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Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
Biopharmaceutics & Drug Disposition, ISSN 0142-2782, 09/2015, Volume 36, Issue 6, pp. 352 - 363
Loxoprofen (LX) is a prodrug‐type non‐steroidal anti‐inflammatory drug which is used not only as an oral drug but also as a transdermal formulation. As a... 
carbonyl reductase 1 | active metabolite | NSAID | human skin | DRUG | BIOTRANSFORMATION | SODIUM | HUMAN CARBONYL REDUCTASE | LIVER | PHARMACOLOGY & PHARMACY | PERMEATION | Enzymes | Metabolites | Fluocinolone acetonide | Analysis | Skin care products | Physiological aspects | Skin | Dosage and administration
Journal Article
Biopharmaceutics & Drug Disposition, ISSN 0142-2782, 09/2015, Volume 36, Issue 6, pp. 352 - 363
Journal Article
Journal Article
09/1992, Volume 8, Issue 6
Magazine Article
by Abbey Kazuya and Kawakami Hayato and Kobayashi Takeo and Hirano Hiroshi and ABE Hiromichi and TOMIDA Yasunobu and OCHI Junzo and SHIMADA Morimi and IENAGA Kazuharu and KIMURA Hiroshi and Akiyama Junko and Kawagoe Koh and Kawana Takashi and Araki Masaya and Umemoto Kouichiro and ARAKI Nobukazu and LEE Masao and TAKASHIMA Yoichiro and OGAWA Kazuo and Araki Tsutomu and Yamamoto Akira and Asaka Youko and Watanabe Jun and Kanai Kazuo and Kanamura Shinsuke and DAIMON T and KAWAI K and UCHIDA K and Doi Naoto and Moriyama Nobuo and Higashihara Eiji and Murahashi Isao and Aso Yoshio and FUJIMORI Osamu and TSUKISE Azuma and YAMADA Kazuyori and FUKUSHIMA Akimune and IZUTSU Toshihiko and MATSUDA Morimasa and KAGABU Teruo and NISHIYA Iwao and FUNATSUMARU Sadayuki and YONEMITSU Nobuhisa and SUGIHARA Hajime and Furuta Yasushi and Shinohara Toshiya and Sano Kimiaki and Meguro Mizuho and Nagashima Kazuo and Minghu HAN and Yingjie PIAO and HARA Makoto and HOSHINO Yoshinobu and MORIYAMA Nobuo and HARA Masayuki and YAMASHITA Kayoko and ISHIGE Yumi and SUZUKI Takuro and HASEGAWA Hideaki and TSUKAMOTO Hideo and WATANABE Keiichi and HIKITA Hiroshi and KAGAWA Keizo and DEGUCHI Takeshi and TAKEUCHI Takayuki and TADA Hisashi and SAKABE Kazuo and MIZUMO Masayuki and MATSUMOTO Masafumi and OKANOUE Takeshi and KASHIMA Kei and ASHIHARA Tsukasa and HIRABAYASHI Tomoko and ISHIMURA Kazunori and TSURI Hideaki and FUJITA Hisao and HIRAKAWA Makoto and KAWATA Mitsuhiro and SANO Yutaka and HIRAYAMA Yoshiaki and AMEMIYA Tsugio and HIROHATA Tajimi and KUMAMOTO Tetsuzo and HOSOKAWA Yohei and ISETANI Kazushi and TOKITA Kazuhiko and MITSUFUJI Shoji and TANI Toshio and MARUYAMA Kyohei and KODAMA Tadashi and TSUCHIHASHI Yasunari and Ichimal H and Makita T and ICHTANI Yukio and MURAKAMI Sadatsugu and OKAMURA Hitoshi and NAGATSU Ikuko and YANAIHARA Noboru and IBATA Yasuhiko and IGARASHI Hiroaki and ...
ACTA HISTOCHEMICA ET CYTOCHEMICA, ISSN 0044-5991, 1989, Volume 22, Issue 6, pp. 708 - 717
Journal Article
by Abbey, Kazuya and Kawakami, Hayato and Kobayashi, Takeo and Hirano, Hiroshi and ABE, Hiromichi and TOMIDA, Yasunobu and OCHI, Junzo and SHIMADA, Morimi and IENAGA, Kazuharu and KIMURA, Hiroshi and Akiyama, Junko and Kawagoe, Koh and Kawana, Takashi and Araki, Masaya and Umemoto, Kouichiro and ARAKI, Nobukazu and LEE, Masao and TAKASHIMA, Yoichiro and OGAWA, Kazuo and Araki, Tsutomu and Yamamoto, Akira and Asaka, Youko and Watanabe, Jun and Kanai, Kazuo and Kanamura, Shinsuke and DAIMON, T and KAWAI, K and UCHIDA, K and Doi, Naoto and Moriyama, Nobuo and Higashihara, Eiji and Murahashi, Isao and Aso, Yoshio and FUJIMORI, Osamu and TSUKISE, Azuma and YAMADA, Kazuyori and FUKUSHIMA, Akimune and IZUTSU, Toshihiko and MATSUDA, Morimasa and KAGABU, Teruo and NISHIYA, Iwao and FUNATSUMARU, Sadayuki and YONEMITSU, Nobuhisa and SUGIHARA, Hajime and Furuta, Yasushi and Shinohara, Toshiya and Sano, Kimiaki and Meguro, Mizuho and Nagashima, Kazuo and Minghu, HAN and Yingjie, PIAO and HARA, Makoto and HOSHINO, Yoshinobu and MORIYAMA, Nobuo and HARA, Masayuki and YAMASHITA, Kayoko and ISHIGE, Yumi and SUZUKI, Takuro and HASEGAWA, Hideaki and TSUKAMOTO, Hideo and WATANABE, Keiichi and HIKITA, Hiroshi and KAGAWA, Keizo and DEGUCHI, Takeshi and TAKEUCHI, Takayuki and TADA, Hisashi and SAKABE, Kazuo and MIZUMO, Masayuki and MATSUMOTO, Masafumi and OKANOUE, Takeshi and KASHIMA, Kei and ASHIHARA, Tsukasa and HIRABAYASHI, Tomoko and ISHIMURA, Kazunori and TSURI, Hideaki and FUJITA, Hisao and HIRAKAWA, Makoto and KAWATA, Mitsuhiro and SANO, Yutaka and HIRAYAMA, Yoshiaki and AMEMIYA, Tsugio and HIROHATA, Tajimi and KUMAMOTO, Tetsuzo and HOSOKAWA, Yohei and ISETANI, Kazushi and TOKITA, Kazuhiko and MITSUFUJI, Shoji and TANI, Toshio and MARUYAMA, Kyohei and KODAMA, Tadashi and TSUCHIHASHI, Yasunari and Ichimal, H and Makita, T and ICHTANI, Yukio and MURAKAMI, Sadatsugu and OKAMURA, Hitoshi and NAGATSU, Ikuko and YANAIHARA, Noboru and IBATA, Yasuhiko and IGARASHI, Hiroaki and ...
ACTA HISTOCHEMICA ET CYTOCHEMICA, ISSN 0044-5991, 1989, Volume 22, Issue 6, pp. 708 - 717
Journal Article
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