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1. Full Text Eradicating polio with a vaccine we must stop using
by Grassly, Nicholas C
The Lancet Infectious Diseases, ISSN 1473-3099, 06/2018, Volume 18, Issue 6, pp. 590 - 591
Khalequ Zaman and colleagues provide helpful new information on the performance of serotype 2 monovalent oral poliovirus vaccine (mOPV2).2 This vaccine is held... 
INFECTIOUS DISEASES | POLIOVIRUSES | Humans | Poliomyelitis - epidemiology | Disease Outbreaks - prevention & control | Poliovirus Vaccine, Inactivated | Poliovirus Vaccine, Oral | Poliovirus | Diabetes Mellitus, Type 2 - epidemiology | Poliomyelitis | Vaccines
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2. Full Text Unravelling mucosal immunity to poliovirus
by Parker, Edward P K and Grassly, Nicholas C
Lancet Infectious Diseases, The, ISSN 1473-3099, 2016, Volume 16, Issue 12, pp. 1310 - 1311
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S1473-3099(16)30371-1 Byline: Edward P K Parker, Nicholas C Grassly... 
Infectious Disease | INFECTIOUS DISEASES | VACCINE | Epidemiology | Viruses | Immunoglobulins | Vaccines | Surveillance | Poliomyelitis | Mucous membrane
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3. Full Text Vaccine schedules and the effect on humoral and intestinal immunity against poliovirus: a systematic review and network meta-analysis
by Macklin, Grace R and Grassly, Nicholas C and Sutter, Roland W and Mach, Ondrej and Bandyopadhyay, Ananda S and Edmunds, W John and O'Reilly, Kathleen M
The Lancet Infectious Diseases, ISSN 1473-3099, 10/2019, Volume 19, Issue 10, pp. 1121 - 1128
The eradication of wild and vaccine-derived poliovirus requires the global withdrawal of oral poliovirus vaccines (OPVs) and replacement with inactivated... 
IMMUNIZATION | INFECTIOUS DISEASES | IMMUNOGENICITY | IMPACT | MUCOSAL IMMUNITY | ANTIBODY | ENDGAME | Medicine, Experimental | Medical research | Infants | Vaccines | Analysis | World health | Schedules | Immunization | Mucosal immunity | Mucosa | Clinical trials | Systematic review | Immunity | Seroconversion | Meta-analysis | Studies | Heterogeneity | Immunogenicity | Intestine | Poliomyelitis | Data search | Serotypes | Immunity (humoral) | Paralysis | Bayesian analysis | Age
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4. Full Text Seasonal infectious disease epidemiology
by Nicholas C Grassly and Christophe Fraser
Proceedings of the Royal Society B: Biological Sciences, ISSN 0962-8452, 10/2006, Volume 273, Issue 1600, pp. 2541 - 2550
disease outbreaks, endemic dynamics and persistence. Finally, a mathematical analysis of routine and pulse vaccination programmes for seasonal infections is... 
Epidemics | Disease transmission | Infectious diseases | Disease models | Vaccination | Disease outbreaks | Measles | Infections | Stochastic models | Epidemiology | Seasons | Communicable diseases | UNITED-STATES | seasons | MASS VACCINATION | PERSISTENCE | INFLUENZA | communicable diseases | MEASLES | ELIMINATION | disease outbreaks | epidemiology | EVOLUTIONARY BIOLOGY | TRANSMISSION | MODELS | BIOLOGY | DYNAMICS | ECOLOGY | RECURRENT OUTBREAKS | vaccination | Communicable Diseases - epidemiology | Humans | Microbial Viability | Communicable Disease Control | Incidence | Endemic Diseases | Animals | Disease Outbreaks | Communicable Diseases - immunology | Disease Vectors | Child
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5. Full Text Mathematical models of infectious disease transmission
by Fraser, Christophe and Grassly, Nicholas C
Nature Reviews Microbiology, ISSN 1740-1526, 06/2008, Volume 6, Issue 6, pp. 477 - 487
Mathematical analysis and modelling is central to infectious disease epidemiology. Here, we provide an intuitive introduction to the process of disease... 
