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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, ISSN 0098-7484, 01/2019, Volume 321, Issue 1, pp. 69 - 79
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 10/2014, Volume 12, Issue 37, pp. 7261 - 7269
The advent of Adcetris™ and Kadcyla™, two recently FDA-approved antibody-drug conjugates (ADCs), in the clinic has had a major impact on the treatment of... 
Disulfides - chemistry | Antibodies - chemistry | Maleimides - chemical synthesis | Doxorubicin - chemistry | Molecular Structure | Maleimides - chemistry | Trastuzumab | Antibodies, Monoclonal, Humanized - chemistry
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0520, 04/2017, Volume 15, Issue 14, pp. 2947 - 2952
Disulfide bridging offers a convenient approach to generate site-selective antibody conjugates from native antibodies. To optimise the reagents available to... 
Journal Article
Circulation, ISSN 0009-7322, 01/2019, Volume 139, Issue 3, pp. 351 - 361
Background: Individuals with type 2 diabetes mellitus are at increased risk for heart failure (HF), particularly those with coexisting atherosclerotic... 
chronic kidney diseases | MORTALITY | cardiovascular disease | heart failure | EVENTS | SAXAGLIPTIN | SITAGLIPTIN | type 2 diabetes mellitus | ASSOCIATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PERIPHERAL VASCULAR DISEASE | Heart failure | Diabetics | Patient outcomes | Kidney diseases | Cardiovascular diseases | Health aspects | Risk factors
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 08/2015, Volume 13, Issue 29, pp. 7946 - 7949
Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine... 
HALF-LIFE | IN-VITRO | IMPACT | PROTEIN | STABILITY | CHEMISTRY, ORGANIC | DELIVERY | Albumins - chemistry | Hydrolysis | Protein Structure, Secondary | Click Chemistry | Humans | Mass Spectrometry | Sulfhydryl Compounds - chemistry | Cysteine - chemistry | Maleates - chemistry | Hydrogen-Ion Concentration
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2017, Volume 15, Issue 14, pp. 2947 - 2952
Disulfide bridging offers a convenient approach to generate site-selective antibody conjugates from native antibodies. To optimise the reagents available to... 
DRUG | POLYMERS | IMPACT | POTENT | STABILIZATION | STABILITY | CONSTRUCTION | CHEMISTRY, ORGANIC | ADCS | LINKER | PHARMACOLOGICAL-PROPERTIES
Journal Article
by Sullivan, Patrick and Yuan, Maoli and Coleman, John and Destefano, Joanne and Zhang, Xinsheng and Yates, Nicole and Barouch, Dan and Ackerman, Margaret and Decamp, Allan and Alter, Galit and Tomaras, Georgia and Tomaras, Georgia and Montefiori, David and Montefiori, David and Rasmussen, Beth and Morrow, Gavin and Koff, Wayne and Kashuba, Angela and Kashuba, Angela and Mascola, John and Picker, Louis and Kent, Stephen and Selhorst, Philippe and Masson, Lindi and Ngandu, Nobubelo and Rademeyer, Cecilia and Karim, Quarraisha Abdool and Kijak, Gustavo and Barouch, Dan and Rasheed, Ata Ur and Havenar-Daughton, Colin and Pham, Matthew and Kovalenkov, Yevgeniy and Gumber, Sanjeev and Johnson, Matthew and Wrammert, Jens and Villinger, Francois and Haynes, Barton and Haynes, Barton and Fox, Christopher and Reed, Steve and Vasilakos, John and Tomai, Mark and Crotty, Shane and Ahmed, Rafi and Pulendran, Bali and Fukazawa, Yoshinori and Lifson, Jeffrey and Lifson, Jeffrey and Moore, Penny and Chatora, Kumbirai and Skorochod, Elisabeth and Madidi, Ngonidzashe and Gomez, Anabel and Ncube, Getrude and Sundaram, Maaya and Kretschmer, Steve and Pauthner, Matthias and Briney, Bryan and Lee, Jeong Hyun and Saye-Francisco, Karen and Hsueh, Jessica and Ramos, Alejandra and Le, Khoa and Jones, Meaghan and Jardine, Joseph and Bastidas, Raiza and Sarkar, Anita and Liang, Chi-Hui and Wilson, Ian and Ward, Andrew and Zhu, Jiang and Poignard, Pascal and Burton, Dennis and Krebs, Shelly and Law, Wiliam and Gift, Syna and Chenine, Agnes and Rolland, Morgane and Moody, M. Anthony and Jarosinski, Marissa and Georgiev, Ivelin and Chuang, Gwo-Yu and Chuang, Gwo-Yu and Asokan, Mangaiarkarasi and Bailer, Robert T and Cale, Evan M and Louder, Mark and Kwong, Peter D and Polonis, Victoria and Tovanabutra, Sodsai and Robb, Merlin and Mascola, John R and Wibmer, Constantinos Kurt and Wibmer, Constantinos Kurt and Madzorera, Vimbai S and Doria-Rose, Nicole A and Morris, Lynn and Moore, Penny L and Anthony, Colin and ...
