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1. Full Text Elbasvir-grazoprevir to treat hepatitis C virus infection in persons receiving opioid agonist therapy a randomized trial
by Dore, Gregory J and Altice, Frederick and Litwin, Alain H and Dalgard, Olav and Gane, Edward J and Shibolet, Oren and Luetkemeyer, Anne and Nahass, Ronald and Peng, Cheng-Yuan and Conway, Brian and Grebely, Jason and Howe, Anita Y.M and Gendrano, Isaias N and Chen, Erluo and Huang, Hsueh-Cheng and Dutko, Frank J and Nickle, David C and Nguyen, Bach-Yen and Wahl, Janice and Barr, Eliav and Robertson, Michael N and Platt, Heather L and C-EDGE CO-STAR Study Grp and C-EDGE CO-STAR Study Group and on behalf of the C-EDGE CO-STAR Study Group
Annals of internal medicine, ISSN 0003-4819, 11/2016, Volume 165, Issue 9, pp. 625 - 634
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Quinoxalines - adverse effects | Recurrence | Opioid-Related Disorders - drug therapy | Humans | Middle Aged | Drug Resistance, Viral | Methadone - therapeutic use | Male | Hepatitis C, Chronic - complications | Young Adult | Substance Abuse, Intravenous - drug therapy | Adult | Female | Opiate Substitution Treatment | Imidazoles - therapeutic use | Quinoxalines - therapeutic use | Benzofurans - therapeutic use | Double-Blind Method | Antiviral Agents - therapeutic use | Imidazoles - adverse effects | Genotype | Hepatitis C, Chronic - drug therapy | Benzofurans - adverse effects | Medication Adherence | Buprenorphine - therapeutic use | Antiviral Agents - adverse effects | Adolescent | Buprenorphine, Naloxone Drug Combination - therapeutic use | Aged | Hepatitis C, Chronic - genetics | Drug Combinations | Opioid-Related Disorders - complications | Physiological aspects | Drug addicts | Hepatitis C | Drug therapy | Clinical trials | Hepatitis | Narcotics | Medical treatment | Index Medicus | Abridged Index Medicus
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2. Full Text Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
by Ji, X and Bossé, Y and Landi, M.T and Gui, Jiang and Xiao, X and Qian, D.C and Kiemeney, L.A.L.M and Heijden, E. van der and Brennan, P and Amos, C.I and et al
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 3221 - 15
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - genetics | Smoking - adverse effects | Genetic Predisposition to Disease | Reproducibility of Results | Humans | Middle Aged | Risk Factors | Child, Preschool | Infant | Male | Chromosomes, Human, Pair 15 - genetics | Gene Regulatory Networks | Young Adult | Adolescent | Adult | Female | Aged | Polymorphism, Single Nucleotide | Child | Gene Ontology | Infant, Newborn | Cohort Studies | Quantitative Trait Loci - genetics | Channel gating | Lung cancer | Health risks | Risk | Genomes | Single-nucleotide polymorphism | Loci | Quantitative trait loci | Annotations | Pathways | Etiology | Ligands | Health risk assessment | Chromosome 15 | Chromosomes | Cancer | Index Medicus | Clinical Medicine | Medicinsk genetik | Basic Medicine | Medical Genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin | Cancer and Oncology | Cancer och onkologi
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3. Full Text Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
by McKay, J.D and Hung, R.J and Han, Y and Zong, X and Carreras-Torres, R and Christiani, D.C and Caporaso, N and Johansson, M and Li, Y and Byun, J.Y and Dunning, A and Pooley, K.A and Qian, D.C and Liu, G and Bojesen, S.E and Wu, X and Marchand, L. le and Albanes, D and Bickeböller, H and Alich, M.C and Bush, W.S and Tardon, A and Rennert, G and Teare, M.D and Field, J.K and Kiemeney, L.A and Lazarus, P and Haugen, A and Schabath, M.B and Anew, A.S and Shen, H and Hong, Y.C and Yuan, J.M and Bertazzi, P.A and Pesatori, A.C and Ye, Y and Diao, N and Su, L and Zhang, R and Brhane, Y and Leighl, N and Johansen, J.S and Mellemgaard, A and Saliba, W and Haiman, C.A and Wilkens, L.R and Fernandez-Somoano, A and