POPULATION | RATES | COITAL ACT | PANDEMIC INFLUENZA | DYNAMICS | MICROBIOLOGY | NETWORK STRUCTURE | EPIDEMIC | SPREAD | HIV-1 TRANSMISSION | BAYESIAN-INFERENCE | Communicable Diseases - transmission | Communicable Diseases - epidemiology | Humans | Influenza, Human - epidemiology | Mathematics | Influenza, Human - transmission | Models, Statistical | Host-Pathogen Interactions | Stochastic Processes | Disease Outbreaks | Epidemiologic Methods | Models, Biological | Ecosystem | Usage | Mathematical analysis | Communicable diseases | Analysis | Distribution | Epidemiology | Risk factors | Methods
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6. Full Text The final stages of the global eradication of poliomyelitis
by Nicholas C. Grassly
Philosophical Transactions: Biological Sciences, ISSN 0962-8436, 8/2013, Volume 368, Issue 1623, pp. 1 - 14
The global incidence of poliomyelitis has dropped by more than 99 per cent since the governments of the world committed to eradication in 1988. One of the... 
Immunization | Oral poliovirus vaccine | Poliomyelitis | Vaccination | Polio | Viruses | Children | Poliovirus | Immunity | Environmental surveillance
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7. Full Text Systematic review of mucosal immunity induced by oral and inactivated poliovirus vaccines against virus shedding following oral poliovirus challenge
by Hird, Thomas R and Grassly, Nicholas C
PLoS Pathogens, ISSN 1553-7366, 04/2012, Volume 8, Issue 4, p. e1002599
Inactivated poliovirus vaccine (IPV) may be used in mass vaccination campaigns during the final stages of polio eradication. It is also likely to be adopted by... 
MICROBIOLOGY | EXCRETION | LIVE | CHILDREN | TRIAL | IMMUNIZATION | RESPONSES | TRANSMISSION | VIROLOGY | HOUSEHOLD CONTACTS | POLIOMYELITIS VIRUS | OUTBREAK | PARASITOLOGY | Poliovirus Vaccine, Oral - immunology | Virus Shedding - drug effects | Virus Shedding - immunology | Humans | Poliomyelitis - prevention & control | Poliomyelitis - immunology | Poliovirus Vaccine, Inactivated - immunology | Poliovirus Vaccine, Inactivated - pharmacology | Immunity, Mucosal - drug effects | Animals | Poliovirus - immunology | Poliomyelitis - virology | Poliovirus Vaccine, Oral - pharmacology | Immunology | Poliomyelitis vaccine | Physiological aspects | Virulence (Microbiology) | Research | Poliovirus | Health aspects | Confidence intervals | Infections | Vaccines | Poliomyelitis | Programming languages
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8. Full Text Introduction: Biological challenges to effective vaccines in the developing world
by Nicholas C. Grassly and Gagandeep Kang and Beate Kampmann
Philosophical Transactions: Biological Sciences, ISSN 0962-8436, 6/2015, Volume 370, Issue 1671, pp. 1 - 7
The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue... 
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9. The seasonality of nonpolio enteroviruses in the United States: Patterns and drivers
by Margarita Pons-Salort and M Steven Oberste and Mark A Pallansch and Glen R Abedi and Saki Takahashi and Bryan T Grenfell and Nicholas C Grassly
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2018, Volume 115, Issue 12, p. 3078
Nonpolio enteroviruses are diverse and common viruses that can circulate year-round but tend to peak in summer. Although most infections are asymptomatic, they... 
Demography | Climate effects | Dew point | Climatic data | Viruses | Climate models | Infections | Disease control | Epidemiology | Seasonal variations | Enteroviruses | Demographics | Disease transmission | Poliomyelitis | Annual variations | Serotypes | Viral infections
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10. Full Text New vaccine strategies to finish polio eradication
by Grassly, Nicholas C
Lancet Infectious Diseases, The, ISSN 1473-3099, 2015, Volume 15, Issue 8, pp. 864 - 865
  [...]circulating vaccine-derived polioviruses are continuing to cause poliomyelitis in a few countries, a rare outcome associated with continued use of the... 
