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Vaccine, ISSN 0264-410X, 04/2014, Volume 32, Issue 18, pp. 2109 - 2116
Immunogens based on the human immunodeficiency virus type-1 (HIV-1) Envelope (Env) glycoprotein have to date failed to elicit potent and broadly neutralizing... 
HIV-1 | Env | Adjuvants
Journal Article
Science, ISSN 0036-8075, 07/2015, Volume 349, Issue 6245, pp. 320 - 324
Journal Article
Nature, ISSN 0028-0836, 06/2016, Volume 536, Issue 7617, pp. 474 - 478
Zika virus (ZIKV) is a flavivirus that is responsible for the current epidemic in Brazil and the Americas(1,2). ZIKV has been causally associated with fetal... 
CHALLENGE | HEALTHY-ADULTS | IMMUNOGENICITY | AMERICA | NEUTRALIZING ANTIBODY | SAFETY | MULTIDISCIPLINARY SCIENCES | INFECTION | MICE | MODEL | Antibody Specificity | Immunoglobulin G - isolation & purification | Vaccines, DNA - genetics | Zika Virus - genetics | Vaccines, Subunit - genetics | Humans | Viral Vaccines - genetics | Vaccines, DNA - immunology | Adoptive Transfer | Microcephaly - virology | CD4-Positive T-Lymphocytes - immunology | Zika Virus Infection - virology | Antibodies, Neutralizing - immunology | Immunoglobulin G - immunology | Gene Deletion | Brazil | Zika Virus Infection - complications | Female | Zika Virus Infection - prevention & control | Zika Virus - immunology | Microcephaly - complications | Vaccines, Inactivated - genetics | Viral Envelope Proteins - genetics | Vaccines, Subunit - chemistry | Vaccines, Subunit - immunology | Zika Virus - chemistry | Vaccines, DNA - chemistry | Vaccines, Inactivated - immunology | Animals | Viral Envelope Proteins - chemistry | Viral Vaccines - chemistry | Zika Virus Infection - immunology | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Viral Vaccines - immunology | Vaccines, Inactivated - chemistry | Product development | Viral vaccines | Studies | Epidemics | Encephalitis | Immunization | Fetuses | Zika virus | Vaccines | Microcephaly | Deoxyribonucleic acid--DNA
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7475, pp. 224 - 228
Journal Article
Nature, ISSN 0028-0836, 12/2016, Volume 540, Issue 7632, pp. 284 - 287
The development of immunologic interventions that can target the viral reservoir in HIV-1-infected individuals is a major goal of HIV-1 research(1,2). However,... 
INDIVIDUALS | VIREMIA | PERSISTENCE | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | MACAQUES | LATENT RESERVOIR | T-CELLS | CHALLENGES | VIRAL RESERVOIR | HIV-1 REMISSION | AIDS Vaccines - immunology | Simian Immunodeficiency Virus - growth & development | DNA, Viral - analysis | Male | RNA, Viral - blood | Macaca mulatta | Vaccinia virus - genetics | Simian Immunodeficiency Virus - isolation & purification | HIV Infections - immunology | Simian Acquired Immunodeficiency Syndrome - virology | Simian Immunodeficiency Virus - genetics | Time Factors | Toll-Like Receptor 7 - immunology | Adenoviridae - genetics | Female | Simian Acquired Immunodeficiency Syndrome - therapy | Simian Immunodeficiency Virus - immunology | Toll-Like Receptor 7 - genetics | RNA, Viral - analysis | Immunity, Innate | Viral Load - immunology | Genetic Vectors - genetics | DNA, Viral - blood | SAIDS Vaccines - genetics | Animals | SAIDS Vaccines - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | Anti-Retroviral Agents - administration & dosage | HIV Infections - therapy | AIDS Vaccines - genetics | Immunity, Cellular | Prevention | TLR7 | Dosage and administration | Viral vaccines | Health aspects | HIV infection | Immunization | Adenoviruses | Human immunodeficiency virus--HIV | Viruses | Vaccines | Monkeys & apes | Viral infections | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 11/2018, Volume 563, Issue 7731, pp. 360 - 364
The latent viral reservoir is the critical barrier for the development of a cure for HIV-1 infection. Previous studies have shown direct antiviral activity of... 
