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index medicus (60) 60
carbonic anhydrase (47) 47
chemistry, medicinal (43) 43
sulfonamides (37) 37
biochemistry & molecular biology (36) 36
humans (28) 28
carbonic anhydrase inhibitors - chemistry (26) 26
carbonic anhydrase inhibitors - pharmacology (26) 26
chemistry, organic (23) 23
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carbonic anhydrases - metabolism (18) 18
discovery (18) 18
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potent (17) 17
sulfonamides - chemistry (16) 16
dose-response relationship, drug (15) 15
molecular docking (14) 14
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isozyme-ii (13) 13
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functional foods (11) 11
synthesis (11) 11
benzenesulfonamide (10) 10
benzenesulfonamides (10) 10
inhibition (10) 10
inhibitor (10) 10
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therapeutics. pharmacology (10) 10
carbonic anhydrase inhibitors (9) 9
carbonic anhydrase ix - antagonists & inhibitors (9) 9
xii (9) 9
animals (8) 8
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carbonic anhydrase ii - antagonists & inhibitors (8) 8
carbonic anhydrase ix - metabolism (8) 8
enzymes (8) 8
glaucoma (8) 8
sulfonamides - chemical synthesis (8) 8
tumors (8) 8
activators (7) 7
carbonic anhydrase ii - metabolism (7) 7
carbonic anhydrases - chemistry (7) 7
drug discovery (7) 7
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inhibitors (7) 7
models, molecular (7) 7
pharmacy (7) 7
research paper (7) 7
selective inhibitors (7) 7
zinc-binding group (7) 7
anticancer (6) 6
antigens, neoplasm - metabolism (6) 6
carbonic anhydrase inhibition (6) 6
chemistry, multidisciplinary (6) 6
crystal-structure (6) 6
drug design (6) 6
isatin (6) 6
isoenzymes - antagonists & inhibitors (6) 6
malassezia globosa (6) 6
acetazolamide (5) 5
agents (5) 5
antineoplastic agents - pharmacology (5) 5
carbonic anhydrase i - antagonists & inhibitors (5) 5
crystallography, x-ray (5) 5
docking (5) 5
expression (5) 5
fungi (5) 5
in-vitro (5) 5
isoenzymes - metabolism (5) 5
isoform-selective inhibitors (5) 5
ix inhibitors (5) 5
male (5) 5
metalloenzymes (5) 5
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phenols (5) 5
vii (5) 5
anion inhibition (4) 4
anti-tumor (4) 4
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antineoplastic agents - chemistry (4) 4
benzoxaborole (4) 4
carbonic anhydrases - drug effects (4) 4
cell line, tumor (4) 4
cell proliferation - drug effects (4) 4
chemical properties (4) 4
click chemistry (4) 4
coumarin (4) 4
coumarins (4) 4
coumarins - chemistry (4) 4
hypoxia (4) 4
molecular docking simulation (4) 4
selectivity (4) 4
triazoles - chemistry (4) 4
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Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 10/2019, Volume 29, Issue 10, pp. 805 - 815
Introduction: Glaucoma is a neurodegenerative disease of the eye characterized by selective retinal ganglion cell loss that provokes progressive defects in the... 
Glaucoma | ocular hypertension | α-adrenoceptor | modulator | β-adrenoceptor | drug delivery system | multi-target | combination
Journal Article
Expert Opinion on Drug Discovery, ISSN 1746-0441, 11/2019, Volume 14, Issue 11, pp. 1175 - 1197
Introduction: Of the 15 human carbonic anhydrase (CA, EC 4.2.1.1) isoforms known to date, for 11 the crystal structure is known. Many different classes of CA... 
X-ray crystallography | inhibition mechanism | Carbonic anhydrase | inhibitor | SLC-0111 | sulfonamide | coumarin | activator
Journal Article
Expert opinion on drug discovery, 08/2019, p. 1
: Of the 15 human carbonic anhydrase (CA, EC 4.2.1.1) isoforms known to date, for 11 the crystal structure is known. Many different classes of CA inhibitors... 
