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1. Full Text Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
by Weiner, Daniel J and Wigdor, Emilie M and Ripke, Stephan and Walters, Raymond K and Kosmicki, Jack A and Grove, Jakob and Samocha, Kaitlin E and Goldstein, Jacqueline I and Okbay, Aysu and Bybjerg-Grauholm, Jonas and Werge, Thomas and Hougaard, David M and Taylor, Jacob and Skuse, David and Devlin, Bernie and Anney, Richard and Sanders, Stephan J and Bishop, Somer and Mortensen, Preben Bo and Børglum, Anders D and Smith, George Davey and Daly, Mark J and Robinson, Elise B and Bækvad-Hansen, Marie and Dumont, Ashley and Hansen, Christine and Hansen, Thomas F and Howrigan, Daniel and Mattheisen, Manuel and Moran, Jennifer and Mors, Ole and Nordentoft, Merete and Nørgaard-Pedersen, Bent and Poterba, Timothy and Poulsen, Jesper and Stevens, Christine and Anttila, Verneri and Holmans, Peter and Huang, Hailiang and Klei, Lambertus and Lee, Phil H and Medland, Sarah E and Neale, Benjamin and Weiss, Lauren A and Zwaigenbaum, Lonnie and Yu, Timothy W and Wittemeyer, Kerstin and Willsey, A Jeremy and Wijsman, Ellen M and Wassink, Thomas H and Waltes, Regina and Walsh, Christopher A and Wallace, Simon and Vorstman, Jacob A. S and Vieland, Veronica J and Vicente, Astrid M and Van Engeland, Herman and Tsang, Kathryn and Thompson, Ann P and Szatmari, Peter and Svantesson, Oscar and Steinberg, Stacy and Stefansson, Kari and Stefansson, Hreinn and State, Matthew W and Soorya, Latha and Silagadze, Teimuraz and Scherer, Stephen W and Schellenberg, Gerard D and Sandin, Sven and Saemundsen, Evald and Rouleau, Guy A and Rogé, Bernadette and Roeder, Kathryn and Roberts, Wendy and Reichert, Jennifer and Reichenberg, Abraham and Rehnström, Karola and Regan, Regina and Poustka, Fritz and Poultney, Christopher S and Piven, Joseph and Pinto, Dalila and Pericak-Vance, Margaret A and Pejovic-Milovancevic, Milica and Pedersen, Marianne G and Pedersen, Carsten B and Paterson, Andrew D and Parr, Jeremy R and Pagnamenta, Alistair T and Oliveira, Guiomar and Nurnberger, John I and Murtha, Michael T and Mouga, Susana and Morrow, Eric M and DeLuca, Daniel Moreno and Monaco, Anthony P and Minshew, Nancy and Merikangas, Alison and McMahon, William M and ... and Psychiat Genomics Consortium and iPSYCH-Broad Autism Grp and iPSYCH-Broad Autism Group and Psychiatric Genomics Consortium Autism Group and Gillberg Neuropsychiatry Centre and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Gillbergcentrum and Sahlgrenska Academy
Nature Genetics, ISSN 1061-4036, 07/2017, Volume 49, Issue 7, pp. 978 - 985
Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to... 
DE-NOVO | VARIANTS | GENETIC RISK | GENETICS & HEREDITY | MUTATIONS | SIMONS SIMPLEX COLLECTION | GENOME-WIDE ASSOCIATION | INSIGHTS | Autism Spectrum Disorder - genetics | Sequence Deletion | Genetic Predisposition to Disease | Genetic Association Studies | Humans | Risk Factors | Family Health | Genetics, Behavioral | Male | Educational Status | Intelligence - genetics | Multifactorial Inheritance | Intellectual Disability - genetics | Genetic Variation | Phenotype | Ethnic Groups - genetics | Schizophrenia - genetics | Autism Spectrum Disorder - epidemiology | Adult | Female | Child | Cohort Studies | Family | Genetic aspects | Genetic transformation | Research | Risk factors | Pervasive developmental disorders | Mental disorders | Intellectual disabilities | Disorders | Schizophrenia | Risk | Genomes | Cases (containers) | Subgroups | Educational attainment | Children & youth | Proteins | Studies | Consortia | Autism | Parents & parenting | Etiology | Population | Mutation | Children | Psychiatry | Index Medicus | Life Sciences | Neurons and Cognition | Neurologi | disease | biology | insights | variants | Genetics & Heredity | de-novo | Neurology | mutations | general-population | genetic risk | genome-wide association | loci
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2. Full Text Simultaneous Measurement of 25 Inflammatory Markers and Neurotrophins in Neonatal Dried Blood Spots by Immunoassay with xMAP Technology
by Skogstrand, Kristin and Thorsen, Poul and Norgaard-Pedersen, Bent and Schendel, Diana E and Sorensen, Line C and Hougaard, David M
Clinical Chemistry, ISSN 0009-9147, 10/2005, Volume 51, Issue 10, pp. 1854 - 1866
Background: Inflammatory reactions and other events in early life may be part of the etiology of late-onset diseases, including cerebral palsy, autism, and... 