AIDS Research and Human Retroviruses, ISSN 0889-2229, 10/2016, Volume 32, Issue S1, pp. 1 - 409
Journal Article
RSC Advances, ISSN 2046-2069, 2017, Volume 7, Issue 15, pp. 9073 - 9077
Herein we report the use of pyridazinediones to functionalise the native solvent accessible interstrand disulfide bonds in trastuzumab with monomethyl... 
Journal Article
RSC Advances, ISSN 2046-2069, 2017, Volume 7, Issue 15, pp. 9073 - 9077
Herein we report the use of pyridazinediones to functionalise the native solvent accessible interstrand disulfide bonds in trastuzumab with monomethyl... 
THERAPEUTIC INDEX | BREAST-CANCER | ATTACHMENT | REAGENTS | TRASTUZUMAB | BIOCONJUGATION | LINKER STABILITY | STRATEGY | TECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | SITE-SPECIFIC CONJUGATION | Drugs | Conjugates | Biotechnology | Drug delivery systems | Effectiveness | Accessibility | Conjugation | Bonding
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 10/2014, Volume 12, Issue 37, pp. 7261 - 7269
The advent of Adcetris (TM) and Kadcyla (TM), two recently FDA-approved antibody-drug conjugates (ADCs), in the clinic has had a major impact on the treatment... 
THERAPEUTIC INDEX | BREAST-CANCER | TRASTUZUMAB | LINKERS | STABILITY | DOXORUBICIN | CHEMISTRY, ORGANIC | BRENTUXIMAB VEDOTIN SGN-35 | MONOCLONAL-ANTIBODIES | CANCER-THERAPY | DELIVERY
Journal Article
RSC Advances, ISSN 2046-2069, 2017, Volume 7, Issue 40, pp. 24828 - 24832
Herein we demonstrate that conjugation of a next generation maleimide (NGM) to engineered cysteines in a THIOMAB (TM) antibody delivers a THIOMAB (TM)... 
THERAPEUTIC INDEX | PROTEIN | EFFICACY | PHARMACOKINETICS | BIOCONJUGATION | AMINO-ACIDS | STABILITY | ENABLES | ADCS | CHEMISTRY, MULTIDISCIPLINARY | SITE-SPECIFIC CONJUGATION | Conjugates | Biotechnology | Cysteine | Antibodies | Conjugation | Criteria | Serums | Blood
Journal Article
Molecular Genetics and Metabolism, ISSN 1096-7192, 09/2017, Volume 122, Issue 1-2, pp. 4 - 17
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 07/2013, Volume 54, Issue 27, pp. 3493 - 3495
Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of... 
Thiomaleimides | Reagent synthesis | Bromomaleimides | Pyridazinediones | Reagents for cysteine modification | PROTEIN | BIOCONJUGATION | CHEMISTRY, ORGANIC | Proteins | Tetrahedrons | Synthesis (chemistry)
Journal Article
RSC Advances, ISSN 2046-2069, 2017, Volume 7, Issue 40, pp. 24828 - 24832
Herein we demonstrate that conjugation of a next generation maleimide (NGM) to engineered cysteines in a THIOMAB™ antibody delivers a THIOMAB™ antibody-drug... 
Journal Article