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science & technology (145) 145
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systemic lupus erythematosus (76) 76
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1. Full Text Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus
by Jenks, Scott A and Cashman, Kevin S and Zumaquero, Esther and Marigorta, Urko M and Patel, Aakash V and Wang, Xiaoqian and Tomar, Deepak and Woodruff, Matthew C and Simon, Zoe and Bugrovsky, Regina and Blalock, Emily L and Scharer, Christopher D and Tipton, Christopher M and Wei, Chungwen and Lim, S. Sam and Petri, Michelle and Niewold, Timothy B and Anolik, Jennifer H and Gibson, Greg and Lee, F. Eun-Hyung and Boss, Jeremy M and Lund, Frances E and Sanz, Ignacio
Immunity (Cambridge, Mass.), ISSN 1074-7613, 10/2018, Volume 49, Issue 4, pp. 725 - 739.e6
Systemic Lupus Erythematous | Autoimmunity | human B cells | TRAF5 | Toll-like receptor 7 | effector | plasma cells | T-bet | CD11c | Life Sciences & Biomedicine | Immunology | Science & Technology | Toll-Like Receptor 7 - genetics | Gene Regulatory Networks - genetics | Toll-Like Receptor 7 - metabolism | Humans | Middle Aged | Lupus Erythematosus, Systemic - metabolism | Male | Transcriptome - genetics | Transcriptome - immunology | Young Adult | B-Lymphocytes - immunology | B-Lymphocyte Subsets - metabolism | Lupus Erythematosus, Systemic - genetics | Toll-Like Receptor 7 - immunology | Lupus Erythematosus, Systemic - immunology | Aged, 80 and over | Adult | B-Lymphocyte Subsets - immunology | Female | Plasma Cells - metabolism | Aged | Gene Regulatory Networks - immunology | B-Lymphocytes - metabolism | Plasma Cells - immunology | Lupus | Autoantibodies | Systemic lupus erythematosus | Interleukins | Microbiology | B cells | CD27 antigen | Flow cytometry | Nephritis | Target recognition | Transcription | Interleukin | Effector cells | Immunoglobulin D | Proteins | Cell activation | CXCR5 protein | Human immunodeficiency virus--HIV | Interleukin 21 | Toll-like receptors | Immune system | CD11c antigen | Statistical analysis | TLR7 protein | Therapeutic applications | T cell receptors | Gene expression | Ribonucleic acid--RNA | Polymerase chain reaction | Chronic conditions | Lymphocytes B | Plasma cells | Software | Autoimmune diseases | Differentiation | Index Medicus | Toll like receptor 7 | T-Bet
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2. Full Text Spotlight on blisibimod and its potential in the treatment of systemic lupus erythematosus: Evidence to date
by Lenert, Aleksander and Niewold, Timothy B and Lenert, Petar
Drug design, development and therapy, ISSN 1177-8881, 03/2017, Volume 11, pp. 747 - 757
Lupus | BAFF | B cells | APRIL | Blisibimod | B-Cell Activating Factor - metabolism | Recombinant Fusion Proteins - pharmacology | B-Cell Activating Factor - antagonists & inhibitors | Humans | Recombinant Fusion Proteins - therapeutic use | Lupus Erythematosus, Systemic - drug therapy | Lupus Erythematosus, Systemic - metabolism | Systemic lupus erythematosus | Physiological aspects | Monoclonal antibodies | Drug therapy | Health aspects | Testing | Disease | Peptides | Immunoglobulin G | Clinical trials | Arthritis | Experiments | Cell growth | Immunology | Tumor necrosis factor-TNF | Safety | Medical research | Antigens | Immunoglobulins | Cytokines | Rheumatology | Trimers | Patients | Chronic conditions | Immunogenicity | Lymphocytes B | Tumor necrosis factor | BLyS protein | Affinity | Avidity | Autoimmune diseases | Index Medicus
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3. Full Text Interferon Alpha as a Primary Pathogenic Factor in Human Lupus
