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1. Full Text A meta-Analysis of Alzheimer's disease brain transcriptomic data
by Patel, Hamel and Dobson, Richard J.B and Newhouse, Stephen J
Journal of Alzheimer's Disease, ISSN 1387-2877, 2019, Volume 68, Issue 4, pp. 1635 - 1656
Background: Microarray technologies have identified imbalances in the expression of specific genes and biological pathways in Alzheimer's disease (AD) brains.... 
Human | Meta-Analysis | Mental disorders | Neuropathology | Gene expression | Alzheimer's disease | Neurodegenerative disorders | Microarray analysis | microarray analysis | INVOLVEMENT | meta-analysis | PATHOLOGY | neurodegenerative disorders | BIPOLAR DISORDER | NEUROSCIENCES | mental disorders | METABOLISM | AMYLOID-BETA | GENES | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GAPDH | O-GLCNAC | ALTERED EXPRESSION | human | gene expression | neuropathology | GENOME-WIDE ASSOCIATION
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2. Full Text Microarray, qPCR, and KCNJ5 Sequencing of Aldosterone-Producing Adenomas Reveal Differences in Genotype and Phenotype between Zona Glomerulosa- and Zona Fasciculata-Like Tumors
by Azizan, Elena A. B and Lam, Brian Y. H and Newhouse, Stephen J and Zhou, Junhua and Kuc, Rhoda E and Clarke, Jennifer and Happerfield, Lisa and Marker, Alison and Hoffman, Gary J and Brown, Morris J
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 05/2012, Volume 97, Issue 5, pp. E819 - E829
Context: Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of somatic KCNJ5 mutations suggests a genetic explanation. Objectives: The... 
CELLS | ENDOCRINOLOGY & METABOLISM | UPRIGHT POSTURE | EXPRESSION PROFILES | MUTATIONS | HYPERTENSION | RECEPTORS | ANGIOTENSIN | BLOOD-PRESSURE | GENOME-WIDE ASSOCIATION | Adenoma - genetics | Aldosterone - biosynthesis | Humans | Hyperaldosteronism - pathology | Middle Aged | Hyperaldosteronism - genetics | Zona Glomerulosa - pathology | Genotype | Male | Hyperaldosteronism - metabolism | Zona Glomerulosa - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Adenoma - metabolism | Phenotype | Adenoma - pathology | Adrenal Gland Neoplasms - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Zona Fasciculata - pathology | Adult | Female | Zona Fasciculata - metabolism | Aged | Adrenal Gland Neoplasms - genetics | Adrenal Gland Neoplasms - pathology
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3. Full Text A Meta-Analysis of Alzheimer’s Disease Brain Transcriptomic Data
by Patel, Hamel and Dobson, Richard J.B and Newhouse, Stephen J
Journal of Alzheimer's Disease, ISSN 1387-2877, 04/2019, Volume 68, Issue 4, pp. 1635 - 1656
Background: Microarray technologies have identified imbalances in the expression of specific genes and biological pathways in Alzheimer’s disease (AD) brains.... 
