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Drug Design, Development and Therapy, ISSN 1177-8881, 07/2015, Volume 9, pp. 3767 - 3777
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2018, Volume 379, Issue 4, pp. 341 - 351
Journal Article
by Cohen, Ezra E W and Soulières, Denis and Le Tourneau, Christophe and Dinis, José and Licitra, Lisa and Ahn, Myung-Ju and Soria, Ainara and Machiels, Jean-Pascal and Mach, Nicolas and Mehra, Ranee and Burtness, Barbara and Zhang, Pingye and Cheng, Jonathan and Swaby, Ramona F and Harrington, Kevin J and Acosta-Rivera, Mirelis and Adkins, Douglas R and Aghmesheh, Morteza and Ahn, Myung-Ju and Airoldi, Mario and Aleknavicius, Eduardas and Al-Farhat, Yousuf and Algazi, Alain P and Almokadem, Salah and Alyasova, Anna and Bauman, Jessica R and Benasso, Marco and Berrocal, Alfonso and Bray, Victoria and Burtness, Barbara Ann and Caponigro, Francesco and Castro, Ana and Cescon, Terrence P and Chan, Kelvin and Chaudhry, Arvind and Chauffert, Bruno and Cohen, Ezra and Csoszi, Tibor and De Boer, J.P and Delord, Jean-Pierre and Dietz, Andreas and Dinis, Jose and Dupuis, Charlotte and Digue, Laurence and Erfan, Jozsef and Escobar Alvarez, Yolanda and Evans, Mererid and Fidler, Mary Jo and Forster, Martin David and Friesland, Signe and Ganti, Apar K and Geoffrois, Lionnel and Grant, Cliona and Gruenwald, Viktor and Harrington, Kevin and Hoffmann, Thomas and Horvai, Geza and Inciura, Arturas and Jang, Raymond and Jankowska, Petra and Jimeno, Antonio and Joseph, Mano and Juarez Ramiro, Alejandro and Karaszewska, Boguslawa and Kawecki, Andrzej and Keilholz, Ulrich and Keller, Ulrich and Kim, Sung-Bae and Kocsis, Judit and Kotecki, Nuria and Kozloff, Mark F and Lambea, Julio and Landherr, Laszlo and Lantsukhay, Yuri and Lazarev, Sergey Alexandrovich and Lee, Lip Way and Le Tourneau, Christophe and Licitra, Lisa and Lifirenko, Igor Dmitrievich and Mach, Nicolas and Martincic, Danko and Matorin, Oleg Vladmirovhich and McGrath, Margaret and Machiels, Jean-Pascal and Mehra, Ranee and Misiukiewicz, Krzysztof and Morris, John C and Mufazalov, Fagim Fanisovich and Niu, Jiaxin and Pamoorthy Srinivasan, Devraj and Perez Segura, Pedro and Rauch, Daniel and Ribeiro, Maria Leonor and Rodriguez, Cristina and Rolland, Frederic and Russo, Antonio and Ruzsa, Agnes and Sanches, Frederico and Shin, Sang-Won and Shtiveland, Mikhail and ... and KEYNOTE-040 investigators and Keynote-040 Investigators
The Lancet, ISSN 0140-6736, 01/2019, Volume 393, Issue 10167, pp. 156 - 167
There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour... 
