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Pharmaceutical Research, ISSN 0724-8741, 03/2014, Volume 31, Issue 3, p. 670
The aims were to quantify the in vivo time-course between the oral dose, the plasma and brain exposure and the inhibitory effect on Amyloid [beta] (A[beta]) in... 
Neurosciences | Peptides | Neurons | Analysis | Amyloid beta-protein | Models | Alzheimer's disease | Brain | Body fluids | Enzymes | Inhibitor drugs | Rodents | Alzheimers disease | Pharmaceutical sciences
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2013, Volume 33, Issue 24, pp. 10075 - 10084
A beta, the product of APP (amyloid precursor protein), has been implicated in the pathophysiology of Alzheimer's disease (AD). beta-Site APP cleaving enzyme1... 
NERVOUS-SYSTEM | REDUCTION | ALZHEIMERS-DISEASE | MOUSE MODEL | BETA-SECRETASE BACE1 | A-BETA | PRECURSOR PROTEIN | PATHOLOGY | NEUROSCIENCES | BRAIN | TRANSGENIC MICE | Embryo, Mammalian | Humans | Cerebral Cortex - pathology | Male | Alzheimer Disease - pathology | Dose-Response Relationship, Drug | Amyloid - metabolism | Time Factors | Enzyme Inhibitors - chemistry | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Isoindoles - therapeutic use | Female | Neurons - metabolism | Isoindoles - pharmacology | Neurons - drug effects | Disease Models, Animal | Peptide Fragments - metabolism | Guinea Pigs | Aspartic Acid Endopeptidases - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Mice, Transgenic | Mutation - genetics | Enzyme Inhibitors - therapeutic use | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Aspartic Acid Endopeptidases - metabolism | Mice | Pyridones - therapeutic use | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Alzheimer Disease - genetics | Pyridones - pharmacology | Naturvetenskap | Kemi | neurokemi med molekylär neurobiologi | Natural Sciences | Annan kemi | Chemical Sciences | Other Chemistry Topics | Neurochemistry with Molecular Neurobiology
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 06/2013, Volume 69, Issue 6, p. 1247
  To date, γ-secretase inhibition is the most frequently studied mechanism of reducing A[beta] in clinical trials with as yet no therapeutic success for AD... 
Enzymes | Pharmacology | Alzheimers disease | Meta-analysis
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 06/2013, Volume 69, Issue 6, p. 1247
To date, I3-secretase inhibition is the most frequently studied mechanism of reducing A[beta] in clinical trials with as yet no therapeutic success for AD... 
Drugs | Neurosciences | Analysis | Amyloid beta-protein | Amyloidosis | Health aspects | Alzheimer's disease
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 3/2014, Volume 31, Issue 3, pp. 670 - 683
Journal Article
by Wahlberg, Anna-Maria and Alenström, Magdalena and Udin, Stina and Johansson, Tore and Lundgren, Anna and Romany Johansson, Birgitta and Ekström, Carin and Eriksson, Nils and Andersson, Lisbeth and Eklund, Hanna and Robertsson, Lotta and Bjerhag, Gunilla and Gustavsson, Ann-Charlotte and Israelsson, Madelene and Karlsson, Sofia and Westerlund, Maria and Ek, Yvonne and Stenbäck, Birgitta and Andersson, Barbro and Andersson, Elisabeth and Leppämäki, Kristina and Ramirez, Anette and Wallin, Victoria and Lundberg, Alexandra and Sahlin, Benny and Mälberg, Hasse and Liljeroos, Maria and Gustafsson, Caroline and Nyström, Kerstin and Siklo, Susanne and Zelleroth, Eva and Hjortevang, Finn and Mohammed, Kamaran and Hellblad, Agneta and Schön, Iwona and Carlsson, Kristina and Ole´rs, Marita and Ågren, Pär Lennart and Sjögren, Iwar and Zedigh, Crister and Eriksson, Kristina and Sundkvist, Kristina and Thorsell, Anna-Karin and Kuoljok, Ann-Kristin and Liinanki, Linda and Liljergren, Mona and Turtola, Sara and Nylander, Britt-Marie and Nordvall, Lena and Nilsson, Malin and Blomqvist, Annelie and Sjöberg, Håkan and Nylander, Jenny and Berglund, Linda and Mossberg, Linda and Svennberg, Lars and Haugen, Espen and Hellsten, Lars and Johansson, Staffan and Johansson, Birgitta and Larsson, Pethra and Kellerth, Susanne and Bergström, Monika and Gustafsson, Carola and Nährström, Cecilia and Evenås, Eva and Sundin, Hanna and Lönn, Helena and Svensson, Johan and Kihlgren, Moa and Larsson, Per and Palosaari, Pirjo and Johansson, Susann and Cedermark magnusson, Malin and Ravn-Fischer, Annica and Wittfeldt, Ann and Perers, Elisabeth and Hellberg, Nina and Holmberg, Mikael and Andersson, Bert and Jangsten, Berit and Selimovic, Nedim and Enström, Anna and Dellgren, Göran and Scherstén, Henrik and Biveby-Nilsson, Anna and Lundberg, Johan and Omerovic, Elmir and Petursson, Petur and Albertsson, Per and Ankarstrand, Carina and Flinck, Agneta and Larsson, Titti and Samuelsson, Maria and Bergman, Peter and Nyström, Lotten and Bågenholm, Magnus and Linnér, Anneli and Hornestam, Björn and Sjöland, Helén and ...
Scandinavian Cardiovascular Journal, ISSN 1401-7431, 08/2014, Volume 48, Issue S63, pp. 2 - 133
Journal Article
05/2019
FIELD: immunology.SUBSTANCE: this invention relates to immunology. What is presented is an anti-human beta-amyloid antibody and its antigen-binding fragment.... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
11/2018
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
09/2018
PROBLEM TO BE SOLVED: To provide fully human antibodies that are specific for Aβ1-42 and N-terminal truncates thereof and bind to an epitope between amino... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
08/2018
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
07/2016
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
04/2018
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
12/2017
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
01/2016
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
12/2015
The invention provides an antibody for human amyloid beta. The antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide.... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
10/2015
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
08/2015
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
06/2015
본 발명은 인간 아밀로이드 베타에 대한 항체에 관한 것이다. 이 항체는 인간 아밀로이드 베타 40 펩티드에 비해 인간 아밀로이드 베타 42 펩티드에 선택적으로 결합한다. 본 발명은 아밀로이드 베타 42 펩티드에 결합하고 아밀로이드증과 관련된 질병, 예컨대, 알츠하이머병을 치료하기 위한... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | WINE | HYGIENE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | ORGANIC CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | MICROBIOLOGY | HUMAN NECESSITIES | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | BIOCHEMISTRY | CULTURE MEDIA | CHEMISTRY | VINEGAR
Patent
05/2015
Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
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