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Current Opinion in Infectious Diseases, ISSN 0951-7375, 12/2019, Volume 32, Issue 6, pp. 647 - 655
PURPOSE OF REVIEWAntimicrobial resistance among Gram-negative organisms is a rapidly escalating global challenge. Pharmacologic dose optimization based on... 
Journal Article
Open Forum Infectious Diseases, ISSN 2328-8957, 11/2018, Volume 5, Issue suppl_1, pp. S642 - S642
Journal Article
by White, Harvey D and Held, Claes and Stewart, Ralph and Tarka, Elizabeth and Brown, Rebekkah and Davies, Richard Y and Budaj, Anzej and Harrington, Robert A and Steg, P. Gabriel and Ardissino, Diego and Armstrong, Paul W and Avezum, Alvaro and Aylward, Philip E and Bryce, Alfonso and Chen, Hong and Chen, Ming-Fong and Corbalan, Ramon and Dalby, Anthony J and Danchin, Nicolas and de Winter, Robbert J and Denchev, Stefan and Diaz, Rafael and Elisaf, Moses and Flather, Marcus D and Goudev, Assen R and Granger, Christopher B and Grinfeld, Liliana and Hochman, Judith S and Husted, Steen and Kim, Hyo-Soo and Koenig, Wolfgang and Linhart, Ales and Lonn, Eva and López-Sendón, José and Manolis, Athanasios J and Mohler, Emile R and Nicolau, José C and Pais, Prem and Parkhomenko, Alexander and Pedersen, Terje R and Pella, Daniel and Ramos-Corrales, Marco A and Ruda, Mikhail and Sereg, Mátyás and Siddique, Saulat and Sinnaeve, Peter and Smith, Peter and Sritara, Piyamitr and Swart, Henk P and Sy, Rody G and Teramoto, Tamio and Tse, Hung-Fat and Watson, David and Weaver, W. Douglas and Weiss, Robert and Viigimaa, Margus and Vinereanu, gos and Zhu, Junren and Cannon, Christopher P and Wallentin, Lars and Steg, Ph Gabriel and Bucan, Olga and Elfström, Charlotta and Hegg, Lisa and Jarosz, Marie and Krug-Gourley, Sue and Rudman, Jerry and Collins, Rory and Anderson, Jeffrey and DeMets, David and Ganz, Peter and Sandercock, Peter and Weber, Michael and Fisher, Marian and Buhr, Kevin and Diegel, Scott and Schultz, Melissa and Mahaffey, Kenneth W and Alexander, John H and Al-Khatib, Sana and Baron, Tomasz and Bergström, Olle and Bushnell, Cheryl and Christersson, Christina and Eggers, Kai and Fredlund, Bengt-Olov and Hagström, Emil and Hijazi, Ziad and Örndahl, Lovisa Holm and James, Stefan K and Jernberg, Tomas and Johnston, Nina and Lopez, Renato D and Mehta, Rajena H and Newby, Kristin L and Nordmark, Örjan and Oldgren, Jonas and Roe, Matthew T and Saldéen, Katarina and Stenborg, Anna and ... and The STABILITY Investigators and STABILITY Investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Kardiologi and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Uppsala universitet and Institutionen för medicinska vetenskaper and Uppsala kliniska forskningscentrum (UCR)
The New England Journal of Medicine, ISSN 0028-4793, 05/2014, Volume 370, Issue 18, pp. 1702 - 1711
Darapladib, an oral inhibitor of lipoprotein-associated phospholipase A2, was compared with placebo in 15,828 patients with stable coronary heart disease.... 
TRIAL | LIPOPROTEIN | MEDICINE, GENERAL & INTERNAL | THERAPY | ACTIVATING-FACTOR ACETYLHYDROLASE | OXIDIZED LDL | RISK | PHOSPHOLIPASE A | ATHEROSCLEROTIC PLAQUE | INHIBITOR | CLINICAL-OUTCOMES | Stroke - prevention & control | Double-Blind Method | Follow-Up Studies | Oximes - adverse effects | Phospholipase A2 Inhibitors - administration & dosage | Humans | Middle Aged | Kaplan-Meier Estimate | Oximes - administration & dosage | Male | Coronary Artery Disease - drug therapy | Coronary Disease - mortality | Phospholipase A2 Inhibitors - adverse effects | Benzaldehydes - adverse effects | Benzaldehydes - administration & dosage | Coronary Artery Disease - complications | Treatment Failure | Coronary Disease - drug therapy | Female | Aged | Myocardial Infarction - prevention & control | Prevention | Care and treatment | Ischemia | Dosage and administration | Research | Coronary heart disease | Cardiovascular agents | Myocardial infarction | Cerebral infarction | Phospholipase A2 | Clinical trials | Myocardial ischemia | Cardiovascular disease | Angina | Preventive medicine | Coronary artery disease | Phospholipase | Arteriosclerosis | Death | Plasma levels | Drug therapy | Heart diseases | Plaques | Malalties cardiovasculars | Infart de miocardi | Malalties coronàries | Assaigs clínics de medicaments | Cardiovascular diseases | Drug testing | Coronary diseases | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
Open Forum Infectious Diseases, ISSN 2328-8957, 11/2018, Volume 5, Issue suppl_1, pp. S642 - S643
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 07/2019, Volume 63, Issue 7
A novel antibiotic combination of the oral cephalosporin ceftibuten (CTB) and the (beta-lactamase inhibitor clavulanate (CLA) is currently in development for... 
