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Trends in Cell Biology, ISSN 0962-8924, 01/2019, Volume 29, Issue 1, pp. 80 - 92
Microtubules are subjected to a variety of post-translational modifications (PTMs). The combination of different α- and β-tubulin isoforms and PTMs are... 
detyrosination cycle | microtubules | vasohibins | tubulin tyrosine ligase | TYROSINE-LIGASE | STRUCTURAL BASIS | IN-VIVO | MITOTIC SPINDLE | ALPHA-TUBULIN | POSTTRANSLATIONAL MODIFICATIONS | RAT-BRAIN | GROWTH-FACTOR | ASTRAL MICROTUBULES | TUMOR-GROWTH | CELL BIOLOGY | Tyrosine | Proteins | Enzymes | Angiogenesis | Tubulin | Cellular biology | Mitosis | Microtubules | Isoforms | Post-translation | Cytoskeleton | Contraction
Journal Article
PLoS Biology, ISSN 1544-9173, 11/2013, Volume 11, Issue 11, p. e1001708
Several myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the... 
PATHOGENESIS | SYNTHASE KINASE-3 | STRUCTURAL BASIS | MOBILIZATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RABBIT SKELETAL-MUSCLE | DISEASE | BIOLOGY | ACCUMULATION | CELL-DEATH | POMPE | Proteins | Enzymes | Disease | Microscopy | Genes | Rodents | Muscular system | Kinases | Autophagy
Journal Article
Science, ISSN 0036-8075, 12/2017, Volume 358, Issue 6369, pp. 1453 - 1456
Tubulin is subjected to a number of posttranslational modifications to generate heterogeneous microtubules. The modifications include removal and ligation of... 
MICROTUBULES | ROLES | MULTIDISCIPLINARY SCIENCES | Tubulins | Cells | Tyrosine | Brain | Enzymes | Angiogenesis | Regulators | Tubulin | Microtubules | Carboxypeptidase | Genetic screening
Journal Article
Nature, ISSN 0028-0836, 01/2017, Volume 541, Issue 7637, pp. 412 - 416
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7657, pp. 307 - 307
As key executers of biological functions, the activity and abundance of proteins are subjected to extensive regulation. Deciphering the genetic architecture... 
YEAST | UBIQUITINATION | CIRCUITS | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | COMPLEXES | VIRUS ENTRY | SCREENS | NETWORKS | BETA-GAMMA-SUBUNITS | HUMAN INTERACTOME | Proto-Oncogene Proteins c-akt - chemistry | Receptors, G-Protein-Coupled - metabolism | Histones - chemistry | Humans | Cells, Cultured | Heterotrimeric GTP-Binding Proteins - metabolism | Signal Transduction - genetics | Potassium Channels - genetics | Potassium Channels - metabolism | Haploidy | Phenotype | Phosphorylation - genetics | Mutagenesis | Proteolysis | Single-Cell Analysis - methods | Receptors, G-Protein-Coupled - antagonists & inhibitors | Interferons - metabolism | Histones - metabolism | Potassium Channels - deficiency | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Wnt Signaling Pathway | Mitogen-Activated Protein Kinases - metabolism | Cell receptors | Genetic aspects | Cellular signal transduction | G proteins | Proteins | Cells | Networks | Deregulation | G protein-coupled receptors | Wnt protein | Transcription | Genes | Gene regulation | Switching theory | AKT protein | Kinases | Guanine nucleotide-binding protein | Gene sequencing | Wiring | Signal transduction | Maps | Pathways | Cascades | Random mutagenesis | Single-cell protein | Genetics | Cues | Splicing | Architecture | MAP kinase | Abundance | Exposure | Gene expression | Suppressors | Biological activity | Protein kinase | Interferon | Mutation | Methylation | Gene mapping | Cancer | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 02/2015, Volume 11, Issue 2
  Given the diversity of autophagy targets and regulation, it is important to characterize autophagy in various cell types and conditions. We used a primary... 
Proteins | Musculoskeletal system | Yeast | Insects | Rodents | Regulation | Kinases | Metabolism | Mammals | Experiments | Autophagy | Cytoplasm
Journal Article
NATURE STRUCTURAL & MOLECULAR BIOLOGY, ISSN 1545-9993, 07/2019, Volume 26, Issue 7, pp. 567 - 567
Journal Article
PLoS Biology, ISSN 1544-9173, 11/2013, Volume 11, Issue 11
  Several myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the... 
Proteins | Enzymes | Disease | Microscopy | Genes | Rodents | Muscular system | Kinases | Autophagy
Journal Article
PLoS Genetics, ISSN 1553-7390, 2015, Volume 11, Issue 2, pp. 1 - 27
Given the diversity of autophagy targets and regulation, it is important to characterize autophagy in various cell types and conditions. We used a primary... 
RAB3 SUBFAMILY | FUSION | HIT SELECTION | GENETICS & HEREDITY | DYNAMICS | TRAFFICKING | NEURODEGENERATION | PRIMARY-CELLS | PROTEINS | IDENTIFICATION | HOPS COMPLEX | Proteins | Musculoskeletal system | Yeast | Insects | Rodents | Regulation | Kinases | Metabolism | Mammals | Experiments | Autophagy | Cytoplasm
Journal Article
Journal Article
Molecular Oncology, ISSN 1574-7891, 06/2018, Volume 12, Issue 6, pp. 953 - 971
The absence of biomarkers to accurately predict anticancer therapy response remains a major obstacle in clinical oncology. We applied a genome‐wide... 
vinorelbine | haploid screens | docetaxel | FBXW7 | VINCA ALKALOIDS | UBIQUITIN LIGASE | SPINDLE ASSEMBLY CHECKPOINT | RETINOBLASTOMA GENE | CELL LUNG-CANCER | BREAST-CANCER | ONCOLOGY | MITOTIC SPINDLE | RESISTANCE | TUMOR-SUPPRESSOR | ANTICANCER DRUGS | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 12/2018, Volume 78, Issue 23, pp. 6621 - 6631
Neuroblastoma is the second most common tumor in children. The cause of neuroblastoma is thought to lie in aberrant development of embryonic neural crest cells... 
APOPTOSIS | ACTIVATION | ONCOLOGY | CLASS-I | GENE-EXPRESSION | NEURONAL DIFFERENTIATION | ANTIGENS | INHIBITOR | NF-KAPPA-B | CANCER | CHILDREN
Journal Article