Journal Article
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2018, Volume 33, Issue 1, pp. 1453 - 1459
Bile acids have been shown to inhibit human (h) carbonic anhydrases (CA, EC 4.2.1.1) along the gastrointestinal tract, including hCA II. The elucidation of the... 
phenol | steroids | Carbonic anhydrase | inhibitor | bile acid | DESIGN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SULFONAMIDE | IX INHIBITORS | DISCOVERY | ENZYME | MALASSEZIA-GLOBOSA | PURIFICATION | ISOZYME-II | BILE-ACIDS | INSIGHTS
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 09/2019, Volume 20, Issue 19, p. 4724
The increase in the incidence of neurodegenerative diseases, in particular Alzheimer’s Disease (AD), is a consequence of the world′s population aging but... 
neurodegenerative diseases | aging | cognition | mitochondria | oxidative stress
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 1193 - 1198
A series of histamine bis-Schiff bases and bis-spinaceamine derivatives were synthesised and investigated as activators of four human (h) carbonic anhydrase... 
spinaceamine | histamine | activator | Carbonic anhydrase | proton shuttle | L-HISTIDINE | CHEMISTRY, MEDICINAL | SERIES | ACTIVE-SITE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTALLOGRAPHIC ANALYSIS | AMINES | BIOLOGICAL EVALUATION | ISOZYME-II | INHIBITORS
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 1078 - 1082
Journal Article
ISSN 1359-7345, 5/2019, Volume 55, Issue 4, pp. 572 - 5723
Epacadostat ( EPA ), a selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, has been investigated in vitro as a human (h) Carbonic Anhydrase Inhibitor... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2019, Volume 183, p. 111698
A library of twenty two novel 1,2,3-triazole benzenesulfonamides incorporating thiosemicarbazide, 5(4 )-thione-1,2,4-triazole and variously substituted... 
1,2,4-Triazole | Carbonic anhydrase inhibitors | Tail approach synthesis | 1,2,3-Triazole | CA isoforms | Benzenesulfonamide
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111638
Four new series of aromatic sulfamates were synthesized and investigated for the inhibition of four human (h) isoforms of zinc enzyme carbonic anhydrase (CA,... 
Carbonic anhydrase | Sulfamoylation | Aromatic sulfamates | Enzyme inhibition | Pyrazolines | Molecular docking | Zinc-binding group
Journal Article
ISSN 1359-7345, 1/2019, Volume 55, Issue 5, pp. 648 - 651
Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs),... 
Journal Article
Chemical Communications : Chem Comm, ISSN 1359-7345, 01/2019, Volume 55, Issue 5, pp. 648 - 651
Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs),... 
Inhibitors | Carbonic anhydrase | Aromatic compounds | Crystallography
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2017, Volume 32, Issue 1, pp. 722 - 730
Carbonic anhydrase IX (CA-IX) is a marker for tumor hypoxia, and its expression is negatively correlated with patient survival. CA-IX represents a potential... 
Carbonic anhydrase IX | fluorine-18 | molecular imaging | positron emission tomography | Enzymes | Medical imaging | Kidney cancer | Colorectal cancer | Tomography | Hypoxia | Cancer therapies | Pharmaceutical sciences | Tumors | Index Medicus
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2020, Volume 35, Issue 1, pp. 59 - 64
A primary strategy to combat antimicrobial resistance is the identification of novel therapeutic targets and anti-infectives with alternative mechanisms of... 
selectivity | carbonic anhydrase | inhibition | phosphonamidate | Virulence | resistance | virulence
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 04/2019, Volume 20, Issue 9, p. 2149
Ewing Sarcoma (ES) is an aggressive paediatric tumour where oxidative stress and antioxidants play a central role in cancer therapy response. Inhibiting... 
β3-adrenoreceptor | apigenin | Ewing Sarcoma
Journal Article
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