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Nature, ISSN 0028-0836, 04/2009, Volume 458, Issue 7242, pp. 1180 - 1184
Gene silencing by double-stranded RNA, denoted RNA interference, represents a new paradigm for rational drug design. However, the transformative therapeutic... 
NONHUMAN-PRIMATES | RNA INTERFERENCE | TUMOR-NECROSIS-FACTOR | IN-VIVO DELIVERY | INHIBITION | LETHALITY | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | RESISTANCE | ADULT MICE | GALACTOSAMINE | Tumor Necrosis Factor-alpha - metabolism | Protein-Serine-Threonine Kinases - deficiency | RNA, Small Interfering - genetics | Substrate Specificity | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | Drug Delivery Systems | Glucans - metabolism | Interleukin-1beta - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Administration, Oral | Mice, Inbred C57BL | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | Enzyme Activation - drug effects | Organ Specificity | Macrophages - metabolism | Animals | MAP Kinase Signaling System - drug effects | Lipopolysaccharides - pharmacology | Inflammation - genetics | Macrophages - drug effects | Inflammation - prevention & control | Mice | RNA, Small Interfering - administration & dosage | Tumor Necrosis Factor-alpha - biosynthesis | RNA, Small Interfering - metabolism | Usage | Control | Genetic engineering | Inflammation | Genetic aspects | Research | Macrophages | Health aspects | Methods | Spleen | Tissue | E coli | Rodents | Rheumatoid arthritis | Kinases | Autoimmune diseases | Cells | Inflammatory diseases | Transfer RNA | Crohns disease | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 22, pp. 7833 - 7838
Storage of energy as triglyceride in large adipose-specific lipid droplets is a fundamental need in all mammals. Efficient sequestration of fat in adipocytes... 
Adipose tissues | Proteins | Obesity | White adipose tissue | Messenger RNA | Lipids | Insulin resistance | Adipocytes | Insulin | Lipolysis | Adipocyte | Fat droplet | Fat metabolism | Diabetes | Cide | fat droplet | MULTIDISCIPLINARY SCIENCES | cide | MOUSE-LIVER | NECROSIS-FACTOR-ALPHA | PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY | ACTIVATED-RECEPTOR-ALPHA | OBESITY | DNA-FRAGMENTATION-FACTOR | EFFECTOR-A | FREE FATTY-ACIDS | adipocyte | fat metabolism | diabetes | TRANSCRIPTIONAL REGULATION | ADIPOSE-TISSUE | Humans | Apoptosis Regulatory Proteins - analysis | Adipose Tissue, White - metabolism | Molecular Sequence Data | Male | PPAR gamma - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Adipose Tissue, White - cytology | Phosphoproteins - analysis | RNA Interference | Apoptosis Regulatory Proteins - genetics | Thiazolidinediones - pharmacology | Carrier Proteins | PPAR gamma - genetics | Body Mass Index | Amino Acid Sequence | Mice, Inbred C57BL | Insulin Resistance | 3T3-L1 Cells | Apoptosis Regulatory Proteins - metabolism | Obesity - metabolism | Triglycerides - metabolism | Proteins - genetics | Animals | Proteins - metabolism | Adipocytes - metabolism | PPAR gamma - agonists | Mice | Perilipin-1 | Fat cells | Development and progression | Influence | Genetic aspects | Research | Human genetics | Rodents | Metabolism | Gene expression | Fatty acids | Index Medicus | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7698, pp. 673 - 677
Obesity-induced metabolic disease involves functional integration among several organs via circulating factors, but little is known about crosstalk between... 
TISSUE INFLAMMATION | DIPEPTIDYL PEPTIDASE-4 INHIBITOR | GLYCEMIC CONTROL | DOSE-RESPONSE | LINKING OBESITY | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | BODY-MASS INDEX | TYPE-2 DIABETES-MELLITUS | EXPRESSION | Dipeptidyl Peptidase 4 - metabolism | Sitagliptin Phosphate - pharmacology | Humans | Receptor, PAR-2 - metabolism | Male | Hepatocytes - metabolism | Receptor, PAR-2 - deficiency | Obesity - genetics | Inflammation - metabolism | Hepatocytes - drug effects | Receptor, PAR-2 - genetics | Sitagliptin Phosphate - administration & dosage | Administration, Oral | Caveolin 1 - genetics | Caveolin 1 - deficiency | Dipeptidyl Peptidase 4 - genetics | Intra-Abdominal Fat - metabolism | Factor Xa - metabolism | Obesity - metabolism | Caveolin 1 - metabolism | Macrophages - metabolism | Animals | Dipeptidyl Peptidase 4 - deficiency | Insulin Resistance - genetics | Inflammation - genetics | Mice, Obese | Mice | Obesity - enzymology | Intra-Abdominal Fat - pathology | Inflammation - enzymology | Hepatocytes - enzymology | Physiological aspects | Obesity | Insulin resistance | Observations | Caveolin-1 | Peptidase | Adipose tissue | Caveolin | Liver | Crosstalk | Oral administration | Organs | Inflammation | Kinases | Macrophages | Insulin | Proteins | Disease resistance | Functional integration | Hepatocytes | Rodents | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 11/2008, Volume 295, Issue 5, pp. 1056 - 1064
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 20, pp. 8278 - 8283
Journal Article
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 3485 - 3485
Journal Article
ISSN 1476-4687, 2018
Obesity-induced metabolic disease involves functional integration among several organs via circulating factors, but little is known about crosstalk between... 
Adipose tissues | Obesity | CD26 antigen | Insulin resistance | Metabolism--Disorders
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2019, Volume 202, Issue 8, pp. 2451 - 2459
Macrophages, B cells, and adipocytes are among the adipose tissue (AT) APCs that differentiate and activate naive CD4(+) T cells. Mice with adipocyte loss of... 
RECRUITMENT | OBESITY | INSULIN-RESISTANCE | INFLAMMATION | REGULATORY T-CELLS | FAT | SENSITIVITY | PPAR-GAMMA | MICE | IMMUNOLOGY | INFILTRATION
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 08/2014, Volume 307, Issue 4, pp. E374 - E383
Journal Article
Journal Article
Journal Article