Fernandez-Tardon, G and Heijden, H.F.M. van der and Kim, J.H and Hu, Z and Davies, M and Brunnström, H and Manjer, J and Melander, O and Muller, D and Overvad, K and Trichopoulou, A and Tumino, R and Doherty, J.A and Barnett, M.P and Chen, C and Goodman, G.E and Cox, A and Taylor, F and Woll, P.J and Brüske, I and Wichmann, H.E and Manz, J and Muley, T.R and Risch, A and Rosenberger, A and Grankvist, K and Shepherd, F.A and Tsao, M.S and Haura, E.B and Bolca, C and Holcatova, I and Janout, V and Kontic, M and Lissowska, J and Mukeria, A and Ognjanovic, S and Orlowski, T.M and Scelo, G and Swiatkowska, B and Zaridze, D and Bakke, P and Skaug, V and Zienolddiny, S and Duell, E.J and Butler, L.M and Koh, W.P and Gao, Y.T and Houlston, R.S and McLaughlin, J and Stevens, V.L and Joubert, P and Lamontagne, M and Nickle, D.C and ... and SpiroMeta Consortium
Nature genetics, ISSN 1061-4036, 2017, Volume 49, Issue 7, pp. 1126 - 1132
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Lung Neoplasms - genetics | Lung Neoplasms - ethnology | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Adenocarcinoma of Lung | Humans | Middle Aged | Family Health | Genotype | Male | Chromosome Mapping | Telomere Homeostasis - genetics | Lung Neoplasms - epidemiology | Smoking - epidemiology | Adult | Female | Adenocarcinoma - genetics | Aged | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Adenocarcinoma | Genealogy | Disease | Genes | Lung cancer | Association analysis | Genomes | Gene expression | Loci | Quantitative trait loci | Studies | Consortia | Heterogeneity | Etiology | Chronic obstructive pulmonary disease | Heritability | Cancer | Smoking | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
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4. Full Text Protein-altering germline mutations implicate novel genes related to lung cancer development
by Ji, X and Mukherjee, Semanti and Landi, Maria Teresa and Bossé, Y and Joubert, P and Zhu, D and Kiemeney, L.A.L.M and Heijden, E. van der and McKay, J.D and Amos, Christopher, I and et al
Nature communications, ISSN 2041-1723, 2020, Volume 11, Issue 1, pp. 2220 - 2220
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Adenocarcinoma | Lung cancer | Health risks | Gene expression | Risk analysis | Population genetics | Heterozygosity | Genetic variance | Loss of heterozygosity | Replication | Mutation | Health risk assessment | Tumors | Index Medicus | health risk | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | heterozygosity | mutation | Medicinsk genetik | Medical Genetics | genetic analysis | tumor | allele | Medicinska och farmaceutiska grundvetenskaper | cancer | gene expression
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5. Full Text Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
by Wain, Louise V and Shrine, Nick R. G and Artigas, Maria Soler and Erzurumluoglu, A Mesut and Noyvert, Boris and Bossini-Castillo, Lara and Obeidat, Ma'en and Henrys, Amanda P and Portelli, Michael A and Hall, Robert J and Billington, Charlotte K and Rimington, Tracy L and Fenech, Anthony G and John, Catherine and Blake, Tineka and Jackson, Victoria E and Allen, Richard J and Prins, Bram P and Campbell, Archie and Porteous, David J and Jarvelin, Marjo-Riitta and Wielscher, Matthias and Jamess, Alan L and Hui, Jennie and Wareham, Nicholas J and Zhao, Jing Hua and Wilson, James F and Joshi, Peter K and Stubbe, Beate and Rawal, Rajesh and Schulz, Holger and Imboden, Medea and Probst-Hensch, Nicole M and Karrasch, Stefan and Gieger, Christian and Deary, Ian J and Harris, Sarah E and Marten, Jonathan and Rudan, Igor and Enroth, Stefan and Gyllensten, Ulf and Kerr, Shona M and Polasek, Ozren and Kahonen, Mika and Surakka, Ida and Vitart, Veronique and Hayward, Caroline and van den Berge, Maarten and Brandsma, Corry-Anke and Trynka, Gosia and Geisinger-Regeneron DiscovEHR and Understanding Soc Sci Grp and Understanding Society Scientific Group and Geisinger-Regeneron DiscovEHR Collaboration