Cerebellum | Brain | Frontal lobe | Mental disorders | Identification methods | Genes | Mental health | Disorders | Schizophrenia | Bipolar disorder | Mapping | Mental depression | Proteins | Replicating | Pathways | Alzheimer's disease | Plaques | Temporal lobe | Therapeutic applications | Brain mapping | Metabolism | Gene expression | Ribonucleic acid--RNA | DNA microarrays | Reproducibility | Parietal lobe
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4. Full Text Genome-wide association study identifies eight loci associated with blood pressure
by Newton-Cheh, Christopher and Johnson, Toby and Gateva, Vesela and Tobin, Martin D and Bochud, Murielle and Coin, Lachlan and Najjar, Samer S and Zhao, Jing Hua and Heath, Simon C and Eyheramendy, Susana and Papadakis, Konstantinos and Voight, Benjamin F and Scott, Laura J and Zhang, Feng and Farrall, Martin and Tanaka, Toshiko and Wallace, Chris and Chambers, John C and Khaw, Kay-Tee and Nilsson, Peter and van der Harst, Pim and Polidoro, Silvia and Grobbee, Diederick E and Onland-Moret, N. Charlotte and Bots, Michiel L and Wain, Louise V and Elliott, Katherine S and Teumer, Alexander and Luan, Jian'an and Lucas, Gavin and Kuusisto, Johanna and Burton, Paul R and Hadley, David and McArdle, Wendy L and Brown, Morris and Dominiczak, Anna and Newhouse, Stephen J and Samani, Nilesh J and Webster, John and Zeggini, Eleftheria and Beckmann, Jacques S and Bergmann, Sven and Lim, Noha and Song, Kijoung and Vollenweider, Peter and Waeber, Gerard and Waterworth, Dawn M and Yuan, Xin and Groop, Leif and Orho-Melander, Marju and Allione, Alessana and Di Gregorio, Alessana and Guarrera, Simonetta and Panico, Salvatore and Ricceri, Fulvio and Romanazzi, Valeria and Sacerdote, Carlotta and Vineis, Paolo and Barroso, Ines and Sandhu, Manjinder S and Luben, Robert N and Crawford, Gabriel J and Jousilahti, Pekka and Perola, Markus and Boehnke, Michael and Bonnycastle, Lori L and Collins, Francis S and Jackson, Anne U and Mohlke, Karen L and Stringham, Heather M and Valle, Timo T and Willer, Cristen J and Bergman, Richard N and Morken, Mario A and Doering, Angela and Gieger, Christian and Illig, Thomas and Meitinger, Thomas and Org, Elin and Pfeufer, Arne and Wichmann, H. Erich and Kathiresan, Sekar and Marrugat, Jaume and O'Donnell, Christopher J and Schwartz, Stephen M and Siscovick, David S and Subirana, Isaac and Freimer, Nelson B and Hartikainen, Anna-Liisa and McCarthy, Mark I and O'Reilly, Paul F and Peltonen, Leena and Pouta, Anneli and de Jong, Paul E and Snieder, Harold and van Gilst, Wiek H and Clarke, Robert and Goel, Anuj and Hamsten, Anders and Peden, John F and ... and Wellcome Trust Case Control Consor and Wellcome Trust Case Control Consortium and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Uppsala universitet and Institutionen för medicinska vetenskaper
Nature Genetics, ISSN 1061-4036, 06/2009, Volume 41, Issue 6, pp. 666 - 676
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood... 
LOW-RENIN HYPERTENSION | COMMON VARIANTS | POPULATION | PUBLIC-HEALTH | GENETICS & HEREDITY | METHYLENETETRAHYDROFOLATE REDUCTASE GENE | RISK | POLYMORPHISM | MUTATIONS | CELL-DIFFERENTIATION | BARTTERS-SYNDROME | Cardiovascular Diseases - physiopathology | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Blood Pressure - genetics | Europe | Humans | Diastole - genetics | Chromosome Mapping | Systole - genetics | DNA-Binding Proteins - genetics | Fibroblast Growth Factor 5 - genetics | Open Reading Frames - genetics | Cardiovascular Diseases - genetics | India | Genetic Variation | Proteins - genetics | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Cytochrome P-450 CYP1A2 - genetics | Phospholipase C delta - genetics | Steroid 17-alpha-Hydroxylase - genetics | Polymorphism, Single Nucleotide | Hypertension | Physiological aspects | Genetic aspects | Blood pressure | Research | Single nucleotide polymorphisms | Cardiovascular diseases | Risk factors | Studies | Data analysis | Genomics | Cardiovascular disease | Gene loci | Statistics | Meta-analysis | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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5. Full Text Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia
by Wallace, Chris and Newhouse, Stephen J and Braund, Peter and Zhang, Feng and Tobin, Martin and Falchi, Mario and Ahmadi, Kourosh and Dobson, Richard J and Marçano, Ana Carolina B and Hajat, Cother and Burton, Paul and Deloukas, Panagiotis and Brown, Morris and Connell, John M and Dominiczak, Anna and Lathrop, G. Mark and Webster, John and Farrall, Martin and Spector, Tim and Samani, Nilesh J and Caulfield, Mark J and Munroe, Patricia B
The American Journal of Human Genetics, ISSN 0002-9297, 2008, Volume 82, Issue 1, pp. 139 - 149
Many common diseases are accompanied by disturbances in biochemical traits. Identifying the genetic determinants could provide novel insights into disease... 
