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1. Full Text Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib
by Nicholls, Stephen J., MD, PhD and Ruotolo, Giacomo, MD, PhD and Brewer, H. Bryan, MD and Kane, John P., MD, PhD and Wang, Ming-Dauh, PhD and Krueger, Kathryn A., MD and Adelman, Steven J., PhD and Nissen, Steven E., MD and Rader, Daniel J., MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 66, Issue 20, pp. 2201 - 2210
Abstract Background Potent cholesteryl ester transfer protein (CETP) inhibitors have been shown to substantially increase high-density lipoprotein cholesterol... 
Cardiovascular | Internal Medicine | cholesterol | apolipoproteins | lipoproteins | CARDIAC & CARDIOVASCULAR SYSTEMS | ESTER TRANSFER PROTEIN | EFFICACY | SAFETY | ATHEROSCLEROSIS | TORCETRAPIB | HIGH-DENSITY-LIPOPROTEIN | LDL CHOLESTEROL | HIGH-RISK | ABC TRANSPORTERS | INHIBITOR | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Dyslipidemias - drug therapy | High-Density Lipoproteins, Pre-beta - blood | Double-Blind Method | Cholesterol - blood | Humans | Middle Aged | Male | ATP Binding Cassette Transporter 1 - metabolism | Dyslipidemias - blood | Anticholesteremic Agents - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Female | Drug Therapy, Combination | Benzodiazepines - therapeutic use | Cholesterol Ester Transfer Proteins - metabolism | Sects | Apolipoproteins | Pharmaceutical industry | Statins | Cholesterol | Cardiovascular agents | Blood lipids | Low density lipoproteins | Analysis | Heart attacks | Low density lipoprotein
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2. Full Text Reply
by Nicholls, Stephen J., MBBS, PhD and Wolski, Kathy, MPH and Nissen, Steven E., MD, PhD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2010, Volume 56, Issue 21, pp. 1765 - 1765
Cardiovascular | Internal Medicine
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3. Full Text Detection by Near-Infrared Spectroscopy of Large Lipid Core Plaques at Culprit Sites in Patients With Acute ST-Segment Elevation Myocardial Infarction
by Madder, Ryan D., MD and Goldstein, James A., MD and Madden, Sean P., PhD and Puri, Rishi, MBBS and Wolski, Kathy, MPH and Hendricks, Michael, BS and Sum, Stephen T., PhD and Kini, Annapoorna, MD and Sharma, Samin, MD and Rizik, David, MD and Brilakis, Emmanouil S., MD, PhD and Shunk, Kendrick A., MD, PhD and Petersen, John, MD and Weisz, Giora, MD and Virmani, Renu, MD and Nicholls, Stephen J., MBBS, PhD and Maehara, Akiko, MD and Mintz, Gary S., MD and Stone, Gregg W., MD and Muller, James E., MD
JACC: Cardiovascular Interventions, ISSN 1936-8798, 2013, Volume 6, Issue 8, pp. 838 - 846
Objectives This study sought to describe near-infrared spectroscopy (NIRS) findings of culprit lesions in ST-segment elevation myocardial infarction (STEMI).... 
Cardiovascular | vulnerable plaque | near-infrared spectroscopy | myocardial infarction | myocardial infarction near-infrared spectroscopy vulnerable plaque | CARDIAC & CARDIOVASCULAR SYSTEMS | ATHEROSCLEROTIC PLAQUES | RANDOMIZED CONTROLLED-TRIAL | ACUTE CORONARY SYNDROME | ANGIOGRAPHY | STATIN THERAPY | DISEASE | CARDIOLOGY TASK-FORCE | PROGRESSION | SERIAL INTRAVASCULAR ULTRASOUND | Coronary Vessels - diagnostic imaging | Predictive Value of Tests | Prognosis | Area Under Curve | Coronary Vessels - chemistry | Humans | Ultrasonography, Interventional | Case-Control Studies | Myocardial Infarction - therapy | Spectroscopy, Near-Infrared | Myocardial Infarction - pathology | Coronary Artery Disease - pathology | Myocardial Infarction - etiology | Myocardial Infarction - diagnosis | Coronary Vessels - pathology | Coronary Artery Disease - metabolism | Logistic Models | Myocardial Infarction - metabolism | Plaque, Atherosclerotic | Coronary Angiography | Coronary Artery Disease - therapy | Coronary Artery Disease - diagnosis | Coronary Artery Disease - complications | ROC Curve | Lipids - analysis | Percutaneous Coronary Intervention | Rupture, Spontaneous
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4. Full Text Assessment of the clinical effects of cholesteryl ester transfer protein inhibition with evacetrapib in patients at high-risk for vascular outcomes: Rationale and design of the ACCELERATE trial
by Nicholls, Stephen J., MBBS, PhD and Lincoff, A. Michael, MD and Barter, Philip J., MBBS, PhD and Brewer, H. Bryan, MD and Fox, Keith A.A., MBChB, F MedSci and Gibson, C. Michael, MD and Grainger, Christopher, MD and Menon, Venugopal, MD and Montalescot, Gilles, MD and Rader, Daniel, MD and Tall, Alan R., MBBS and McErlean, Ellen, MSN and Riesmeyer, Jeffrey, MD and Vangerow, Burkhard, MD and Ruotolo, Giacomo, MD, PhD and Weerakkody, Govinda J., PhD and Nissen, Steven E., MD
American Heart Journal, ISSN 0002-8703, 2015, Volume 170, Issue 6, pp. 1061 - 1069
Background Potent pharmacologic inhibition of cholesteryl ester transferase protein by the investigational agent evacetrapib increases high-density lipoprotein... 