CRITERIA | TRIAL | MEDICINE, GENERAL & INTERNAL | NIVOLUMAB | CANCER | CHEMOTHERAPY | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Docetaxel - adverse effects | Humans | Middle Aged | Squamous Cell Carcinoma of Head and Neck - pathology | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Cetuximab - therapeutic use | Cetuximab - adverse effects | Docetaxel - administration & dosage | Antibodies, Monoclonal, Humanized - administration & dosage | Squamous Cell Carcinoma of Head and Neck - drug therapy | Female | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Drug Administration Schedule | Head and Neck Neoplasms - drug therapy | Kaplan-Meier Estimate | Disease Progression | Head and Neck Neoplasms - pathology | Methotrexate - adverse effects | Squamous Cell Carcinoma of Head and Neck - secondary | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cetuximab - administration & dosage | Methotrexate - administration & dosage | Aged | Methotrexate | Squamous cell carcinoma | Metastasis | Therapy | Toxicity | Perforation | Clinical trials | Oncology | Cancer therapies | Metastases | Skin cancer | Anticancer properties | Pembrolizumab | Randomization | Motivation | Platinum | Neck | Safety | Medical treatment | Fatigue | Hypothyroidism | Survival | Patients | Chemotherapy | Interactive systems | Large intestine | Head and neck cancer | Ligands | Tumors
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2017, Volume 117, Issue 1, pp. 33 - 40
Background: Pembrolizumab (P) is an anti-PD-1 antibody that blocks the interaction between programmed cell death protein 1 (PD-1) on T-cells and PD-L1 and... 
clinical trial | pembrolizumab | advanced/metastatic solid tumours | phase I | chemotherapy | immunotherapy | CRITERIA | EFFICACY | CELL LUNG-CANCER | ONCOLOGY | ADVANCED MELANOMA | COHORT | NIVOLUMAB | IPILIMUMAB | Lung Neoplasms - drug therapy | Nausea - chemically induced | Humans | Middle Aged | Male | Fatigue - chemically induced | Vinblastine - administration & dosage | Diarrhea - chemically induced | Small Cell Lung Carcinoma - drug therapy | Pancreatic Neoplasms - drug therapy | Antibodies, Monoclonal, Humanized - administration & dosage | Vinblastine - analogs & derivatives | Doxorubicin - analogs & derivatives | Adult | Camptothecin - administration & dosage | Female | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Camptothecin - analogs & derivatives | Doxorubicin - administration & dosage | Drug Eruptions - etiology | Deoxycytidine - administration & dosage | Albumins - administration & dosage | Treatment Outcome | Sarcoma - drug therapy | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Taxoids - administration & dosage | Vomiting - chemically induced | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Deoxycytidine - analogs & derivatives | Index Medicus | metastatic solid tumours | advanced | Clinical Study
Journal Article
AIP Advances, ISSN 2158-3226, 09/2018, Volume 8, Issue 9, pp. 95108 - 095108-9
The steady-state spectra and fluorescence lifetimes are investigated under vacuum for methylammonium lead bromide and iodide (CH3NH3PbBr3 or MAPbBr3, and... 
Thin films | Temperature dependence | Temperature | Ambient temperature | Optical properties | Decay | Photoluminescence | Fluorescence | Perovskites | Service life assessment | Phase transitions
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2016, Volume 138, Issue 34, pp. 10730 - 10733
Enzymatic transamination is catalyzed by pyridoxal/pyridoxamine, and it involves remarkable cooperative catalysis of a Lys residue in the transaminase.... 
PROTEIN CAVITY | ASPARTATE-AMINOTRANSFERASE | ALPHA-KETO ESTERS | EFFICIENT SYNTHESIS | LYSINE RESIDUE | SHIFT REACTION | CATALYTIC ASYMMETRIC-SYNTHESIS | COVALENT CATALYSIS | CHEMISTRY, MULTIDISCIPLINARY | REDUCTIVE AMINATION | AQUEOUS SYSTEMS | Amino acids | Usage | Chemical properties | Catalysis | Chirality | Analysis
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 09/2019, Volume 234, Issue 9, pp. 15472 - 15486
Most prostate cancers (Pcas) develop into castration‐resistant prostate cancer (CRPC) after receiving androgen deprivation therapy (ADT). The expression levels... 
docetaxel | PLCε | wnt3a | CRPC | enzalutamide | bicalutamide | proliferation and bone metastasis | Cell proliferation | Deprivation | Drug resistance | Biological activity | Metastases | Bone growth | Androgens | Castration | In vivo methods and tests | Prostate cancer | Prostate | Catenin | Cancer
Journal Article
Linear Algebra and Its Applications, ISSN 0024-3795, 02/2019, Volume 563, pp. 313 - 330
In this paper, we first characterize the structure of symmetries J such that a projection P is J-contractive. Then the minimal and maximal elements of the... 