Dyslipidemias - genetics | Humans | Middle Aged | Biomarkers | Female | Male | Aged | Polymorphism, Single Nucleotide | Uric Acid - blood | Lipids - analysis | Genome, Human | Cardiovascular Diseases - genetics | Genetic aspects | Research | Single nucleotide polymorphisms | Cardiovascular diseases | Biological markers
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6. Full Text Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
by Burton, Paul R and Clayton, David G and Cardon, Lon R and Craddock, Nick and Deloukas, Panos and Duncanson, Audrey and Kwiatkowski, Dominic P and McCarthy, Mark I and Ouwehand, Willem H and Samani, Nilesh J and Todd, John A and Donnelly, Peter and Barrett, Jeffrey C and Davison, Dan and Easton, Doug and Evans, David and Leung, Hin-Tak and Marchini, Jonathan L and Morris, Andrew P and Spencer, Chris C. A and Tobin, Martin D and Attwood, Antony P and Boorman, James P and Cant, Barbara and Everson, Ursula and Hussey, Judith M and Jolley, Jennifer D and Knight, Alexandra S and Koch, Kerstin and Meech, Elizabeth and Nutland, Sarah and Prowse, Christopher V and Stevens, Helen E and Taylor, Niall C and Walters, Graham R and Walker, Neil M and Watkins, Nicholas A and Winzer, Thilo and Jones, Richard W and McArdle, Wendy L and Ring, Susan M and Strachan, David P and Pembrey, Marcus and Breen, Gerome and St. Clair, David and Caesar, Sian and Gordon-Smith, Katherine and Jones, Lisa and Fraser, Christine and Green, Elaine K and Grozeva, Detelina and Hamshere, Marian L and Holmans, Peter A and Jones, Ian R and Kirov, George and Moskvina, Valentina and Nikolov, Ivan and O'Donovan, Michael C and Owen, Michael J and Collier, David A and Elkin, Amanda and Farmer, Anne and Williamson, Richard and McGuffin, Peter and Young, Allan H and Ferrier, I. Nicol and Ball, Stephen G and Balmforth, Anthony J and Barrett, Jennifer H and Bishop, D. Timothy and Iles, Mark M and Maqbool, Azhar and Yuldasheva, Nadira and Hall, Alistair S and Braund, Peter S and Dixon, Richard J and Mangino, Massimo and Stevens, Suzanne and Thompson, John R and Bredin, Francesca and Tremelling, Mark and Parkes, Miles and Drummond, Hazel and Lees, Charles W and Nimmo, Elaine R and Satsangi, Jack and Fisher, Sheila A and Forbes, Alastair and Lewis, Cathryn M and Onnie, Clive M and Prescott, Natalie J and Sanderson, Jeremy and Mathew, Christopher G and Barbour, Jamie and Mohiuddin, M. Khalid and Todhunter, Catherine E and Mansfield, John C and Ahmad, Tariq and Cummings, Fraser R and Jewell, Derek P and ... and Breast Canc Susceptib Collaborat and Wellcome Trust Case Control Cons and Biol RA Genet & Genom Study and Wellcome Trust Case Control Consortium and The Wellcome Trust Case Control Consortium
Nature, ISSN 0028-0836, 06/2007, Volume 447, Issue 7145, pp. 661 - 678
There is increasing evidence that genome-wide association ( GWA) studies represent a powerful approach to the identification of genes involved in common human... 