CELLS | VIREMIA | STIMULATION | EFFICACY | MULTIDISCIPLINARY SCIENCES | HUMANS | AIDS | LATENT RESERVOIR | HIV-1 REMISSION | Humans | Macaca mulatta - immunology | DNA, Viral - analysis | Male | Adoptive Transfer | CD8 Antigens - deficiency | Viral Load | Anti-HIV Agents - administration & dosage | Macaca mulatta - virology | Antibodies, Neutralizing - immunology | Simian Immunodeficiency Virus - genetics | Immunity, Cellular - drug effects | HIV Antibodies - immunology | Toll-Like Receptor 7 - immunology | Anti-HIV Agents - therapeutic use | Female | Simian Acquired Immunodeficiency Syndrome - therapy | Simian Immunodeficiency Virus - immunology | Toll-Like Receptor 7 - agonists | Pteridines - pharmacology | Immunity, Innate - drug effects | HIV-1 - drug effects | HIV-1 - genetics | CD8 Antigens - immunology | Immunity, Cellular - immunology | Immunity, Innate - immunology | HIV-1 - immunology | Animals | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | Antibodies, Viral - immunology | Simian Immunodeficiency Virus - drug effects | Viral antibodies | Antiviral agents | Antibodies | Toll-like receptors | Dosage and administration | Drug therapy | Health aspects | HIV infection | Antiretroviral drugs | Lymphatic system | Immunoglobulins | TLR7 protein | CD8 antigen | Viruses | Infections | Monkeys | Adoptive transfer | Antiretroviral therapy | Glycan | Proteins | Depletion | Antiretroviral agents | Human immunodeficiency virus--HIV | Antiviral activity | Reservoirs | Binding sites | Deoxyribonucleic acid--DNA | Immune system
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2018, Volume 24, Issue 6, pp. 721 - 723
Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against... 
MEDICINE, RESEARCH & EXPERIMENTAL | CHALLENGE | POTENT | VIRUS-INFECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | VACCINE | ENHANCEMENT | CROSS-REACTIVITY | CELL BIOLOGY | Monoclonal antibodies | Monkeys | Dosage and administration | Research | Health aspects | Vector-borne diseases | Effectiveness | Dengue | Viral diseases | Viruses | Dimers | Zika virus | Infections | Monkeys & apes
Journal Article
Immunity, ISSN 1074-7613, 06/2017, Volume 46, Issue 6, pp. 1073 - 1088.e6
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 03/2016, Volume 19, Issue 3, pp. 323 - 335
AIDS caused by simian immunodeficiency virus (SIV) infection is associated with gastrointestinal disease, systemic immune activation, and, in cross-sectional... 
virome | SIV | vaccine | circovirus | adenovirus | AIDS | microbiome | picornavirus | RHESUS-MONKEYS | GUT | MICROBIOLOGY | MUCOSAL | COMMUNITIES | VIRUS TYPE-1 INFECTION | VIROLOGY | DISEASE | IMMUNE ACTIVATION | ENTERIC VIROME | CELL COUNT | PROGRESSION | PARASITOLOGY | Viruses - isolation & purification | Simian Immunodeficiency Virus - pathogenicity | Viruses - genetics | SAIDS Vaccines - administration & dosage | Gastrointestinal Diseases - prevention & control | Gastrointestinal Diseases - etiology | Gastrointestinal Microbiome | Macaca mulatta | Simian Acquired Immunodeficiency Syndrome - complications | Bacteria - genetics | Gastrointestinal Diseases - virology | Gastrointestinal Diseases - microbiology | CD4-Positive T-Lymphocytes - immunology | Genetic Variation | Viruses - classification | Bacteria - isolation & purification | Animals | SAIDS Vaccines - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | Bacteria - classification | Longitudinal Studies | Simian Acquired Immunodeficiency Syndrome - pathology | Simian Immunodeficiency Virus - immunology | Antigens | Medical colleges | AIDS vaccines | Wildlife conservation | Microbiology | Vaccination | Immunodeficiency | Development and progression | Monkeys | Prevention | Viral proteins | Adenoviruses | Gastrointestinal diseases | Simian immunodeficiency virus | Health aspects
Journal Article
The Lancet, ISSN 0140-6736, 07/2018, Volume 392, Issue 10143, pp. 232 - 243
More than 1·8 million new cases of HIV-1 infection were diagnosed worldwide in 2016. No licensed prophylactic HIV-1 vaccine exists. A major limitation to date... 
MEDICINE, GENERAL & INTERNAL | IPCAVD 001 | IMMUNOGENICITY | SAFETY | EFFICACY TRIAL | CELLULAR IMMUNE-RESPONSES | SIV CHALLENGES | ENV VACCINE | PREVENTION | INFECTION | PROTECTIVE EFFICACY | Back Pain - etiology | Abdominal Pain - etiology | Adenoviridae | Double-Blind Method | Aspartate Aminotransferases - analysis | Humans | Middle Aged | Fatigue - etiology | Macaca mulatta | Healthy Volunteers | AIDS Vaccines - adverse effects | Dose-Response Relationship, Drug | Young Adult | Dizziness - etiology | HIV-1 - immunology | Animals | Immunity, Humoral | Adolescent | Adult | Diarrhea - etiology | AIDS Vaccines - administration & dosage | Genetic Vectors | Immunity, Cellular | Clinical trials | Product development | Vaccines | HIV (Viruses) | Back pain | Pandemics | Laboratories | Aluminum | Viruses | Lymphocytes T | Monkeys | Infections | Dosage | Posture | Proteins | Prevention | Randomization | Pain | Gag protein | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Peripheral blood | Safety | Pharmaceutical industry | Vaccinia | Enzyme-linked immunosorbent assay | Binding | Antigens | Medical research | Phenotypes | Immune response | Effectiveness | Health risks | Diarrhea | Durability | Studies | Immunogenicity | Adenoviruses | Federal agencies | Aspartate aminotransferase | Phagocytosis
Journal Article