Nature genetics, ISSN 1061-4036, 03/2017, Volume 49, Issue 3, pp. 416 - 425
POPULATION | VARIANTS | GENETICS | SUSCEPTIBILITY | FAM13A | HEALTH | EPIDEMIOLOGY | AIR-FLOW OBSTRUCTION | COPD | HISTORY | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetic Predisposition to Disease - genetics | Humans | Middle Aged | Risk Factors | Genetic Loci - genetics | Male | Lung - physiopathology | Asthma - genetics | Epigenesis, Genetic - genetics | Alleles | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Adult | Female | Aged | Genome-Wide Association Study - methods | Pulmonary Disease, Chronic Obstructive - genetics | Quantitative trait loci | Molecular targeted therapy | Lung diseases, Obstructive | Care and treatment | Innovations | Development and progression | Genetic aspects | Health aspects | Studies | Chronic obstructive pulmonary disease | Genomes | Health risk assessment | Index Medicus
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6. Full Text HLA Class I-Driven Evolution of Human Immunodeficiency Virus Type 1 Subtype C Proteome: Immune Escape and Viral Load
by Christine M. Rousseau and Marcus G. Daniels and Jonathan M. Carlson and Carl Kadie and Hayley Crawford and Andrew Prendergast and Philippa Matthews and Rebecca Payne and Morgane Rolland and Dana N. Raugi and Brandon S. Maust and Gerald H. Learn and David C. Nickle and Hoosen Coovadia and Thumbi Ndung'u and Nicole Frahm and Christian Brander and Bruce D. Walker and Philip J. R. Goulder and Tanmoy Bhattacharya and David E. Heckerman and Bette T. Korber and James I. Mullins
Journal of Virology, ISSN 0022-538X, 07/2008, Volume 82, Issue 13, pp. 6434 - 6446
Life Sciences & Biomedicine | Science & Technology | Virology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Miscellaneous | Microbiology | T-Lymphocytes, Cytotoxic - immunology | Amino Acid Sequence | HIV Infections - genetics | Humans | Genes, MHC Class I - genetics | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Phylogeny | HIV-1 - genetics | Sequence Analysis, DNA | HIV Infections - immunology | Immunity, Cellular - immunology | HIV-1 - immunology | Base Sequence | South Africa | Viremia - blood | Evolution, Molecular | Index Medicus | Pathogenesis and Immunity
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7. Full Text Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations
by Fehringer, G and Kraft, Peter and Pharoah, Paul and Eeles, Rosalind and Chatterjee, N and Schumacher, Freick R and Schildkraut, Joellen and Lindstrom, Stephen and Brennan, Paul and Bickeböller, Heike and Houlston, Richard and Landi, Maria Teresa and Caporaso, Neil and Risch, A and Al Olama, Ali Amin and Berndt, Sonja and Giovannucci, E.L and Grönberg, Henrik and Kote-Jarai, Z and Ma, J and Muir, K and Stampfer, Meir J and Stevens, V.L and Wiklund, Freik and Willett, Walter C and Goode, Ellen and Permuth, J.B and Risch, Harvey and Reid, B.M and Bezieau, S and Brenner, Hermann and Chan, A.T and Chang-Claude, Jenny and Hudson, Thomas and Kocarnik, J.K and Newcomb, Polly and Schoen, R.E and Slattery, M.L and White, E and Adank, Muriel and Ahsan, Habibul and Aittomäki, Kristiina and Baglietto, L and Blomquist, C and Canzian, Federico and Czene, Kamila and Santos Silva, Isabel and Eliassen, A.H and Figueroa, Jonine and Flesch-Janys, Dieter and Fletcher, Olivia and García-Closas, Montserrat and Gaudet, Mia and Johnson, N and Hall, Per and Hazra, Aditi and Hein, Rebecca and Hofman, A and Hopper, John and Irwanto, Astrid and Johansson, Mattias and Kaaks, Rudolf and Kibriya, Muhammad and Lichtner, Peter and Liu, Jianjun and Lund, Eiliv and Makalic, E and Meindl, Alfons and Müller-Myhsok, B and Muranen, T.A and Nevanlinna, Heli and Peeters, P.H.M and Peto, Julian and Prentice, Ross and Rahman, Nazneen and Sanchez, Maria-Jose and Schmidt, Daniel and Schmutzler, Rita and Southey, Melissa and Tamimi, R and Travis, Simon and Turnbull, Clare and Uitterlinden, A.G and Wang, Zhaoming and Whittemore, Alice and