J-projection | J-contractive projection | Symmetry | SPACE | MATHEMATICS | MATHEMATICS, APPLIED | KREIN | Information science
Journal Article
Urology, ISSN 0090-4295, 05/2019, Volume 127, p. 61
To investigate how hepatocyte cell adhesion molecule (hepaCAM) regulates cancer energy metabolism through hypoxia-inducible factor (HIF-1[alpha]) in renal cell... 
Immunohistochemistry | Lactates | Medical colleges | RNA | Luciferase | Carcinoma, Renal cell | Glucose | Dextrose
Journal Article
PLOS GENETICS, ISSN 1553-7404, 08/2019, Volume 15, Issue 8, p. e1008136
The S-phase checkpoint plays an essential role in regulation of the ribonucleotide reductase (RNR) activity to maintain the dNTP pools. How eukaryotic cells... 
NUCLEAR IMPORT | SURVIVAL | LOCALIZATION | RIBONUCLEOTIDE REDUCTASE INHIBITOR | DNA-DAMAGE RESPONSE | PROTEIN-KINASE | TRANSCRIPTION | EXPANSION | GENETICS & HEREDITY | MECHANISMS | STRESS | Phosphorylation | Hydroxyurea - toxicity | DNA Replication - drug effects | Saccharomyces cerevisiae - drug effects | Promoter Regions, Genetic - genetics | S Phase Cell Cycle Checkpoints - genetics | Gene Expression Regulation, Fungal - drug effects | Gene Expression Regulation, Fungal - physiology | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Saccharomyces cerevisiae - physiology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Gene Knockout Techniques | Glycogen Synthase Kinase 3 - metabolism | Nucleotides - metabolism | Glycogen Synthase Kinase 3 - genetics | Ribonucleotide Reductases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Ribonucleotide Reductases - genetics | DNA Damage | S Phase Cell Cycle Checkpoints - drug effects | Transcriptional coactivators | DNA replication | Usage | Safety and security measures | Genetic regulation | Analysis | Biotechnology | Yeast | Transcription | Laboratories | Funding | Genes | DNA damage | Homeostasis | Hydroxyurea | Genomes | Kinases | Cancer therapies | Lethal dose | Clonal deletion | Cell cycle | Post-translation | Deoxyribonucleic acid--DNA | Food | Enzymes | Cell survival | Nutrition | Cellular biology | Replication | Molecular biology | Reductase | Basic Medicine | Medical Biotechnology | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Medicinsk bioteknologi | Cell and Molecular Biology | Cell- och molekylärbiologi | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Deoxyribonucleic acid | DNA
Journal Article
Case Reports in Oncology, ISSN 1662-6575, 09/2017, Volume 10, Issue 3, pp. 840 - 845
Background: Leptomeningeal metastasis (LM) is an uncommon complication in patients with solid tumors, associated with poor survival. However, LM appears to be... 
Case Report | EGFR mutation | Leptomeningeal metastasis | Liquid biopsy | T790M | Lung cancer | Back pain | Nuclear magnetic resonance--NMR | Medical imaging | Nervous system | Metastasis | Patients | Cancer therapies | Studies | Chemotherapy | Epidermal growth factor | Medical prognosis | Mutation | Tumors
Journal Article
Cell Death & Disease, ISSN 2041-4889, 01/2020, Volume 11, Issue 1, pp. 1 - 17
Ubiquitin-conjugating enzyme E2O (UBE2O) is a large E2 ubiquitin-conjugating enzyme that possesses both E2 and E3 ligase activities. Ectopic UBE2O... 
Cell proliferation | Ubiquitin | Enzymes | Animal models | Ubiquitin-conjugating enzyme | Mesenchyme | Transcription | Breast cancer | Metastasis | Myc protein | Metastases | Ubiquitination | Cell growth | Feedback | Xenografts | E2 ubiquitin-conjugating enzyme | Tumorigenesis | Ubiquitin-protein ligase | Tumors
Journal Article