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BMC bioinformatics, ISSN 1471-2105, 06/2019, Volume 20, Issue 1, pp. 304 - 20
Journal Article
BMC Bioinformatics, ISSN 1471-2105, 11/2018, Volume 19, Issue 1, pp. 453 - 19
BackgroundLarge-scale pairwise drug combination analysis has lately gained momentum in drug discovery and development projects, mainly due to the employment of... 
Therapeutic synergy | Drug combination analysis | Time-lapse video microscopy | Parallel image processing | Systematic parameter optimization | Label-free | Glioblastoma multiforme | MapReduce | BIOCHEMICAL RESEARCH METHODS | MODEL | CELL-LINES | DISCOVERY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SYNERGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | RESISTANCE | LEUKEMIA | Cell Survival - drug effects | Microscopy, Video - methods | Algorithms | Image Processing, Computer-Assisted | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Humans | Brain Neoplasms - drug therapy | Drug Therapy, Combination | Glioblastoma - drug therapy | Drug Discovery | Motion Pictures | Science | Usage | Drug therapy, Combination | Analysis | Time-lapse photography | Computer programs | Neuroimaging | Brain | Image processing | Toxicity | Computational neuroscience | Brain cancer | Leukemia | Brain tumors | Glioblastoma | Cytology | Medical services | Cytotoxicity | Cancer therapies | Cell morphology | Personal computers | Microprocessors | Glioma cells | Cell cycle | Parallel processing | Bioinformatics | Automation | Medical imaging | Astrocytes | Medical treatment | Pharmacology | Pipelining (computers) | Microscopy | Computation | Modular equipment | Morphology | Computer applications | Software | Drug discovery | Viability | Cancer | Development projects | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinsk bioteknologi | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medical Biotechnology
Journal Article
EBioMedicine, ISSN 2352-3964, 10/2015, Volume 2, Issue 10, pp. 1351 - 1363
Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is essentially incurable and its resistance to therapy is attributed to... 
Cell culture | Xenograft models | Molecular subtype | Stem cell culture condition | Glioblastoma | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | SENSITIVITY | MARKERS | IDENTIFICATION | LINES | GLIAL TUMORS | HETEROGENEITY | EXPRESSION | BRAIN | PROGRESSION | Genomic Instability | Cell Proliferation | Prognosis | Humans | Middle Aged | Gene Expression Profiling | Biomarkers, Tumor | DNA Copy Number Variations | Young Adult | Heterografts | Neoplasm Grading | Glioblastoma - genetics | Aged, 80 and over | Adult | Tumor Cells, Cultured | Disease Models, Animal | Kaplan-Meier Estimate | Glioblastoma - surgery | Animals | Cell Transformation, Neoplastic | Biological Specimen Banks | Glioblastoma - pathology | Cell Line, Tumor | Aged | Mice | Neoplasm Staging | Glioblastoma - mortality | Cluster Analysis | Clinical Laboratory Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinsk bioteknologi | Patologi | Klinisk medicin | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Klinisk laboratoriemedicin | Clinical Medicine | Medical Biotechnology | Pathology | Cancer and Oncology | Cancer och onkologi
Journal Article
Quality of Life Research, ISSN 0962-9343, 11/2015, Volume 24, Issue 11, pp. 2795 - 2805
Journal Article
Cancer Research, ISSN 0008-5472, 04/2017, Volume 77, Issue 7, pp. 1741 - 1752
Glioma-initiating cells (GIC) are considered the underlying cause of recurrences of aggressive glioblastomas, replenishing the tumor population and undermining... 