Yang, Xiaohong and Zheng, Wei and Buchanan, Daniel and Casey, Graham and Conti, Giario and Edlund, Christopher and Gallinger, Steve and Haile, Robert and Jenkins, Mark and Marchand, L and Li, L and Lindor, Noralane and Schmit, S.L and Thibodeau, Stephen and Woods, Michael and ... and African Ancestry Prostate Canc and OCAC and Hereditary Breast Ovarian Canc Res and PRACTICAL Consortium and Colorectal Transdisciplinary and African Amer Breast Canc and Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) and Ovarian Cancer Association Consortium (OCAC) and Colorectal Transdisciplinary (CORECT) Study and African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC) and on behalf of The PRACTICAL Consortium and on behalf of Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) and on behalf of African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC) and on behalf of Colorectal Transdisciplinary (CORECT) Study and on behalf of Ovarian Cancer Association Consortium (OCAC)
Cancer research (Chicago, Ill.), ISSN 0008-5472, 09/2016, Volume 76, Issue 17, pp. 5103 - 5114
Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - genetics | Ovarian Neoplasms - genetics | Genome-Wide Association Study | Breast Neoplasms - genetics | Prostatic Neoplasms - genetics | Colorectal Neoplasms - genetics | Humans | Female | Genotype | Male | Index Medicus | Medicin och hälsovetenskap
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8. Full Text Antiviral activity and resistance analysis of NS3/4A protease inhibitor grazoprevir and NS5A inhibitor elbasvir in hepatitis C virus GT4 replicons
by Asante-Appiah, Ernest and Curry, Stephanie and McMonagle, Patricia and Ingravallo, Paul and Chase, Robert and Nickle, David and Qiu, Ping and Howe, Anita and Lahser, Frederick C
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 07/2017, Volume 61, Issue 7
Resistance | Antiviral agents | NS5A | Antiviral | Drug resistance mechanisms | HCV | Elbasvir | Hepatitis C virus | NS3/4A | Genotype 4 | Grazoprevir | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Hepacivirus - drug effects | Quinoxalines - pharmacology | Protease Inhibitors - pharmacology | Antiviral Agents - pharmacology | Hepatitis C, Chronic - enzymology | Hepacivirus - genetics | Serine Proteases | Benzofurans - pharmacology | Genotype | Imidazoles - pharmacology | Viral Nonstructural Proteins - antagonists & inhibitors | Replicon - genetics | Index Medicus
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9. Full Text Virologic Resistance Analysis From a Phase 2 Study of MK-5172 Combined With Pegylated Interferon/Ribavirin in Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Infection
by Anita Y. M. Howe and Stuart Black and Stephanie Curry and Steven W. Ludmerer and Rong Liu and Richard J. O. Barnard and William Newhard and Peggy M. T. Hwang and David Nickle and Christopher Gilbert and Luzelena Caro and Mark J. DiNubile and Niloufar Mobashery
Clinical infectious diseases, ISSN 1058-4838, 12/2014, Volume 59, Issue 12, pp. 1657 - 1665
RNA | Protease inhibitors | Antivirals | Viruses | Infections | ARTICLES AND COMMENTARIES | Hepacivirus | Sequencing | Genotypes | Virology | Replicon | MK-5172 | treatment-naive | resistance-associated variants | hepatitis C genotype 1 | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antiviral agents | Viral hepatitis | Infectious diseases | Pharmacology. Drug treatments | Viral diseases | Biological and medical sciences | Medical sciences | Human viral diseases | Antibiotics. Antiinfectious agents. Antiparasitic agents | Hepatitis C - drug therapy | Humans | Ribavirin - therapeutic use | Drug Resistance, Viral | Genotype | Interferons - therapeutic use | Quinoxalines - therapeutic use | Care and treatment | Analysis | Genetic aspects | Dosage and administration | Hepatitis C | Risk factors | Hepatitis | Genotype & phenotype | Interferon | Ribonucleic acid--RNA | Drug resistance | Index Medicus
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