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The Journal of Cell Biology, ISSN 0021-9525, 05/2015, Volume 209, Issue 3, p. 327
Circulating platelets were thought to arise solely from the protrusion and fragmentation of megakaryocyte cytoplasm. Now, Nishimura et al. (2015. J. Cell Biol,... 
Bone marrow cells | Blood platelets | Interleukins | Health aspects
Journal Article
The Journal of Experimental Medicine, ISSN 0022-1007, 05/2015, Volume 212, Issue 5, pp. 2125 - 2125OIA24
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2014, Volume 124, Issue 1, pp. 273 - 284
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 26, pp. 3025 - 3026
A unique feature of megakaryocyte maturation is the switch from mitosis to replication of DNA without cell division, a process termed endomitosis. In this... 
MEGAKARYOCYTES | HEMATOLOGY | PROPLATELET FORMATION | MACROTHROMBOCYTOPENIA | rho-Associated Kinases - genetics | Polyploidy | rhoA GTP-Binding Protein - genetics | Humans | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2013, Volume 123, Issue 8, pp. 3331 - 3342
Platelets are anuclear organelle-rich cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity. The major platelet... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLYCOPROTEIN-VI | ALPHA-GRANULES | BLEEDING-TIME | INTEGRIN | IN-VIVO | ARTERIAL THROMBOSIS | NBEAL2 | GROWTH-FACTOR | PROTEINS | ISCHEMIC-STROKE | Care and treatment | Genetic aspects | Diagnosis | Research | Gene expression | Blood platelet disorders | Thrombosis | Blood clot | Proteins | Wound healing | Heart attacks | Blood platelets | Microscopy | Colleges & universities | Defects
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2013, Volume 19, Issue 9, pp. 1161 - 1165
The blood-brain barrier (BBB) is an integral part of the neurovascular unit (NVU). The NVU is comprised of endothelial cells that are interconnected by tight... 
MEDICINE, RESEARCH & EXPERIMENTAL | FATTY-ACIDS | MULTIPLE-SCLEROSIS | BLOOD-BRAIN-BARRIER | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Interferon-alpha - pharmacology | Peptide Fragments | Dendritic Cells | Encephalomyelitis, Autoimmune, Experimental - metabolism | Coculture Techniques | Humans | Actins - metabolism | Cell Adhesion Molecules - immunology | Anticonvulsants - pharmacology | MAP Kinase Signaling System | Brain - metabolism | Transendothelial and Transepithelial Migration | HEK293 Cells | Female | Potassium Channels, Tandem Pore Domain - metabolism | Blood-Brain Barrier - immunology | Cell Adhesion Molecules - biosynthesis | Endothelial Cells - metabolism | Intercellular Adhesion Molecule-1 - immunology | Down-Regulation | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Cells, Cultured | Myelin-Oligodendrocyte Glycoprotein | Potassium Channels, Tandem Pore Domain - genetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Intercellular Adhesion Molecule-1 - metabolism | Animals | Mice | Riluzole - pharmacology | Brain - immunology | Leukocytes - metabolism | Linseed Oil - administration & dosage | Cell Movement | Blood-brain barrier | Cellular control mechanisms | Central nervous system | Physiological aspects | Potassium channels | Research | Endothelium | Neurophysiology | Nervous system | Gene expression | Immune system | Cell adhesion & migration | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, pp. e0157607 - e0157607
Obesity is a major risk factor predisposing to the development of peripheral insulin resistance and type 2 diabetes (T2D). Elevated food intake and/or... 
SIGNALING PATHWAYS | INHIBITION | MULTIDISCIPLINARY SCIENCES | HUMAN PLATELETS | PPAR-GAMMA | CANCER | MTOR | Appetite | Glucose Intolerance - metabolism | Eating | Glucose Intolerance - genetics | Gene Expression Regulation | Insulin Resistance | Overweight - genetics | Male | Overweight - physiopathology | Hypothalamus - physiopathology | Phospholipase D - metabolism | Glucose Intolerance - blood | Overweight - metabolism | Animals | Hypothalamus - metabolism | Overweight - blood | Gene Deletion | Female | Mice | Phospholipase D - genetics | Fatty Acids - blood | Fatty Acids - metabolism | Glucose Intolerance - physiopathology | Neurosciences | Adipose tissue | Nuclear magnetic resonance--NMR | Body weight | Homeostasis | Lipids | Nervous system | Neuropeptides | Kinases | Body composition | Risk factors | Control | Clonal deletion | Energy | Energy dissipation | Rodents | Deletion | Diabetes mellitus (non-insulin dependent) | Phosphatidic acid | Energy intake | Enzymes | Hyperlipidemia | Diabetes mellitus | Cascade control | Energy expenditure | Metabolism | Mammals | Insulin | Body weight gain | Fatty acids | Thrombosis | Phospholipase D | Blood clots | Phospholipase | Signaling | Acids | Food intake | Isoforms | Insulin resistance | Alzheimers disease | Animal cognition | Index Medicus | Nuclear magnetic resonance | NMR
Journal Article
Journal Article