Immunologic - adverse effects | Toll-Like Receptor 8 - immunology | Animals | Psoriasis - pathology | Psoriasis - chemically induced | Toll-Like Receptor 7 - immunology | Mice | Membrane Glycoproteins - immunology | Aminoquinolines - pharmacology | Receptors, Purinergic P1 - immunology | Aminoquinolines - adverse effects | Cytokines - immunology | Disease Models, Animal | Toll-Like Receptor 8 - agonists | Skin | Analysis | Medical research | Rodents
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6. Full Text Mechanisms regulating skin immunity and inflammation
by Pasparakis, Manolis and Haase, Ingo and Nestle, Frank O
Nature Reviews Immunology, ISSN 1474-1733, 2014, Volume 14, Issue 5, pp. 289 - 301
Immune responses in the skin are important for host defence against pathogenic microorganisms. However, dysregulated immune reactions can cause chronic... 
CHRONIC INTESTINAL INFLAMMATION | EPIDERMAL LANGERHANS CELLS | DERMAL DENDRITIC CELLS | MOUSE MODEL | MAST-CELLS | DELTA-T-CELLS | INNATE LYMPHOID-CELLS | TNF-ALPHA | IMMUNOLOGY | PSORIASIFORM DERMATITIS | NF-KAPPA-B | Immunity - immunology | Skin Diseases - immunology | Inflammation - immunology | Animals | Humans | Skin - immunology | Prevention | Care and treatment | Immune response | Physiological aspects | Skin | Inflammation | Regulation | Research
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7. Full Text Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells
by Murakami, Takashi and Maki, Wusi and Cardones, Adela R and Fang, Hui and Tun Kyi, Adrian and Nestle, Frank O and Hwang, Sam T
Cancer Research, ISSN 0008-5472, 12/2002, Volume 62, Issue 24, pp. 7328 - 7334
The chemokine receptors CC chemokine receptor (CCR) 7 and CXC cbemokine receptor (CXCR) 4 have been implicated in cancer metastasis. To evaluate whether CXCR4... 
MIGRATION | ENGRAFTMENT | ONCOLOGY | INTEGRINS | BREAST-CANCER METASTASIS | LYMPH-NODES | NOD/SCID MICE | PROLIFERATION | FACTOR-I | INHIBITOR | CUTTING EDGE | Endothelium, Vascular - cytology | Amino Acid Sequence | Chemokine CXCL12 | Transduction, Genetic | Receptors, CXCR4 - antagonists & inhibitors | Lung Neoplasms - metabolism | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Molecular Sequence Data | Melanoma, Experimental - metabolism | Luciferases - genetics | Skin Neoplasms - metabolism | Cell Division - physiology | Animals | Melanoma, Experimental - genetics | Lung Neoplasms - secondary | Receptors, CXCR4 - biosynthesis | Cell Adhesion - physiology | Melanoma, Experimental - secondary | Chemokines, CXC - pharmacology | Female | Receptors, CXCR4 - genetics | Mice | Oligopeptides - pharmacology
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8. Full Text The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis
by Di Cesare, Antonella and Di Meglio, Paola and Nestle, Frank O
Journal of Investigative Dermatology, ISSN 0022-202X, 06/2009, Volume 129, Issue 6, pp. 1339 - 1350
Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in... 
GROWTH-FACTOR-BETA | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS LESIONS | INFLAMMATORY-BOWEL-DISEASE | ROR-GAMMA-T | ARYL-HYDROCARBON RECEPTOR | NECROSIS-FACTOR-ALPHA | ACTIVE CROHNS-DISEASE | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | T-HELPER-CELLS | DERMATOLOGY | Protein Structure, Tertiary | Psoriasis - immunology | Phosphorylation | Cell Proliferation | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | Humans | Clinical Trials as Topic | Interleukin-23 - immunology | Receptors, Interleukin - metabolism | Animals | Immune System | Models, Biological | Mice | Interleukin-23 - physiology | Psoriasis - therapy
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9. Full Text Translational drug discovery and development with the use of tissue-relevant biomarkers: Towards more physiological relevance and better prediction of clinical efficacy
by Florian, Peter and Flechsenhar, Klaus R and Bartnik, Eckart and Ding-Pfennigdorff, Danping and Herrmann, Matthias and Bryce, Paul J and Nestle, Frank O
Experimental Dermatology, ISSN 0906-6705, 2019
Due to the clinical development of drugs such as secukinumab, ustekinumab and dupilumab, major changes have been achieved in the treatment of patients... 