Infectious Disease | EFFICACY | CONTROLLED-TRIAL | INFECTIOUS DISEASES | Poliovirus Vaccine, Oral - immunology | Antibody Formation - immunology | Poliovirus - immunology | Humans | Antibodies, Viral - immunology | Poliomyelitis - prevention & control | Poliomyelitis - immunology | Poliovirus Vaccine, Oral - administration & dosage | Vaccines | Clinical trials | Poliomyelitis | Regulatory approval
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11. Full Text Pandemic Potential of a Strain of Influenza a (H1N1): Early Findings
by Christophe Fraser and Christl A. Donnelly and Simon Cauchemez and William P. Hanage and Maria D. Van Kerkhove and T. Déirdre Hollingsworth and Jamie Griffin and Rebecca F. Baggaley and Helen E. Jenkins and Emily J. Lyons and Thibaut Jombart and Wes R. Hinsley and Nicholas C. Grassly and Francois Balloux and Azra C. Ghani and Neil M. Ferguson and Andrew Rambaut and Oliver G. Pybus and Hugo Lopez-Gatell and Celia M. Alpuche-Aranda and Ietza Bojorquez Chapela and Ethel Palacios Zavala and Dulce Ma. Espejo Guevara and Francesco Checchi and Erika Garcia and Stephane Hugonnet and Cathy Roth and WHO Rapid Pandemic Assessment Coll and WHO Rapid Pandemic Assessment Collaboration and The WHO Rapid Pandemic Assessment Collaboration
Science, ISSN 0036-8075, 6/2009, Volume 324, Issue 5934, pp. 1557 - 1561
A novel influenza A (H1N1) virus has spread rapidly across the globe. Judging its pandemic potential is difficult with limited data, but nevertheless essential... 
Epidemics | Pandemics | Disease models | Influenza A virus | Surveillance | Analytical estimating | Travelers | Death | Viruses | Reports | Infections | MORTALITY | IMPACT | TRANSMISSIBILITY | MULTIDISCIPLINARY SCIENCES | STRATEGIES | Travel | Global Health | Disease Outbreaks | Mexico - epidemiology | Humans | Influenza A Virus, H1N1 Subtype | Influenza, Human - mortality | Molecular Sequence Data | Influenza, Human - epidemiology | Influenza, Human - virology | Influenza, Human - transmission | Disease transmission | Research | Statistics | Swine influenza | Distribution
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12. The Potential Impact of Routine Immunization with Inactivated Poliovirus Vaccine on Wild-type or Vaccine-derived Poliovirus Outbreaks in a Posteradication Setting
by Tara D Mangal and R Bruce Aylward and Nicholas C Grassly
American Journal of Epidemiology, ISSN 0002-9262, 11/2013, Volume 178, Issue 10, p. 1579
  The "endgame" for worldwide poliomyelitis eradication will entail eventual cessation of the use of oral poliovirus vaccine (OPV) in all countries to prevent... 
Epidemics | Immunization | Disease transmission | Poliomyelitis | Vaccines
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13. Full Text The Burden of Typhoid and Paratyphoid in India: Systematic Review and Meta-analysis
by John, Jacob and Van Aart, Carola J. C and Grassly, Nicholas C
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 04/2016, Volume 10, Issue 4, p. e0004616
Background Typhoid is an important public health challenge for India, especially with the spread of antimicrobial resistance. The decision about whether to... 
TRIAL | COUNTRIES | CONJUGATE VACCINE | EFFICACY | TY21A | PREVENTION | VI CAPSULAR POLYSACCHARIDE | SALMONELLA-TYPHI | PARASITOLOGY | TROPICAL MEDICINE | FEVER | Prevalence | Age Factors | Typhoid Fever - epidemiology | Humans | Middle Aged | Child, Preschool | India - epidemiology | Infant | Paratyphoid Fever - epidemiology | Topography, Medical | Incidence | Young Adult | Adolescent | Aged, 80 and over | Adult | Aged | Child | Infant, Newborn | Cohort Studies | Drug resistance in microorganisms | Care and treatment | Antibiotics | Analysis | Typhoid fever | Infants | Dosage and administration | Management | Drug therapy | Health aspects | Public health | Studies | Trends | Vaccines | Typhoid | Mortality
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14. Full Text Effect of a single inactivated poliovirus vaccine dose on intestinal immunity against poliovirus in children previously given oral vaccine: an open-label, randomised controlled trial
by John, Jacob, MD and Giri, Sidhartha, MD and Karthikeyan, Arun S, MSc and Iturriza-Gomara, Miren, PhD and Muliyil, Jayaprakash, Prof and Abraham, Asha, Prof and Grassly, Nicholas C, Prof and Kang, Gagandeep, Prof
Lancet, The, ISSN 0140-6736, 2014, Volume 384, Issue 9953, pp. 1505 - 1512
Summary Background Intestinal immunity induced by oral poliovirus vaccine (OPV) is imperfect and wanes with time, permitting transmission of infection by... 
