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1. Full Text Capillary dynamics, interstitial fluid and the lymphatic system
by Haggerty, Andrew and Nirmalan, Mahesh
Anaesthesia & Intensive Care Medicine, ISSN 1472-0299, 03/2019, Volume 20, Issue 3, pp. 182 - 189
The regulation of small blood vessels (arterioles, venules and capillaries) and the formation of interstitial fluid at the capillary beds is an important... 
endothelial glycocalyx | Circulating volume | oedema | Starling's forces | sub-glycocalyx space
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2. Full Text Homeostasis in dynamic self-regulatory physiological systems
by Nirmalan, Niroshini and Nirmalan, Mahesh
Anaesthesia & Intensive Care Medicine, ISSN 1472-0299, 10/2017, Volume 18, Issue 10, pp. 513 - 518
Understanding the general principles of homeostasis and its regulation in health and disease is key to managing patients in intensive care units and operating... 
Homeostasis | physiological steady state | neural and hormonal control | self-regulatory systems | regulation | milieu-interieur
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3. Full Text Hormonal control of metabolism: regulation of plasma glucose
by Nirmalan, Niroshini and Nirmalan, Mahesh
Anaesthesia & Intensive Care Medicine, ISSN 1472-0299, 10/2017, Volume 18, Issue 10, pp. 502 - 507
Blood glucose concentrations are required to be maintained within a narrow therapeutic range in order to ensure the normal functioning of the body. This is... 
glucose homeostasis | Brain-islet axis | insulin | glycogenolysis | glucagon | gluconeogenesis | neuro-hormonal regulation
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4. Full Text Broader applications of arterial pressure wave form analysis
by Nirmalan, Mahesh and Dark, Paul M
Continuing Education in Anaesthesia Critical Care & Pain, ISSN 1743-1816, 12/2014, Volume 14, Issue 6, pp. 285 - 290
1A03 | 2A04
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5. Full Text Emerging trends in minimally invasive haemodynamic monitoring and optimization of fluid therapy
by Benington, Steve and Ferris, Paul and Nirmalan, Mahesh
European Journal of Anaesthesiology, ISSN 0265-0215, 11/2009, Volume 26, Issue 11, pp. 893 - 905
BACKGROUNDFor decades the pulmonary artery catheter has been the mainstay of cardiac output monitoring in critically ill patients, and pressure-based indices... 
Cardiac output | History | Physiologic | Analysis | Methods | Monitoring | CENTRAL VENOUS-PRESSURE | methods | INTRATHORACIC BLOOD-VOLUME | physiologic | CRITICALLY-ILL | history | PULMONARY-ARTERY | analysis | monitoring | EXTRAVASCULAR LUNG WATER | cardiac output | CONTINUOUS CARDIAC-OUTPUT | MECHANICALLY VENTILATED PATIENTS | STROKE VOLUME VARIATION | ANESTHESIOLOGY | ARTERIAL-PRESSURE WAVE | PULSE-CONTOUR ANALYSIS
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6. Full Text Biophysical Characterization of the Underappreciated and Important Relationship Between Heart Rate Variability and Heart Rate
by Monfredi, Oliver and Lyashkov, Alexey E and Johnsen, Anne-Berit and Inada, Shin and Schneider, Heiko and Wang, Ruoxi and Nirmalan, Mahesh and Wisloff, Ulrik and Maltsev, Victor A and Lakatta, Edward G and Zhang, Henggui and Boyett, Mark R
Hypertension, ISSN 0194-911X, 12/2014, Volume 64, Issue 6, pp. 1334 - 1343
Heart rate (HR) variability (HRV; beat-to-beat changes in the R-wave to R-wave interval) has attracted considerable attention during the past 30+ years (PubMed... 