FLOW-CYTOMETRIC ASSAYS | WHITE-MATTER LESIONS | HUMAN CYTOKINES | NEWBORN | PERIVENTRICULAR LEUKOMALACIA | CORD BLOOD | PRETERM INFANTS | SERUM | MEDICAL LABORATORY TECHNOLOGY | CEREBRAL-PALSY | INTERLEUKIN-6 | Enzyme-Linked Immunosorbent Assay - methods | Guinea Pigs | Humans | Membrane Glycoproteins - blood | Male | Reference Values | Neonatal Screening - methods | Enzyme-Linked Immunosorbent Assay - standards | Reference Standards | Animals | Triggering Receptor Expressed on Myeloid Cells-1 | Swine | Sensitivity and Specificity | Adult | Female | Nerve Growth Factors - blood | C-Reactive Protein - analysis | Blood Specimen Collection - methods | Infant, Newborn | Receptors, Immunologic - blood | Cytokines - blood | Cerebral palsy | Autism | Medical research | C-reactive protein | Genetic disorders | Infants (Premature) | Type 1 diabetes | Analysis | Medicine, Experimental | Development and progression | Medical screening | Growth factors | Index Medicus
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3. Full Text Toxoplasma Infection and Later Development of Schizophrenia in Mothers
by Pedersen, Marianne Giørtz and Stevens, Hanne and Pedersen, Carsten Bøcker and Nørgaard-Pedersen, Bent and Mortensen, Preben Bo
American Journal of Psychiatry, ISSN 0002-953X, 8/2011, Volume 168, Issue 8, pp. 814 - 821
Objective:Several studies based on clinical samples have found an association between Toxoplasma gondii infection and schizophrenia, and a case-control study... 
ANTIBODIES | SYSTEM | GONDII INFECTION | ACID | PSYCHIATRY | DISEASE | AGENTS | MOLECULAR MIMICRY | BRAIN | Toxoplasma - immunology | Prospective Studies | Follow-Up Studies | Immunoglobulin G - blood | Toxoplasmosis - immunology | Toxoplasmosis, Congenital - psychology | Humans | Male | Risk | Neonatal Screening | Toxoplasmosis, Congenital - immunology | Toxoplasmosis - epidemiology | Young Adult | Schizophrenia - diagnosis | Adult | Female | Toxoplasmosis, Congenital - epidemiology | Infant, Newborn | Cross-Sectional Studies | Toxoplasmosis - diagnosis | Schizophrenia - epidemiology | Pregnancy | Pregnancy Complications, Parasitic - immunology | Schizophrenia - immunology | Pregnancy Complications, Parasitic - diagnosis | Denmark | Pregnancy Complications, Parasitic - epidemiology | Pregnancy Complications, Parasitic - psychology | Toxoplasmosis - psychology | Toxoplasmosis, Congenital - diagnosis | Cohort Studies | Schizophrenia | Complications and side effects | Toxoplasmosis | Mothers | Health aspects | Risk factors | Infections | Parasites | Psychopathology | Health risk assessment | Index Medicus | Abridged Index Medicus | Infection | Mental disorders | Immunoglobulin G | Risk assessment | Military personnel | Military
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4. Full Text Common variants conferring risk of schizophrenia
by Stefansson, Hreinn and Ophoff, Roel A and Steinberg, Stacy and Aneassen, Ole A and Cichon, Sven and Rujescu, Dan and Werge, Thomas and Pietiläinen, Olli P. H and Mors, Ole and Mortensen, Preben B and Sigurdsson, Engilbert and Gustafsson, Omar and Nyegaard, Mette and Tuulio-Henriksson, Annamari and Ingason, Anes and Hansen, Thomas and Suvisaari, Jaana and Lonnqvist, Jouko and Paunio, Tiina and Børglum, Anders D and Hartmann, Annette and Fink-Jensen, Anders and Nordentoft, Merete and Hougaard, David and Norgaard-Pedersen, Bent and Böttcher, Yvonne and Olesen, Jes and Breuer, René and Möller, Hans-Jürgen and Giegling, Ina