by Niewold, Timothy B
Journal of interferon & cytokine research, ISSN 1079-9907, 12/2011, Volume 31, Issue 12, pp. 887 - 892
Reviews | Biochemistry & Molecular Biology | Immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Genetic Predisposition to Disease | Virus Diseases - immunology | Humans | Interferon Regulatory Factors - genetics | Lupus Erythematosus, Systemic - blood | Signal Transduction - genetics | Interferon-alpha - immunology | Polymorphism, Genetic | Signal Transduction - immunology | Interferon Regulatory Factors - immunology | Models, Immunological | Interferon-alpha - blood | Lupus Erythematosus, Systemic - genetics | Lupus Erythematosus, Systemic - immunology | Receptors, Immunologic - immunology | Receptors, Immunologic - genetics | Virus Diseases - genetics | Index Medicus
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4. Full Text Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification
by Munroe, Melissa E and Lu, Rufei and Zhao, Yan D and Fife, Dustin A and Robertson, Julie M and Guthridge, Joel M and Niewold, Timothy B and Tsokos, George C and Keith, Michael P and Harley, John B and James, Judith A
Annals of the rheumatic diseases, ISSN 0003-4967, 11/2016, Volume 75, Issue 11, pp. 2014 - 2021
Autoimmunity | Systemic Lupus Erythematosus | Autoantibodies | Cytokines | Chemokines | Life Sciences & Biomedicine | Rheumatology | Science & Technology | Multivariate Analysis | Autoantibodies - blood | Humans | Male | Lupus Erythematosus, Systemic - blood | Case-Control Studies | Lupus Erythematosus, Systemic - diagnosis | Time Factors | Interferon Type I - blood | Interferon-alpha - blood | Lupus Erythematosus, Systemic - immunology | Adult | Female | B-Cell Activating Factor - blood | Interferon-gamma - blood | Interferon alfa-2a | Usage | Systemic lupus erythematosus | Diagnosis | Patients | Health aspects | Index Medicus | Humoral Immunity | Interferons | Pre-clinical Autoimmunity
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5. Full Text Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus
by Ritterhouse, Lauren L and Crowe, Sherry R and Niewold, Timothy B and Kamen, Diane L and Macwana, Susan R and Roberts, Virginia C and Dedeke, Amy B and Harley, John B and Scofield, R Hal and Guthridge, Joel M and James, Judith A
Annals of the rheumatic diseases, ISSN 0003-4967, 09/2011, Volume 70, Issue 9, pp. 1569 - 1574
Life Sciences & Biomedicine | Rheumatology | Science & Technology | Biological and medical sciences | Medical sciences | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Diseases of the osteoarticular system | Vitamin D Deficiency - complications | Humans | Lupus Erythematosus, Systemic - etiology | Case-Control Studies | Vitamin D - blood | Lymphocyte Activation - immunology | B-Lymphocytes - immunology | Autoimmunity - immunology | Antibodies, Antinuclear - blood | Interferon-alpha - blood | Lupus Erythematosus, Systemic - immunology | Female | Vitamin D - analogs & derivatives | Vitamin D Deficiency - immunology | Vitamin D deficiency | Autoantibodies | Systemic lupus erythematosus | Patient outcomes | Interferon alpha | Development and progression | B cells | Research | Studies | Lupus | Inflammatory bowel disease | Vitamin D | Disease | Dendritic cells | Pathogenesis | Vitamin deficiency | Diabetes | Index Medicus
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6. Full Text Immunogenetics of systemic lupus erythematosus: A comprehensive review
by Ghodke-Puranik, Yogita and Niewold, Timothy B
Journal of autoimmunity, ISSN 0896-8411, 2015, Volume 64, pp. 125 - 136
