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Nature Medicine, ISSN 1078-8956, 11/2015, Volume 21, Issue 11, pp. 1262 - 1271
Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER CACHEXIA | CELLS | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | CELL BIOLOGY | DYSTROPHIC MUSCLE | GROWTH-FACTOR-BETA | HORMONE-RELATED PROTEIN | RYANODINE RECEPTOR | CAMURATI-ENGELMANN-DISEASE | IN-VIVO | Neoplasms - metabolism | Prostatic Neoplasms - metabolism | Up-Regulation | Calcium - metabolism | Humans | Lung Neoplasms - metabolism | NADPH Oxidases - metabolism | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Muscle, Skeletal - metabolism | Osteolysis - etiology | Ryanodine Receptor Calcium Release Channel - metabolism | X-Ray Microtomography | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Neoplasms - complications | MCF-7 Cells | Osteolysis - diagnostic imaging | Muscle Proteins - metabolism | NADPH Oxidases - genetics | Female | Camurati-Engelmann Syndrome - metabolism | Muscle Strength | Calcium Signaling | Disease Models, Animal | Muscle Weakness - etiology | Prostatic Neoplasms - pathology | Oxidation-Reduction | Bone Neoplasms - diagnostic imaging | NADPH Oxidase 4 | Mice, SCID | Multiple Myeloma - metabolism | Absorptiometry, Photon | Osteolysis - metabolism | Multiple Myeloma - pathology | Animals | Muscle Contraction | Breast Neoplasms - pathology | Mice, Nude | Muscle Weakness - metabolism | Cell Line, Tumor | Mice | Neoplasms - pathology | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2015, Volume 21, Issue 11, p. 1262
  Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no effective treatment. Here we find that seven different mouse models of... 
Genetically modified mice | Care and treatment | Analysis | Muscles | Research | Bone diseases | Transforming growth factors | Prostate cancer | Musculoskeletal system | Signal transduction | Bones | Metastasis | Growth factors | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2009, Volume 4, Issue 9, pp. e6896 - e6896
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2009, Volume 4, Issue 4, pp. e5275 - e5275
During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these,... 
MULTIDISCIPLINARY SCIENCES | Bone Matrix - metabolism | Bone Development - drug effects | Calcification, Physiologic - drug effects | Mice, Inbred C57BL | Male | Core Binding Factor Alpha 1 Subunit - metabolism | Osteoclasts - metabolism | Receptor, EphB4 - metabolism | Bone and Bones - anatomy & histology | Bone Density - drug effects | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Cell Differentiation - drug effects | Bone and Bones - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Bone Resorption - metabolism | Female | Mice | Protein Kinase Inhibitors - pharmacology | Osteoblasts - metabolism | Transforming Growth Factor beta - metabolism | Bone and Bones - cytology | Laboratories | Materials science | Hormones | Bone (trabecular) | Osteoblasts | Bone resorption | Biomedical materials | Bone growth | Quality standards | Electric power | Surgery | Bone marrow | Extracellular matrix | Biocompatibility | Bones | Test methods | Skeleton | Inhibition | Bone matrix | Growth factors | Bone strength | Cbfa-1 protein | Vertebrae | Architecture | Internal medicine | Mechanical properties | Pharmacology | Fragility | Fracture toughness | Medicine | Studies | Osteoclastogenesis | Osteoblastogenesis | Bone mass | Inhibitors | Osteoclasts | Genetic engineering | Bone | Differentiation | Endocrinology | Osteogenesis | Index Medicus
Journal Article
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 2001, Volume 16, Issue 8, pp. 1486 - 1495
Breast cancer has a predilection for spreading to bone. The mechanism of preferential metastasis of breast cancer to bone is unknown. We hypothesize that... 
Bone metastasis | Breast cancer | Insulin-like growth factor | Transforming growth factor β | Parathyroid hormone-related protein | ONCOPROTEIN | ANTAGONIST | bone metastasis | SMAD PROTEINS | transforming growth factor beta | parathyroid hormone-related protein | METASTASES | breast cancer | RECEPTOR | GROWTH-FACTOR-BETA | INHIBITION | HORMONE-RELATED PROTEIN | PROSTATE-CANCER | ENDOCRINOLOGY & METABOLISM | insulin-like growth factor | MODULATION | Insulin-Like Growth Factor I - pharmacology | Protein Biosynthesis | Humans | Transcriptional Activation | Parathyroid Hormone-Related Protein | Bone Neoplasms - secondary | Brain - physiology | Cell Culture Techniques - methods | Brain Neoplasms - secondary | Chemotaxis - physiology | Cell Division | Insulin-Like Growth Factor II - pharmacology | Mammary Neoplasms, Experimental - pathology | Neoplasms, Experimental | Female | Clone Cells | Plasminogen Activator Inhibitor 1 - genetics | Tumor Cells, Cultured | Promoter Regions, Genetic | Gene Expression | Transforming Growth Factor beta1 | Bone and Bones - physiology | Signal Transduction | Agar | Cell Adhesion | Insulin-Like Growth Factor II - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Breast Neoplasms - pathology | Mice, Nude | Mice | Transforming Growth Factor beta - metabolism | Insulin-Like Growth Factor I - metabolism | Index Medicus
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 733 - 733
Journal Article
Oncotarget, ISSN 1949-2553, 10/2017, Volume 8, Issue 49, pp. 86447 - 86462
More efficient therapies that target multiple molecular mechanisms are needed for the treatment of incurable bone metastases. Halofuginone is a plant... 
Halofuginone | Zoledronic acid | TGF-β | BMP | Bone metastases | FIBROSIS | CELLS | ACTIVATION | MECHANISMS | halofuginone | CELL BIOLOGY | TGF-beta | BISPHOSPHONATES | RECEPTOR KINASE INHIBITOR | zoledronic acid | GROWTH | DISEASE | bone metastases | MORPHOGENETIC PROTEINS | PROGRESSION
Journal Article