physiology | sinoatrial node | autonomic nervous system | ion channels | MORTALITY | CELLS | MYOCARDIAL-INFARCTION | PACEMAKER ACTIVITY | HUMANS | RISK | CARDIOVASCULAR CONTROL | PERIPHERAL VASCULAR DISEASE | MICE | SPECTRAL-ANALYSIS | Heart - physiopathology | Rabbits | Animals | Heart Diseases - physiopathology | Humans | Electrocardiography | Heart Rate - physiology | Rats | Autonomic Nervous System - physiopathology | Disease Models, Animal | Heart - innervation
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7. Full Text Steroid-sensitive post-viral inflammatory pneumonitis (PVIP)
by Roberts, Catherine and Nirmalan, Mahesh and O'Shea, Sarah
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2010, Volume 182, Issue 8, pp. 1089 - 1090
RESPIRATORY SYSTEM | RESPIRATORY-DISTRESS-SYNDROME | CRITICAL CARE MEDICINE | Methylprednisolone - therapeutic use | Humans | Pneumonia, Viral - complications | Respiratory Distress Syndrome, Adult - virology | Anti-Inflammatory Agents - therapeutic use | Influenza A Virus, H1N1 Subtype | Adult | Male | Respiratory Distress Syndrome, Adult - drug therapy | Pneumonia, Viral - virology
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8. Full Text High positive end-expiratory pressure and mortality in acute respiratory distress syndrome
by Phoenix, Susan I and Nirmalan, Mahesh
Anesthesiology, ISSN 0003-3022, 2009, Volume 111, Issue 6, pp. 1390 - 1391
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9. Full Text Does a higher positive end expiratory pressure decrease mortality in acute respiratory distress syndrome?: A systematic review and meta-analysis
by Phoenix, Susan I and Paravastu, Sharath and Columb, Malachy and Vincent, Jean-Louis and Nirmalan, Mahesh
Anesthesiology, ISSN 0003-3022, 2009, Volume 110, Issue 5, pp. 1098 - 1105
Background: Positive end expiratory pressure (PEEP) is an important component of therapy in patients with acute lung injury or acute respiratory distress... 
RECRUITMENT | TIDAL VOLUME | QUALITY | VENTILATION STRATEGY | BIAS | ACUTE LUNG INJURY | ANESTHESIOLOGY | RANDOMIZED CONTROLLED-TRIAL | Positive-Pressure Respiration - trends | Respiratory Distress Syndrome, Adult - physiopathology | Respiratory Distress Syndrome, Adult - mortality | Randomized Controlled Trials as Topic - methods | Humans | Positive-Pressure Respiration - mortality
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10. Full Text TGF-β1-Mediated Fibrosis and Ion Channel Remodeling Are Key Mechanisms in Producing the Sinus Node Dysfunction Associated With SCN5A Deficiency and Aging
by Hao, Xiaojin and Zhang, Yanmin and Zhang, Xinzhao and Nirmalan, Mahesh and Davies, Laura and Konstantinou, Dimitrios and Yin, Fei and Dobrzynski, Halina and Wang, Xin and Grace, Andrew and Zhang, Henggui and Boyett, Mark and Huang, Christopher L.-H and Lei, Ming
Circulation: Arrhythmia and Electrophysiology, ISSN 1941-3149, 06/2011, Volume 4, Issue 3, pp. 397 - 406
BACKGROUND—Mutations in the cardiac Na channel gene (SCN5A) can adversely affect electric function in the heart, but effects can be age dependent. We explored... 
Aging | Nav1.5 protein | Ion channels | Remodeling | Sinoatrial node | Immunohistochemistry | Heart - embryology | Humans | RNA - genetics | Aging - genetics | Computer Simulation | Myocardium - metabolism | Polymerase Chain Reaction | Sick Sinus Syndrome - genetics | NAV1.5 Voltage-Gated Sodium Channel | Sodium Channels - deficiency | Disease Models, Animal | Heart Conduction System - metabolism | Cells, Cultured | Sinoatrial Node - physiopathology | Myocardium - pathology | Mice, Knockout | Sinoatrial Node - pathology | Animals | Heart Conduction System - physiopathology | Sick Sinus Syndrome - metabolism | Sick Sinus Syndrome - physiopathology | Myocytes, Cardiac - metabolism | Sinoatrial Node - metabolism | Mice | Sodium Channels - genetics | Mutation | Ion Channel Gating | Aging - metabolism
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11. Short Cold Ischaemic Times Improve Cytokine, Diabetic and Clinical Markers in Pancreas Transplantation
by Khambalia, Hussein and Moinuddin, Zia and van Dellen, David and Nirmalan, Mahesh and Alexander, Yvonne and Augustine, Titus
Transplantation, ISSN 0041-1337, 09/2013, Volume 96, pp. 287 - 287
Prolonged cold ischaemic time (CIT) correlates to poor immediate outcomes following pancreas transplantation, possibly due to increased effects of... 