and Rasmussen, Henrik B and Timm, Sally and Mattheisen, Manuel and Bitter, István and Réthelyi, János M and Magnusdottir, Brynja B and Sigmundsson, Thordur and Olason, Pall and Masson, Gisli and Gulcher, Jeffrey R and Haraldsson, Magnus and Fossdal, Ragnheidur and Thorgeirsson, Thorgeir E and Thorsteinsdottir, Unnur and Ruggeri, Mirella and Tosato, Sarah and Franke, Barbara and Strengman, Eric and Kiemeney, Lambertus A and Melle, Ingrid and Djurovic, Srdjan and Abramova, Lilia and Kaleda, Vasily and Sanjuan, Julio and de Frutos, Rosa and Bramon, Elvira and Vassos, Evangelos and Fraser, Gillian and Ettinger, Ulrich and Picchioni, Marco and Walker, Nicholas and Toulopoulou, Timi and Need, Anna C and Ge, Dongliang and Yoon, Joeng Lim and Shianna, Kevin V and Freimer, Nelson B and Cantor, Rita M and Murray, Robin and Kong, Augustine and Golimbet, Vera and Carracedo, Angel and Arango, Celso and Costas, Javier and Jönsson, Erik G and Terenius, Lars and Agartz, Ingrid and Petursson, Hannes and Nöthen, Markus M and Rietschel, Marcella and Matthews, Paul M and Muglia, Pieranea and Peltonen, Leena and St Clair, David and Goldstein, David B and Stefansson, Kari and Collier, David A and Kahn, René S and Linszen, Don H and van Os, Jim and Wiersma, Durk and Bruggeman, Richard and Cahn, Wiepke and de Haan, Lieuwe and Krabbendam, Lydia and Myin-Germeys, Inez and GROUP and Genetic Risk and Outcome in Psychosis (GROUP)
Nature, ISSN 0028-0836, 2009, Volume 460, Issue 7256, pp. 744 - 747
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally... 
NEUROGRANIN | POPULATION | DISEASES | MENTAL-RETARDATION | GENE | MEMORY | MULTIDISCIPLINARY SCIENCES | 1Q21.1 | SCAN | DELETIONS | GENOME-WIDE ASSOCIATION | Neurogranin - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Transcription Factor 4 | Major Histocompatibility Complex - genetics | Humans | Genotype | Chromosomes, Human, Pair 11 - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Chromosomes, Human, Pair 6 - genetics | Genome, Human - genetics | Schizophrenia - immunology | Schizophrenia - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors | Genetic Markers - genetics | Polymorphism, Single Nucleotide - genetics | Chromosomes, Human, Pair 18 - genetics | Major histocompatibility complex | Schizophrenia | Development and progression | Genetic aspects | Research | Single nucleotide polymorphisms | Health aspects | Risk factors | Celiac disease | Genetics | Disease | Autoimmune diseases | Mass spectrometry | Index Medicus
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5. Full Text Perfluorooctane sulfonate concentrations in amniotic fluid, biomarkers of fetal leydig cell function, and cryptorchidism and hypospadias in Danish boys (1980-1996)
by Toft, Gunnar and Jönsson, Bo A.G and Bonde, Jens Peter and Nørgaard-Pedersen, Bent and Hougaard, David M and Cohen, Arieh and Lindh, Christian H and Ivell, Richard and Anand-Ive, Ravinder and Lindhard, Morten S and Applied Mass Spectrometry in Environmental Medicine and Tillämpad masspektrometri inom miljömedicin and Lund University and Avdelningen för arbets- och miljömedicin and Division of Occupational and Environmental Medicine, Lund University and Lunds universitet
Environmental Health Perspectives, ISSN 0091-6765, 01/2016, Volume 124, Issue 1, pp. 151 - 156
BACKGROUND: Exposure to perfluorooctane sulfonate (PFOS) may potentially disturb fetal Leydig cell hormone production and male genital development. OBJECTIVES:... 
