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Cerebral Cortex, ISSN 1047-3211, 12/2018, Volume 28, Issue 12, pp. 4291 - 4304
Abstract Dysregulated fear memory can lead to a broad spectrum of anxiety disorders. The brain systems underlying fear memory are manifold, with the... 
LTP | plasticity | mGlu5 | hippocampus | ALLOSTERIC MODULATORS | PROTEIN-SYNTHESIS | SYNAPTIC PLASTICITY | NEUROSCIENCES | PREFRONTAL CORTEX | MEMORY | MOUSE MODEL | MGLUR5 | LONG-TERM POTENTIATION | INTRINSIC PLASTICITY
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 12/2018, Volume 94, Issue 6, pp. 1352 - 1362
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 12/2018, Volume 94, Issue 6, pp. 1352 - 1362
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2019, Volume 29, Issue 18, pp. 2670 - 2674
This letter describes the further optimization of a series of mGlu NAMs based on an -aryl phenoxyethoxy pyridinone core. A multidimensional optimization... 
mGlu3 | Negative allosteric modulator (NAM) | Structure-Activity Relationship (SAR) | Metabotropic glutamate receptor
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2019, Volume 29, Issue 18, p. 2670
This letter describes the further optimization of a series of mGlu.sub.3 NAMs based on an N-aryl phenoxyethoxy pyridinone core. A multidimensional optimization... 
Medical colleges | Neurosciences | Antidepressants | Drug discovery | G proteins | Glutamate | Antianxiety agents
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 10, pp. 1211 - 1214
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile... 
Negative allosteric modulator (NAM) | Structure-activity relationship (SAR) | mGlu7 | VU6019278 | Metabotropic glutamate receptor
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 10, p. 1211
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile... 
Surveys | Medical colleges | Neurosciences | Lubrication and lubricants | Drug discovery | Glutamate | Blood proteins | Protein binding
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 10, pp. 1211 - 1214
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile... 
mGlu | Negative allosteric modulator (NAM) | Structure-activity relationship (SAR) | VU6019278 | Metabotropic glutamate receptor
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 3, pp. 362 - 366
This letter describes a focused exercise to explore the role of the β-amino carboxamide moiety found in all of the first generation M PAMs and question if the... 
Tricycle | Structure-Activity Relationship (SAR) | Positive allosteric modulator (PAM) | Muscarinic acetylcholine receptor
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2019, Volume 29, Issue 3, p. 362
This letter describes a focused exercise to explore the role of the [beta]-amino carboxamide moiety found in all of the first generation M.sub.4 PAMs and... 
Medical colleges | Hydrogen | Liability (Law) | Drug discovery | Hydrogen bonding
Journal Article
Chemical Reviews, ISSN 0009-2665, 06/2016, Volume 116, Issue 11, p. 6707
  Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery, filled with therapeutic promise yet fraught with caveats.... 
Molecules | Ligands | Pharmacology
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 02/2015, Volume 25, Issue 3, pp. 690 - 694
This Letter describes the continued optimization of the MLPCN probe ML375, a highly selective M sub(5) negative allosteric modulator (NAM), through a... 
Journal Article