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Trends in Genetics, ISSN 0168-9525, 08/1999, Volume 15, Issue 8, pp. 314 - 319
Formation of the head during vertebrate embryogenesis has been one of the most-studied topics in development, probably because we are such cephalized beings... 
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 12/2016, Volume 26, Issue 12, p. 956
Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP... 
β-catenin | Molecular modelling | Cellular biology | Wnt protein | Transcription | Genes | Cascades | Gene regulation | Cell division | Physiology | Gene expression
Journal Article
Trends in Cell Biology, ISSN 0962-8924, 12/2016, Volume 26, Issue 12, p. 956
Wnt/LRP6 signaling is best known for the [beta]-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including... 
Molecular biology | Cells
Journal Article
Science, ISSN 0036-8075, 1/2010, Volume 327, Issue 5964, pp. 459 - 463
Wnt/ß-catenin signaling is important in stem cell biology, embryonic development, and disease, including cancer. However, the mechanism of Wnt signal... 
Receptors | Phosphorylation | Blastomeres | Messenger RNA | HEK293 cells | Neurons | Genes | Small interfering RNA | Acidification | Reports | Embryos | CELLS | ACTIVATION | PROTEIN | RENIN | PATHWAY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | ANGIOTENSIN-II | (PRO)RENIN RECEPTOR | BETA-CATENIN | LRP6 | LDL-Receptor Related Proteins - metabolism | Xenopus Proteins - genetics | Homeodomain Proteins - metabolism | Humans | Embryo, Nonmammalian - metabolism | Wnt Proteins - metabolism | Central Nervous System - embryology | Vacuolar Proton-Translocating ATPases - metabolism | Xenopus - embryology | Gene Expression Regulation, Developmental | Body Patterning | Cell Line | Low Density Lipoprotein Receptor-Related Protein-6 | Signal Transduction | Frizzled Receptors - metabolism | Receptors, Cell Surface - metabolism | Nerve Tissue Proteins - genetics | beta Catenin - metabolism | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | Vacuolar Proton-Translocating ATPases - antagonists & inhibitors | Animals | Xenopus - metabolism | Central Nervous System - cytology | Cell Line, Tumor | Wnt3 Protein | Xenopus Proteins - metabolism | Mice | RNA, Small Interfering | Hydrogen-Ion Concentration | Receptors, Cell Surface - genetics | Proteins | Signal transduction | Biochemistry | Cellular biology | Index Medicus
Journal Article
Science, ISSN 0036-8075, 6/2007, Volume 316, Issue 5831, pp. 1619 - 1622
Multiple signaling pathways, including Wnt signaling, participate in animal development, stem cell biology, and human cancer. Although many components of the... 
Aggregation | Phosphorylation | Receptors | Microscopy | Caveolins | Cell aggregates | HeLa cells | Fluorescent antibody techniques | Small interfering RNA | Reports | Cell membranes | ENCODES | AXIN | ACTIVATION | DOMAIN | POLARITY | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | RECEPTOR-RELATED PROTEIN-5 | BETA-CATENIN | PLASMA-MEMBRANE | LDL-Receptor Related Proteins - metabolism | Humans | Cytoplasm - metabolism | Glycogen Synthase Kinase 3 beta | Phosphoproteins - metabolism | Wnt Proteins - metabolism | LDL-Receptor Related Proteins - genetics | Repressor Proteins - analysis | Transfection | Cell Membrane - metabolism | Dishevelled Proteins | Repressor Proteins - metabolism | Cell Line | Drosophila Proteins | Centrifugation, Density Gradient | Low Density Lipoprotein Receptor-Related Protein-6 | Signal Transduction | Drosophila | LDL-Receptor Related Proteins - analysis | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - metabolism | Glycogen Synthase Kinase 3 - analysis | Animals | Models, Biological | Axin Protein | Cell Line, Tumor | Wnt3 Protein | Mice | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Fetus | Genetic aspects | Research | Growth | Proteins | Signal transduction | Molecular biology | Binding sites | Bulging | Pathways | Aggregates | Imaging | Agglomeration | Index Medicus
Journal Article
Differentiation, ISSN 0301-4681, 2010, Volume 80, pp. S8 - S8
Journal Article
Mechanisms of Development, ISSN 0925-4773, 08/2009, Volume 126, pp. S12 - S13
Journal Article
Science, ISSN 0036-8075, 3/2013, Volume 339, Issue 6126, pp. 1436 - 1441
Casein kinase 1 (CK1) members play key roles in numerous biological processes. They are considered "rogue" kinases, because their enzymatic activity appears... 