STEROIDOGENESIS | ENDOCRINE | SERUM | HUMAN SEMEN QUALITY | ENVIRONMENTAL SCIENCES | IN-VITRO | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TOXICOLOGY | INSULIN-LIKE FACTOR-3 | INSL3 | PERFLUORINATED COMPOUNDS | EXPOSURE | HORMONES | Biomarkers - metabolism | Cryptorchidism - metabolism | Hypospadias - metabolism | Amniotic Fluid - metabolism | Leydig Cells - metabolism | Humans | Biomarkers - analysis | Fluorocarbons - metabolism | Alkanesulfonic Acids - analysis | Male | Alkanesulfonic Acids - metabolism | Fluorocarbons - analysis | Physiological aspects | Environmental aspects | Organofluorine compounds | Health aspects | Amniotic fluid | Leydig cells | Pregnancy | Testosterone | Surface active agents | Hypospadias | Cryptorchism | Mass spectrometry | Steroid hormones | Amniocentesis | Enzymes | Multiple births | Sperm | Prenatal development | Obstetrics | Studies | Mens health | Quality | Population | Health risk assessment | Index Medicus | Children's Health | Arbetsmedicin och miljömedicin | Hälsovetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Health Sciences | Environmental Health and Occupational Health
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6. Full Text Maternal CASPR2 antibodies and neurodevelopmental disorders in the offspring: epidemiological findings and an animal model
by Coutinho, Ester, Dr and Menassa, David, DPhil and Jacobson, Leslie, DPhil and West, Steven, DPhil and Domingos, Joana, MD and Moloney, Teresa, PhD and Pedersen, Marianne G, MSc and Benros, Michael E, PhD and Lang, Bethan, PhD and Bennett, David, PhD and Harrison, Paul J, PhD and Mortensen, Preben B, DrMedSc and Nørgaard-Pedersen, Bent, DrMedSc and Bannerman, David, PhD and Vincent, Angela, FRS
Lancet, The, ISSN 0140-6736, 2017, Volume 389, pp. S18 - S18
Abstract Background CNS disorders can be caused by IgG antibodies to neuronal surface proteins, and these antibodies have the potential to cross the placenta.... 
Internal Medicine | Proteins | Medicine, Experimental | Medical research | Epidemiology | Immunoglobulin G | Psychiatric services | Brain | Analysis | Disabled children | Social aspects | Mental illness
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7. Full Text Congenital toxoplasmosis—a report on the Danish neonatal screening programme 1999–2007
by Röser, Dennis and Nielsen, Henrik Vedel and Petersen, Eskild and Saugmann-Jensen, Peter and Nørgaard-Pedersen, Peter Bent
Journal of Inherited Metabolic Disease, ISSN 0141-8955, 10/2010, Volume 33, Issue S2, pp. 241 - 247
This paper reports on the national neonatal screening programme for congenital toxoplasmosis (CT) in Denmark conducted from 1999 to 2007, including background,... 
Biochemistry, general | Human Genetics | Pediatrics | Internal Medicine | Medicine & Public Health | Metabolic Diseases | SULFADIAZINE | PLASMA | PYRIMETHAMINE | MOTHER | INFANTS | SEQUELAE | ENDOCRINOLOGY & METABOLISM | GENETICS & HEREDITY | PRENATAL TREATMENT | INFECTION | CHILDREN | Toxoplasma - immunology | Leucovorin - administration & dosage | Predictive Value of Tests | Prevalence | Humans | Child, Preschool | Infant | National Health Programs | Antibodies, Protozoan - blood | Program Development | Sulfadiazine - administration & dosage | Pyrimethamine - administration & dosage | Time Factors | Toxoplasmosis, Congenital - epidemiology | Drug Therapy, Combination | Child | Infant, Newborn | Drug Administration Schedule | Treatment Outcome | Neonatal Screening - methods | Toxoplasmosis, Congenital - drug therapy | Immunoglobulin M - blood | Antiprotozoal Agents - administration & dosage | Denmark | Program Evaluation | Toxoplasmosis, Congenital - diagnosis | Index Medicus
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8. Full Text DNA methylome profiling using neonatal dried blood spot samples: A proof-of-principle study
by Hollegaard, Mads Vilhelm and Grauholm, Jonas and Nørgaard-Pedersen, Bent and Hougaard, David Michael
Molecular Genetics and Metabolism, ISSN 1096-7192, 04/2013, Volume 108, Issue 4, pp. 225 - 231
DNA methylation is the most common DNA modification and perhaps the best described epigenetic modification. It is believed to be important for genomic... 