Allergy and Immunology | Genetics | Interferon | Systemic lupus erythematosus | Autoimmune diseases | Life Sciences & Biomedicine | Immunology | Science & Technology | Genetic Predisposition to Disease | Major Histocompatibility Complex - genetics | Signal Transduction | Epigenesis, Genetic | Humans | Open Reading Frames | Regulatory Sequences, Nucleic Acid | Autoimmune Diseases - immunology | Lupus Erythematosus, Systemic - metabolism | Genetic Loci | Multifactorial Inheritance | Polymorphism, Genetic | Autoimmune Diseases - genetics | Immunogenetics | Animals | Lupus Erythematosus, Systemic - genetics | Lupus Erythematosus, Systemic - immunology | Interferon Type I - genetics | Interferon Type I - metabolism | Major Histocompatibility Complex - immunology | Autoimmune Diseases - metabolism | Lupus | Epigenetic inheritance | Genetic polymorphisms | Index Medicus | autoimmune diseases | systemic lupus erythematosus | genetics | interferon
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7. Full Text Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study
by Lessard, Christopher J and Adrianto, Indra and Ice, John A and Wiley, Graham B and Kelly, Jennifer A and Glenn, Stuart B and Adler, Adam J and Li, He and Rasmussen, Astrid and Williams, Adrienne H and Ziegler, Julie and Comeau, Mary E and Marion, Miranda and Wakeland, Benjamin E and Liang, Chaoying and Ramos, Paula S and Grundahl, Kiely M and Gallant, Caroline J and Alarcón, Graciela S and Anaya, Juan-Manuel and Bae, Sang-Cheol and Boackle, Susan A and Brown, Elizabeth E and Chang, Deh-Ming and Cho, Soo-Kyung and Criswell, Lindsey A and Edberg, Jeffrey C and Freedman, Barry I and Gilkeson, Gary S and Jacob, Chaim O and James, Judith A and Kamen, Diane L and Kimberly, Robert P and Kim, Jae-Hoon and Martin, Javier and Merrill, Joan T and Niewold, Timothy B and Park, So-Yeon and Petri, Michelle A and Pons-Estel, Bernardo A and Ramsey-Goldman, Rosalind and Reveille, John D and Scofield, R. Hal and Song, Yeong Wook and Stevens, Anne M and Tsao, Betty P and Vila, Luis M and Vyse, Timothy J and Yu, Chack-Yung and Guthridge, Joel M and Kaufman, Kenneth M and Harley, John B and Wakeland, Edward K and Langefeld, Carl D and Gaffney, Patrick M and Montgomery, Courtney G and Moser, Kathy L and Marta E. Alarcón-Riquelme for the BIOLUPUS and GENLES Networks and BIOLUPUS Network and GENLES Network
American journal of human genetics, ISSN 0002-9297, 04/2012, Volume 90, Issue 4, pp. 648 - 660
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Hispanic Americans - genetics | Membrane Proteins - genetics | Humans | Asian Continental Ancestry Group - genetics | Interferon Regulatory Factors - genetics | Male | Chromosome Mapping | Sequence Analysis, DNA | Ikaros Transcription Factor - genetics | Haplotypes - genetics | Lupus Erythematosus, Systemic - ethnology | Lupus Erythematosus, Systemic - genetics | Indians, North American - genetics | Polymorphism, Single Nucleotide - genetics | Female | African Continental Ancestry Group - genetics | Egg Proteins - genetics | Europeans | Lupus erythematosus | Genetic aspects | Research | Genetic transcription | Gene expression | Genetic regulation | Risk factors | Diseases | Lupus | Disease susceptibility | Systemic lupus erythematosus | Racially mixed people | Analysis | Haplotypes | Genetics | Gene loci | Minority & ethnic groups | Genomics | Ikaros protein | Autoantigens | Environmental factors | Immunological tolerance | Zona pellucida | Membrane proteins | Etiology | Interleukin 1 | Replication | Zinc finger proteins | Autoimmune diseases | Gene mapping | Interferon regulatory factor | Index Medicus | Medicin och hälsovetenskap
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