Proteins | Protein isoforms | Phosphorylation | Messenger RNA | RNA | HEK293 cells | REPORTS | Small interfering RNA | HeLa cells | Fibroblast growth factors | Embryos | PROTEIN | WNT/BETA-CATENIN | CELL-MIGRATION | MULTIDISCIPLINARY SCIENCES | I-EPSILON | C-ELEGANS | MUTATIONS | INDUCTION | MEDULLOBLASTOMA | PROMOTES | FAMILY | RNA Helicases - metabolism | Xenopus Proteins - genetics | Xenopus - genetics | Humans | Caenorhabditis elegans Proteins - metabolism | RNA Helicases - chemistry | Phosphoproteins - metabolism | Wnt Proteins - metabolism | Xenopus - embryology | Xenopus Proteins - chemistry | Casein Kinase Iepsilon - chemistry | Casein Kinase Iepsilon - metabolism | HEK293 Cells | RNA Helicases - genetics | DEAD-box RNA Helicases - metabolism | Dishevelled Proteins | DEAD-box RNA Helicases - chemistry | Wnt Signaling Pathway | Protein Structure, Tertiary | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - growth & development | Caenorhabditis elegans - genetics | beta Catenin - metabolism | DEAD-box RNA Helicases - genetics | Animals | Xenopus - metabolism | Protein Binding | Xenopus Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Caenorhabditis elegans Proteins - genetics | Index Medicus | Pathways | Ribonucleic acids | Asymmetry | Genes | Division | Kinases | Gene expression
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e14060 - e14060
Gemcitabine is a cytotoxic cytidine analog, which is widely used in anti-cancer therapy. One mechanism by which gemcitabine acts is by inhibiting nucleotide... 
EXCISION-REPAIR | METHYLATION | MECHANISM | CISPLATIN | HUMAN-CELLS | BIOLOGY | MISMATCH REPAIR | DRUG-RESISTANCE | CANCER | DAMAGE | 2',2'-DIFLUORODEOXYCYTIDINE | Xenopus | MutL Protein Homolog 1 | Xenopus Proteins - genetics | Humans | Deoxycytidine - pharmacology | HEK293 Cells | Cell Cycle Proteins - genetics | Oocytes - drug effects | Antimetabolites, Antineoplastic - pharmacology | Female | Epigenesis, Genetic - drug effects | Nuclear Proteins - genetics | DNA Repair - drug effects | Oocytes - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Gene Expression Regulation - drug effects | Animals | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Xenopus Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | DNA Methylation - drug effects | Deoxycytidine - analogs & derivatives | Epigenetic inheritance | Care and treatment | Gemcitabine | Analysis | Genes | DNA | Genetic engineering | Methylation | Health aspects | DNA repair | Cells | Cancer | Camptothecin | Leukemia | Oct-4 protein | Cytotoxicity | Kinases | Drug resistance | Cancer therapies | Base excision repair | Neurogenesis | Oocytes | Mammalian cells | Proteins | Demethylation | Embryology | Reporter gene | DNA methylation | Inhibition | Repair | Deoxyribonucleic acid--DNA | Enzymes | MLH1 protein | DNA topoisomerase | Polymerization | Nucleotide excision repair | DNA biosynthesis | Gene silencing | Chemotherapy | Gadd45A protein | Plasmids | Epigenetics | GADD45 protein | Tumors | Index Medicus | Deoxyribonucleic acid
Journal Article
Journal Article
Journal Article
EMBO reports, ISSN 1469-221X, 05/2017, Volume 18, Issue 5, pp. 712 - 725
Wnt/β‐catenin signaling plays a key role in embryonic development, stem cell biology, and neurogenesis. However, the mechanisms of Wnt signal transmission,... 
associated degradation | R | Wnt signaling | 37 | 6 | GPR | LRP | ER | PAEL | GPR37 | PAEL-R | ER-associated degradation | LRP6 | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | MICE LACKING | CELL BIOLOGY | DEGRADATION | BONE | DIFFERENTIATION | WNT | PROTEINS | COMMON GENETIC-VARIATION | BINDING | Endoplasmic Reticulum-Associated Degradation | Phosphorylation | Molecular Chaperones - metabolism | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Endoplasmic Reticulum - metabolism | Wnt Proteins - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Wnt Proteins - genetics | Proteolysis | Mice | Parkinson Disease - metabolism | Receptors, G-Protein-Coupled - genetics | Neural Stem Cells - metabolism | Wnt Signaling Pathway | Propellers | Parkinson's disease | Wnt protein | Neurodegenerative diseases | Maturation | Parkinsons disease | Genomes | siRNA | Neurogenesis | Embryos | Proteins | Degradation | Embryonic growth stage | β-catenin | Receptors | Embryogenesis | Cellular biology | Quality control | Cells (biology) | Neural stem cells | Signal transmission | Hsc70 protein | Adenosine triphosphatase | Movement disorders | Index Medicus | Neuroscience | Scientific Reports | PAEL‐R | ER‐associated degradation | Protein Biosynthesis & Quality Control | Scientific Report | Basic Medicine | ER-associated degradation; GPR37; LRP6; PAEL-R; Wnt signaling | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cell- och molekylärbiologi
Journal Article
Developmental Cell, ISSN 1534-5807, 03/2016, Volume 36, Issue 5, pp. 485 - 486
Wnt ligands are secreted lipid-modified proteins that are essential for development and homeostasis. Published recently in , report that Wnt3 acts at a short... 
DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | Intestinal Mucosa - cytology | Animals | Stem Cell Niche | Female | Male | Wnt3 Protein - metabolism | Cell Membrane - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Wnt Signaling Pathway | Proteins | Protein binding | Index Medicus
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 09/2018, Volume 33, Issue 9, pp. 1698 - 1707
Journal Article