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12. Full Text The effects of tumor necrosis factor‐alpha on systolic and diastolic function in rat ventricular myocytes
by Greensmith, David J and Nirmalan, Mahesh
Physiological Reports, ISSN 2051-817X, 09/2013, Volume 1, Issue 4, pp. e00093 - n/a
The proinflammatory cytokine tumor necrosis factor‐alpha (TNF‐α) is associated with myocardial dysfunction observed in sepsis and septic shock. There are two... 
tumor necrosis factor‐alpha | Calcium | myocyte | L‐type calcium channel | sarcoplasmic reticulum | Calcium (intracellular) | Cardiac muscle | Contractility | Septic shock | Inflammation | Myocytes | Glucose | Muscle contraction | Studies | Sarcoplasmic reticulum | Tumor necrosis factor | Sepsis | Tumor necrosis factor-TNF | Ventricle | Heart diseases | tumor necrosis factor-alpha | L-type calcium channel | Original Research
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13. Full Text The effects of hydrogen peroxide on intracellular calcium handling and contractility in the rat ventricular myocyte
by Greensmith, David J and Eisner, David A and Nirmalan, Mahesh
Cell Calcium, ISSN 0143-4160, 2010, Volume 48, Issue 6, pp. 341 - 351
Abstract Elevations in reactive oxygen species are implicated in many disease states and cause systolic and diastolic myocardial dysfunction. To understand the... 
Advanced Basic Science | Reactive oxygen species | Calcium | Sarcoplasmic reticulum | Myocyte | OXIDATIVE STRESS | LIPID-PEROXIDATION | CA2+ RELEASE | NA+/CA-2+ EXCHANGE | CELL BIOLOGY | CARDIAC SARCOPLASMIC-RETICULUM | RECEPTOR/CALCIUM-RELEASE CHANNEL | REDOX REGULATION | SEPTIC SHOCK | OXYGEN-FREE-RADICALS | SARCOLEMMAL VESICLES | Myocardial Contraction | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Reactive Oxygen Species - metabolism | Rats, Wistar | Calcium - metabolism | Hydrogen Peroxide - pharmacology | Rats | Cell Size | Male | Ryanodine Receptor Calcium Release Channel - metabolism | Animals | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - physiology | Sodium-Calcium Exchanger - metabolism | Calcium Channels, L-Type - metabolism | In Vitro Techniques | Hydrogen peroxide
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14. Full Text BIOPHYSICAL CHARACTERISATION OF THE UNDER-APPRECIATED AND IMPORTANT RELATIONSHIP BETWEEN HEART RATE VARIABILITY AND HEART RATE
by Monfredi, Oliver and Lyashkov, Alexey E and Johnsen, Anne-Berit and Inada, Shin and Schneider, Heiko and Wang, Ruoxi and Nirmalan, Mahesh and Wisloff, Ulrik and Maltsev, Victor A and Lakatta, Edward G and Zhang, Henggui and Boyett, Mark R
Hypertension, ISSN 0194-911X, 12/2014, Volume 64, Issue 6, pp. 1334 - 1343
Heart rate variability (beat-to-beat changes in the RR interval) has attracted considerable attention over the last 30+ years (PubMed currently lists >17,000... 
sinoatrial node | physiology | autonomic | intervals | nervous system | ion channels
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15. Full Text Clinical trials in ventilator treatment: Current perspectives and future challenges
by Edwards, Dave and Nirmalan, Mahesh
Current Opinion in Critical Care, ISSN 1070-5295, 02/2010, Volume 16, Issue 1, pp. 34 - 38
Purpose of review Mortality/morbidity-based end points have been useful in evaluating treatments that modulate 'mediator variables' with a large effect size.... 