Cardiovascular | LIPID-LEVEL MANAGEMENT | LDL CHOLESTEROL | HDL | CARDIAC & CARDIOVASCULAR SYSTEMS | ATTENUATES ATHEROSCLEROSIS | TORCETRAPIB | CORONARY-HEART-DISEASE | CETP INHIBITION | HIGH-DENSITY-LIPOPROTEIN | TRANSGENIC MICE | ARTERY-DISEASE | Cholesterol Ester Transfer Proteins - antagonists & inhibitors | Peripheral Vascular Diseases - prevention & control | Outcome Assessment (Health Care) | Humans | Middle Aged | Male | Cerebrovascular Disorders - metabolism | Cerebrovascular Disorders - prevention & control | Peripheral Vascular Diseases - metabolism | Cholesterol, LDL - blood | Female | Double-Blind Method | Risk Assessment | Coronary Artery Disease - metabolism | Coronary Artery Disease - prevention & control | Anticholesteremic Agents - adverse effects | Peripheral Vascular Diseases - diagnosis | Cerebrovascular Disorders - diagnosis | Coronary Artery Disease - diagnosis | Anticholesteremic Agents - administration & dosage | Cholesterol, HDL - blood | Benzodiazepines - administration & dosage | Benzodiazepines - adverse effects | Drug Monitoring | Cholesterol Ester Transfer Proteins - metabolism | Low density lipoproteins | Stroke | Heart attacks | Medical imaging | Mortality | Cardiovascular disease | Lipids | Triglycerides | Family medical history | Cholesterol | Studies | Lipoproteins | Ultrasonic imaging | Atherosclerosis | Blood pressure | Research centers
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5. Full Text Treatment With Dalcetrapib Modifies the Relationship Between High-Density Lipoprotein Cholesterol and C-Reactive Protein
by Pitts, Reynaria, MD and Gunzburger, Elise, MS and Ballantyne, Christie M., MD and Barter, Philip J., MD, PhD and Kallend, David, MBBS and Leiter, Lawrence A., MD and Leitersdorf, Eran, MD and McMurray, John J.V., MBChB and Nicholls, Stephen J., MBBS, PhD and Niesor, Eric J., PhD and Olsson, Anders G., MD, PhD and Shah, Prediman K., MD and Tardif, Jean-Claude, MD and Kittelson, John, PhD and Schwartz, Gregory G., MD, PhD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 68, Issue 22, pp. 2488 - 2490
  The 2 regression lines differ (p < 0.001), with an upward shift and a decreased slope with dalcetrapib. [...]for any given change in HDL-C, the associated... 
Cardiovascular | Internal Medicine | HDL | CARDIAC & CARDIOVASCULAR SYSTEMS | Continuing medical education | C-reactive protein | Coronary heart disease | Cardiac patients | Cholesterol | Proteins | Heart attacks | Cardiovascular disease | Regression analysis | Health risk assessment | Acute coronary syndromes | Low density lipoprotein | Patients
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6. Full Text Impact of Statins on Serial Coronary Calcification During Atheroma Progression and Regression
by Puri, Rishi, MBBS, PhD and Nicholls, Stephen J., MBBS, PhD and Shao, Mingyuan, MS and Kataoka, Yu, MD and Uno, Kiyoko, MD, PhD and Kapadia, Samir R., MD and Tuzcu, E. Murat, MD and Nissen, Steven E., MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 65, Issue 13, pp. 1273 - 1282
Abstract Background Statins can regress coronary atheroma and lower clinical events. Although pre-clinical studies suggest procalcific effects of statins... 