UNITED-STATES | URINARY-TRACT-INFECTIONS | ESCHERICHIA-COLI | SUSCEPTIBILITY | MICROBIOLOGY | extended-spectrum beta-lactamase | cephalosporin | AVIBACTAM | PHARMACOKINETICS-PHARMACODYNAMICS | CEFTAZIDIME | beta-lactam/beta-lactamase inhibitor | PHARMACOLOGY & PHARMACY | MICE | BETA-LACTAMASE INHIBITOR | TAZOBACTAM | urinary tract infection
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 05/2019, Volume 68, Issue 10, pp. 1650 - 1657
Abstract Background Currently, there is debate over whether the daptomycin susceptibility breakpoint for enterococci (ie, minimum inhibitory concentration... 
Enterococcus | Pharmacodynamics | Bacteremia | Daptomycin | HIGH-DOSE DAPTOMYCIN | INFECTIOUS DISEASES | INFECTIONS | FAECIUM | ANTIMICROBIAL THERAPY | pharmacodynamics | MICROBIOLOGY | VANCOMYCIN-RESISTANT ENTEROCOCCI | IMMUNOLOGY | COMBINATION | PREDICTION | PHARMACOKINETICS | daptomycin | FAECALIS | bacteremia | CLINICAL-OUTCOMES
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2019
Siderophore-antibiotic conjugates have increased in vitro activity in low iron environments where bacteria express siderophores and associated transporters.... 
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2019
Cefiderocol is a siderophore-cephalosporin conjugate with greater in vitro potency in iron-depleted conditions. During infection, iron is scarce in host... 
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2019, Volume 41, Issue 10, pp. 2162 - 2170
AbstractPurposeEravacycline is a broad-spectrum, intravenous fluorocycline antibiotic approved for the treatment of complicated intra-abdominal infections in... 
Internal Medicine | Medical Education | Drugs | Intravenous administration | Laboratories | Amiodarone | Infusion | Chloride | Albumins | Turbidity | Sodium bicarbonate | Meropenem | Propofol | Intravenous infusion | Drug dosages | Incompatibility | Carbohydrates | Inspection | Admixtures | Antimicrobial agents | FDA approval | Micafungin | Sodium chloride | Furosemide | Antibiotics | Simulation | Compatibility
Journal Article
Journal of clinical microbiology, ISSN 0095-1137, 07/2019, Volume 57, Issue 10
Blood culture bottles containing antibiotic binding resins are routinely used to minimize artificial sterilization in the presence of antibiotics. However, the... 
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 10/2019
Abstract Objectives WCK 5222 combines cefepime with zidebactam, a β-lactam enhancer that binds PBP2 and inhibits class A and C β-lactamases. The efficacy of... 
Journal Article
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, ISSN 0066-4804, 07/2019, Volume 63, Issue 7
Ceftibuten-clavulanate (CTB-CLA) is a novel beta-lactam-beta-lactamase combination with potential utility for the management of urinary tract infections caused... 
extended-spectrum beta-lactamases | URINARY-TRACT-INFECTIONS | clavulanic acid | PYELONEPHRITIS | pharmacodynamics | urinary tract infections | ESCHERICHIA-COLI | pharmacokinetics | beta-lactamase inhibitor | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | human-simulated regimens
Journal Article
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, ISSN 0305-7453, 08/2018, Volume 73, Issue 8, pp. 2264 - 2265
Journal Article
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, ISSN 0305-7453, 08/2019, Volume 74, Issue 8, pp. 2269 - 2273
Objectives: To assess activity of the combination of ceftriaxone and ampicillin against clinical isolates of ampicillin-susceptible Enterococcus faecium.... 
INFECTIOUS DISEASES | MANAGEMENT | ANTIMICROBIAL THERAPY | RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | ENDOCARDITIS
Journal Article