Clinical trials | Critical illness | Ventilation | Nonlinear systems | Mortality | Morbidity | SURGERY | METAANALYSIS | critical illness | ventilation | ACUTE LUNG INJURY | ADAPTIVE-SUPPORT VENTILATION | RANDOMIZED CONTROLLED-TRIAL | FAILURE | RESPIRATORY-DISTRESS-SYNDROME | nonlinear systems | END-EXPIRATORY PRESSURE | NONINVASIVE MECHANICAL VENTILATION | SEDATION | mortality | clinical trials | morbidity | CRITICAL CARE MEDICINE | Respiration, Artificial - methods | Respiration, Artificial - mortality | Humans | Treatment Outcome | Clinical Trials as Topic | Respiratory Insufficiency - therapy | Ventilator Weaning
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16. The role of gravity and non-gravitational factors in determining pulmonary ventilation perfusion distribution
by Galvin, I and Nirmalan, Mahesh
British Journal of Intensive Care, ISSN 0961-7930, 12/2008, Volume 18, Issue 4, pp. 135 - 141
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17. Full Text A novel model of heart rate variability based on stochastic ion channel kinetics in the sino-atrial node (SA node)
by Nirmalan, Mahesh and Willard, Terry B and Niranjan, Mahesan
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 06/2006, Volume 40, Issue 6, pp. 987 - 987
Models | Heart beat
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18. Administration of human recombinant activated protein c is not associated with pancreatic parenchymal haemorrhage in l-arginine-induced experimental acute pancreatitis
by Jamdar, Saurabh and Babu, Benoy I and Nirmalan, Mahesh and Jeziorska, Maria and Mcmahon, Raymond F. T and Siriwardena, Ajith K
Journal of the Pancreas, ISSN 1590-8577, 2013, Volume 14, Issue 6, pp. 610 - 617
Microvascular thrombosis is a critical event in severe acute pancreatitis. Human recombinant activated protein C (Xigris®, Eli Lilly, Indianapolis, IN, USA)... 
Pancreatitis, Acute necrotizing | Drotrecogin alfa activated | Protein c | Arginine | Recombinant proteins | Amylases - blood | Lipase - blood | Anti-Infective Agents - pharmacology | Humans | Male | Pancreas - blood supply | Pancreatitis - prevention & control | Recombinant Proteins - adverse effects | Protein C - pharmacology | Acute Disease | Anti-Infective Agents - adverse effects | Pancreatic Diseases - diagnosis | Injections, Intraperitoneal | Pancreas - drug effects | Pancreas - pathology | Rats | Treatment Outcome | Recombinant Proteins - pharmacology | Pancreatic Diseases - chemically induced | Pancreatitis - chemically induced | Rats, Sprague-Dawley | Recombinant Proteins - administration & dosage | Animals | Anti-Infective Agents - administration & dosage | Pancreatitis - blood | Protein C - administration & dosage | Hemorrhage - chemically induced | Protein C - adverse effects
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19. Intrathoracic blood volume and extravascular lung water in critical illness: Methods of measurement, clinical applications and limitations
by Moore, John and Nirmalan, Mahesh
Journal of Organ Dysfunction, ISSN 1747-1060, 2008, Volume 4, Issue 1, pp. 51 - 56
Extravascular lung water | Indicator dilution | Intrathoracic blood volume | Transpulmonary
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20. Full Text Estimation of errors in determining intrathoracic blood volume using the single transpulmonary thermal dilution technique in hypovolemic shock
by Nirmalan, Mahesh and Willard, Terrance M and Edwards, Dennis J and Little, Rod A and Dark, Paul M
Anesthesiology, ISSN 0003-3022, 2005, Volume 103, Issue 4, pp. 805 - 812
Background: The transpulmonary thermal dilution technique has been widely adopted for monitoring cardiac preload and extravascular lung water in critically ill... 
CARDIAC-OUTPUT | THERMODILUTION | DYE INDICATOR DILUTION | HEMORRHAGE | PRELOAD | INJURY | ANESTHESIOLOGY | PULMONARY-ARTERY | EXTRAVASCULAR LUNG WATER | CRITICALLY-ILL PATIENTS | RESUSCITATION | Blood Volume Determination - methods | Animals | Thermodilution | Swine | Cardiac Output | Shock - physiopathology | Blood Volume | Female | Indicator Dilution Techniques
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