INHIBITION | ONCOLOGY | HUMAN GLIOBLASTOMA | HIGH-THROUGHPUT | GENE-EXPRESSION | T-TYPE | MULTIDRUG-RESISTANCE | IDENTIFICATION | CULTURE | TUMOR-INITIATING CELLS | CANCER STEM-CELLS | Unfolded Protein Response - drug effects | Calcium Channels, T-Type - physiology | Humans | Brain Neoplasms - pathology | Sodium - metabolism | Brain Neoplasms - drug therapy | Calcium Channel Blockers - pharmacology | Brain Neoplasms - metabolism | Glioma - metabolism | Amino Acids - metabolism | Animals | Biological Transport | Glioma - pathology | Cell Death | Proteomics | Cell Line, Tumor | Dihydropyridines - pharmacology | Neoplastic Stem Cells - pathology | Mice | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Mycotoxins - pharmacology | Glioma - drug therapy | Drugs | Brain tumors | Glioblastoma | Bioelectricity | Amino acids | Drug development | Channels | Potassium channels (calcium-gated) | Depolarization | Protein folding | Glioma cells | Nutrients | Membrane potential | Protein transport | Calcium channels | Starvation | Integrated approach | Nutrient transport | Cell survival | Mortality | Calcium channels (voltage-gated) | Calcium channels (T-type) | Signaling | Chemotherapy | Acids | Cell death | Transport | Cancer | Apoptosis | Life Sciences | Cellular Biology | Medical Biotechnology | Medical and Health Sciences | Medicin och hälsovetenskap | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medicinsk bioteknologi
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e42488
Platelet-derived growth factor (PDGF) plays an important role in development of the central nervous system, including the retina. Excessive PDGF signaling is... 
OPTIC-NERVE | PERSISTENT FETAL VASCULATURE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DEVELOPING MOUSE EYE | MICE | OVEREXPRESSING PDGF-B | DIFFERENTIATION | GLIAL-CELLS | ASTROCYTES | PRECURSOR CELLS APCS | Retina - metabolism | Intraocular Pressure - drug effects | Retina - growth & development | Capillaries - pathology | Gene Expression - drug effects | Neuroglia - pathology | Humans | Astrocytes - pathology | Capillaries - drug effects | Stem Cells - metabolism | Cell Lineage - drug effects | Neovascularization, Pathologic - pathology | Retinal Vessels - pathology | Time Factors | Neovascularization, Pathologic - physiopathology | Cell Death - drug effects | Capillaries - metabolism | Biomarkers - metabolism | Astrocytes - drug effects | Proto-Oncogene Proteins c-sis - metabolism | Retinal Vessels - metabolism | Retina - physiopathology | Transgenes - genetics | Mice, Transgenic | Pyrimidines - pharmacology | Capillaries - growth & development | Imatinib Mesylate | Piperazines - pharmacology | Cell Movement - drug effects | Animals | Retinal Vessels - growth & development | Retinal Vessels - physiopathology | Stem Cells - drug effects | Stem Cells - pathology | Neuroglia - metabolism | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Protein Kinase Inhibitors - pharmacology | Benzamides | Photoreceptor Cells, Vertebrate - metabolism | Photoreceptor Cells, Vertebrate - pathology | Retina - pathology | Genetic engineering | Platelet-derived growth factor | Glaucoma | Diabetic retinopathy | Neurosciences | Nestin | Genes | Central nervous system | Retina | Kinases | Proteins | Immunology | Transgenic animals | Rodents | Neostriatum | Capillaries | Growth factors | Ventricle (lateral) | Phenotypes | Abnormalities | Transgenic mice | Blood vessels | Corpus striatum | Laminates | Pathology | Signaling | Overexpression | Lamination | Photoreceptors | Adults | Laboratory animals | Apoptosis | Intraocular pressure | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Cell Reports, ISSN 2211-1247, 12/2016, Volume 17, Issue 11, pp. 2994 - 3009
Journal Article
Cell, ISSN 0092-8674, 07/2017, Volume 170, Issue 2, p. 407
Our study reported the discovery of a class of small molecules that induces the massive vacuolization and cell death of glioblastoma cells in vitro, attenuates... 
Journal Article
Experimental Cell Research, ISSN 0014-4827, 2010, Volume 316, Issue 17, pp. 2779 - 2789
Journal Article