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2011, ISBN 0521116481, xxviii, 565
Crimes against humanity were one of the three categories of crimes elaborated in the Nuremberg Charter. However, unlike genocide and war crimes, they were... 
International Law | Crimes against humanity
Book
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A16589 - A16589
IntroductionIt has been demonstrated using statistical methods that smaller lipoprotein (a) [Lp(a)] particles are more strongly associated with... 
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2014, Volume 34, Issue 3, pp. 676 - 683
Journal Article
Nature Communications, ISSN 2041-1723, 11/2016, Volume 7, Issue 1, p. 13457
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A17608 - A17608
ETC-1002 is a first-in-class oral small molecule that significantly lowers levels of low- density lipoprotein-cholesterol (LDL-C) by 30-40% in... 
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 647 - 656
OBJECTIVE—Bempedoic acid (ETC-1002, 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel low-density lipoprotein cholesterol–lowering compound. In... 
Lipids | Inflammation | Adenosine triphosphate citrate lyase | Atherosclerosis | atherosclerosis | lipids | ACTIVATED PROTEIN-KINASE | CHOLESTEROL | LOWERING THERAPY | LOW-DENSITY-LIPOPROTEIN | ENDOPLASMIC-RETICULUM STRESS | RECEPTOR-DEFICIENT MICE | adenosine triphosphate citrate lyase | inflammation | STATIN THERAPY | INSULIN-RESISTANCE | ETC-1002 | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | HEPATIC STEATOSIS | Dyslipidemias - genetics | ATP Citrate (pro-S)-Lyase - antagonists & inhibitors | Liver - enzymology | Atherosclerosis - genetics | Male | Dicarboxylic Acids - pharmacology | Insulin - blood | Obesity - blood | Obesity - genetics | Inflammation - blood | Dyslipidemias - enzymology | Atherosclerosis - enzymology | Dyslipidemias - blood | Liver - drug effects | Time Factors | Diet, High-Fat | Lipids - blood | Receptors, LDL - deficiency | Dyslipidemias - prevention & control | ATP Citrate (pro-S)-Lyase - metabolism | Disease Models, Animal | Receptors, LDL - genetics | Genetic Predisposition to Disease | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Inflammation Mediators - blood | Biomarkers - blood | Mice, Knockout | Atherosclerosis - blood | Blood Glucose - drug effects | Phenotype | Animals | Obesity - prevention & control | Inflammation - genetics | Inflammation - prevention & control | Obesity - enzymology | Blood Glucose - metabolism | Inflammation - enzymology | Atherosclerosis - prevention & control | Fatty Acids - pharmacology
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A14653 - A14653
ETC-1002 (8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel LDL cholesterol-lowering compound. Preclinical studies revealed that ETC-1002... 
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 01/2013, Volume 54, Issue 1, pp. 134 - 151
ETC-1002 (8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel investigational drug being developed for the treatment of dyslipidemia and other... 
Fatty acid oxidation | LDL-cholesterol | Cardiovascular disease | Cholesterol synthesis | Metabolic syndrome | Fatty acid synthesis | RAT-LIVER | cardiovascular disease | cholesterol synthesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACETYL-COA CARBOXYLASE | RECEPTOR-ALPHA | metabolic syndrome | fatty acid synthesis | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | DENSITY-LIPOPROTEIN | fatty acid oxidation | HEXADECANEDIOIC ACID | PEROXISOME PROLIFERATORS | HEPATOCYTE NUCLEAR FACTOR-4-ALPHA | ALPHA,OMEGA-DICARBOXYLIC ACIDS | Carbohydrate Metabolism - drug effects | AMP-Activated Protein Kinases - metabolism | ATP Citrate (pro-S)-Lyase - antagonists & inhibitors | Liver - enzymology | Fatty Acids - therapeutic use | Obesity - drug therapy | Calcium - metabolism | Diet - adverse effects | Humans | Male | Glucose - biosynthesis | Dicarboxylic Acids - pharmacology | Sterols - biosynthesis | Obesity - blood | Dicarboxylic Acids - therapeutic use | Dyslipidemias - blood | Liver - drug effects | Enzyme Inhibitors - chemistry | Female | Obesity - etiology | ATP Citrate (pro-S)-Lyase - metabolism | Molecular Targeted Therapy - methods | Protein-Serine-Threonine Kinases - metabolism | Biomarkers - metabolism | Cricetinae | Dyslipidemias - drug therapy | Fatty Acids - chemistry | Liver - metabolism | Enzyme Inhibitors - pharmacology | Rats | Biomarkers - blood | Enzyme Activation - drug effects | Enzyme Inhibitors - therapeutic use | Hep G2 Cells | Obesity - metabolism | Dicarboxylic Acids - chemistry | Animals | Signal Transduction - drug effects | Lipid Metabolism - drug effects | Dyslipidemias - metabolism | Glucagon - metabolism | Liver - cytology | Mice | Energy Metabolism - drug effects | Fatty Acids - biosynthesis | Fatty Acids - pharmacology
Journal Article