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Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 1215
Journal Article
Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 235
Journal Article
Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 1214
Journal Article
Diabetes, ISSN 0012-1797, 05/2018, Volume 67, Issue Supplement 1, p. 1785
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 312 - 318
Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | WHITE | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT HUMANS | BROWN ADIPOSE-TISSUE | IDENTIFICATION | CELL BIOLOGY | OBESITY | GENE | INFLAMMATION | EXPRESSION | Enkephalins - metabolism | Humans | Middle Aged | Ion Channels - genetics | Male | RNA, Messenger - metabolism | Enkephalins - genetics | Mitochondrial Proteins - metabolism | Diet, High-Fat | Iodide Peroxidase - metabolism | Adipocytes, Brown - transplantation | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Oxygen Consumption | Apoptosis Regulatory Proteins - metabolism | Protein Precursors - metabolism | Mice | Iodide Peroxidase - genetics | Blood Glucose - metabolism | Integrin beta1 - genetics | Adipocytes, White - metabolism | Glucose Intolerance - metabolism | Proprotein Convertase 1 - genetics | Adipocytes, Brown - metabolism | Homeostasis | Mitochondrial Proteins - genetics | DNA-Binding Proteins - metabolism | Polymerase Chain Reaction | Apoptosis Regulatory Proteins - genetics | Adult | Female | Capillaries | Glucose Tolerance Test | Protein Precursors - genetics | Proprotein Convertase 1 - metabolism | Cell Transplantation | Adipocytes, White - transplantation | DNA-Binding Proteins - genetics | Obesity - metabolism | Integrin beta1 - metabolism | Interleukin-33 - genetics | Animals | Ion Channels - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adipocytes - metabolism | Fluorescent Antibody Technique | Interleukin-33 - metabolism | Adipocytes - transplantation | Aged | Glucose Clamp Technique | Uncoupling Protein 1 | Neovascularization, Physiologic | Adipose tissues | Physiological aspects | Genetic aspects | Research | cytokine | human adipocyte | glucose | progenitors | adipokine | capillary | adrenergic | thermogenic adipose tissue | implant
Journal Article
Metabolism, ISSN 0026-0495, 04/2019, Volume 93, pp. 33 - 43
CEACAM1 regulates insulin sensitivity by promoting insulin clearance. Accordingly, global C57BL/6J. null mice display hyperinsulinemia due to impaired insulin... 
Hyperinsulinemia | Insulin clearance | Energy balance | Insulin resistance | Fatty acid synthase | Hyperphagia | Exercise | Synthesis | Analysis | Liver | Leptin | Mice | Fatty acids
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2008, Volume 49, Issue 10, pp. 2101 - 2112
Ceramide is among a number of potential lipotoxic molecules that are thought to modulate cellular energy metabolism. The heart is one of the tissues thought to... 
Heart | Glucose | Serine palmitoyltransferase | Lipotoxicity | Fatty acid | glucose | PROTEIN-KINASE-C | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | fatty acid | CARDIAC DYSFUNCTION | serine palmitoyltransferase | ENDOPLASMIC-RETICULUM STRESS | SATURATED FATTY-ACIDS | heart | INDUCED INSULIN-RESISTANCE | SPHINGOLIPID METABOLISM | SIGNAL-TRANSDUCTION | GLUCOSE-TRANSPORTER | lipotoxicity | Cardiomyopathy, Dilated - pathology | Fatty Acids, Monounsaturated - pharmacology | Humans | Heart Failure - physiopathology | Glycogen Synthase Kinase 3 beta | Serine C-Palmitoyltransferase - genetics | Cattle | Gene Deletion | Myocardium - metabolism | Cardiotoxins - antagonists & inhibitors | Phosphorylation - drug effects | Fatty Acids - metabolism | Lipoprotein Lipase - metabolism | Biomarkers - metabolism | Heart - physiopathology | Ceramides - metabolism | Oxidation-Reduction | Mice, Transgenic | Serine C-Palmitoyltransferase - antagonists & inhibitors | Survival Rate | Ceramides - antagonists & inhibitors | Heart Failure - metabolism | Heart Failure - pathology | Serine C-Palmitoyltransferase - metabolism | Glycogen Synthase Kinase 3 - metabolism | Cardiomyopathy, Dilated - metabolism | Gene Expression Regulation - drug effects | Animals | Myocytes, Cardiac - drug effects | Cardiomyopathy, Dilated - physiopathology | Glycosylphosphatidylinositols - metabolism | Glucose - metabolism | Heart - drug effects | Myocytes, Cardiac - metabolism | Mice | Cardiotoxins - metabolism | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2016, Volume 126, Issue 11, pp. 4372 - 4386
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant.... 
RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | DE-NOVO LIPOGENESIS | TRANSCRIPTION FACTOR FOXO1 | FATTY LIVER-DISEASE | OB/OB MICE | ELEMENT-BINDING PROTEIN | HEPATIC STEATOSIS | ADIPOSE-TISSUE | PLASMA TRIGLYCERIDES | Glucose Intolerance - metabolism | Glucose-6-Phosphatase - genetics | Fatty Liver - pathology | Humans | Male | Glucose - biosynthesis | Glucose Intolerance - pathology | Fatty Liver - chemically induced | Glycolysis - drug effects | Glycolysis - genetics | Lipogenesis - genetics | Female | Glucose Intolerance - chemically induced | Insulin - genetics | Nuclear Proteins - genetics | Fatty Liver - genetics | Forkhead Box Protein O1 - metabolism | Glucose Intolerance - genetics | Fatty Liver - metabolism | Fructose - toxicity | Insulin Resistance | Glucose - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | Glucose-6-Phosphatase - metabolism | Mice, Knockout | Transcription Factors - metabolism | Insulin - metabolism | Animals | Signal Transduction - drug effects | Lipogenesis - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Forkhead Box Protein O1 - genetics | Obesity | Analysis | Insulin resistance | Genetic aspects | Genetic transcription | Research | Risk factors | Protein binding | Glucose | Metabolites | Rodents | Liver
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2017, Volume 114, Issue 52, p. E11238
Sclerostin has traditionally been thought of as a local inhibitor of bone acquisition that antagonizes the profound osteoanabolic capacity of activated... 
Animal models | Adipose tissue | Wnt protein | Liver | Homeostasis | Viruses | SOST protein | Glucose | Adipocytes | Body composition | Genotype & phenotype | Tissue | β-catenin | Biomedical materials | Body composition (biology) | Bioaccumulation | Rodents | Biocompatibility | Skeleton | Diabetes mellitus | Metabolism | Insulin | Fatty acids | Signaling | Correlation analysis | Mice | Bone | Hypertrophy
Journal Article
Diagnostic Microbiology & Infectious Disease, ISSN 0732-8893, 2015, Volume 83, Issue 2, pp. 130 - 132
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 1991
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2019, Volume 116, Issue 24, pp. 11936 - 11945
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 1992
Journal Article
Nature Communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, p. 10686
Journal Article
Diabetologia, ISSN 0012-186X, 12/2017, Volume 60, Issue 12, pp. 2463 - 2474
The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1 −/−) or with... 
Insulin clearance | Human Physiology | Metabolic Diseases | Internal Medicine | Normoinsulinaemia | Lipolysis | Energy balance | CEACAM1 | Medicine & Public Health | Steatohepatitis | Insulin resistance | Fatty acid synthase | Hyperinsulinaemia | LIPID-METABOLISM | FOOD-INTAKE | HEPATIC CEACAM1 | HYPERINSULINEMIA | INDUCED INSULIN-RESISTANCE | CELL-ADHESION MOLECULE-1 | ENERGY-BALANCE | BODY-WEIGHT | ACID SYNTHASE INHIBITOR | Fatty acid | synthase | ENDOCRINOLOGY & METABOLISM | LEPTIN RESISTANCE | Fatty Liver - genetics | Hyperinsulinism - metabolism | Fatty Liver - metabolism | Fatty Acid Synthases - metabolism | Liver - metabolism | Carcinoembryonic Antigen - genetics | Male | Carcinoembryonic Antigen - metabolism | Lipolysis - genetics | Animals | Insulin Resistance - physiology | Insulin Resistance - genetics | Hyperinsulinism - genetics | Mice | Energy Metabolism - genetics | Energy Metabolism - physiology | Lipolysis - physiology | Fatty Acid Synthases - genetics | Synthesis | Analysis | Liver | Body weight | Genetic engineering | Fatty acids | Insulin | CEA (Oncology) | Body fat | Homeostasis | Hypothalamus | Metabolism | Fatty-acid synthase | Cell adhesion molecules | Genotype & phenotype | Carcinoembryonic antigen | Signal transduction | Clonal deletion | Rodents | CEACAM1 protein | Calorimetry | CD66 antigen | Hyperphagia
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2017, Volume 114, Issue 52, pp. E11238 - E11247
Sclerostin has traditionally been thought of as a local inhibitor of bone acquisition that antagonizes the profound osteoanabolic capacity of activated... 
Sclerostin | Adipose | Bone | Metabolism | Wnt | BONE-MINERAL DENSITY | MULTIDISCIPLINARY SCIENCES | bone | adipose | sclerostin | PLURIPOTENT STEM-CELLS | ANOREXIA-NERVOSA | SIGNALING PATHWAY | INSULIN-RESISTANCE | MOUSE MODEL | SERUM SCLEROSTIN | HUMAN OBESITY | metabolism | POSTMENOPAUSAL WOMEN | TYPE-2 DIABETES-MELLITUS | Glycoproteins | Observations | Health aspects | Body composition | Biological Sciences | PNAS Plus
Journal Article