in vivo models | drug development in autoimmune disease | molecular understanding | ex vivo | in vitro
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10. Full Text TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis
: HIGHLIGHTS
by Flutter, Barry and Nestle, Frank O
European Journal of Immunology, ISSN 0014-2980, 12/2013, Volume 43, Issue 12, pp. 3138 - 3146
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11. Full Text Psoriasis
by Perera, Gayathri K and Di Meglio, Paola and Nestle, Frank O
Annual Review of Pathology: Mechanisms of Disease, ISSN 1553-4006, 2012, Volume 7, Issue 1, pp. 385 - 422
Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints. This review focuses on current... 
Keratinocytes | PSORS | Cytokines | Lymphocytes | Biologics | Immunopathogenesis | lymphocytes | biologics | NECROSIS-FACTOR-ALPHA | keratinocytes | RANDOMIZED CONTROLLED-TRIAL | PATHOLOGY | CONTROLLED PHASE-III | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | PLASMACYTOID DENDRITIC CELLS | immunopathogenesis | IL-17-PRODUCING T-CELLS | DOUBLE-BLIND | cytokines | PLAQUE-TYPE PSORIASIS | GENOME-WIDE ASSOCIATION | ENDOTHELIAL GROWTH-FACTOR | Psoriasis - immunology | Psoriasis - genetics | Psoriasis - drug therapy | Psoriasis - pathology | Humans | Cytokines - antagonists & inhibitors | Skin - pathology | Cytokines - immunology | Care and treatment | Immune response | Psoriasis | Immunotherapy | Research | Health aspects | Risk factors
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12. Full Text What on "Irf" Is This Gene4?Irf4Transcription-Factor-Dependent Dendritic Cells Are Required for T Helper 2 Cell Responses in Murine Skin
by Barry Flutter and Frank O Nestle
Immunity, ISSN 1074-7613, 10/2013, Volume 39, Issue 4, p. 625
  Interferon regulatory factors play an important role in the transcriptional regulation of immunity. In this issue ofImmunity,Kumamoto et al. (2013)andGao et... 
Studies | Antigens | Lymphocytes | Cytotoxicity | T cell receptors | Skin | Immune system
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13. Full Text The Multitasking Organ: Recent Insights into Skin Immune Function
by Di Meglio, Paola and Perera, Gayathri K and Nestle, Frank O
Immunity, ISSN 1074-7613, 2011, Volume 35, Issue 6, pp. 857 - 869
The skin provides the first line defense of the human body against injury and infection. By integrating recent findings in cutaneous immunology with... 
EPIDERMAL LANGERHANS CELLS | INTERLEUKIN 22 | MOUSE MODEL | CONTACT HYPERSENSITIVITY | ANTIMICROBIAL PEPTIDE | LANGERIN(+) DENDRITIC CELLS | TNF INHIBITION | IMMUNOLOGY | MEMORY T-CELLS | INNATE IMMUNITY | CUTTING EDGE | Skin Diseases - immunology | Animals | Skin - metabolism | Humans | Skin - immunology | Autoimmunity | Dermatologic agents | Skin | Psoriasis | Dermatology | Formulae, receipts, prescriptions | Wound healing | Biomedical research | Pathogenesis | Acne | Homeostasis | Genetic diversity | Gene expression | Scholarships & fellowships | Rodents | Bacteria | Immune system
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