DNA methylation | DBSS | Guthrie | Neonatal dried blood spot | Methylome | Epigenome | MEDICINE, RESEARCH & EXPERIMENTAL | COMMON VARIANTS | METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCHIZOPHRENIA | CANCER | CONFERRING RISK | PROMOTERS | DISEASE | GENETICS & HEREDITY | CEREBRAL-PALSY | Oligonucleotide Array Sequence Analysis | Humans | Genotype | DNA Methylation - genetics | Neonatal Screening | DNA Fingerprinting - methods | Specimen Handling | Blood Specimen Collection | DNA - analysis | Dried Blood Spot Testing - methods | Biological Specimen Banks | Genome | Infant, Newborn | Index Medicus
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9. Full Text CASPR2 autoantibodies are raised during pregnancy in mothers of children with mental retardation and disorders of psychological development but not autism
by Coutinho, Ester and Jacobson, Leslie and Pedersen, Marianne Giørtz and Benros, Michael Eriksen and Nørgaard-Pedersen, Bent and Mortensen, Preben Bo and Harrison, Paul J and Vincent, Angela
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 09/2017, Volume 88, Issue 9, pp. 718 - 721
Background, Methods and ObjectivesMaternal autoantibodies to neuronal proteins may be one cause of neurodevelopmental disorders. This exploratory study used... 
antibodies | CASPR2 | autism | intellectual disability | ANTIBODIES | SURGERY | SCHIZOPHRENIA | PSYCHIATRY | ENCEPHALITIS | CLINICAL NEUROLOGY | Mothers - psychology | Pregnancy | Autoantibodies - immunology | Nerve Tissue Proteins - immunology | Humans | Intellectual Disability - diagnosis | Denmark | Female | Membrane Proteins - immunology | Receptors, N-Methyl-D-Aspartate | Brain - immunology | Infant, Newborn | Reports | Autoantibodies | Research | Mental retardation | Psychology | Encephalitis | Immunoglobulins | Intellectual disabilities | Fetuses | Schizophrenia | Mothers | Children & youth | Studies | Psychosis | Proteins | Autism | Brain research | Womens health | Psychiatry | Public health | Index Medicus | Neuropsychiatry | 1272 | 1506
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10. Full Text Phthalates and Perfluorooctanesulfonic Acid in Human Amniotic Fluid: Temporal Trends and Timing of Amniocentesis in Pregnancy
by Morten Søndergaard Jensen and Bent Nørgaard-Pedersen and Gunnar Toft and David M. Hougaard and Jens Peter Bonde and Arieh Cohen and Ane Marie Thulstrup and Richard Ivell and Ravinder Anand-Ivell and Christian H. Lindh and Bo A.G. Jönsson and Lund University and Avdelningen för arbets- och miljömedicin and Division of Occupational and Environmental Medicine, Lund University and Lunds universitet
Environmental Health Perspectives, ISSN 0091-6765, 6/2012, Volume 120, Issue 6, pp. 897 - 903
Background: Measures of prenatal environmental exposures are important, and amniotic fluid levels may directly reflect fetal exposures during hypothesized... 
Pregnancy | Chemical hazards | Amniocentesis | Maternal age | Metabolites | Amniotic fluid | Patent foramen ovale | Pollutants | Phthalates | Gestational age | Children's Health | Biomonitoring | Biobank | Perfluorinated compounds | Temporal trend | POPULATION | amniocentesis | METABOLITES | biomonitoring | PLACENTA PERFUSION SYSTEM | PERFLUOROALKYL ACIDS | temporal trend | pregnancy | DI(2-ETHYLHEXYL) PHTHALATE | perfluorinated compounds | amniotic fluid | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MATERNAL SERUM | TOXICOLOGY | UMBILICAL-CORD BLOOD | SAMPLES | phthalates | biobank | EXPOSURE | Humans | Linear Models | Male | Gestational Age | Maternal Exposure - statistics & numerical data | Amniotic Fluid - chemistry | Mass Spectrometry | Amniocentesis - methods | Phthalic Acids - analysis | Chromatography, Liquid | Denmark | Alkanesulfonic Acids - analysis | Female | Environmental Pollutants - analysis | Fluorocarbons - analysis | Environmental aspects | Physiological aspects | Properties | Health aspects | Biological monitoring | Methods | Index Medicus | Research | Hälsovetenskap | perfluorinated | Medical and Health Sciences | Medicin och hälsovetenskap | Environmental Health and Occupational Health | Arbetsmedicin och miljömedicin | compounds | Health Sciences
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