INFLAMMATORY-BOWEL-DISEASE | MULTILOCUS GENOTYPE DATA | TYPE-1 DIABETES LOCUS | MULTIDISCIPLINARY SCIENCES | RHEUMATOID-ARTHRITIS FAMILIES | MITOCHONDRIAL C-1-TETRAHYDROFOLATE SYNTHASE | AFFECTED SIBLING PAIRS | BIPOLAR DISORDER | LYMPHOID TYROSINE PHOSPHATASE | SINGLE-NUCLEOTIDE POLYMORPHISMS | CORONARY-ARTERY-DISEASE | Geography | Crohn Disease - genetics | Genetics, Population | Genetic Predisposition to Disease - genetics | Diabetes Mellitus - genetics | Chromosomes, Human - genetics | Gene Frequency | Humans | United Kingdom | Bipolar Disorder - genetics | Case-Control Studies | Genome, Human - genetics | Arthritis, Rheumatoid - genetics | Genetic Markers - genetics | Coronary Artery Disease - genetics | Hypertension - genetics | Data analysis | Disease | Genomics | Data collection | Gene loci | Epidemiology | Risk factors
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7. Full Text High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
by Eyre, Steve and Bowes, John and Diogo, Dorothee and Lee, Annette and Barton, Anne and Martin, Paul and Zhernakova, Alexana and Stahl, Eli and Viatte, Sebastien and McAllister, Kate and Amos, Christopher I and Padyukov, Leonid and Toes, Rene E. M and Huizinga, Tom W. J and Wijmenga, Cisca and Trynka, Gosia and Franke, Lude and Westra, Harm-Jan and Alfredsson, Lars and Hu, Xinli and Sandor, Cynthia and de Bakker, Paul I. W and Davila, Sonia and Khor, Chiea Chuen and Heng, Khai Koon and Anews, Robert and Edkins, Sarah and Hunt, Sarah E and Langford, Cordelia and Symmons, Deborah and Concannon, Pat and Onengut-Gumuscu, Suna and Rich, Stephen S and Deloukas, Panos and Gonzalez-Gay, Miguel A and Roiguez-Roiguez, Luis and Arlsetig, Lisbeth and Martin, Javier and Rantapaa-Dahlqvist, Solbritt and Plenge, Robert M and Raychaudhuri, Soumya and Klareskog, Lars and Gregersen, Peter K and Worthington, Jane and Biol Rheumatoid Arthrit Genetics G and Wellcome Trust Case Control Consor and Wellcome Trust Case Control Consortium and Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Umeå universitet and Reumatologi
Nature Genetics, ISSN 1061-4036, 12/2012, Volume 44, Issue 12, pp. 1336 - 1340
Using the Immunochip custom SNP array, which was designed for dense genotyping of 186 loci identified through genome-wide association studies (GWAS), we... 
INTERLEUKIN-6 RECEPTOR | RISK LOCI | METAANALYSIS | GENETICS & HEREDITY | CORONARY-HEART-DISEASE | EXPRESSION | ASSOCIATION | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Oligonucleotide Array Sequence Analysis | Autoantibodies - blood | Humans | Male | Genetic Loci | Chromosome Mapping - instrumentation | Arthritis, Rheumatoid - genetics | Chromosome Mapping - methods | Female | Polymorphism, Single Nucleotide | Autoantibodies - genetics | Rheumatoid arthritis | Physiological aspects | Genetic aspects | Disease susceptibility | Single nucleotide polymorphisms | Research | Chromosomes | Studies | Medical research | Autoimmune diseases | Rheumatology and Autoimmunity | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Reumatologi och inflammation
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