Internal Medicine | WILD-TYPE | IMMUNIZATION | RESPONSES | MEDICINE, GENERAL & INTERNAL | IMMUNOGENICITY | OUTBREAKS | MUCOSAL IMMUNITY | INFECTION | SILENT CIRCULATION | INDIA | Poliovirus Vaccine, Inactivated - administration & dosage | Virus Shedding - immunology | Humans | Child, Preschool | Immunization, Secondary - methods | Infant | Male | Poliomyelitis - prevention & control | Treatment Outcome | Poliomyelitis - immunology | Injections, Intramuscular | Poliovirus Vaccine, Oral - administration & dosage | Antibodies, Viral - blood | Intestines - immunology | Vaccination - methods | Poliovirus - immunology | Female | Studies | Antigens | Poliomyelitis | Vaccines | Drug dosages | Age | Children & youth
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15. Full Text Efficacy of inactivated poliovirus vaccine in India
by Jafari, Hamid and Deshpande, Jagadish M and Sutter, Roland W and Bahl, Sunil and Verma, Harish and Ahmad, Mohammad and Kunwar, Abhishek and Vishwakarma, Rakesh and Agarwal, Ashutosh and Jain, Shilpi and Estivariz, Concepcion and Sethi, Raman and Molodecky, Natalie A and Grassly, Nicholas C and Pallansch, Mark A and Chatterjee, Arani and Aylward, R. Bruce
Science, ISSN 0036-8075, 08/2014, Volume 345, Issue 6199, pp. 922 - 925
Inactivated poliovirus vaccine (IPV) is efficacious against paralytic disease, but its effect on mucosal immunity is debated. We assessed the efficacy of IPV... 
TRIAL | INTESTINAL IMMUNITY | IMMUNOGENICITY | MUCOSAL IMMUNITY | POLIOMYELITIS | MULTIDISCIPLINARY SCIENCES | MONOVALENT | STRATEGIES | CHILDREN | Pharmaceutical research | Dosage and administration | Research | Poliomyelitis vaccine | Drug interactions | Disease prevention | Vaccines | Poliomyelitis | Public health | Shedding | Effectiveness | Viruses | Attenuation | Children | Patients | Immunity
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16. Full Text Securing the Eradication of All Polioviruses
by Grassly, Nicholas C and Orenstein, Walter A
Clinical Infectious Diseases, ISSN 1058-4838, 10/2018, Volume 67, Issue suppl_1, pp. S1 - S3
policy making | poliomyelitis | disease transmission | disease eradication | vaccination | INFECTIOUS DISEASES | MICROBIOLOGY | IMMUNOLOGY
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17. The role of older children and adults in wild poliovirus transmission
by Isobel M Blake and Rebecca Martin and Ajay Goel and Nino Khetsuriani and Johannes Everts and Christopher Wolff and Steven Wassilak and R Bruce Aylward and Nicholas C Grassly
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2014, Volume 111, Issue 29, p. 10604
  As polio eradication inches closer, the absence of poliovirus circulation in most of the world and imperfect vaccination coverage are resulting in immunity... 
Immunization | Disease transmission | Time series | Viruses | Mathematical models | Maximum likelihood method
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18. Full Text New Strategies for the Elimination of Polio from India
by Nicholas C. Grassly and Christophe Fraser and Jay Wenger and Jagadish M. Deshpande and Roland W. Sutter and David L. Heymann and R. Bruce Aylward
Science, ISSN 0036-8075, 11/2006, Volume 314, Issue 5802, pp. 1150 - 1153
The feasibility of global polio eradication is being questioned as a result of continued transmission in a few localities that act as sources for outbreaks... 
Disease transmission | Oral poliovirus vaccine | Vaccination | Polio | Viruses | Reports | Infections | Children | Dosage | Poliovirus | Population density | POPULATION | TRIVALENT | IMMUNOGENICITY | DIARRHEA | EFFICACY | POLIOMYELITIS | MULTIDISCIPLINARY SCIENCES | VACCINE | ERADICATION | DEVELOPING-COUNTRIES | BRAZIL | Poliovirus Vaccine, Oral - chemistry | Dose-Response Relationship, Immunologic | Humans | Population Density | Sanitation | Immunization Programs | India - epidemiology | Poliomyelitis - epidemiology | Disease Outbreaks - prevention & control | Poliomyelitis - prevention & control | Poliovirus Vaccine, Oral - administration & dosage | Child | Prevention | Poliomyelitis | Causes of | Vaccines | Health aspects | Risk factors
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19. Context-dependent amphibian host population response to an invading pathogen
by Benjamin J Doddington and Jaime Bosch and Joan A Oliver and Nicholas C Grassly and Gerardo Garcia and Benedikt R Schmidt and Trenton WJ Garner and Matthew C Fisher
Ecology, ISSN 0012-9658, 08/2013, Volume 94, Issue 8, p. 1795
  Amphibian chytridiomycosis, caused by the chytrid fungus Batrachochy