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Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2008, Volume 51, Issue 15, pp. 4632 - 4640
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 2006, Volume 17, Issue 6, pp. 1373 - 1375
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e77448
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2012, Volume 55, Issue 23, pp. 10601 - 10609
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2014, Volume 289, Issue 30, pp. 20477 - 20488
Journal Article
Journal Article
AIDS Research and Human Retroviruses, ISSN 0889-2229, 10/2018, Volume 34, Issue S1, pp. 1 - 407
Journal Article
Structure, ISSN 0969-2126, 04/2016, Volume 24, Issue 4, pp. 502 - 508
Journal Article
Acta Crystallographica Section F, ISSN 2053-230X, 04/2019, Volume 75, Issue 4, pp. 239 - 245
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19681 - 19696
2',5'-Oligoadenylate synthetase (OAS) enzymes and RNase-L constitute a major effector arm of interferon (IFN)-mediated antiviral defense. OAS produces a unique... 
APOPTOSIS | INTERFERON | L PATHWAY | PROTEIN | REPLICATION | RNASE-L | BIOCHEMISTRY & MOLECULAR BIOLOGY | PURIFICATION | MITOCHONDRIA | 2-5A SYSTEM | BINDING | Interferon-alpha - pharmacology | Small Molecule Libraries - pharmacology | Endoribonucleases - genetics | Exoribonucleases - genetics | Encephalomyocarditis virus - genetics | Humans | Exoribonucleases - chemistry | Crystallography, X-Ray | Encephalomyocarditis virus - metabolism | Structure-Activity Relationship | Oligoribonucleotides - metabolism | Escherichia coli - metabolism | Respiratory Syncytial Viruses - metabolism | Antiviral Agents - pharmacology | Poly I-C - pharmacology | Adenine Nucleotides - immunology | Signal Transduction | Exoribonucleases - immunology | Gene Expression Regulation | Exoribonucleases - antagonists & inhibitors | Models, Molecular | Recombinant Proteins - chemistry | Small Molecule Libraries - chemical synthesis | Recombinant Proteins - genetics | Gene Knockout Techniques | Immunity, Innate | 2',5'-Oligoadenylate Synthetase - genetics | 2',5'-Oligoadenylate Synthetase - immunology | Recombinant Proteins - immunology | Adenine Nucleotides - metabolism | Escherichia coli - genetics | Respiratory Syncytial Viruses - genetics | Antiviral Agents - chemical synthesis | Rhinovirus - metabolism | HeLa Cells | Oligoribonucleotides - immunology | Rhinovirus - genetics | Endoribonucleases - immunology | protein structure | Molecular Bases of Disease | gene knockout | antiviral agent | innate immunity | interferon
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2010, Volume 17, Issue 7, pp. 808 - 814
Repression of gene transcription by the nuclear receptor Rev-erb alpha plays an integral role in the core molecular circadian clock. We report the crystal... 
RECRUITMENT | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORPHAN RECEPTOR | MOLECULAR DETERMINANTS | CELL BIOLOGY | COREPRESSOR | BIOPHYSICS | GENE | LIGAND-BINDING DOMAIN | THYROID-HORMONE RECEPTOR | TRANSCRIPTIONAL REGULATION | EXPRESSION
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 02/2019, Volume 62, Issue 3, pp. 1348 - 1361
A series of 5,6,7,8-tetrahydro-1,6-naphthyridine derivatives targeting the allosteric lens-epithelium-derived growth-factor-p75 (LEDGF/p75)-binding site on... 
BI 224436 | CHEMISTRY, MEDICINAL | RALTEGRAVIR | HIV-1 INTEGRASE | ACIDS | NCINI | RESISTANCE | LEDGF/P75 | INTEGRASE INHIBITOR | ALLOSTERIC INHIBITORS | DISCOVERY
Journal Article
Nature, ISSN 0028-0836, 02/2002, Volume 415, Issue 6873, pp. 813 - 817
Repression of gene transcription by nuclear receptors is mediated by interactions with co-repressor proteins such as SMRT and N-CoR, which in turn recruit... 
COREPRESSORS | COACTIVATOR | ACTIVATED RECEPTOR-GAMMA | PROMYELOCYTIC LEUKEMIA | RECOGNITION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTIONAL REPRESSION | SMRT | BINDING | HISTONE DEACETYLASE | HORMONE RECEPTORS
Journal Article