Cardiovascular | Internal Medicine | atherosclerosis | intravascular ultrasound | calcium | statins | CARDIAC & CARDIOVASCULAR SYSTEMS | CLINICAL-TRIAL | VASCULAR CALCIFICATION | RANDOMIZED CONTROLLED-TRIAL | BEAM COMPUTED-TOMOGRAPHY | LIPID-LOWERING THERAPY | ARTERY CALCIFICATION | IN-VITRO | CALCIFIED PLAQUE BURDEN | SMOOTH-MUSCLE-CELLS | Coronary Vessels - diagnostic imaging | Plaque, Atherosclerotic - diagnostic imaging | Coronary Vessels - drug effects | Coronary Vessels - pathology | Prospective Studies | Humans | Middle Aged | Ultrasonography, Interventional | Vascular Calcification - diagnostic imaging | Male | Coronary Artery Disease - drug therapy | Vascular Calcification - drug therapy | Disease Progression | Calcium - blood | Coronary Artery Disease - diagnostic imaging | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Coronary Artery Disease - pathology | Female | Aged | Plaque, Atherosclerotic - drug therapy | Plaque, Atherosclerotic - pathology | Calcification | Pharmaceutical industry | Atherosclerotic plaque | Statins | Cardiovascular agents | Medical research | Analysis | Cardiac patients | Medicine, Experimental | Coronary heart disease | Proteins | Lipoproteins | Medical imaging | Laboratories | Coronary vessels | Atherosclerosis | Cardiovascular disease | Lipids | Triglycerides | Cholesterol
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7. Full Text Intravascular Ultrasound-Derived Measures of Coronary Atherosclerotic Plaque Burden and Clinical Outcome
by Nicholls, Stephen J., MBBS, PhD and Hsu, Amy, MS and Wolski, Kathy, MPH and Hu, Bo, PhD and Bayturan, Ozgur, MD and Lavoie, Andrea, MD and Uno, Kiyoko, MD, PhD and Tuzcu, E. Murat, MD and Nissen, Steven E., MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2010, Volume 55, Issue 21, pp. 2399 - 2407
Objectives The aim of this study was to investigate the relationship between intravascular ultrasound (IVUS)-derived measures of atherosclerosis and... 
Cardiovascular | Internal Medicine | atherosclerosis | intravascular ultrasound | risk factors | imaging | INTIMA-MEDIA THICKNESS | REGRESSION | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | CARDIOVASCULAR EVENTS | RANDOMIZED CONTROLLED-TRIAL | LIPID-LOWERING THERAPY | PIOGLITAZONE | GLIMEPIRIDE | PROGRESSION | ARTERY-DISEASE | Multivariate Analysis | Confidence Intervals | Myocardial Infarction - mortality | Follow-Up Studies | Humans | Middle Aged | Cardiovascular Diseases - therapy | Ultrasonography, Interventional | Myocardial Revascularization - methods | Male | Myocardial Infarction - diagnostic imaging | Myocardial Infarction - therapy | Cardiovascular Diseases - diagnostic imaging | Cardiovascular Diseases - mortality | Female | Severity of Illness Index | Risk Assessment | Probability | Logistic Models | Treatment Outcome | Coronary Artery Disease - mortality | Disease Progression | Coronary Artery Disease - diagnostic imaging | Coronary Artery Disease - therapy | Survival Analysis | Aged | Myocardial Revascularization - adverse effects | Cohort Studies | Prevention | Pharmaceutical industry | Patient outcomes | Cells | Atherosclerosis | Cardiovascular agents | Studies | Confidence intervals | Heart attacks | Medical imaging | Coronary vessels | Mortality | Clinical trials | Cardiovascular disease | Lipids | Clinical outcomes | Catheters
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8. Full Text Pharmacological lipid-modification therapies for prevention of ischaemic heart disease: current and future options
by Ray, Kausik K and Corral, Pablo and Morales, Enrique and Nicholls, Stephen J
The Lancet, ISSN 0140-6736, 08/2019, Volume 394, Issue 10199, pp. 697 - 708
Atherosclerosis and its clinical manifestation as ischaemic heart disease remains a considerable health burden. Given that many factors contribute to ischaemic... 
