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The New England Journal of Medicine, ISSN 0028-4793, 10/2012, Volume 367, Issue 17, pp. 1596 - 1606
In this study, mortality from colorectal cancer was reduced by about 80% in a subgroup of patients with tumors that expressed a mutated, activated form of... 
ISLAND METHYLATOR PHENOTYPE | COLON-CANCER | MEDICINE, GENERAL & INTERNAL | METASTASIS | INHIBITION | RANDOMIZED-TRIALS | BRAF MUTATION | MICROSATELLITE INSTABILITY | RISK | PERSONALIZED MEDICINE | MOLECULAR PATHOLOGICAL EPIDEMIOLOGY | Colorectal Neoplasms - mortality | Cyclooxygenase 2 Inhibitors - pharmacology | Colorectal Neoplasms - genetics | Humans | Middle Aged | Proportional Hazards Models | Male | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | Signal Transduction - drug effects | Colorectal Neoplasms - drug therapy | Cyclooxygenase 2 Inhibitors - therapeutic use | Survival Analysis | Female | Aged | Aspirin - therapeutic use | Biomarkers, Tumor - genetics | Aspirin - pharmacology | Mutation | Drugs | Dose-response relationship (Biochemistry) | Aspirin | Gene mutations | Analysis | Colorectal cancer | Dosage and administration | Genetic aspects | Product/Service Evaluations | Research | Drug therapy | Oncogenes | Phenotypes | Tumor markers | Colorectal carcinoma | AKT protein | Microsatellite instability | Long interspersed nucleotide elements | Survival | Epidemiology | 1-Phosphatidylinositol 3-kinase | Prostaglandin endoperoxide synthase | Colon cancer | Rectum | DNA methylation | Death | Cyclooxygenase-2 | Diagnosis | Colon | Methylation | CpG islands | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Clinical chemistry, ISSN 0009-9147, 7/2016, Volume 62, Issue 7, pp. 1039 - 1040
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2013, Volume 369, Issue 12, pp. 1095 - 1105
Journal Article
Gut, ISSN 0017-5749, 06/2012, Volume 61, Issue 6, pp. 847 - 854
ObjectiveColorectal cancer is typically classified into proximal colon, distal colon and rectal cancer. Tumour genetic and epigenetic features differ by tumour... 
ISLAND METHYLATOR PHENOTYPE | COLON-CANCER | POPULATION-BASED SAMPLE | DNA METHYLATION | LINE-1 HYPOMETHYLATION | BRAF MUTATION | MICROSATELLITE INSTABILITY | BODY-MASS INDEX | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | P-GLYCOPROTEIN | ras Proteins - genetics | Colonic Neoplasms - genetics | Microsatellite Instability | Proto-Oncogene Proteins p21(ras) | Cecal Neoplasms - pathology | Colorectal Neoplasms - genetics | Humans | Long Interspersed Nucleotide Elements - genetics | Male | Colonic Neoplasms - metabolism | Sigmoid Neoplasms - genetics | Rectal Neoplasms - genetics | Female | Rectal Neoplasms - pathology | Colorectal Neoplasms - metabolism | Cecal Neoplasms - genetics | Mutation Rate | Proto-Oncogene Proteins - genetics | DNA Methylation - genetics | Mutation - genetics | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | CpG Islands - genetics | Aged | Rectal Neoplasms - metabolism | DNA, Neoplasm - genetics | Colorectal Neoplasms - pathology | Sigmoid Neoplasms - pathology | Development and progression | Genetic aspects | Colon (Anatomy) | Research | Gene mutations | Colorectal cancer | Medical personnel | Studies | Hypotheses | Hospitals | Biopsy | Rodents | Epigenetics | Mutation | Data bases | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
Clinical Chemistry, ISSN 0009-9147, 07/2016, Volume 62, Issue 7, pp. 1039 - 1040
  Unfortunately, the vast majority of researchers who conduct clinical studies have not received adequate training in study design, data analysis, and... 
MEDICAL LABORATORY TECHNOLOGY | Training | Scientists | Information management | Physicians | Studies | Pathology | Data analysis | Researchers | Laboratories | Science | Research | Statistics | Epidemiology | Index Medicus
Journal Article
Gut, ISSN 0017-5749, 12/2016, Volume 65, Issue 12, pp. 1973 - 1980
Journal Article
Cell Reports, ISSN 2211-1247, 04/2016, Volume 15, Issue 4, pp. 857 - 865
Large-scale genomic characterization of tumors from prospective cohort studies may yield new insights into cancer pathogenesis. We performed whole-exome... 
Journal Article
JAMA, ISSN 0098-7484, 06/2013, Volume 309, Issue 24, pp. 2563 - 2571
Journal Article
Gut, ISSN 0017-5749, 08/2017, Volume 66, Issue 8, pp. 1463 - 1473
ObjectiveEvidence suggests that CD274 (programmed death-ligand 1, B7-H1) immune checkpoint ligand repress antitumour immunity through its interaction with the... 
COLORECTAL CANCER | T LYMPHOCYTES | CANCER EPIDEMIOLOGY | IMMUNE RESPONSE | MOLECULAR PATHOLOGY | ISLAND METHYLATOR PHENOTYPE | COLON-CANCER | IMMUNE CELLS | PROGRAMMED DEATH-1 | BRAF MUTATION | MICROSATELLITE INSTABILITY | ASPIRIN USE | PIK3CA MUTATION | PERSONALIZED MEDICINE | GASTROENTEROLOGY & HEPATOLOGY | CLINICAL-SIGNIFICANCE | Colonic Neoplasms - genetics | Microsatellite Instability | Humans | Middle Aged | Programmed Cell Death 1 Receptor - analysis | Male | Rectal Neoplasms - chemistry | Carcinoma - chemistry | CD8-Positive T-Lymphocytes | Leukocyte Common Antigens - analysis | Rectal Neoplasms - genetics | Colonic Neoplasms - chemistry | DNA, Bacterial - analysis | Female | Rectal Neoplasms - pathology | Carcinoma - pathology | Lymphocytes - chemistry | Survival Rate | CD3 Complex - analysis | Fusobacterium nucleatum | Colonic Neoplasms - pathology | Forkhead Transcription Factors - analysis | Lymphocyte Count | Carcinoma - genetics | Aged | B7-H1 Antigen - analysis | Reports | Research | T cells | Colorectal cancer | Tumors | Immunohistochemistry | PD-1 protein | CD8 antigen | Colorectal carcinoma | Lymphocytes T | Microsatellite instability | Epidemiology | B7 antigen | Cell density | Proteins | Colon cancer | Lymphocytes | Immunotherapy | DNA methylation | Foxp3 protein | CpG islands | Phenotypes | Cell survival | Immunoregulation | CD3 antigen | Long interspersed nucleotide elements | Studies | Pathology | Immune checkpoint | Womens health | Cell death | Stromal cells | PD-L1 protein | Rectum | Ligands | Methylation | Apoptosis | Index Medicus | Abridged Index Medicus | colorectum | adenocarcinoma | immunoprevention | molecular pathology | immunotherapy
Journal Article