MEDICINE, GENERAL & INTERNAL | DENSITY-LIPOPROTEIN CHOLESTEROL | CARDIOVASCULAR OUTCOMES | STATIN THERAPY | TARGETING APOLIPOPROTEIN(A) | ATHEROGENIC DYSLIPIDEMIA | HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | HIGH-RISK | LOWERING LDL CHOLESTEROL | DOUBLE-BLIND | POLYUNSATURATED FATTY-ACIDS | Niemann-Pick disease | Heart | Lipoproteins (low density) | Clinical trials | Lipids | Cardiovascular disease | Epidemiology | Risk factors | Prevention | Atherosclerosis | Blood pressure | Lipid metabolism | Heart diseases | Statins | Cardiovascular system | Drug addiction | Stroke | RNA-mediated interference | Health risks | Triglycerides | Pharmacology | Ribonucleic acid--RNA | Metabolism | Risk analysis | Apolipoproteins | Cigarette smoking | Coronary artery disease | Low density lipoprotein | Cholesterol | Disease prevention | Acids | Collaboration | Arteriosclerosis | Monoclonal antibodies | Cardiovascular diseases | Health risk assessment | Risk management | Smoking
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9. Full Text Evaluation of the dual peroxisome proliferator–activated receptor α/γ agonist aleglitazar to reduce cardiovascular events in patients with acute coronary syndrome and type 2 diabetes mellitus: Rationale and design of the AleCardio trial
by Lincoff, A. Michael, MD and Tardif, Jean-Claude, MD and Neal, Bruce, PhD and Nicholls, Stephen J., MBBS, PhD and Rydén, Lars, MD and Schwartz, Gregory G., MD, PhD and Malmberg, Klas, MD and Buse, John B., MD, PhD and Henry, Robert R., MD and Wedel, Hans, PhD and Weichert, Arlette, MD and Cannata, Ruth, RN and Grobbee, Diederick E., MD, PhD and AleCardio Study Investigators
American Heart Journal, ISSN 0002-8703, 2013, Volume 166, Issue 3, pp. 429 - 434.e1
Background Peroxisome proliferator–activated receptors (PPARs) regulate transcription of genes involved in glucose uptake, lipid metabolism, and inflammation.... 
Cardiovascular | HEART-DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | PIOGLITAZONE | METAANALYSIS | MYOCARDIAL-INFARCTION | RISK | RANDOMIZED CONTROLLED-TRIAL | ROSIGLITAZONE | BLOOD-GLUCOSE CONTROL | SECONDARY PREVENTION | FENOFIBRATE THERAPY | Peroxisome Proliferator-Activated Receptors - agonists | Thiophenes - therapeutic use | Myocardial Infarction - mortality | Stroke - prevention & control | Double-Blind Method | Humans | Middle Aged | Risk Factors | Acute Coronary Syndrome - mortality | Hospitalization - statistics & numerical data | Male | Treatment Outcome | Morbidity | Acute Coronary Syndrome - complications | Female | Myocardial Infarction - prevention & control | Stroke - mortality | Diabetes Mellitus, Type 2 - drug therapy | Oxazoles - therapeutic use | Diabetes Mellitus, Type 2 - complications | Kardiologi | Endokrinologi och diabetes | Klinisk medicin | Medicin och hälsovetenskap
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10. Full Text A VOYAGER Meta-Analysis of the Impact of Statin Therapy on Low-Density Lipoprotein Cholesterol and Triglyceride Levels in Patients With Hypertriglyceridemia
by Karlson, Björn W., MD, PhD and Palmer, Michael K., PhD and Nicholls, Stephen J., MBBS, PhD and Lundman, Pia, MD, PhD and Barter, Philip J., MBBS, PhD and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
American Journal of Cardiology, The, ISSN 0002-9149, 2016, Volume 117, Issue 9, pp. 1444 - 1448
Elevated triglyceride (TG) levels are associated with increased cardiovascular disease risk. In patients with mild-to-moderate hypertriglyceridemia, defined by... 
Cardiovascular | TRIAL | CARDIAC & CARDIOVASCULAR SYSTEMS | EFFICACY | REDUCTION | SAFETY | RESIDUAL VASCULAR RISK | CARDIOVASCULAR-DISEASE | PRAVASTATIN | SIMVASTATIN | ROSUVASTATIN | ATORVASTATIN | Hypertriglyceridemia - drug therapy | Simvastatin - therapeutic use | Rosuvastatin Calcium - therapeutic use | Humans | Middle Aged | Male | Hypertriglyceridemia - blood | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Triglycerides - blood | Cholesterol, LDL - blood | Female | Aged | Atorvastatin Calcium - therapeutic use | Databases, Factual | Care and treatment | Hyperlipidemia | Analysis | Low density lipoproteins | Atherosclerosis | Triglycerides | Statins | Cholesterol | Studies | Heart attacks | Low density lipoprotein | pravastatin | simvastatin | cardiovascular-disease | high-risk | atorvastatin | efficacy | Kardiologi | rich lipoproteins | Cardiac and Cardiovascular Systems | Cardiovascular System & Cardiology | safety | reduction | rosuvastatin
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11. Full Text Clinical Predictors of Plaque Progression Despite Very Low Levels of Low-Density Lipoprotein Cholesterol
by Bayturan, Ozgur, MD and Kapadia, Samir, MD and Nicholls, Stephen J., MBBS, PhD and Tuzcu, E. Murat, MD and Shao, Mingyuan, MS and Uno, Kiyoko, MD, PhD and Shreevatsa, Ajai, MD and Lavoie, Andrea J., MD and Wolski, Kathy, MPH and Schoenhagen, Paul, MD and Nissen, Steven E., MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2010, Volume 55, Issue 24, pp. 2736 - 2742
Objectives The purpose of this study was to characterize the determinants of plaque progression despite achieving very low levels of low-density lipoprotein... 
Cardiovascular | Internal Medicine | atherosclerosis | intravascular ultrasound | apolipoprotein B | low low-density lipoprotein | CARDIAC & CARDIOVASCULAR SYSTEMS | Coronary Vessels - diagnostic imaging | Coronary Disease - blood | Predictive Value of Tests | Ultrasonography, Interventional - methods | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Male | Disease Progression | Atherosclerosis - blood | Atherosclerosis - diagnostic imaging | Coronary Disease - diagnostic imaging | Cholesterol, LDL - blood | Female | Continuing medical education | Low density lipoproteins | Cells | Cholesterol | Cardiovascular agents | Heart attacks | Mortality | Clinical trials | Cardiovascular disease | Lipids | Glucose | Family medical history | Apolipoproteins | Catheters | Proteins | Studies | Lipoproteins | Coronary vessels | Atherosclerosis | Blood pressure | Diabetes
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12. Full Text Cardiac Allograft Vasculopathy by Intravascular Ultrasound in Heart Transplant Patients
by Kobashigawa, Jon A and Pauly, Daniel F and Starling, Randall C and Eisen, Howard and Ross, Heather and Wang, Shoei-Shen and Cantin, Bernard and Hill, James A and Lopez, Patricia and Dong, Gaohong and Nicholls, Stephen J and A2310 IVUS Substudy Investigators
JACC: Heart Failure, ISSN 2213-1779, 10/2013, Volume 1, Issue 5, pp. 389 - 399
A pre-planned substudy of a larger multicenter randomized trial was undertaken to compare the efficacy of everolimus with reduced-dose cyclosporine in the... 
cardiac allograft vasculopathy | heart transplant | everolimus | intravascular ultrasound | CARDIAC & CARDIOVASCULAR SYSTEMS
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13. Full Text Cholesterol Crystals Associate With Coronary Plaque Vulnerability In Vivo
by Kataoka, Yu, MD and Puri, Rishi, MBBS, PhD and Hammadah, Muhammad, MD and Duggal, Bhanu, MD and Uno, Kiyoko, MD, PhD and Kapadia, Samir R., MD and Tuzcu, E. Murat, MD and Nissen, Steven E., MD and Nicholls, Stephen J., MBBS, PhD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 65, Issue 6, pp. 630 - 632
  Cholesterol crystals on FD-OCT are not histopathologically validated. Because of the relatively small study population, a larger study is required to... 
Cardiovascular | Internal Medicine | RUPTURE | ARTERIES | CARDIAC & CARDIOVASCULAR SYSTEMS | Diagnostic Imaging - methods | Plaque, Atherosclerotic - diagnosis | Plaque, Atherosclerotic - metabolism | Coronary Artery Disease - diagnosis | Coronary Artery Disease - metabolism | Humans | Cholesterol - metabolism | Coronary Vessels - metabolism | Pharmaceutical industry | Cholesterol | Cardiovascular disease | Lipids | Coronary vessels | Apoptosis
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